3H63A

Catalytic domain of human serine/threonine phosphatase 5 (pp5c) with two mn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form)
Total Genus 116
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
sequence length
315
structure length
315
Chain Sequence
YSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMAYA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Serine/threonine-protein phosphatase 5
publication title Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin
pubmed doi rcsb
source organism Homo sapiens
total genus 116
structure length 315
sequence length 315
chains with identical sequence C
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2009-04-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3h63A00
2WDDA 1S3NA 1OI8A 2IE4C 1MF8A 2P6BA 3H63A 4KBPA 1Z2WA 3K7VC 4LTYA 3LL8A 4ZVZA 2KKNA 5C1VA 3P71C 3KBPA 4YKEA 3DSDA 1KBPA 3THNA 4MOYA 5JPEA 1TCOA 3H64A 1HO5A 1T71A 3H62B 4MP0A 4B2OA 1W24A 3H67A 1Z2XA 4O43A 4NZVA 4ZX2A 5DNYA 4O24A 2BCDA 3ZTVA 4DSYA 1UF3A 2O8GA 1AUIA 1S95A 4H2BA 4UT3A 2NYLC 1HPUA 2QFPA 3C9FA 4UWQA 4H1SA 2WDCA 4ORCA 2R17A 3DW8C 1FJMA 5INBA 4G9JA 3FGAC 3RQZA 1S70A 5EQVA 2HY1A 5HPEA 3H66A 3QFNA 2XMOA 1XM7A 2Z1AA 1G5BA 4HD0A 2Z72A 1JK7A 3ZU0A 3AUZA 4H2FA 3JYFA 2BQ8X 4O4KA 4V0XA 1M63A 2O8AA 3AV0A 4V0WA 3RL4A 4F0ZA 3QFOA 1OIDA 2HYPA 4JA7A 3DSCA 1U32A 4I5NC 2Z06A 3N5UA 4Q7FA 3H68A 4TUGA 1SU1A 4DT2A 1IT6A 1II7A 5J28A 4WWLA 2JOGA 2NPPC 2BDXA 4O5GA 4IYPC 3IVEA 4OR9A 2ZBMA 4H2GA 4ORBA 5JPFA 1NNWA 4UT3B 2USHA 1QHWA 2A22A 3V4YA 4DHLA 3GVEA 1XZWA 3T1IA 5JJTA 3QFKA 1WAO1 2NYMC 2QJCA 3K7WC 3C5WC 4UT2A 3IB8A 2WDFA 1QFCA 3CK2A 4H1YP 4FBKA 3EGHA 5GTUA 2NXFA 3HVQA 4TUIA 2QFRA 4I5LC 5B8IA 2HYOA 1HP1A 3PSNA 4MOVA 4H2IA 2GJUA 4FCXA 2AHDA 3H61A 3ICFA 1OIEA 3TGHA 3QG5C 5F3WA 1S8EA 5IOHA 3RL3A 1S3MA 2DFJA 3QFMA 4FBQA 4M0VA 2WDEA 3E7BA 3THOB 1T70A 2CV9A 4J6OA 4V0VA 4LACC 3IVDA 3RL5A 4KKZA 3EGGA 1UTEA 2IAEC 2IE3C 1WARA 1USHA 3IB7A 3H60A 3PSOA 4IL1A 4FBWA 1S3LA 1V73A 4ORAA 3H69A 2YVTA 4JA9A 4LU9A 3E7AA 4XPNA 2Q8UA
chains in the Genus database with same CATH superfamily
2WDDA 1S3NA 1OI8A 2IE4C 1MF8A 2DXNA 2P6BA 3H63A 1Z2WA 3K7VC 4KBPA 4LTYA 3LL8A 4ZVZA 2KKNA 5C1VA 3P71C 2YEQA 3KBPA 4YKEA 3DSDA 2ZO9B 1KBPA 3THNA 4MOYA 5JPEA 1TCOA 3H64A 1HO5A 1T71A 3H62B 4MP0A 4B2OA 1W24A 3H67A 1Z2XA 4O43A 4NZVA 4ZX2A 5DNYA 4O24A 2BCDA 3ZTVA 4DSYA 1UF3A 2O8GA 1AUIA 1S95A 3D03A 4H2BA 4UT3A 2NYLC 1HPUA 2QFPA 3C9FA 4UWQA 4H1SA 2WDCA 4ORCA 2R17A 3DW8C 2DXLA 1FJMA 5INBA 4G9JA 3FGAC 3RQZA 1S70A 5EQVA 2HY1A 5HPEA 3H66A 3QFNA 2XMOA 1XM7A 2Z1AA 1G5BA 4HD0A 2Z72A 1JK7A 3ZU0A 3AUZA 4H2FA 3JYFA 2BQ8X 4O4KA 4V0XA 1M63A 2O8AA 3AV0A 4V0WA 3RL4A 4F0ZA 3QFOA 1OIDA 2HYPA 4JA7A 3DSCA 1U32A 4I5NC 2Z06A 3N5UA 4Q7FA 3H68A 4TUGA 1SU1A 4DT2A 1IT6A 1II7A 5J28A 4WWLA 2JOGA 2NPPC 2BDXA 4O5GA 4IYPC 3IVEA 4OR9A 2ZBMA 4H2GA 4ORBA 5JPFA 3FLOA 1NNWA 4UT3B 2USHA 1QHWA 2A22A 3V4YA 4DHLA 3GVEA 1XZWA 3T1IA 5JJTA 3QFKA 1WAO1 2NYMC 2QJCA 3K7WC 3C5WC 4UT2A 3IB8A 2WDFA 1QFCA 3CK2A 4H1YP 4FBKA 3EGHA 5GTUA 2NXFA 3HVQA 4TUIA 2QFRA 4I5LC 5B8IA 2HYOA 1HP1A 3PSNA 4MOVA 4H2IA 2GJUA 4FCXA 2AHDA 3H61A 3ICFA 1OIEA 3TGHA 3QG5C 5F3WA 2ZOAA 1S8EA 5IOHA 3RL3A 1S3MA 2DFJA 3QFMA 4FBQA 4M0VA 2WDEA 3E7BA 3THOB 1T70A 2CV9A 4J6OA 4V0VA 4LACC 3IVDA 3RL5A 4KKZA 3EGGA 1UTEA 2IAEC 2IE3C 1WARA 1USHA 3IB7A 3H60A 3PSOA 4IL1A 4FBWA 1S3LA 1V73A 4ORAA 3E0JA 3H69A 2YVTA 4JA9A 4LU9A 3E7AA 4XPNA 2Q8UA
chains in the Genus database with same CATH topology
2WDDA 1S3NA 1OI8A 2IE4C 1MF8A 2DXNA 2P6BA 3H63A 1Z2WA 3K7VC 4KBPA 4LTYA 3LL8A 4ZVZA 2KKNA 5C1VA 3P71C 2YEQA 3KBPA 4YKEA 3DSDA 2ZO9B 1KBPA 3THNA 4MOYA 5JPEA 1TCOA 3H64A 1HO5A 1T71A 3H62B 4MP0A 4B2OA 1W24A 3H67A 1Z2XA 4O43A 4NZVA 4ZX2A 5DNYA 4O24A 2BCDA 3ZTVA 4DSYA 1UF3A 2O8GA 1AUIA 1S95A 3D03A 4H2BA 4UT3A 2NYLC 1HPUA 2QFPA 3C9FA 4UWQA 4H1SA 2WDCA 4ORCA 2R17A 3DW8C 2DXLA 1FJMA 5INBA 4G9JA 3FGAC 3RQZA 1S70A 5EQVA 2HY1A 5HPEA 3H66A 3QFNA 2XMOA 1XM7A 2Z1AA 1G5BA 4HD0A 2Z72A 1JK7A 3ZU0A 3AUZA 4H2FA 3JYFA 2BQ8X 4O4KA 4V0XA 1M63A 2O8AA 3AV0A 4V0WA 3RL4A 4F0ZA 3QFOA 1OIDA 2HYPA 4JA7A 3DSCA 1U32A 4I5NC 2Z06A 3N5UA 4Q7FA 3H68A 4TUGA 1SU1A 4DT2A 1IT6A 1II7A 5J28A 4WWLA 2JOGA 2NPPC 2BDXA 4O5GA 4IYPC 3IVEA 4OR9A 2ZBMA 4H2GA 4ORBA 5JPFA 3FLOA 1NNWA 4UT3B 2USHA 1QHWA 2A22A 3V4YA 4DHLA 3GVEA 1XZWA 3T1IA 5JJTA 3QFKA 1WAO1 2NYMC 2QJCA 3K7WC 3C5WC 4UT2A 3IB8A 2WDFA 1QFCA 3CK2A 4H1YP 4FBKA 3EGHA 5GTUA 2NXFA 3HVQA 4TUIA 2QFRA 4I5LC 5B8IA 2HYOA 1HP1A 3PSNA 4MOVA 4H2IA 2GJUA 4FCXA 2AHDA 3H61A 3ICFA 1OIEA 3TGHA 3QG5C 5F3WA 2ZOAA 1S8EA 5IOHA 3RL3A 1S3MA 2DFJA 3QFMA 4FBQA 4M0VA 2WDEA 3E7BA 3THOB 1T70A 2CV9A 4J6OA 4V0VA 4LACC 3IVDA 3RL5A 4KKZA 3EGGA 1UTEA 2IAEC 2IE3C 1WARA 1USHA 3IB7A 3H60A 3PSOA 4IL1A 4FBWA 1S3LA 1V73A 4ORAA 3E0JA 3H69A 2YVTA 4JA9A 4LU9A 3E7AA 4XPNA 2Q8UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WDD A;  1S3N A;  1OI8 A;  2IE4 C;  1MF8 A;  2P6B A;  3H63 A;  4KBP A;  1Z2W A;  3K7V C;  4LTY A;  3LL8 A;  4ZVZ A;  2KKN A;  5C1V A;  3P71 C;  3KBP A;  4YKE A;  3DSD A;  1KBP A;  3THN A;  4MOY A;  5JPE A;  1TCO A;  3H64 A;  1HO5 A;  1T71 A;  3H62 B;  4MP0 A;  4B2O A;  1W24 A;  3H67 A;  1Z2X A;  4O43 A;  4NZV A;  4ZX2 A;  5DNY A;  4O24 A;  2BCD A;  3ZTV A;  4DSY A;  1UF3 A;  2O8G A;  1AUI A;  1S95 A;  4H2B A;  4UT3 A;  2NYL C;  1HPU A;  2QFP A;  3C9F A;  4UWQ A;  4H1S A;  2WDC A;  4ORC A;  2R17 A;  3DW8 C;  1FJM A;  5INB A;  4G9J A;  3FGA C;  3RQZ A;  1S70 A;  5EQV A;  2HY1 A;  5HPE A;  3H66 A;  3QFN A;  2XMO A;  1XM7 A;  2Z1A A;  1G5B A;  4HD0 A;  2Z72 A;  1JK7 A;  3ZU0 A;  3AUZ A;  4H2F A;  3JYF A;  2BQ8 X;  4O4K A;  4V0X A;  1M63 A;  2O8A A;  3AV0 A;  4V0W A;  3RL4 A;  4F0Z A;  3QFO A;  1OID A;  2HYP A;  4JA7 A;  3DSC A;  1U32 A;  4I5N C;  2Z06 A;  3N5U A;  4Q7F A;  3H68 A;  4TUG A;  1SU1 A;  4DT2 A;  1IT6 A;  1II7 A;  5J28 A;  4WWL A;  2JOG A;  2NPP C;  2BDX A;  4O5G A;  4IYP C;  3IVE A;  4OR9 A;  2ZBM A;  4H2G A;  4ORB A;  5JPF A;  1NNW A;  4UT3 B;  2USH A;  1QHW A;  2A22 A;  3V4Y A;  4DHL A;  3GVE A;  1XZW A;  3T1I A;  5JJT A;  3QFK A;  1WAO 1;  2NYM C;  2QJC A;  3K7W C;  3C5W C;  4UT2 A;  3IB8 A;  2WDF A;  1QFC A;  3CK2 A;  4H1Y P;  4FBK A;  3EGH A;  5GTU A;  2NXF A;  3HVQ A;  4TUI A;  2QFR A;  4I5L C;  5B8I A;  2HYO A;  1HP1 A;  3PSN A;  4MOV A;  4H2I A;  2GJU A;  4FCX A;  2AHD A;  3H61 A;  3ICF A;  1OIE A;  3TGH A;  3QG5 C;  5F3W A;  1S8E A;  5IOH A;  3RL3 A;  1S3M A;  2DFJ A;  3QFM A;  4FBQ A;  4M0V A;  2WDE A;  3E7B A;  3THO B;  1T70 A;  2CV9 A;  4J6O A;  4V0V A;  4LAC C;  3IVD A;  3RL5 A;  4KKZ A;  3EGG A;  1UTE A;  2IAE C;  2IE3 C;  1WAR A;  1USH A;  3IB7 A;  3H60 A;  3PSO A;  4IL1 A;  4FBW A;  1S3L A;  1V73 A;  4ORA A;  3H69 A;  2YVT A;  4JA9 A;  4LU9 A;  3E7A A;  4XPN A;  2Q8U A; 
#chains in the Genus database with same CATH topology
 2WDD A;  1S3N A;  1OI8 A;  2IE4 C;  1MF8 A;  2DXN A;  2P6B A;  3H63 A;  1Z2W A;  3K7V C;  4KBP A;  4LTY A;  3LL8 A;  4ZVZ A;  2KKN A;  5C1V A;  3P71 C;  2YEQ A;  3KBP A;  4YKE A;  3DSD A;  2ZO9 B;  1KBP A;  3THN A;  4MOY A;  5JPE A;  1TCO A;  3H64 A;  1HO5 A;  1T71 A;  3H62 B;  4MP0 A;  4B2O A;  1W24 A;  3H67 A;  1Z2X A;  4O43 A;  4NZV A;  4ZX2 A;  5DNY A;  4O24 A;  2BCD A;  3ZTV A;  4DSY A;  1UF3 A;  2O8G A;  1AUI A;  1S95 A;  3D03 A;  4H2B A;  4UT3 A;  2NYL C;  1HPU A;  2QFP A;  3C9F A;  4UWQ A;  4H1S A;  2WDC A;  4ORC A;  2R17 A;  3DW8 C;  2DXL A;  1FJM A;  5INB A;  4G9J A;  3FGA C;  3RQZ A;  1S70 A;  5EQV A;  2HY1 A;  5HPE A;  3H66 A;  3QFN A;  2XMO A;  1XM7 A;  2Z1A A;  1G5B A;  4HD0 A;  2Z72 A;  1JK7 A;  3ZU0 A;  3AUZ A;  4H2F A;  3JYF A;  2BQ8 X;  4O4K A;  4V0X A;  1M63 A;  2O8A A;  3AV0 A;  4V0W A;  3RL4 A;  4F0Z A;  3QFO A;  1OID A;  2HYP A;  4JA7 A;  3DSC A;  1U32 A;  4I5N C;  2Z06 A;  3N5U A;  4Q7F A;  3H68 A;  4TUG A;  1SU1 A;  4DT2 A;  1IT6 A;  1II7 A;  5J28 A;  4WWL A;  2JOG A;  2NPP C;  2BDX A;  4O5G A;  4IYP C;  3IVE A;  4OR9 A;  2ZBM A;  4H2G A;  4ORB A;  5JPF A;  3FLO A;  1NNW A;  4UT3 B;  2USH A;  1QHW A;  2A22 A;  3V4Y A;  4DHL A;  3GVE A;  1XZW A;  3T1I A;  5JJT A;  3QFK A;  1WAO 1;  2NYM C;  2QJC A;  3K7W C;  3C5W C;  4UT2 A;  3IB8 A;  2WDF A;  1QFC A;  3CK2 A;  4H1Y P;  4FBK A;  3EGH A;  5GTU A;  2NXF A;  3HVQ A;  4TUI A;  2QFR A;  4I5L C;  5B8I A;  2HYO A;  1HP1 A;  3PSN A;  4MOV A;  4H2I A;  2GJU A;  4FCX A;  2AHD A;  3H61 A;  3ICF A;  1OIE A;  3TGH A;  3QG5 C;  5F3W A;  2ZOA A;  1S8E A;  5IOH A;  3RL3 A;  1S3M A;  2DFJ A;  3QFM A;  4FBQ A;  4M0V A;  2WDE A;  3E7B A;  3THO B;  1T70 A;  2CV9 A;  4J6O A;  4V0V A;  4LAC C;  3IVD A;  3RL5 A;  4KKZ A;  3EGG A;  1UTE A;  2IAE C;  2IE3 C;  1WAR A;  1USH A;  3IB7 A;  3H60 A;  3PSO A;  4IL1 A;  4FBW A;  1S3L A;  1V73 A;  4ORA A;  3E0J A;  3H69 A;  2YVT A;  4JA9 A;  4LU9 A;  3E7A A;  4XPN A;  2Q8U A; 
#chains in the Genus database with same CATH homology
 2WDD A;  1S3N A;  1OI8 A;  2IE4 C;  1MF8 A;  2DXN A;  2P6B A;  3H63 A;  1Z2W A;  3K7V C;  4KBP A;  4LTY A;  3LL8 A;  4ZVZ A;  2KKN A;  5C1V A;  3P71 C;  2YEQ A;  3KBP A;  4YKE A;  3DSD A;  2ZO9 B;  1KBP A;  3THN A;  4MOY A;  5JPE A;  1TCO A;  3H64 A;  1HO5 A;  1T71 A;  3H62 B;  4MP0 A;  4B2O A;  1W24 A;  3H67 A;  1Z2X A;  4O43 A;  4NZV A;  4ZX2 A;  5DNY A;  4O24 A;  2BCD A;  3ZTV A;  4DSY A;  1UF3 A;  2O8G A;  1AUI A;  1S95 A;  3D03 A;  4H2B A;  4UT3 A;  2NYL C;  1HPU A;  2QFP A;  3C9F A;  4UWQ A;  4H1S A;  2WDC A;  4ORC A;  2R17 A;  3DW8 C;  2DXL A;  1FJM A;  5INB A;  4G9J A;  3FGA C;  3RQZ A;  1S70 A;  5EQV A;  2HY1 A;  5HPE A;  3H66 A;  3QFN A;  2XMO A;  1XM7 A;  2Z1A A;  1G5B A;  4HD0 A;  2Z72 A;  1JK7 A;  3ZU0 A;  3AUZ A;  4H2F A;  3JYF A;  2BQ8 X;  4O4K A;  4V0X A;  1M63 A;  2O8A A;  3AV0 A;  4V0W A;  3RL4 A;  4F0Z A;  3QFO A;  1OID A;  2HYP A;  4JA7 A;  3DSC A;  1U32 A;  4I5N C;  2Z06 A;  3N5U A;  4Q7F A;  3H68 A;  4TUG A;  1SU1 A;  4DT2 A;  1IT6 A;  1II7 A;  5J28 A;  4WWL A;  2JOG A;  2NPP C;  2BDX A;  4O5G A;  4IYP C;  3IVE A;  4OR9 A;  2ZBM A;  4H2G A;  4ORB A;  5JPF A;  3FLO A;  1NNW A;  4UT3 B;  2USH A;  1QHW A;  2A22 A;  3V4Y A;  4DHL A;  3GVE A;  1XZW A;  3T1I A;  5JJT A;  3QFK A;  1WAO 1;  2NYM C;  2QJC A;  3K7W C;  3C5W C;  4UT2 A;  3IB8 A;  2WDF A;  1QFC A;  3CK2 A;  4H1Y P;  4FBK A;  3EGH A;  5GTU A;  2NXF A;  3HVQ A;  4TUI A;  2QFR A;  4I5L C;  5B8I A;  2HYO A;  1HP1 A;  3PSN A;  4MOV A;  4H2I A;  2GJU A;  4FCX A;  2AHD A;  3H61 A;  3ICF A;  1OIE A;  3TGH A;  3QG5 C;  5F3W A;  2ZOA A;  1S8E A;  5IOH A;  3RL3 A;  1S3M A;  2DFJ A;  3QFM A;  4FBQ A;  4M0V A;  2WDE A;  3E7B A;  3THO B;  1T70 A;  2CV9 A;  4J6O A;  4V0V A;  4LAC C;  3IVD A;  3RL5 A;  4KKZ A;  3EGG A;  1UTE A;  2IAE C;  2IE3 C;  1WAR A;  1USH A;  3IB7 A;  3H60 A;  3PSO A;  4IL1 A;  4FBW A;  1S3L A;  1V73 A;  4ORA A;  3E0J A;  3H69 A;  2YVT A;  4JA9 A;  4LU9 A;  3E7A A;  4XPN A;  2Q8U A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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