3PPMA

Crystal structure of a noncovalently bound alpha-ketoheterocycle inhibitor (phenhexyl/oxadiazole/pyridine) to a humanized variant of fatty acid amide hydrolase
Total Genus 224
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
224
sequence length
546
structure length
546
Chain Sequence
GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSTGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNNMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Fatty-acid amide hydrolase 1
publication title Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent alpha-ketoheterocycle inhibitor of fatty acid amide hydrolase.
pubmed doi rcsb
source organism Rattus norvegicus
total genus 224
structure length 546
sequence length 546
chains with identical sequence B
ec nomenclature ec 3.5.1.99: Fatty acid amide hydrolase.
pdb deposition date 2010-11-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01425 Amidase Amidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1300.10 Alpha Beta Alpha-Beta Complex Amidase signature (AS) enzymes Amidase signature (AS) domain 3ppmA00
3LJ6A 3A2QA 2GI3A 3IP4A 3K83A 2WAPA 3QJ8A 4DO3A 2F2AA 3LJ7A 2VYAA 2WJ2A 2DQNA 3PR0A 2DF4A 4GYSA 4N0HA 2G5HA 3PPMA 3QK5A 3A1IA 3K84A 1OBKA 4CP8A 3KFUE 3QKVA 4GYRA 3K7FA 2DC0A 4ISSA 1OCHA 1M22A 3H0MA 1O9OA 3QJ9A 1O9NA 1O9QA 1OBLA 2WJ1A 1OBIA 1OCLA 4HBPA 3AL0A 3A1KA 4ISTA 4WJ3A 3H0LA 4N0IA 3H0RA 5EWQA 5AC3A 4YJ6A 3A2PA 3OJ8A 1OCKA 4J5PA 1OBJA 4YJIA 1O9PA 1M21A 1MT5A 1OCMA 2G5IA
chains in the Genus database with same CATH superfamily
3LJ6A 3A2QA 2GI3A 3IP4A 3K83A 2WAPA 3QJ8A 4DO3A 2F2AA 3LJ7A 2VYAA 2WJ2A 2DQNA 3PR0A 2DF4A 4GYSA 4N0HA 2G5HA 3PPMA 3QK5A 3A1IA 3K84A 1OBKA 4CP8A 3KFUE 3QKVA 4GYRA 3K7FA 2DC0A 4ISSA 1OCHA 1M22A 3H0MA 1O9OA 3QJ9A 1O9NA 1O9QA 1OBLA 2WJ1A 1OBIA 1OCLA 4HBPA 3AL0A 3A1KA 4ISTA 4WJ3A 3H0LA 4N0IA 3H0RA 5EWQA 5AC3A 4YJ6A 3A2PA 3OJ8A 1OCKA 4J5PA 1OBJA 4YJIA 1O9PA 1M21A 1MT5A 1OCMA 2G5IA
chains in the Genus database with same CATH topology
3LJ6A 3A2QA 2GI3A 3IP4A 3K83A 2WAPA 3QJ8A 4DO3A 2F2AA 3LJ7A 2VYAA 2WJ2A 2DQNA 3PR0A 2DF4A 4GYSA 4N0HA 2G5HA 3PPMA 3QK5A 3A1IA 3K84A 1OBKA 4CP8A 3KFUE 3QKVA 4GYRA 3K7FA 2DC0A 4ISSA 1OCHA 1M22A 3H0MA 1O9OA 3QJ9A 1O9NA 1O9QA 1OBLA 2WJ1A 1OBIA 1OCLA 4HBPA 3AL0A 3A1KA 4ISTA 4WJ3A 3H0LA 4N0IA 3H0RA 5EWQA 5AC3A 4YJ6A 3A2PA 3OJ8A 1OCKA 4J5PA 1OBJA 4YJIA 1O9PA 1M21A 1MT5A 1OCMA 2G5IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LJ6 A;  3A2Q A;  2GI3 A;  3IP4 A;  3K83 A;  2WAP A;  3QJ8 A;  4DO3 A;  2F2A A;  3LJ7 A;  2VYA A;  2WJ2 A;  2DQN A;  3PR0 A;  2DF4 A;  4GYS A;  4N0H A;  2G5H A;  3PPM A;  3QK5 A;  3A1I A;  3K84 A;  1OBK A;  4CP8 A;  3KFU E;  3QKV A;  4GYR A;  3K7F A;  2DC0 A;  4ISS A;  1OCH A;  1M22 A;  3H0M A;  1O9O A;  3QJ9 A;  1O9N A;  1O9Q A;  1OBL A;  2WJ1 A;  1OBI A;  1OCL A;  4HBP A;  3AL0 A;  3A1K A;  4IST A;  4WJ3 A;  3H0L A;  4N0I A;  3H0R A;  5EWQ A;  5AC3 A;  4YJ6 A;  3A2P A;  3OJ8 A;  1OCK A;  4J5P A;  1OBJ A;  4YJI A;  1O9P A;  1M21 A;  1MT5 A;  1OCM A;  2G5I A; 
#chains in the Genus database with same CATH topology
 3LJ6 A;  3A2Q A;  2GI3 A;  3IP4 A;  3K83 A;  2WAP A;  3QJ8 A;  4DO3 A;  2F2A A;  3LJ7 A;  2VYA A;  2WJ2 A;  2DQN A;  3PR0 A;  2DF4 A;  4GYS A;  4N0H A;  2G5H A;  3PPM A;  3QK5 A;  3A1I A;  3K84 A;  1OBK A;  4CP8 A;  3KFU E;  3QKV A;  4GYR A;  3K7F A;  2DC0 A;  4ISS A;  1OCH A;  1M22 A;  3H0M A;  1O9O A;  3QJ9 A;  1O9N A;  1O9Q A;  1OBL A;  2WJ1 A;  1OBI A;  1OCL A;  4HBP A;  3AL0 A;  3A1K A;  4IST A;  4WJ3 A;  3H0L A;  4N0I A;  3H0R A;  5EWQ A;  5AC3 A;  4YJ6 A;  3A2P A;  3OJ8 A;  1OCK A;  4J5P A;  1OBJ A;  4YJI A;  1O9P A;  1M21 A;  1MT5 A;  1OCM A;  2G5I A; 
#chains in the Genus database with same CATH homology
 3LJ6 A;  3A2Q A;  2GI3 A;  3IP4 A;  3K83 A;  2WAP A;  3QJ8 A;  4DO3 A;  2F2A A;  3LJ7 A;  2VYA A;  2WJ2 A;  2DQN A;  3PR0 A;  2DF4 A;  4GYS A;  4N0H A;  2G5H A;  3PPM A;  3QK5 A;  3A1I A;  3K84 A;  1OBK A;  4CP8 A;  3KFU E;  3QKV A;  4GYR A;  3K7F A;  2DC0 A;  4ISS A;  1OCH A;  1M22 A;  3H0M A;  1O9O A;  3QJ9 A;  1O9N A;  1O9Q A;  1OBL A;  2WJ1 A;  1OBI A;  1OCL A;  4HBP A;  3AL0 A;  3A1K A;  4IST A;  4WJ3 A;  3H0L A;  4N0I A;  3H0R A;  5EWQ A;  5AC3 A;  4YJ6 A;  3A2P A;  3OJ8 A;  1OCK A;  4J5P A;  1OBJ A;  4YJI A;  1O9P A;  1M21 A;  1MT5 A;  1OCM A;  2G5I A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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