4V2OA

Structure of saposin b in complex with chloroquine
Total Genus 28
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
78
structure length
78
Chain Sequence
GDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Hydrolase activator
molecule keywords SAPOSIN-B
publication title The Lysosomal Protein Saposin B Binds Chloroquine.
pubmed doi rcsb
source organism Homo sapiens
total genus 28
structure length 78
sequence length 78
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2014-10-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03489 SapB_2 Saposin-like type B, region 2
A PF05184 SapB_1 Saposin-like type B, region 1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.225.10 Mainly Alpha Orthogonal Bundle NK-Lysin Saposin-like 4v2oA00
4BITA 2QYPA 2R0RA 4DDJA 3BQQA 3S64A 1L9LA 2R1QA 2W51A 3BQPA 2RB3A 2JSAA 1SN6A 1M12A 1N69A 1NKLA 3RFIA 1QDMA 2W50A 4UEXA 2GTGA 1OF9A 2DOBA 2KVDA 4V2OA 2JS9A 2Z9AA 2LPNA 2RQYA 3S63A
chains in the Genus database with same CATH superfamily
4BITA 2QYPA 2R0RA 4DDJA 3BQQA 3S64A 1L9LA 2R1QA 2W51A 3EUJB 3BQPA 3EUKE 2RB3A 2JSAA 1SN6A 1M12A 1N69A 1NKLA 3RFIA 3CJLA 1QDMA 2W50A 4UEXA 2GTGA 1OF9A 2DOBA 2KVDA 4V2OA 2JS9A 2Z9AA 2LPNA 2RQYA 3S63A 2JQ3A
chains in the Genus database with same CATH topology
4BITA 2QYPA 2R0RA 4DDJA 3BQQA 3S64A 1L9LA 2R1QA 2W51A 3BQPA 2RB3A 2JSAA 1SN6A 1M12A 1N69A 1NKLA 3RFIA 1QDMA 2W50A 4UEXA 2GTGA 1OF9A 2DOBA 2KVDA 4V2OA 2JS9A 2Z9AA 2LPNA 2RQYA 3S63A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BIT A;  2QYP A;  2R0R A;  4DDJ A;  3BQQ A;  3S64 A;  1L9L A;  2R1Q A;  2W51 A;  3BQP A;  2RB3 A;  2JSA A;  1SN6 A;  1M12 A;  1N69 A;  1NKL A;  3RFI A;  1QDM A;  2W50 A;  4UEX A;  2GTG A;  1OF9 A;  2DOB A;  2KVD A;  4V2O A;  2JS9 A;  2Z9A A;  2LPN A;  2RQY A;  3S63 A; 
#chains in the Genus database with same CATH topology
 4BIT A;  2QYP A;  2R0R A;  4DDJ A;  3BQQ A;  3S64 A;  1L9L A;  2R1Q A;  2W51 A;  3EUJ B;  3BQP A;  3EUK E;  2RB3 A;  2JSA A;  1SN6 A;  1M12 A;  1N69 A;  1NKL A;  3RFI A;  3CJL A;  1QDM A;  2W50 A;  4UEX A;  2GTG A;  1OF9 A;  2DOB A;  2KVD A;  4V2O A;  2JS9 A;  2Z9A A;  2LPN A;  2RQY A;  3S63 A;  2JQ3 A; 
#chains in the Genus database with same CATH homology
 4BIT A;  2QYP A;  2R0R A;  4DDJ A;  3BQQ A;  3S64 A;  1L9L A;  2R1Q A;  2W51 A;  3BQP A;  2RB3 A;  2JSA A;  1SN6 A;  1M12 A;  1N69 A;  1NKL A;  3RFI A;  1QDM A;  2W50 A;  4UEX A;  2GTG A;  1OF9 A;  2DOB A;  2KVD A;  4V2O A;  2JS9 A;  2Z9A A;  2LPN A;  2RQY A;  3S63 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...