2HYOA

Crystal structure of rv0805 n97a mutant
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
256
structure length
227
Chain Sequence
PRPDYVLLHISDTHLIDADDRLGELLEQLNQSGLRPDAIVFTGDLADKGEPAAYRKLRGLVEPFAAQLGAELVWVMGAHDDRAELRKFLLDEAPSMAPLDRVCMIDGLRIIVLDTSVPGHHHGEIRASQLGWLAEELATPAPDGTILALHHPPIPSVLDMAVTVELRDQAALGRVLRGTDVRAILAGHLHYSTNATFVGIPVSVASATCGCNLVHVYPDTVVHSVIP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Rv0805N97A
publication title Structural and Biochemical Analysis of the Rv0805 Cyclic Nucleotide Phosphodiesterase from Mycobacterium tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
total genus 70
structure length 227
sequence length 256
ec nomenclature ec 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
pdb deposition date 2006-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2hyoA00
2DFJA 3ICFA 1KBPA 5C1VA 3T1IA 3V4YA 4UT3B 4MOYA 2A22A 3H66A 2QFPA 4DT2A 3H63A 2HYPA 3ZU0A 3HVQA 3K7VC 4IL1A 4O24A 3LL8A 5INBA 1S95A 1SU1A 1WAO1 2Z06A 4ORCA 1HP1A 4FBKA 1WARA 1OIEA 2QFRA 2QJCA 4TUIA 1S3NA 2IAEC 2HY1A 2BCDA 3THNA 5HPEA 2BQ8X 1HO5A 3IB7A 4DSYA 3C5WC 3C9FA 3GVEA 2P6BA 4JA9A 2JOGA 4NZVA 1Z2XA 3EGHA 3H68A 4WWLA 2WDCA 3RL5A 3ZTVA 2USHA 5J28A 2XMOA 3RL3A 3IVEA 1V73A 4M0VA 4V0WA 3H62B 3K7WC 2IE3C 3PSOA 2NYLC 5DNYA 1TCOA 4UWQA 3IVDA 4H2IA 1IT6A 4DHLA 1QFCA 4I5LC 4KBPA 1T71A 3THOB 1W24A 4IYPC 4XPNA 4HD0A 4FBWA 4V0VA 3RL4A 4O43A 3QG5C 4MOVA 1OI8A 4LU9A 2O8AA 5IOHA 5EQVA 1XM7A 3TGHA 3H67A 3E7BA 2KKNA 4I5NC 4Q7FA 5JPEA 4ORBA 3DSCA 1NNWA 4G9JA 1UF3A 1UTEA 4MP0A 4B2OA 2AHDA 3QFKA 2WDEA 4UT3A 4FCXA 3CK2A 1XZWA 3AV0A 3H69A 3P71C 3H64A 2HYOA 3H61A 5GTUA 1FJMA 2WDDA 3H60A 1AUIA 4H2BA 4H1SA 1JK7A 4KKZA 1S8EA 4F0ZA 4YKEA 4O4KA 4V0XA 3KBPA 2R17A 5F3WA 4JA7A 2IE4C 3JYFA 3N5UA 4H1YP 2NXFA 2GJUA 2CV9A 1G5BA 4O5GA 4ZX2A 2Q8UA 1T70A 1S3LA 1S70A 2YVTA 4UT2A 2BDXA 4TUGA 4LACC 1USHA 3DW8C 3FGAC 3AUZA 3RQZA 4H2FA 1QHWA 1HPUA 5JPFA 3PSNA 2NYMC 1Z2WA 3QFMA 4ZVZA 1OIDA 1M63A 3QFNA 4OR9A 4J6OA 2O8GA 2WDFA 5B8IA 1U32A 3EGGA 3IB8A 4LTYA 5JJTA 2NPPC 4ORAA 1S3MA 3QFOA 3E7AA 2Z72A 2ZBMA 3DSDA 4FBQA 1MF8A 4H2GA 2Z1AA 1II7A
chains in the Genus database with same CATH superfamily
2DFJA 3ICFA 1KBPA 5C1VA 3T1IA 3V4YA 4UT3B 3D03A 4MOYA 2A22A 3H66A 2QFPA 4DT2A 3FLOA 3H63A 2HYPA 3ZU0A 3HVQA 3K7VC 4IL1A 4O24A 3LL8A 5INBA 1S95A 1SU1A 1WAO1 2Z06A 4ORCA 1HP1A 4FBKA 1WARA 1OIEA 2QFRA 2QJCA 4TUIA 1S3NA 2IAEC 2HY1A 2BCDA 3THNA 5HPEA 2BQ8X 1HO5A 3IB7A 4DSYA 3C5WC 3C9FA 3GVEA 2P6BA 4JA9A 2JOGA 4NZVA 1Z2XA 2YEQA 3EGHA 3H68A 4WWLA 2WDCA 3RL5A 3ZTVA 2USHA 5J28A 2XMOA 3RL3A 3IVEA 1V73A 4M0VA 4V0WA 3H62B 3K7WC 2IE3C 3PSOA 2NYLC 5DNYA 1TCOA 4UWQA 3IVDA 4H2IA 1IT6A 4DHLA 1QFCA 4I5LC 4KBPA 1T71A 3THOB 1W24A 4IYPC 4XPNA 4HD0A 4FBWA 4V0VA 3RL4A 4O43A 3QG5C 4MOVA 1OI8A 4LU9A 2ZO9B 2O8AA 5IOHA 5EQVA 1XM7A 2ZOAA 3TGHA 3H67A 3E7BA 2KKNA 4I5NC 2DXNA 4Q7FA 5JPEA 4ORBA 3DSCA 1NNWA 4G9JA 1UF3A 1UTEA 4MP0A 4B2OA 2Z1AA 2AHDA 3QFKA 2WDEA 4UT3A 4FCXA 3CK2A 1XZWA 3AV0A 3H69A 3P71C 3H64A 2HYOA 3H61A 5GTUA 1FJMA 2WDDA 3H60A 1AUIA 4H2BA 4H1SA 1JK7A 4KKZA 1S8EA 4F0ZA 4YKEA 4O4KA 4V0XA 3KBPA 2R17A 5F3WA 4JA7A 2IE4C 3JYFA 3N5UA 4H1YP 2NXFA 2GJUA 2CV9A 1G5BA 4O5GA 4ZX2A 2Q8UA 1T70A 1S3LA 1S70A 2YVTA 4UT2A 2BDXA 4TUGA 4LACC 1USHA 3DW8C 3E0JA 3FGAC 3AUZA 3RQZA 4H2FA 1HPUA 5JPFA 3PSNA 2NYMC 1Z2WA 3QFMA 4ZVZA 1OIDA 1M63A 3QFNA 4OR9A 4J6OA 2O8GA 2WDFA 5B8IA 1U32A 2DXLA 3EGGA 3IB8A 4LTYA 5JJTA 2NPPC 4ORAA 1S3MA 3QFOA 3E7AA 2Z72A 2ZBMA 3DSDA 4FBQA 1MF8A 4H2GA 1QHWA 1II7A
chains in the Genus database with same CATH topology
2DFJA 3ICFA 1KBPA 5C1VA 3T1IA 3V4YA 4UT3B 3D03A 4MOYA 2A22A 3H66A 2QFPA 4DT2A 3FLOA 3H63A 2HYPA 3ZU0A 3HVQA 3K7VC 4IL1A 4O24A 3LL8A 5INBA 1S95A 1SU1A 1WAO1 2Z06A 4ORCA 1HP1A 4FBKA 1WARA 1OIEA 2QFRA 2QJCA 4TUIA 1S3NA 2IAEC 2HY1A 2BCDA 3THNA 5HPEA 2BQ8X 1HO5A 3IB7A 4DSYA 3C5WC 3C9FA 3GVEA 2P6BA 4JA9A 2JOGA 4NZVA 1Z2XA 2YEQA 3EGHA 3H68A 4WWLA 2WDCA 3RL5A 3ZTVA 2USHA 5J28A 2XMOA 3RL3A 3IVEA 1V73A 4M0VA 4V0WA 3H62B 3K7WC 2IE3C 3PSOA 2NYLC 5DNYA 1TCOA 4UWQA 3IVDA 4H2IA 1IT6A 4DHLA 1QFCA 4I5LC 4KBPA 1T71A 3THOB 1W24A 4IYPC 4XPNA 4HD0A 4FBWA 4V0VA 3RL4A 4O43A 3QG5C 4MOVA 1OI8A 4LU9A 2ZO9B 2O8AA 5IOHA 5EQVA 1XM7A 2ZOAA 3TGHA 3H67A 3E7BA 2KKNA 4I5NC 2DXNA 4Q7FA 5JPEA 4ORBA 3DSCA 1NNWA 4G9JA 1UF3A 1UTEA 4MP0A 4B2OA 2Z1AA 2AHDA 3QFKA 2WDEA 4UT3A 4FCXA 3CK2A 1XZWA 3AV0A 3H69A 3P71C 3H64A 2HYOA 3H61A 5GTUA 1FJMA 2WDDA 3H60A 1AUIA 4H2BA 4H1SA 1JK7A 4KKZA 1S8EA 4F0ZA 4YKEA 4O4KA 4V0XA 3KBPA 2R17A 5F3WA 4JA7A 2IE4C 3JYFA 3N5UA 4H1YP 2NXFA 2GJUA 2CV9A 1G5BA 4O5GA 4ZX2A 2Q8UA 1T70A 1S3LA 1S70A 2YVTA 4UT2A 2BDXA 4TUGA 4LACC 1USHA 3DW8C 3E0JA 3FGAC 3AUZA 3RQZA 4H2FA 1HPUA 5JPFA 3PSNA 2NYMC 1Z2WA 3QFMA 4ZVZA 1OIDA 1M63A 3QFNA 4OR9A 4J6OA 2O8GA 2WDFA 5B8IA 1U32A 2DXLA 3EGGA 3IB8A 4LTYA 5JJTA 2NPPC 4ORAA 1S3MA 3QFOA 3E7AA 2Z72A 2ZBMA 3DSDA 4FBQA 1MF8A 4H2GA 1QHWA 1II7A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2DFJ A;  3ICF A;  1KBP A;  5C1V A;  3T1I A;  3V4Y A;  4UT3 B;  4MOY A;  2A22 A;  3H66 A;  2QFP A;  4DT2 A;  3H63 A;  2HYP A;  3ZU0 A;  3HVQ A;  3K7V C;  4IL1 A;  4O24 A;  3LL8 A;  5INB A;  1S95 A;  1SU1 A;  1WAO 1;  2Z06 A;  4ORC A;  1HP1 A;  4FBK A;  1WAR A;  1OIE A;  2QFR A;  2QJC A;  4TUI A;  1S3N A;  2IAE C;  2HY1 A;  2BCD A;  3THN A;  5HPE A;  2BQ8 X;  1HO5 A;  3IB7 A;  4DSY A;  3C5W C;  3C9F A;  3GVE A;  2P6B A;  4JA9 A;  2JOG A;  4NZV A;  1Z2X A;  3EGH A;  3H68 A;  4WWL A;  2WDC A;  3RL5 A;  3ZTV A;  2USH A;  5J28 A;  2XMO A;  3RL3 A;  3IVE A;  1V73 A;  4M0V A;  4V0W A;  3H62 B;  3K7W C;  2IE3 C;  3PSO A;  2NYL C;  5DNY A;  1TCO A;  4UWQ A;  3IVD A;  4H2I A;  1IT6 A;  4DHL A;  1QFC A;  4I5L C;  4KBP A;  1T71 A;  3THO B;  1W24 A;  4IYP C;  4XPN A;  4HD0 A;  4FBW A;  4V0V A;  3RL4 A;  4O43 A;  3QG5 C;  4MOV A;  1OI8 A;  4LU9 A;  2O8A A;  5IOH A;  5EQV A;  1XM7 A;  3TGH A;  3H67 A;  3E7B A;  2KKN A;  4I5N C;  4Q7F A;  5JPE A;  4ORB A;  3DSC A;  1NNW A;  4G9J A;  1UF3 A;  1UTE A;  4MP0 A;  4B2O A;  2AHD A;  3QFK A;  2WDE A;  4UT3 A;  4FCX A;  3CK2 A;  1XZW A;  3AV0 A;  3H69 A;  3P71 C;  3H64 A;  2HYO A;  3H61 A;  5GTU A;  1FJM A;  2WDD A;  3H60 A;  1AUI A;  4H2B A;  4H1S A;  1JK7 A;  4KKZ A;  1S8E A;  4F0Z A;  4YKE A;  4O4K A;  4V0X A;  3KBP A;  2R17 A;  5F3W A;  4JA7 A;  2IE4 C;  3JYF A;  3N5U A;  4H1Y P;  2NXF A;  2GJU A;  2CV9 A;  1G5B A;  4O5G A;  4ZX2 A;  2Q8U A;  1T70 A;  1S3L A;  1S70 A;  2YVT A;  4UT2 A;  2BDX A;  4TUG A;  4LAC C;  1USH A;  3DW8 C;  3FGA C;  3AUZ A;  3RQZ A;  4H2F A;  1QHW A;  1HPU A;  5JPF A;  3PSN A;  2NYM C;  1Z2W A;  3QFM A;  4ZVZ A;  1OID A;  1M63 A;  3QFN A;  4OR9 A;  4J6O A;  2O8G A;  2WDF A;  5B8I A;  1U32 A;  3EGG A;  3IB8 A;  4LTY A;  5JJT A;  2NPP C;  4ORA A;  1S3M A;  3QFO A;  3E7A A;  2Z72 A;  2ZBM A;  3DSD A;  4FBQ A;  1MF8 A;  4H2G A;  2Z1A A;  1II7 A; 
#chains in the Genus database with same CATH topology
 2DFJ A;  3ICF A;  1KBP A;  5C1V A;  3T1I A;  3V4Y A;  4UT3 B;  3D03 A;  4MOY A;  2A22 A;  3H66 A;  2QFP A;  4DT2 A;  3FLO A;  3H63 A;  2HYP A;  3ZU0 A;  3HVQ A;  3K7V C;  4IL1 A;  4O24 A;  3LL8 A;  5INB A;  1S95 A;  1SU1 A;  1WAO 1;  2Z06 A;  4ORC A;  1HP1 A;  4FBK A;  1WAR A;  1OIE A;  2QFR A;  2QJC A;  4TUI A;  1S3N A;  2IAE C;  2HY1 A;  2BCD A;  3THN A;  5HPE A;  2BQ8 X;  1HO5 A;  3IB7 A;  4DSY A;  3C5W C;  3C9F A;  3GVE A;  2P6B A;  4JA9 A;  2JOG A;  4NZV A;  1Z2X A;  2YEQ A;  3EGH A;  3H68 A;  4WWL A;  2WDC A;  3RL5 A;  3ZTV A;  2USH A;  5J28 A;  2XMO A;  3RL3 A;  3IVE A;  1V73 A;  4M0V A;  4V0W A;  3H62 B;  3K7W C;  2IE3 C;  3PSO A;  2NYL C;  5DNY A;  1TCO A;  4UWQ A;  3IVD A;  4H2I A;  1IT6 A;  4DHL A;  1QFC A;  4I5L C;  4KBP A;  1T71 A;  3THO B;  1W24 A;  4IYP C;  4XPN A;  4HD0 A;  4FBW A;  4V0V A;  3RL4 A;  4O43 A;  3QG5 C;  4MOV A;  1OI8 A;  4LU9 A;  2ZO9 B;  2O8A A;  5IOH A;  5EQV A;  1XM7 A;  2ZOA A;  3TGH A;  3H67 A;  3E7B A;  2KKN A;  4I5N C;  2DXN A;  4Q7F A;  5JPE A;  4ORB A;  3DSC A;  1NNW A;  4G9J A;  1UF3 A;  1UTE A;  4MP0 A;  4B2O A;  2Z1A A;  2AHD A;  3QFK A;  2WDE A;  4UT3 A;  4FCX A;  3CK2 A;  1XZW A;  3AV0 A;  3H69 A;  3P71 C;  3H64 A;  2HYO A;  3H61 A;  5GTU A;  1FJM A;  2WDD A;  3H60 A;  1AUI A;  4H2B A;  4H1S A;  1JK7 A;  4KKZ A;  1S8E A;  4F0Z A;  4YKE A;  4O4K A;  4V0X A;  3KBP A;  2R17 A;  5F3W A;  4JA7 A;  2IE4 C;  3JYF A;  3N5U A;  4H1Y P;  2NXF A;  2GJU A;  2CV9 A;  1G5B A;  4O5G A;  4ZX2 A;  2Q8U A;  1T70 A;  1S3L A;  1S70 A;  2YVT A;  4UT2 A;  2BDX A;  4TUG A;  4LAC C;  1USH A;  3DW8 C;  3E0J A;  3FGA C;  3AUZ A;  3RQZ A;  4H2F A;  1HPU A;  5JPF A;  3PSN A;  2NYM C;  1Z2W A;  3QFM A;  4ZVZ A;  1OID A;  1M63 A;  3QFN A;  4OR9 A;  4J6O A;  2O8G A;  2WDF A;  5B8I A;  1U32 A;  2DXL A;  3EGG A;  3IB8 A;  4LTY A;  5JJT A;  2NPP C;  4ORA A;  1S3M A;  3QFO A;  3E7A A;  2Z72 A;  2ZBM A;  3DSD A;  4FBQ A;  1MF8 A;  4H2G A;  1QHW A;  1II7 A; 
#chains in the Genus database with same CATH homology
 2DFJ A;  3ICF A;  1KBP A;  5C1V A;  3T1I A;  3V4Y A;  4UT3 B;  3D03 A;  4MOY A;  2A22 A;  3H66 A;  2QFP A;  4DT2 A;  3FLO A;  3H63 A;  2HYP A;  3ZU0 A;  3HVQ A;  3K7V C;  4IL1 A;  4O24 A;  3LL8 A;  5INB A;  1S95 A;  1SU1 A;  1WAO 1;  2Z06 A;  4ORC A;  1HP1 A;  4FBK A;  1WAR A;  1OIE A;  2QFR A;  2QJC A;  4TUI A;  1S3N A;  2IAE C;  2HY1 A;  2BCD A;  3THN A;  5HPE A;  2BQ8 X;  1HO5 A;  3IB7 A;  4DSY A;  3C5W C;  3C9F A;  3GVE A;  2P6B A;  4JA9 A;  2JOG A;  4NZV A;  1Z2X A;  2YEQ A;  3EGH A;  3H68 A;  4WWL A;  2WDC A;  3RL5 A;  3ZTV A;  2USH A;  5J28 A;  2XMO A;  3RL3 A;  3IVE A;  1V73 A;  4M0V A;  4V0W A;  3H62 B;  3K7W C;  2IE3 C;  3PSO A;  2NYL C;  5DNY A;  1TCO A;  4UWQ A;  3IVD A;  4H2I A;  1IT6 A;  4DHL A;  1QFC A;  4I5L C;  4KBP A;  1T71 A;  3THO B;  1W24 A;  4IYP C;  4XPN A;  4HD0 A;  4FBW A;  4V0V A;  3RL4 A;  4O43 A;  3QG5 C;  4MOV A;  1OI8 A;  4LU9 A;  2ZO9 B;  2O8A A;  5IOH A;  5EQV A;  1XM7 A;  2ZOA A;  3TGH A;  3H67 A;  3E7B A;  2KKN A;  4I5N C;  2DXN A;  4Q7F A;  5JPE A;  4ORB A;  3DSC A;  1NNW A;  4G9J A;  1UF3 A;  1UTE A;  4MP0 A;  4B2O A;  2Z1A A;  2AHD A;  3QFK A;  2WDE A;  4UT3 A;  4FCX A;  3CK2 A;  1XZW A;  3AV0 A;  3H69 A;  3P71 C;  3H64 A;  2HYO A;  3H61 A;  5GTU A;  1FJM A;  2WDD A;  3H60 A;  1AUI A;  4H2B A;  4H1S A;  1JK7 A;  4KKZ A;  1S8E A;  4F0Z A;  4YKE A;  4O4K A;  4V0X A;  3KBP A;  2R17 A;  5F3W A;  4JA7 A;  2IE4 C;  3JYF A;  3N5U A;  4H1Y P;  2NXF A;  2GJU A;  2CV9 A;  1G5B A;  4O5G A;  4ZX2 A;  2Q8U A;  1T70 A;  1S3L A;  1S70 A;  2YVT A;  4UT2 A;  2BDX A;  4TUG A;  4LAC C;  1USH A;  3DW8 C;  3E0J A;  3FGA C;  3AUZ A;  3RQZ A;  4H2F A;  1HPU A;  5JPF A;  3PSN A;  2NYM C;  1Z2W A;  3QFM A;  4ZVZ A;  1OID A;  1M63 A;  3QFN A;  4OR9 A;  4J6O A;  2O8G A;  2WDF A;  5B8I A;  1U32 A;  2DXL A;  3EGG A;  3IB8 A;  4LTY A;  5JJT A;  2NPP C;  4ORA A;  1S3M A;  3QFO A;  3E7A A;  2Z72 A;  2ZBM A;  3DSD A;  4FBQ A;  1MF8 A;  4H2G A;  1QHW A;  1II7 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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