3A7SA

Catalytic domain of uch37
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
Knots found
sequence length
220
structure length
204
Chain Sequence
EWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNAAATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Ubiquitin carboxyl-terminal hydrolase isozyme L5
total genus 59
structure length 204
sequence length 220
other databases KnotProt 2.0: K -52 -31 -31
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2009-10-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01088 Peptidase_C12 Ubiquitin carboxyl-terminal hydrolase, family 1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.532.10 Alpha Beta 3-Layer(aba) Sandwich Ubiquitin C-terminal Hydrolase UCH-l3 Peptidase C12, ubiquitin carboxyl-terminal hydrolase 3a7sA00
1CMXA 4IG7A 4JKJA 3IFWA 4DM9A 3KW5A 3IRTA 2LENA 3RIIA 3RISA 4UEMA 4I6NA 1UCHA 3KVFA 3A7SA 3TB3A 4UELA 3IHRA 1XD3A 2ETLA
chains in the Genus database with same CATH superfamily
1CMXA 4IG7A 4JKJA 3IFWA 4DM9A 3KW5A 3IRTA 2LENA 3RIIA 3RISA 4UEMA 4I6NA 1UCHA 3KVFA 3A7SA 3TB3A 4UELA 3IHRA 1XD3A 2ETLA
chains in the Genus database with same CATH topology
1CMXA 4IG7A 4JKJA 3IFWA 4DM9A 3KW5A 3IRTA 2LENA 3RIIA 3RISA 4UEMA 4I6NA 1UCHA 3KVFA 3A7SA 3TB3A 4UELA 3IHRA 1XD3A 2ETLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1CMX A;  4IG7 A;  4JKJ A;  3IFW A;  4DM9 A;  3KW5 A;  3IRT A;  2LEN A;  3RII A;  3RIS A;  4UEM A;  4I6N A;  1UCH A;  3KVF A;  3A7S A;  3TB3 A;  4UEL A;  3IHR A;  1XD3 A;  2ETL A; 
#chains in the Genus database with same CATH topology
 1CMX A;  4IG7 A;  4JKJ A;  3IFW A;  4DM9 A;  3KW5 A;  3IRT A;  2LEN A;  3RII A;  3RIS A;  4UEM A;  4I6N A;  1UCH A;  3KVF A;  3A7S A;  3TB3 A;  4UEL A;  3IHR A;  1XD3 A;  2ETL A; 
#chains in the Genus database with same CATH homology
 1CMX A;  4IG7 A;  4JKJ A;  3IFW A;  4DM9 A;  3KW5 A;  3IRT A;  2LEN A;  3RII A;  3RIS A;  4UEM A;  4I6N A;  1UCH A;  3KVF A;  3A7S A;  3TB3 A;  4UEL A;  3IHR A;  1XD3 A;  2ETL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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