2LSRA

Solution structure of harmonin n terminal domain in complex with a exon68 encoded peptide of cadherin23
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
80
structure length
80
Chain Sequence
MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Structural protein/cell adhesion
molecule keywords Harmonin
publication title Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereocilia
doi rcsb
source organism Homo sapiens
total genus 22
structure length 80
sequence length 80
ec nomenclature
pdb deposition date 2012-05-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1160.20 Mainly Alpha Up-down Bundle Paired amphipathic helix 2 (pah2 repeat) Paired amphipathic helix 2 (pah2 repeat) 2lsrA00
2KBRA 2KBQA 4FQNA 4YKCA 4YKDA 2LSRA 5F3XA 4Y5OA 4YL6A 3K1RA
chains in the Genus database with same CATH superfamily
2KBRA 2KBQA 2L9SB 1S5RB 1G1EB 4YL6A 3K1RA 2F05A 1S5QB 1PD7A 2LSRA 2RMRA 2RMSA 1E91A 2LD7B 4YKCA 4YKDA 5F3XA 2CZYA 4FQNA 2CR7A 4Y5OA
chains in the Genus database with same CATH topology
2KBRA 2KBQA 4FQNA 4YKCA 4YKDA 2LSRA 5F3XA 4Y5OA 4YL6A 3K1RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KBR A;  2KBQ A;  4FQN A;  4YKC A;  4YKD A;  2LSR A;  5F3X A;  4Y5O A;  4YL6 A;  3K1R A; 
#chains in the Genus database with same CATH topology
 2KBR A;  2KBQ A;  2L9S B;  1S5R B;  1G1E B;  4YL6 A;  3K1R A;  2F05 A;  1S5Q B;  1PD7 A;  2LSR A;  2RMR A;  2RMS A;  1E91 A;  2LD7 B;  4YKC A;  4YKD A;  5F3X A;  2CZY A;  4FQN A;  2CR7 A;  4Y5O A; 
#chains in the Genus database with same CATH homology
 2KBR A;  2KBQ A;  4FQN A;  4YKC A;  4YKD A;  2LSR A;  5F3X A;  4Y5O A;  4YL6 A;  3K1R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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