4NYJS

Approach for targeting ras with small molecules that activate sos-mediated nucleotide exchange
Total Genus 174
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
174
sequence length
481
structure length
468
Chain Sequence
QMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIANITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Signaling protein
molecule keywords GTPase HRas
publication title Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
pubmed doi rcsb
source organism Homo sapiens
total genus 174
structure length 468
sequence length 481
ec nomenclature
pdb deposition date 2013-12-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00617 RasGEF RasGEF domain
S PF00618 RasGEF_N RasGEF N-terminal motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 4nyjS02
1.20.870.10 Mainly Alpha Up-down Bundle Son of sevenless (SoS) protein; Chain S, domain 1 Son of sevenless (SoS) protein Chain: S domain 1 4nyjS01
4URZS 5CM9A 4MH0E 4MGYE 4URXS 4URUS 4URVS 4US0S 4US1S 4NYIS 4L9MA 1XD4A 1NVVS 1BKDS 4F7ZA 4MGZE 3T6GA 1NVWS 2II0A 3CF6E 1XD2C 4URYS 3KSYA 4MGIE 4URWS 2IJES 1NVXS 3QXLA 4JGWA 4NYMS 4NYJS 2BYVE 4MGKE 5CM8A 4US2S 3T6AA 1NVUS
chains in the Genus database with same CATH superfamily
4URZS 5CM9A 4MH0E 4MGYE 4URXS 4URUS 4URVS 4US0S 4US1S 4NYIS 4L9MA 1XD4A 1NVVS 1BKDS 4F7ZA 4MGZE 3T6GA 1NVWS 2II0A 3CF6E 1XD2C 4URYS 3KSYA 4MGIE 4URWS 2IJES 1NVXS 3QXLA 4JGWA 4NYMS 4NYJS 2BYVE 4MGKE 5CM8A 4US2S 3T6AA 1NVUS
chains in the Genus database with same CATH topology
4URZS 5CM9A 4MH0E 4MGYE 4URXS 4URUS 4URVS 4US0S 4US1S 4NYIS 4L9MA 1XD4A 1NVVS 1BKDS 4F7ZA 4MGZE 3T6GA 1NVWS 2II0A 3CF6E 1XD2C 4URYS 3KSYA 4MGIE 4URWS 2IJES 1NVXS 3QXLA 4JGWA 4NYMS 4NYJS 2BYVE 4MGKE 5CM8A 4US2S 3T6AA 1NVUS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4URZ S;  5CM9 A;  4MH0 E;  4MGY E;  4URX S;  4URU S;  4URV S;  4US0 S;  4US1 S;  4NYI S;  4L9M A;  1XD4 A;  1NVV S;  1BKD S;  4F7Z A;  4MGZ E;  3T6G A;  1NVW S;  2II0 A;  3CF6 E;  1XD2 C;  4URY S;  3KSY A;  4MGI E;  4URW S;  2IJE S;  1NVX S;  3QXL A;  4JGW A;  4NYM S;  4NYJ S;  2BYV E;  4MGK E;  5CM8 A;  4US2 S;  3T6A A;  1NVU S; 
#chains in the Genus database with same CATH topology
 4URZ S;  5CM9 A;  4MH0 E;  4MGY E;  4URX S;  4URU S;  4URV S;  4US0 S;  4US1 S;  4NYI S;  4L9M A;  1XD4 A;  1NVV S;  1BKD S;  4F7Z A;  4MGZ E;  3T6G A;  1NVW S;  2II0 A;  3CF6 E;  1XD2 C;  4URY S;  3KSY A;  4MGI E;  4URW S;  2IJE S;  1NVX S;  3QXL A;  4JGW A;  4NYM S;  4NYJ S;  2BYV E;  4MGK E;  5CM8 A;  4US2 S;  3T6A A;  1NVU S; 
#chains in the Genus database with same CATH homology
 4URZ S;  5CM9 A;  4MH0 E;  4MGY E;  4URX S;  4URU S;  4URV S;  4US0 S;  4US1 S;  4NYI S;  4L9M A;  1XD4 A;  1NVV S;  1BKD S;  4F7Z A;  4MGZ E;  3T6G A;  1NVW S;  2II0 A;  3CF6 E;  1XD2 C;  4URY S;  3KSY A;  4MGI E;  4URW S;  2IJE S;  1NVX S;  3QXL A;  4JGW A;  4NYM S;  4NYJ S;  2BYV E;  4MGK E;  5CM8 A;  4US2 S;  3T6A A;  1NVU S; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...