5EXAA

Small-molecule stabilization of the 14-3-3/gab2 ppi interface
Total Genus 103
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
103
sequence length
229
structure length
229
Chain Sequence
DKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein
molecule keywords 14-3-3 protein zeta/delta
publication title Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface.
pubmed doi rcsb
source organism Homo sapiens
total genus 103
structure length 229
sequence length 229
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-11-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 5exaA00
2WH0A 3M50A 1O9EA 3SMLA 3UBWA 5EWZA 4DHPA 4IEAA 3UZDA 4DHNA 3E6YA 4E2EA 5EXAA 3SMNA 2BQ0A 4BG6A 1QJAA 3IQJA 4HKCA 3EFZA 3SP5A 2B05A 5LU2A 5BTVA 5LU1A 2C74A 2C1JA 4FJ3A 4IHLA 4J6SA 3RDHA 2C23A 4DHUA 4DX0A 3M51A 3P1OA 2O8PA 4DAUA 3CU8A 4F7RA 5BY9A 1QJBA 3NKXA 4FL5A 3UALA 1A37A 4ZDRA 4FR3A 2C63A 5IQPA 1O9DA 2O98A 1A38A 5D3EA 1YZ5A 3SMMA 1A4OA 4O46A 3SMKA 5D2DA 3P1PA 2C1NA 4ZQ0A 1O9CA 4Y3BA 4WRQA 3UX0A 2V7DA 3P1QA 3T0MA 2BTPA 4N7GA 3P1RA 5F74A 4QLIA 3T0LA 4DHOA 5LVZA 2O02A 3P1NA 4N7YA 4JC3A 3LW1A 3IQVA 4Y5IA 5LX2A 2BR9A 4DNKA 4GNTA 1YWTA 4JDDA 4N84A 5D3FA 1O9FA 5J31A 3O8IA 3AXYC 3MHRA 1IB1A 3SPRA 4DHRA 2NPMA 4DHSA 3P1SA 4DHMA 3IQUA 4DHQA 5LHOA 4DATA 3SMOA 3U9XA 5HF3A 4Y32A 4DHTA
chains in the Genus database with same CATH superfamily
2WH0A 3M50A 1O9EA 2C9KA 3SMLA 3UBWA 1W99A 5EWZA 4DHPA 4IEAA 3UZDA 4DHNA 3E6YA 4E2EA 5EXAA 4QX0A 3SMNA 2BQ0A 3CQGA 4BG6A 1QJAA 3IQJA 4HKCA 3EFZA 3SP5A 2B05A 5LU2A 5BTVA 5LU1A 2C74A 2C1JA 4FJ3A 4ARXA 4IHLA 4J6SA 4QX3A 3RDHA 2C23A 4DHUA 3ZHEB 4DX0A 3M51A 3P1OA 3I4RA 2O8PA 1DLCA 4DAUA 3CU8A 1S2XA 4F7RA 5BY9A 1QJBA 3X0UA 3NKXA 4FL5A 3UALA 1A37A 4ZDRA 4FR3A 2C63A 5IQPA 1O9DA 2O98A 1A38A 5D3EA 1YZ5A 3SMMA 1CIYA 1A4OA 4QX2A 4O46A 3SMKA 5D2DA 3P1PA 4ARYA 2C1NA 4ZQ0A 1I5PA 1O9CA 4Y3BA 4WRQA 4D8MA 3UX0A 2V7DA 3P1QA 4MOAA 4QX1A 3T0MA 2BTPA 4N7GA 3P1RA 3CQCA 5F74A 4QLIA 3T0LA 4DHOA 5LVZA 1URJA 2O02A 3P1NA 4N7YA 4JC3A 3LW1A 3EB7A 3IQVA 4Y5IA 5LX2A 2BR9A 4DNKA 4GNTA 1YWTA 4JDDA 4N84A 5D3FA 4W8JA 1O9FA 5J31A 3O8IA 3AXYC 3MHRA 1IB1A 3SPRA 4DHRA 2NPMA 4DHSA 3P1SA 1JI6A 4DHMA 3IQUA 4DHQA 5LHOA 4DATA 3SMOA 3U9XA 5HF3A 4Y32A 4DHTA
chains in the Genus database with same CATH topology
2WH0A 3M50A 1O9EA 3SMLA 3UBWA 5EWZA 4DHPA 4IEAA 3UZDA 4DHNA 3E6YA 4E2EA 5EXAA 3SMNA 2BQ0A 4BG6A 1QJAA 3IQJA 4HKCA 3EFZA 3SP5A 2B05A 5LU2A 5BTVA 5LU1A 2C74A 2C1JA 4FJ3A 4IHLA 4J6SA 3RDHA 2C23A 4DHUA 4DX0A 3M51A 3P1OA 2O8PA 4DAUA 3CU8A 4F7RA 5BY9A 1QJBA 3NKXA 4FL5A 3UALA 1A37A 4ZDRA 4FR3A 2C63A 5IQPA 1O9DA 2O98A 1A38A 5D3EA 1YZ5A 3SMMA 1A4OA 4O46A 3SMKA 5D2DA 3P1PA 2C1NA 4ZQ0A 1O9CA 4Y3BA 4WRQA 3UX0A 2V7DA 3P1QA 3T0MA 2BTPA 4N7GA 3P1RA 5F74A 4QLIA 3T0LA 4DHOA 5LVZA 2O02A 3P1NA 4N7YA 4JC3A 3LW1A 3IQVA 4Y5IA 5LX2A 2BR9A 4DNKA 4GNTA 1YWTA 4JDDA 4N84A 5D3FA 1O9FA 5J31A 3O8IA 3AXYC 3MHRA 1IB1A 3SPRA 4DHRA 2NPMA 4DHSA 3P1SA 4DHMA 3IQUA 4DHQA 5LHOA 4DATA 3SMOA 3U9XA 5HF3A 4Y32A 4DHTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WH0 A;  3M50 A;  1O9E A;  3SML A;  3UBW A;  5EWZ A;  4DHP A;  4IEA A;  3UZD A;  4DHN A;  3E6Y A;  4E2E A;  5EXA A;  3SMN A;  2BQ0 A;  4BG6 A;  1QJA A;  3IQJ A;  4HKC A;  3EFZ A;  3SP5 A;  2B05 A;  5LU2 A;  5BTV A;  5LU1 A;  2C74 A;  2C1J A;  4FJ3 A;  4IHL A;  4J6S A;  3RDH A;  2C23 A;  4DHU A;  4DX0 A;  3M51 A;  3P1O A;  2O8P A;  4DAU A;  3CU8 A;  4F7R A;  5BY9 A;  1QJB A;  3NKX A;  4FL5 A;  3UAL A;  1A37 A;  4ZDR A;  4FR3 A;  2C63 A;  5IQP A;  1O9D A;  2O98 A;  1A38 A;  5D3E A;  1YZ5 A;  3SMM A;  1A4O A;  4O46 A;  3SMK A;  5D2D A;  3P1P A;  2C1N A;  4ZQ0 A;  1O9C A;  4Y3B A;  4WRQ A;  3UX0 A;  2V7D A;  3P1Q A;  3T0M A;  2BTP A;  4N7G A;  3P1R A;  5F74 A;  4QLI A;  3T0L A;  4DHO A;  5LVZ A;  2O02 A;  3P1N A;  4N7Y A;  4JC3 A;  3LW1 A;  3IQV A;  4Y5I A;  5LX2 A;  2BR9 A;  4DNK A;  4GNT A;  1YWT A;  4JDD A;  4N84 A;  5D3F A;  1O9F A;  5J31 A;  3O8I A;  3AXY C;  3MHR A;  1IB1 A;  3SPR A;  4DHR A;  2NPM A;  4DHS A;  3P1S A;  4DHM A;  3IQU A;  4DHQ A;  5LHO A;  4DAT A;  3SMO A;  3U9X A;  5HF3 A;  4Y32 A;  4DHT A; 
#chains in the Genus database with same CATH topology
 2WH0 A;  3M50 A;  1O9E A;  2C9K A;  3SML A;  3UBW A;  1W99 A;  5EWZ A;  4DHP A;  4IEA A;  3UZD A;  4DHN A;  3E6Y A;  4E2E A;  5EXA A;  4QX0 A;  3SMN A;  2BQ0 A;  3CQG A;  4BG6 A;  1QJA A;  3IQJ A;  4HKC A;  3EFZ A;  3SP5 A;  2B05 A;  5LU2 A;  5BTV A;  5LU1 A;  2C74 A;  2C1J A;  4FJ3 A;  4ARX A;  4IHL A;  4J6S A;  4QX3 A;  3RDH A;  2C23 A;  4DHU A;  3ZHE B;  4DX0 A;  3M51 A;  3P1O A;  3I4R A;  2O8P A;  1DLC A;  4DAU A;  3CU8 A;  1S2X A;  4F7R A;  5BY9 A;  1QJB A;  3X0U A;  3NKX A;  4FL5 A;  3UAL A;  1A37 A;  4ZDR A;  4FR3 A;  2C63 A;  5IQP A;  1O9D A;  2O98 A;  1A38 A;  5D3E A;  1YZ5 A;  3SMM A;  1CIY A;  1A4O A;  4QX2 A;  4O46 A;  3SMK A;  5D2D A;  3P1P A;  4ARY A;  2C1N A;  4ZQ0 A;  1I5P A;  1O9C A;  4Y3B A;  4WRQ A;  4D8M A;  3UX0 A;  2V7D A;  3P1Q A;  4MOA A;  4QX1 A;  3T0M A;  2BTP A;  4N7G A;  3P1R A;  3CQC A;  5F74 A;  4QLI A;  3T0L A;  4DHO A;  5LVZ A;  1URJ A;  2O02 A;  3P1N A;  4N7Y A;  4JC3 A;  3LW1 A;  3EB7 A;  3IQV A;  4Y5I A;  5LX2 A;  2BR9 A;  4DNK A;  4GNT A;  1YWT A;  4JDD A;  4N84 A;  5D3F A;  4W8J A;  1O9F A;  5J31 A;  3O8I A;  3AXY C;  3MHR A;  1IB1 A;  3SPR A;  4DHR A;  2NPM A;  4DHS A;  3P1S A;  1JI6 A;  4DHM A;  3IQU A;  4DHQ A;  5LHO A;  4DAT A;  3SMO A;  3U9X A;  5HF3 A;  4Y32 A;  4DHT A; 
#chains in the Genus database with same CATH homology
 2WH0 A;  3M50 A;  1O9E A;  3SML A;  3UBW A;  5EWZ A;  4DHP A;  4IEA A;  3UZD A;  4DHN A;  3E6Y A;  4E2E A;  5EXA A;  3SMN A;  2BQ0 A;  4BG6 A;  1QJA A;  3IQJ A;  4HKC A;  3EFZ A;  3SP5 A;  2B05 A;  5LU2 A;  5BTV A;  5LU1 A;  2C74 A;  2C1J A;  4FJ3 A;  4IHL A;  4J6S A;  3RDH A;  2C23 A;  4DHU A;  4DX0 A;  3M51 A;  3P1O A;  2O8P A;  4DAU A;  3CU8 A;  4F7R A;  5BY9 A;  1QJB A;  3NKX A;  4FL5 A;  3UAL A;  1A37 A;  4ZDR A;  4FR3 A;  2C63 A;  5IQP A;  1O9D A;  2O98 A;  1A38 A;  5D3E A;  1YZ5 A;  3SMM A;  1A4O A;  4O46 A;  3SMK A;  5D2D A;  3P1P A;  2C1N A;  4ZQ0 A;  1O9C A;  4Y3B A;  4WRQ A;  3UX0 A;  2V7D A;  3P1Q A;  3T0M A;  2BTP A;  4N7G A;  3P1R A;  5F74 A;  4QLI A;  3T0L A;  4DHO A;  5LVZ A;  2O02 A;  3P1N A;  4N7Y A;  4JC3 A;  3LW1 A;  3IQV A;  4Y5I A;  5LX2 A;  2BR9 A;  4DNK A;  4GNT A;  1YWT A;  4JDD A;  4N84 A;  5D3F A;  1O9F A;  5J31 A;  3O8I A;  3AXY C;  3MHR A;  1IB1 A;  3SPR A;  4DHR A;  2NPM A;  4DHS A;  3P1S A;  4DHM A;  3IQU A;  4DHQ A;  5LHO A;  4DAT A;  3SMO A;  3U9X A;  5HF3 A;  4Y32 A;  4DHT A; 
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similar chains in the Genus database (?% sequence similarity)
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