3RL4A

Rat metallophosphodiesterase mpped2 g252h mutant
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
281
structure length
275
Chain Sequence
VTITVDEYSSNPTQAFTHYNINQSRFQPPHVHMVDPIPYDTPKPAGHTRFVCISDTHSRTDGIQMPYGDILLHTGDFTELGLPSEVKKFNDWLGNLPYEYKIVIAGNHELTFDKEFMADLVFPSVSKLKPEDFDNVQSLLTNSIYLQDSEVTVKGFRIYGAPWTPWFNGWGFNLPRGQSLLDKWNLIPEGTDILMTHGPPLGFRDWVPKELQRVGCVELLNTVQRRVRPKLHVFGHIHEGYGTMTDGYTTYINASTCTVSFQPTNPPIIFDLPNP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Metallophosphoesterase MPPED2
publication title Unique utilization of a phosphoprotein phosphatase fold by a mammalian phosphodiesterase associated with WAGR syndrome.
pubmed doi rcsb
source organism Rattus norvegicus
total genus 91
structure length 275
sequence length 281
ec nomenclature ec 3.1.-.-:
pdb deposition date 2011-04-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3rl4A00
2HY1A 3EGGA 4FBQA 2IE3C 1U32A 2WDEA 4KBPA 3IB8A 3TGHA 4FBWA 3CK2A 3H69A 3IB7A 1HO5A 3QFMA 4TUGA 1KBPA 1UTEA 3PSNA 2DFJA 1FJMA 1MF8A 1II7A 1Z2WA 2NXFA 4O5GA 3E7BA 2Q8UA 3FGAC 3QG5C 3K7WC 1S70A 4LACC 1JK7A 3ICFA 2Z06A 3C9FA 4HD0A 5HPEA 1M63A 2WDDA 3H68A 5EQVA 2O8GA 2A22A 4Q7FA 3PSOA 2GJUA 1XM7A 3DSCA 4V0VA 2NPPC 3H60A 5JJTA 1TCOA 4V0XA 2IAEC 4B2OA 3RL5A 5INBA 4DSYA 1S95A 4ZVZA 3P71C 3ZTVA 1W24A 3THNA 2BCDA 4LU9A 4IL1A 2AHDA 4M0VA 2QJCA 4UT3A 3RL4A 3EGHA 1OIEA 4YKEA 2JOGA 5JPFA 4FCXA 5DNYA 4ORCA 1OIDA 2HYOA 2WDCA 5IOHA 4O24A 1QHWA 2CV9A 1T71A 1AUIA 3LL8A 5GTUA 5B8IA 2QFRA 4V0WA 2YVTA 4UWQA 5F3WA 1S3LA 3N5UA 1HP1A 3RL3A 3ZU0A 1UF3A 2IE4C 4O43A 3IVDA 2WDFA 1XZWA 4I5LC 4TUIA 4F0ZA 5J28A 3H63A 4G9JA 2R17A 1IT6A 4H2FA 3AUZA 4MP0A 3V4YA 1S3NA 1V73A 4J6OA 4MOYA 2KKNA 4H1YP 4ZX2A 1QFCA 2Z72A 2P6BA 3H66A 3K7VC 3RQZA 4H2IA 4DT2A 4FBKA 4MOVA 2NYMC 5JPEA 1HPUA 4XPNA 3T1IA 4H2GA 1WAO1 3C5WC 3HVQA 2HYPA 2XMOA 2BDXA 3DW8C 3QFKA 4ORAA 4LTYA 4DHLA 3IVEA 3H64A 1S8EA 2O8AA 4UT3B 3DSDA 3H61A 4H1SA 4H2BA 3QFNA 1Z2XA 3AV0A 3THOB 4WWLA 1SU1A 1OI8A 3H67A 4JA7A 4IYPC 4ORBA 3GVEA 4I5NC 1NNWA 3QFOA 1WARA 2USHA 5C1VA 1S3MA 3KBPA 4UT2A 2NYLC 2BQ8X 4KKZA 3H62B 4NZVA 2ZBMA 3JYFA 4JA9A 2Z1AA 4O4KA 3E7AA 2QFPA 4OR9A 1USHA 1T70A 1G5BA
chains in the Genus database with same CATH superfamily
2HY1A 3EGGA 4FBQA 2IE3C 1U32A 2WDEA 4KBPA 3IB8A 3TGHA 4FBWA 3CK2A 3H69A 3IB7A 1HO5A 3QFMA 4TUGA 1KBPA 1UTEA 3PSNA 2DFJA 1FJMA 1MF8A 1II7A 2DXNA 1Z2WA 2NXFA 4O5GA 3E7BA 2Q8UA 3FGAC 3QG5C 3K7WC 1S70A 4LACC 1JK7A 3ICFA 2Z06A 3C9FA 4HD0A 5HPEA 1M63A 2WDDA 3H68A 5EQVA 2O8GA 2A22A 4Q7FA 3PSOA 2GJUA 1XM7A 3DSCA 4V0VA 2NPPC 3H60A 5JJTA 1TCOA 4V0XA 2IAEC 4B2OA 3RL5A 5INBA 3D03A 4DSYA 1S95A 4ZVZA 3P71C 3ZTVA 2ZOAA 1W24A 3THNA 2BCDA 4LU9A 4IL1A 2AHDA 4M0VA 2QJCA 4UT3A 3RL4A 3EGHA 1OIEA 4YKEA 2JOGA 5JPFA 4FCXA 5DNYA 4ORCA 1OIDA 2HYOA 2WDCA 5IOHA 4O24A 1QHWA 2CV9A 1T71A 2YEQA 1AUIA 3LL8A 5GTUA 2DXLA 5B8IA 2QFRA 4V0WA 2YVTA 4UWQA 5F3WA 1S3LA 3N5UA 1HP1A 3RL3A 3ZU0A 1UF3A 2IE4C 4O43A 3IVDA 2WDFA 1XZWA 4I5LC 4TUIA 4F0ZA 5J28A 3H63A 4G9JA 2R17A 1IT6A 4H2FA 3AUZA 4MP0A 3V4YA 1S3NA 1V73A 4J6OA 4MOYA 2KKNA 4H1YP 4ZX2A 1QFCA 2Z72A 2P6BA 3H66A 3K7VC 3RQZA 4H2IA 4DT2A 4FBKA 4MOVA 2NYMC 5JPEA 1HPUA 4XPNA 3T1IA 4H2GA 1WAO1 3C5WC 3E0JA 3HVQA 2ZO9B 2HYPA 2XMOA 2BDXA 3DW8C 3QFKA 4ORAA 4LTYA 4DHLA 3IVEA 3H64A 1S8EA 2O8AA 4UT3B 3DSDA 3H61A 4H1SA 4H2BA 3QFNA 3FLOA 1Z2XA 3AV0A 3THOB 4WWLA 1SU1A 1OI8A 3H67A 4JA7A 4IYPC 4ORBA 3GVEA 4I5NC 1NNWA 3QFOA 1WARA 2USHA 5C1VA 1S3MA 3KBPA 4UT2A 2NYLC 2BQ8X 4KKZA 3H62B 4NZVA 2ZBMA 3JYFA 4JA9A 2Z1AA 4O4KA 3E7AA 2QFPA 4OR9A 1USHA 1T70A 1G5BA
chains in the Genus database with same CATH topology
2HY1A 3EGGA 4FBQA 2IE3C 1U32A 2WDEA 4KBPA 3IB8A 3TGHA 4FBWA 3CK2A 3H69A 3IB7A 1HO5A 3QFMA 4TUGA 1KBPA 1UTEA 3PSNA 2DFJA 1FJMA 1MF8A 1II7A 2DXNA 1Z2WA 2NXFA 4O5GA 3E7BA 2Q8UA 3FGAC 3QG5C 3K7WC 1S70A 4LACC 1JK7A 3ICFA 2Z06A 3C9FA 4HD0A 5HPEA 1M63A 2WDDA 3H68A 5EQVA 2O8GA 2A22A 4Q7FA 3PSOA 2GJUA 1XM7A 3DSCA 4V0VA 2NPPC 3H60A 5JJTA 1TCOA 4V0XA 2IAEC 4B2OA 3RL5A 5INBA 3D03A 4DSYA 1S95A 4ZVZA 3P71C 3ZTVA 2ZOAA 1W24A 3THNA 2BCDA 4LU9A 4IL1A 2AHDA 4M0VA 2QJCA 4UT3A 3RL4A 3EGHA 1OIEA 4YKEA 2JOGA 5JPFA 4FCXA 5DNYA 4ORCA 1OIDA 2HYOA 2WDCA 5IOHA 4O24A 1QHWA 2CV9A 1T71A 2YEQA 1AUIA 3LL8A 5GTUA 2DXLA 5B8IA 2QFRA 4V0WA 2YVTA 4UWQA 5F3WA 1S3LA 3N5UA 1HP1A 3RL3A 3ZU0A 1UF3A 2IE4C 4O43A 3IVDA 2WDFA 1XZWA 4I5LC 4TUIA 4F0ZA 5J28A 3H63A 4G9JA 2R17A 1IT6A 4H2FA 3AUZA 4MP0A 3V4YA 1S3NA 1V73A 4J6OA 4MOYA 2KKNA 4H1YP 4ZX2A 1QFCA 2Z72A 2P6BA 3H66A 3K7VC 3RQZA 4H2IA 4DT2A 4FBKA 4MOVA 2NYMC 5JPEA 1HPUA 4XPNA 3T1IA 4H2GA 1WAO1 3C5WC 3E0JA 3HVQA 2ZO9B 2HYPA 2XMOA 2BDXA 3DW8C 3QFKA 4ORAA 4LTYA 4DHLA 3IVEA 3H64A 1S8EA 2O8AA 4UT3B 3DSDA 3H61A 4H1SA 4H2BA 3QFNA 3FLOA 1Z2XA 3AV0A 3THOB 4WWLA 1SU1A 1OI8A 3H67A 4JA7A 4IYPC 4ORBA 3GVEA 4I5NC 1NNWA 3QFOA 1WARA 2USHA 5C1VA 1S3MA 3KBPA 4UT2A 2NYLC 2BQ8X 4KKZA 3H62B 4NZVA 2ZBMA 3JYFA 4JA9A 2Z1AA 4O4KA 3E7AA 2QFPA 4OR9A 1USHA 1T70A 1G5BA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2HY1 A;  3EGG A;  4FBQ A;  2IE3 C;  1U32 A;  2WDE A;  4KBP A;  3IB8 A;  3TGH A;  4FBW A;  3CK2 A;  3H69 A;  3IB7 A;  1HO5 A;  3QFM A;  4TUG A;  1KBP A;  1UTE A;  3PSN A;  2DFJ A;  1FJM A;  1MF8 A;  1II7 A;  1Z2W A;  2NXF A;  4O5G A;  3E7B A;  2Q8U A;  3FGA C;  3QG5 C;  3K7W C;  1S70 A;  4LAC C;  1JK7 A;  3ICF A;  2Z06 A;  3C9F A;  4HD0 A;  5HPE A;  1M63 A;  2WDD A;  3H68 A;  5EQV A;  2O8G A;  2A22 A;  4Q7F A;  3PSO A;  2GJU A;  1XM7 A;  3DSC A;  4V0V A;  2NPP C;  3H60 A;  5JJT A;  1TCO A;  4V0X A;  2IAE C;  4B2O A;  3RL5 A;  5INB A;  4DSY A;  1S95 A;  4ZVZ A;  3P71 C;  3ZTV A;  1W24 A;  3THN A;  2BCD A;  4LU9 A;  4IL1 A;  2AHD A;  4M0V A;  2QJC A;  4UT3 A;  3RL4 A;  3EGH A;  1OIE A;  4YKE A;  2JOG A;  5JPF A;  4FCX A;  5DNY A;  4ORC A;  1OID A;  2HYO A;  2WDC A;  5IOH A;  4O24 A;  1QHW A;  2CV9 A;  1T71 A;  1AUI A;  3LL8 A;  5GTU A;  5B8I A;  2QFR A;  4V0W A;  2YVT A;  4UWQ A;  5F3W A;  1S3L A;  3N5U A;  1HP1 A;  3RL3 A;  3ZU0 A;  1UF3 A;  2IE4 C;  4O43 A;  3IVD A;  2WDF A;  1XZW A;  4I5L C;  4TUI A;  4F0Z A;  5J28 A;  3H63 A;  4G9J A;  2R17 A;  1IT6 A;  4H2F A;  3AUZ A;  4MP0 A;  3V4Y A;  1S3N A;  1V73 A;  4J6O A;  4MOY A;  2KKN A;  4H1Y P;  4ZX2 A;  1QFC A;  2Z72 A;  2P6B A;  3H66 A;  3K7V C;  3RQZ A;  4H2I A;  4DT2 A;  4FBK A;  4MOV A;  2NYM C;  5JPE A;  1HPU A;  4XPN A;  3T1I A;  4H2G A;  1WAO 1;  3C5W C;  3HVQ A;  2HYP A;  2XMO A;  2BDX A;  3DW8 C;  3QFK A;  4ORA A;  4LTY A;  4DHL A;  3IVE A;  3H64 A;  1S8E A;  2O8A A;  4UT3 B;  3DSD A;  3H61 A;  4H1S A;  4H2B A;  3QFN A;  1Z2X A;  3AV0 A;  3THO B;  4WWL A;  1SU1 A;  1OI8 A;  3H67 A;  4JA7 A;  4IYP C;  4ORB A;  3GVE A;  4I5N C;  1NNW A;  3QFO A;  1WAR A;  2USH A;  5C1V A;  1S3M A;  3KBP A;  4UT2 A;  2NYL C;  2BQ8 X;  4KKZ A;  3H62 B;  4NZV A;  2ZBM A;  3JYF A;  4JA9 A;  2Z1A A;  4O4K A;  3E7A A;  2QFP A;  4OR9 A;  1USH A;  1T70 A;  1G5B A; 
#chains in the Genus database with same CATH topology
 2HY1 A;  3EGG A;  4FBQ A;  2IE3 C;  1U32 A;  2WDE A;  4KBP A;  3IB8 A;  3TGH A;  4FBW A;  3CK2 A;  3H69 A;  3IB7 A;  1HO5 A;  3QFM A;  4TUG A;  1KBP A;  1UTE A;  3PSN A;  2DFJ A;  1FJM A;  1MF8 A;  1II7 A;  2DXN A;  1Z2W A;  2NXF A;  4O5G A;  3E7B A;  2Q8U A;  3FGA C;  3QG5 C;  3K7W C;  1S70 A;  4LAC C;  1JK7 A;  3ICF A;  2Z06 A;  3C9F A;  4HD0 A;  5HPE A;  1M63 A;  2WDD A;  3H68 A;  5EQV A;  2O8G A;  2A22 A;  4Q7F A;  3PSO A;  2GJU A;  1XM7 A;  3DSC A;  4V0V A;  2NPP C;  3H60 A;  5JJT A;  1TCO A;  4V0X A;  2IAE C;  4B2O A;  3RL5 A;  5INB A;  3D03 A;  4DSY A;  1S95 A;  4ZVZ A;  3P71 C;  3ZTV A;  2ZOA A;  1W24 A;  3THN A;  2BCD A;  4LU9 A;  4IL1 A;  2AHD A;  4M0V A;  2QJC A;  4UT3 A;  3RL4 A;  3EGH A;  1OIE A;  4YKE A;  2JOG A;  5JPF A;  4FCX A;  5DNY A;  4ORC A;  1OID A;  2HYO A;  2WDC A;  5IOH A;  4O24 A;  1QHW A;  2CV9 A;  1T71 A;  2YEQ A;  1AUI A;  3LL8 A;  5GTU A;  2DXL A;  5B8I A;  2QFR A;  4V0W A;  2YVT A;  4UWQ A;  5F3W A;  1S3L A;  3N5U A;  1HP1 A;  3RL3 A;  3ZU0 A;  1UF3 A;  2IE4 C;  4O43 A;  3IVD A;  2WDF A;  1XZW A;  4I5L C;  4TUI A;  4F0Z A;  5J28 A;  3H63 A;  4G9J A;  2R17 A;  1IT6 A;  4H2F A;  3AUZ A;  4MP0 A;  3V4Y A;  1S3N A;  1V73 A;  4J6O A;  4MOY A;  2KKN A;  4H1Y P;  4ZX2 A;  1QFC A;  2Z72 A;  2P6B A;  3H66 A;  3K7V C;  3RQZ A;  4H2I A;  4DT2 A;  4FBK A;  4MOV A;  2NYM C;  5JPE A;  1HPU A;  4XPN A;  3T1I A;  4H2G A;  1WAO 1;  3C5W C;  3E0J A;  3HVQ A;  2ZO9 B;  2HYP A;  2XMO A;  2BDX A;  3DW8 C;  3QFK A;  4ORA A;  4LTY A;  4DHL A;  3IVE A;  3H64 A;  1S8E A;  2O8A A;  4UT3 B;  3DSD A;  3H61 A;  4H1S A;  4H2B A;  3QFN A;  3FLO A;  1Z2X A;  3AV0 A;  3THO B;  4WWL A;  1SU1 A;  1OI8 A;  3H67 A;  4JA7 A;  4IYP C;  4ORB A;  3GVE A;  4I5N C;  1NNW A;  3QFO A;  1WAR A;  2USH A;  5C1V A;  1S3M A;  3KBP A;  4UT2 A;  2NYL C;  2BQ8 X;  4KKZ A;  3H62 B;  4NZV A;  2ZBM A;  3JYF A;  4JA9 A;  2Z1A A;  4O4K A;  3E7A A;  2QFP A;  4OR9 A;  1USH A;  1T70 A;  1G5B A; 
#chains in the Genus database with same CATH homology
 2HY1 A;  3EGG A;  4FBQ A;  2IE3 C;  1U32 A;  2WDE A;  4KBP A;  3IB8 A;  3TGH A;  4FBW A;  3CK2 A;  3H69 A;  3IB7 A;  1HO5 A;  3QFM A;  4TUG A;  1KBP A;  1UTE A;  3PSN A;  2DFJ A;  1FJM A;  1MF8 A;  1II7 A;  2DXN A;  1Z2W A;  2NXF A;  4O5G A;  3E7B A;  2Q8U A;  3FGA C;  3QG5 C;  3K7W C;  1S70 A;  4LAC C;  1JK7 A;  3ICF A;  2Z06 A;  3C9F A;  4HD0 A;  5HPE A;  1M63 A;  2WDD A;  3H68 A;  5EQV A;  2O8G A;  2A22 A;  4Q7F A;  3PSO A;  2GJU A;  1XM7 A;  3DSC A;  4V0V A;  2NPP C;  3H60 A;  5JJT A;  1TCO A;  4V0X A;  2IAE C;  4B2O A;  3RL5 A;  5INB A;  3D03 A;  4DSY A;  1S95 A;  4ZVZ A;  3P71 C;  3ZTV A;  2ZOA A;  1W24 A;  3THN A;  2BCD A;  4LU9 A;  4IL1 A;  2AHD A;  4M0V A;  2QJC A;  4UT3 A;  3RL4 A;  3EGH A;  1OIE A;  4YKE A;  2JOG A;  5JPF A;  4FCX A;  5DNY A;  4ORC A;  1OID A;  2HYO A;  2WDC A;  5IOH A;  4O24 A;  1QHW A;  2CV9 A;  1T71 A;  2YEQ A;  1AUI A;  3LL8 A;  5GTU A;  2DXL A;  5B8I A;  2QFR A;  4V0W A;  2YVT A;  4UWQ A;  5F3W A;  1S3L A;  3N5U A;  1HP1 A;  3RL3 A;  3ZU0 A;  1UF3 A;  2IE4 C;  4O43 A;  3IVD A;  2WDF A;  1XZW A;  4I5L C;  4TUI A;  4F0Z A;  5J28 A;  3H63 A;  4G9J A;  2R17 A;  1IT6 A;  4H2F A;  3AUZ A;  4MP0 A;  3V4Y A;  1S3N A;  1V73 A;  4J6O A;  4MOY A;  2KKN A;  4H1Y P;  4ZX2 A;  1QFC A;  2Z72 A;  2P6B A;  3H66 A;  3K7V C;  3RQZ A;  4H2I A;  4DT2 A;  4FBK A;  4MOV A;  2NYM C;  5JPE A;  1HPU A;  4XPN A;  3T1I A;  4H2G A;  1WAO 1;  3C5W C;  3E0J A;  3HVQ A;  2ZO9 B;  2HYP A;  2XMO A;  2BDX A;  3DW8 C;  3QFK A;  4ORA A;  4LTY A;  4DHL A;  3IVE A;  3H64 A;  1S8E A;  2O8A A;  4UT3 B;  3DSD A;  3H61 A;  4H1S A;  4H2B A;  3QFN A;  3FLO A;  1Z2X A;  3AV0 A;  3THO B;  4WWL A;  1SU1 A;  1OI8 A;  3H67 A;  4JA7 A;  4IYP C;  4ORB A;  3GVE A;  4I5N C;  1NNW A;  3QFO A;  1WAR A;  2USH A;  5C1V A;  1S3M A;  3KBP A;  4UT2 A;  2NYL C;  2BQ8 X;  4KKZ A;  3H62 B;  4NZV A;  2ZBM A;  3JYF A;  4JA9 A;  2Z1A A;  4O4K A;  3E7A A;  2QFP A;  4OR9 A;  1USH A;  1T70 A;  1G5B A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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