3PR0A

Crystal structure of a covalently bound alpha-ketoheterocycle inhibitor (phenhexyl/oxadiazole/pyridine) to a humanized variant of fatty acid amide hydrolase
Total Genus 225
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
225
sequence length
545
structure length
545
Chain Sequence
GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSTGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNNMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Fatty Acid Amide Hydrolase 1
publication title Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent alpha-ketoheterocycle inhibitor of fatty acid amide hydrolase.
pubmed doi rcsb
source organism Rattus norvegicus
total genus 225
structure length 545
sequence length 545
chains with identical sequence B
ec nomenclature ec 3.5.1.99: Fatty acid amide hydrolase.
pdb deposition date 2010-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01425 Amidase Amidase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1300.10 Alpha Beta Alpha-Beta Complex Amidase signature (AS) enzymes Amidase signature (AS) domain 3pr0A00
2F2AA 3LJ7A 3H0MA 1OBKA 3A1IA 3A2PA 3PPMA 3QJ8A 4HBPA 4ISTA 4N0HA 1M22A 4ISSA 4YJ6A 4DO3A 3PR0A 2DF4A 2DQNA 2WJ2A 3QJ9A 1O9NA 1OCMA 2VYAA 4GYRA 5AC3A 1OBIA 1O9OA 3H0RA 4GYSA 5EWQA 1MT5A 1OCLA 3LJ6A 3QK5A 4WJ3A 3K83A 3QKVA 1O9QA 2G5IA 2WJ1A 3H0LA 3OJ8A 2G5HA 1OCKA 3KFUE 3A1KA 1M21A 4CP8A 4J5PA 3K84A 2GI3A 3A2QA 1OCHA 1O9PA 3IP4A 4YJIA 2DC0A 1OBLA 4N0IA 2WAPA 1OBJA 3AL0A 3K7FA
chains in the Genus database with same CATH superfamily
2F2AA 3LJ7A 3H0MA 1OBKA 3A1IA 3A2PA 3PPMA 3QJ8A 4HBPA 4ISTA 4N0HA 1M22A 4ISSA 4YJ6A 4DO3A 3PR0A 2DF4A 2DQNA 2WJ2A 3QJ9A 1O9NA 1OCMA 2VYAA 4GYRA 5AC3A 1OBIA 1O9OA 3H0RA 4GYSA 5EWQA 1MT5A 1OCLA 3LJ6A 3QK5A 4WJ3A 3K83A 3QKVA 1O9QA 2G5IA 2WJ1A 3H0LA 3OJ8A 2G5HA 1OCKA 3KFUE 3A1KA 1M21A 4CP8A 4J5PA 3K84A 2GI3A 3A2QA 1OCHA 1O9PA 3IP4A 4YJIA 2DC0A 1OBLA 4N0IA 2WAPA 1OBJA 3AL0A 3K7FA
chains in the Genus database with same CATH topology
2F2AA 3LJ7A 3H0MA 1OBKA 3A1IA 3A2PA 3PPMA 3QJ8A 4HBPA 4ISTA 4N0HA 1M22A 4ISSA 4YJ6A 4DO3A 3PR0A 2DF4A 2DQNA 2WJ2A 3QJ9A 1O9NA 1OCMA 2VYAA 4GYRA 5AC3A 1OBIA 1O9OA 3H0RA 4GYSA 5EWQA 1MT5A 1OCLA 3LJ6A 3QK5A 4WJ3A 3K83A 3QKVA 1O9QA 2G5IA 2WJ1A 3H0LA 3OJ8A 2G5HA 1OCKA 3KFUE 3A1KA 1M21A 4CP8A 4J5PA 3K84A 2GI3A 3A2QA 1OCHA 1O9PA 3IP4A 4YJIA 2DC0A 1OBLA 4N0IA 2WAPA 1OBJA 3AL0A 3K7FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2F2A A;  3LJ7 A;  3H0M A;  1OBK A;  3A1I A;  3A2P A;  3PPM A;  3QJ8 A;  4HBP A;  4IST A;  4N0H A;  1M22 A;  4ISS A;  4YJ6 A;  4DO3 A;  3PR0 A;  2DF4 A;  2DQN A;  2WJ2 A;  3QJ9 A;  1O9N A;  1OCM A;  2VYA A;  4GYR A;  5AC3 A;  1OBI A;  1O9O A;  3H0R A;  4GYS A;  5EWQ A;  1MT5 A;  1OCL A;  3LJ6 A;  3QK5 A;  4WJ3 A;  3K83 A;  3QKV A;  1O9Q A;  2G5I A;  2WJ1 A;  3H0L A;  3OJ8 A;  2G5H A;  1OCK A;  3KFU E;  3A1K A;  1M21 A;  4CP8 A;  4J5P A;  3K84 A;  2GI3 A;  3A2Q A;  1OCH A;  1O9P A;  3IP4 A;  4YJI A;  2DC0 A;  1OBL A;  4N0I A;  2WAP A;  1OBJ A;  3AL0 A;  3K7F A; 
#chains in the Genus database with same CATH topology
 2F2A A;  3LJ7 A;  3H0M A;  1OBK A;  3A1I A;  3A2P A;  3PPM A;  3QJ8 A;  4HBP A;  4IST A;  4N0H A;  1M22 A;  4ISS A;  4YJ6 A;  4DO3 A;  3PR0 A;  2DF4 A;  2DQN A;  2WJ2 A;  3QJ9 A;  1O9N A;  1OCM A;  2VYA A;  4GYR A;  5AC3 A;  1OBI A;  1O9O A;  3H0R A;  4GYS A;  5EWQ A;  1MT5 A;  1OCL A;  3LJ6 A;  3QK5 A;  4WJ3 A;  3K83 A;  3QKV A;  1O9Q A;  2G5I A;  2WJ1 A;  3H0L A;  3OJ8 A;  2G5H A;  1OCK A;  3KFU E;  3A1K A;  1M21 A;  4CP8 A;  4J5P A;  3K84 A;  2GI3 A;  3A2Q A;  1OCH A;  1O9P A;  3IP4 A;  4YJI A;  2DC0 A;  1OBL A;  4N0I A;  2WAP A;  1OBJ A;  3AL0 A;  3K7F A; 
#chains in the Genus database with same CATH homology
 2F2A A;  3LJ7 A;  3H0M A;  1OBK A;  3A1I A;  3A2P A;  3PPM A;  3QJ8 A;  4HBP A;  4IST A;  4N0H A;  1M22 A;  4ISS A;  4YJ6 A;  4DO3 A;  3PR0 A;  2DF4 A;  2DQN A;  2WJ2 A;  3QJ9 A;  1O9N A;  1OCM A;  2VYA A;  4GYR A;  5AC3 A;  1OBI A;  1O9O A;  3H0R A;  4GYS A;  5EWQ A;  1MT5 A;  1OCL A;  3LJ6 A;  3QK5 A;  4WJ3 A;  3K83 A;  3QKV A;  1O9Q A;  2G5I A;  2WJ1 A;  3H0L A;  3OJ8 A;  2G5H A;  1OCK A;  3KFU E;  3A1K A;  1M21 A;  4CP8 A;  4J5P A;  3K84 A;  2GI3 A;  3A2Q A;  1OCH A;  1O9P A;  3IP4 A;  4YJI A;  2DC0 A;  1OBL A;  4N0I A;  2WAP A;  1OBJ A;  3AL0 A;  3K7F A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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