4JDDA

14-3-3 protein interaction with estrogen receptor alpha provides a novel drug target interface
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
236
structure length
236
Chain Sequence
GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein/peptide
molecule keywords 14-3-3 protein sigma
publication title Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface.
pubmed doi rcsb
source organism Homo sapiens
total genus 99
structure length 236
sequence length 236
ec nomenclature
pdb deposition date 2013-02-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 4jddA00
3SMKA 3AXYC 3UALA 1O9EA 3UX0A 4J6SA 4Y3BA 5BTVA 4IHLA 3O8IA 2BTPA 4F7RA 5F74A 5D2DA 4DHOA 3P1PA 1O9CA 3LW1A 4BG6A 2BQ0A 2WH0A 4WRQA 1A4OA 1O9FA 3SMOA 3U9XA 2B05A 1YZ5A 2C74A 3MHRA 3P1RA 3P1SA 4JC3A 4O46A 4Y5IA 2BR9A 2O98A 2NPMA 4DX0A 4GNTA 3SMMA 3E6YA 3EFZA 4FJ3A 4DHNA 4DAUA 3SPRA 5LHOA 4DHMA 4DHTA 3P1QA 4N7YA 4ZDRA 5J31A 4DHUA 3SMLA 2C23A 3CU8A 2V7DA 4JDDA 5LU2A 3T0MA 1A37A 5LU1A 3RDHA 4FR3A 3P1NA 3M50A 4DHRA 4DHSA 1IB1A 5LVZA 4ZQ0A 2O02A 3UZDA 4DNKA 4DHQA 5IQPA 2O8PA 5EXAA 1QJAA 2C1NA 3SP5A 4IEAA 3NKXA 1A38A 3SMNA 5LX2A 5EWZA 4N7GA 2C63A 3T0LA 1O9DA 4N84A 3IQUA 3M51A 4Y32A 3IQJA 5BY9A 1QJBA 5D3EA 4QLIA 5D3FA 3IQVA 2C1JA 4DATA 4FL5A 4HKCA 3P1OA 5HF3A 3UBWA 4DHPA 4E2EA 1YWTA
chains in the Genus database with same CATH superfamily
3SMKA 3AXYC 3UALA 3EB7A 1O9EA 3UX0A 4J6SA 4ARXA 4W8JA 4Y3BA 4QX3A 5BTVA 4QX0A 4IHLA 3O8IA 2BTPA 4F7RA 5F74A 5D2DA 1DLCA 4DHOA 3P1PA 1O9CA 3LW1A 4BG6A 2BQ0A 2WH0A 4WRQA 1A4OA 1O9FA 3CQCA 3SMOA 3U9XA 2B05A 1YZ5A 2C74A 3MHRA 3P1RA 1S2XA 3P1SA 4JC3A 4O46A 4Y5IA 2BR9A 2O98A 2NPMA 4DX0A 4GNTA 3SMMA 1W99A 3E6YA 3EFZA 4FJ3A 4DHNA 4DAUA 3SPRA 5LHOA 4DHMA 4DHTA 3P1QA 4QX2A 4N7YA 4ZDRA 5J31A 4DHUA 3SMLA 2C23A 3CU8A 2V7DA 3X0UA 4JDDA 5LU2A 3T0MA 1A37A 5LU1A 4D8MA 3RDHA 4FR3A 3P1NA 3M50A 4DHRA 4DHSA 1IB1A 1URJA 5LVZA 1JI6A 4ZQ0A 2O02A 3UZDA 4DNKA 1I5PA 4DHQA 2O8PA 5EXAA 5IQPA 1QJAA 2C1NA 4ARYA 2C9KA 3SP5A 3ZHEB 4IEAA 3NKXA 1A38A 3SMNA 5LX2A 5EWZA 4N7GA 2C63A 3T0LA 3I4RA 1O9DA 4N84A 3IQUA 3M51A 4Y32A 4QX1A 3IQJA 5BY9A 1QJBA 5D3EA 4QLIA 5D3FA 3IQVA 1CIYA 2C1JA 4FL5A 4HKCA 4DATA 3P1OA 4MOAA 5HF3A 3UBWA 4DHPA 3CQGA 4E2EA 1YWTA
chains in the Genus database with same CATH topology
3SMKA 3AXYC 3UALA 1O9EA 3UX0A 4J6SA 4Y3BA 5BTVA 4IHLA 3O8IA 2BTPA 4F7RA 5F74A 5D2DA 4DHOA 3P1PA 1O9CA 3LW1A 4BG6A 2BQ0A 2WH0A 4WRQA 1A4OA 1O9FA 3SMOA 3U9XA 2B05A 1YZ5A 2C74A 3MHRA 3P1RA 3P1SA 4JC3A 4O46A 4Y5IA 2BR9A 2O98A 2NPMA 4DX0A 4GNTA 3SMMA 3E6YA 3EFZA 4FJ3A 4DHNA 4DAUA 3SPRA 5LHOA 4DHMA 4DHTA 3P1QA 4N7YA 4ZDRA 5J31A 4DHUA 3SMLA 2C23A 3CU8A 2V7DA 4JDDA 5LU2A 3T0MA 1A37A 5LU1A 3RDHA 4FR3A 3P1NA 3M50A 4DHRA 4DHSA 1IB1A 5LVZA 4ZQ0A 2O02A 3UZDA 4DNKA 4DHQA 5IQPA 2O8PA 5EXAA 1QJAA 2C1NA 3SP5A 4IEAA 3NKXA 1A38A 3SMNA 5LX2A 5EWZA 4N7GA 2C63A 3T0LA 1O9DA 4N84A 3IQUA 3M51A 4Y32A 3IQJA 5BY9A 1QJBA 5D3EA 4QLIA 5D3FA 3IQVA 2C1JA 4DATA 4FL5A 4HKCA 3P1OA 5HF3A 3UBWA 4DHPA 4E2EA 1YWTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SMK A;  3AXY C;  3UAL A;  1O9E A;  3UX0 A;  4J6S A;  4Y3B A;  5BTV A;  4IHL A;  3O8I A;  2BTP A;  4F7R A;  5F74 A;  5D2D A;  4DHO A;  3P1P A;  1O9C A;  3LW1 A;  4BG6 A;  2BQ0 A;  2WH0 A;  4WRQ A;  1A4O A;  1O9F A;  3SMO A;  3U9X A;  2B05 A;  1YZ5 A;  2C74 A;  3MHR A;  3P1R A;  3P1S A;  4JC3 A;  4O46 A;  4Y5I A;  2BR9 A;  2O98 A;  2NPM A;  4DX0 A;  4GNT A;  3SMM A;  3E6Y A;  3EFZ A;  4FJ3 A;  4DHN A;  4DAU A;  3SPR A;  5LHO A;  4DHM A;  4DHT A;  3P1Q A;  4N7Y A;  4ZDR A;  5J31 A;  4DHU A;  3SML A;  2C23 A;  3CU8 A;  2V7D A;  4JDD A;  5LU2 A;  3T0M A;  1A37 A;  5LU1 A;  3RDH A;  4FR3 A;  3P1N A;  3M50 A;  4DHR A;  4DHS A;  1IB1 A;  5LVZ A;  4ZQ0 A;  2O02 A;  3UZD A;  4DNK A;  4DHQ A;  5IQP A;  2O8P A;  5EXA A;  1QJA A;  2C1N A;  3SP5 A;  4IEA A;  3NKX A;  1A38 A;  3SMN A;  5LX2 A;  5EWZ A;  4N7G A;  2C63 A;  3T0L A;  1O9D A;  4N84 A;  3IQU A;  3M51 A;  4Y32 A;  3IQJ A;  5BY9 A;  1QJB A;  5D3E A;  4QLI A;  5D3F A;  3IQV A;  2C1J A;  4DAT A;  4FL5 A;  4HKC A;  3P1O A;  5HF3 A;  3UBW A;  4DHP A;  4E2E A;  1YWT A; 
#chains in the Genus database with same CATH topology
 3SMK A;  3AXY C;  3UAL A;  3EB7 A;  1O9E A;  3UX0 A;  4J6S A;  4ARX A;  4W8J A;  4Y3B A;  4QX3 A;  5BTV A;  4QX0 A;  4IHL A;  3O8I A;  2BTP A;  4F7R A;  5F74 A;  5D2D A;  1DLC A;  4DHO A;  3P1P A;  1O9C A;  3LW1 A;  4BG6 A;  2BQ0 A;  2WH0 A;  4WRQ A;  1A4O A;  1O9F A;  3CQC A;  3SMO A;  3U9X A;  2B05 A;  1YZ5 A;  2C74 A;  3MHR A;  3P1R A;  1S2X A;  3P1S A;  4JC3 A;  4O46 A;  4Y5I A;  2BR9 A;  2O98 A;  2NPM A;  4DX0 A;  4GNT A;  3SMM A;  1W99 A;  3E6Y A;  3EFZ A;  4FJ3 A;  4DHN A;  4DAU A;  3SPR A;  5LHO A;  4DHM A;  4DHT A;  3P1Q A;  4QX2 A;  4N7Y A;  4ZDR A;  5J31 A;  4DHU A;  3SML A;  2C23 A;  3CU8 A;  2V7D A;  3X0U A;  4JDD A;  5LU2 A;  3T0M A;  1A37 A;  5LU1 A;  4D8M A;  3RDH A;  4FR3 A;  3P1N A;  3M50 A;  4DHR A;  4DHS A;  1IB1 A;  1URJ A;  5LVZ A;  1JI6 A;  4ZQ0 A;  2O02 A;  3UZD A;  4DNK A;  1I5P A;  4DHQ A;  2O8P A;  5EXA A;  5IQP A;  1QJA A;  2C1N A;  4ARY A;  2C9K A;  3SP5 A;  3ZHE B;  4IEA A;  3NKX A;  1A38 A;  3SMN A;  5LX2 A;  5EWZ A;  4N7G A;  2C63 A;  3T0L A;  3I4R A;  1O9D A;  4N84 A;  3IQU A;  3M51 A;  4Y32 A;  4QX1 A;  3IQJ A;  5BY9 A;  1QJB A;  5D3E A;  4QLI A;  5D3F A;  3IQV A;  1CIY A;  2C1J A;  4FL5 A;  4HKC A;  4DAT A;  3P1O A;  4MOA A;  5HF3 A;  3UBW A;  4DHP A;  3CQG A;  4E2E A;  1YWT A; 
#chains in the Genus database with same CATH homology
 3SMK A;  3AXY C;  3UAL A;  1O9E A;  3UX0 A;  4J6S A;  4Y3B A;  5BTV A;  4IHL A;  3O8I A;  2BTP A;  4F7R A;  5F74 A;  5D2D A;  4DHO A;  3P1P A;  1O9C A;  3LW1 A;  4BG6 A;  2BQ0 A;  2WH0 A;  4WRQ A;  1A4O A;  1O9F A;  3SMO A;  3U9X A;  2B05 A;  1YZ5 A;  2C74 A;  3MHR A;  3P1R A;  3P1S A;  4JC3 A;  4O46 A;  4Y5I A;  2BR9 A;  2O98 A;  2NPM A;  4DX0 A;  4GNT A;  3SMM A;  3E6Y A;  3EFZ A;  4FJ3 A;  4DHN A;  4DAU A;  3SPR A;  5LHO A;  4DHM A;  4DHT A;  3P1Q A;  4N7Y A;  4ZDR A;  5J31 A;  4DHU A;  3SML A;  2C23 A;  3CU8 A;  2V7D A;  4JDD A;  5LU2 A;  3T0M A;  1A37 A;  5LU1 A;  3RDH A;  4FR3 A;  3P1N A;  3M50 A;  4DHR A;  4DHS A;  1IB1 A;  5LVZ A;  4ZQ0 A;  2O02 A;  3UZD A;  4DNK A;  4DHQ A;  5IQP A;  2O8P A;  5EXA A;  1QJA A;  2C1N A;  3SP5 A;  4IEA A;  3NKX A;  1A38 A;  3SMN A;  5LX2 A;  5EWZ A;  4N7G A;  2C63 A;  3T0L A;  1O9D A;  4N84 A;  3IQU A;  3M51 A;  4Y32 A;  3IQJ A;  5BY9 A;  1QJB A;  5D3E A;  4QLI A;  5D3F A;  3IQV A;  2C1J A;  4DAT A;  4FL5 A;  4HKC A;  3P1O A;  5HF3 A;  3UBW A;  4DHP A;  4E2E A;  1YWT A; 
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similar chains in the Genus database (?% sequence similarity)
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