5IEIA

X-ray crystallographic structure of a high affinity igf2 antagonist (domain11 ab5 rhh) based on human igf2r domain 11
Total Genus 36
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
36
sequence length
137
structure length
132
Chain Sequence
NEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYAKGWGVYMSICGENENCPPGVGACFGRTRISVGKANKRLRYVDQVLQLVYKDGSHCPSKHGLSYKSVISFVCRPNRPMLISLDKQTCTLFFSWHTPLACE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transport protein
molecule keywords Cation-independent mannose-6-phosphate receptor
publication title Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.
pubmed doi rcsb
source organism Homo sapiens
total genus 36
structure length 132
sequence length 137
ec nomenclature
pdb deposition date 2016-02-25
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.130.10 Mainly Beta Distorted Sandwich Cation-dependent Mannose-6-phosphate Receptor; Chain A Mannose-6-phosphate receptor binding domain 5ieiA00
2V5NA 1GP0A 1Q25A 1M6PA 2M6TA 2V5OA 1E6FA 2N1HA 2LVXA 1GQBA 2KVAA 2RL8A 3K43A 2L29A 1SYOA 2RLBA 1GP3A 3K42A 2CNJD 1SZ0A 2M68A 1C39A 2L2AA 4XQMA 2L2GA 2KVBA 3K41A 5IEIA 3CY4A 1KEOA 2L21A 3AIHA 2RL7A 2LLAA 2RL9A
chains in the Genus database with same CATH superfamily
2V5NA 1GP0A 1Q25A 1M6PA 2M6TA 2V5OA 1E6FA 2N1HA 2LVXA 1GQBA 2KVAA 2RL8A 3K43A 2L29A 1SYOA 2RLBA 1GP3A 3K42A 2CNJD 1SZ0A 2M68A 1C39A 2L2AA 4XQMA 2L2GA 2KVBA 3K41A 5IEIA 3CY4A 1KEOA 2L21A 3AIHA 2RL7A 2LLAA 2RL9A
chains in the Genus database with same CATH topology
2V5NA 1GP0A 1Q25A 1M6PA 2M6TA 2V5OA 1E6FA 2N1HA 2LVXA 1GQBA 2KVAA 2RL8A 3K43A 2L29A 1SYOA 2RLBA 1GP3A 3K42A 2CNJD 1SZ0A 2M68A 1C39A 2L2AA 4XQMA 2L2GA 2KVBA 3K41A 5IEIA 3CY4A 1KEOA 2L21A 3AIHA 2RL7A 2LLAA 2RL9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2V5N A;  1GP0 A;  1Q25 A;  1M6P A;  2M6T A;  2V5O A;  1E6F A;  2N1H A;  2LVX A;  1GQB A;  2KVA A;  2RL8 A;  3K43 A;  2L29 A;  1SYO A;  2RLB A;  1GP3 A;  3K42 A;  2CNJ D;  1SZ0 A;  2M68 A;  1C39 A;  2L2A A;  4XQM A;  2L2G A;  2KVB A;  3K41 A;  5IEI A;  3CY4 A;  1KEO A;  2L21 A;  3AIH A;  2RL7 A;  2LLA A;  2RL9 A; 
#chains in the Genus database with same CATH topology
 2V5N A;  1GP0 A;  1Q25 A;  1M6P A;  2M6T A;  2V5O A;  1E6F A;  2N1H A;  2LVX A;  1GQB A;  2KVA A;  2RL8 A;  3K43 A;  2L29 A;  1SYO A;  2RLB A;  1GP3 A;  3K42 A;  2CNJ D;  1SZ0 A;  2M68 A;  1C39 A;  2L2A A;  4XQM A;  2L2G A;  2KVB A;  3K41 A;  5IEI A;  3CY4 A;  1KEO A;  2L21 A;  3AIH A;  2RL7 A;  2LLA A;  2RL9 A; 
#chains in the Genus database with same CATH homology
 2V5N A;  1GP0 A;  1Q25 A;  1M6P A;  2M6T A;  2V5O A;  1E6F A;  2N1H A;  2LVX A;  1GQB A;  2KVA A;  2RL8 A;  3K43 A;  2L29 A;  1SYO A;  2RLB A;  1GP3 A;  3K42 A;  2CNJ D;  1SZ0 A;  2M68 A;  1C39 A;  2L2A A;  4XQM A;  2L2G A;  2KVB A;  3K41 A;  5IEI A;  3CY4 A;  1KEO A;  2L21 A;  3AIH A;  2RL7 A;  2LLA A;  2RL9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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