|
24
|
167
|
9c87S |
Cryo-em structure of a proteolytic clpxp aaa+ machine poised to unfold a linear-degron dhfr-ssra substrate bound with mtx |
|
168
|
603
|
8yq9A |
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts v1/s) complexed with fb6, nadph and dump |
|
174
|
604
|
8yq8A |
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts v1/s) complexed with fb8, nadph and dump |
|
53
|
186
|
8wgnA |
Human dihydrofolate reductase (hsdhfr) complexed with nadph and la1 |
|
176
|
604
|
8wgmA |
Quadruple mutant plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts v1/s, n51i+c59r+s108n+i164l) complexed with la1, nadph and dump |
|
25
|
178
|
8v9rS |
Cryo-em structure of a proteolytic clpxp aaa+ machine poised to unfold a branched-degron dhfr-ssra substrate bound with mtx |
|
51
|
217
|
8rhtA |
Crystal structure of trypanosoma brucei dhfr in complex with the cofactor and inhibitor p25 |
|
46
|
159
|
9kz4A |
Dihydrofolate reductase binding to nadph and trimethoprim-tetramethylrhodamine |
|
44
|
164
|
8vtcA |
Crystal structure of mycobacterium avium dihydrofolate reductase in complex with nadph and trimethoprim |
|
47
|
178
|
9oniA |
Crystal structure of dihydrofolate reductase (dhfr) from the filarial nematode w. bancrofti in complex with nadph and methotrexate (mtx) |
|
41
|
159
|
9pxcA |
Y100f mutant of e. coli dihydrofolate reductase complexed with nadp+ (oxidized form) |
|
51
|
181
|
9ooiA |
Crystal structure of dihydrofolate reductase (dhfr) from the filarial nematode w. bancrofti in complex with nadph and antifolate 2-({4-[(2-amino-4-oxo-4,7-dihydro-1h-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)benzoic acid (og7 or tsd001) |
|
53
|
181
|
9mltA |
Crystal structure of dihydrofolate reductase (dhfr) from the filarial nematode w. bancrofti in complex with nadph and [2-({4-[(2-amino-4-oxo-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-cyanophenyl]acetic acid (tsd25 or ofd) |
|
55
|
180
|
9mlmA |
Crystal structure of dihydrofolate reductase (dhfr) from the filarial nematode w. bancrofti in complex with nadph and [2-({4-[(2-amino-4-oxo-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-methoxyphenyl]acetic acid (tsd10 or oed) |
|
40
|
159
|
8cowA |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 5-(cyclopropylethynyl)-6-(2-fluorophenyl)pyrimidine-2,4-diamine |
|
41
|
159
|
8cq9A |
Mycobacterium tuberculosis dihydrofolate reductase in complex with 5-(cyclopropylethynyl)-6-(4-(trifluoromethyl)phenyl)pyrimidine-2,4-diamine |
|
40
|
157
|
6pboX |
Staphylococcus aureus dihydrofolate reductase in complex with nadph and ucp1232 |
|
42
|
157
|
6p9zX |
Staphylococcus aureus dihydrofolate reductase in complex with nadph and methotrexate |
|
41
|
157
|
7t7sX |
R-27 in complex with s. aureus dhfr and tricyclic-nadph (tnadph) |
|
41
|
157
|
7t7qX |
R-27 in complex with s. aureus dhfr and alpha-nadph - remediated for comparison with tnadph |
|
44
|
164
|
8f83A |
Crystal structure of dihydrofolate reductase (dhfr) from mycobacterium ulcerans agy99 in complex with nadp and inhibitor mam846 |
|
42
|
163
|
8f80A |
Crystal structure of dihydrofolate reductase (dhfr) from mycobacterium ulcerans agy99 in complex with nadp and inhibitor mam738 |
|
45
|
163
|
8f84A |
Crystal structure of dihydrofolate reductase (dhfr) from mycobacterium ulcerans agy99 in complex with nadp and inhibitor mam787 |
|
42
|
163
|
8f81A |
Crystal structure of dihydrofolate reductase (dhfr) from mycobacterium ulcerans agy99 in complex with nadp and inhibitor mam777 |
|
45
|
163
|
8f82A |
Crystal structure of dihydrofolate reductase (dhfr) from mycobacterium ulcerans agy99 in complex with nadp and inhibitor mam845 |
|
45
|
163
|
8f85A |
Crystal structure of dihydrofolate reductase (dhfr) from mycobacterium ulcerans agy99 in complex with nadp and inhibitor mam851 |
|
154
|
605
|
7ctzA |
Wild-type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with fragment 148, nadph, and dump |
|
39
|
166
|
5scrA |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-735 |
|
41
|
166
|
5scuA |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-888 |
|
43
|
173
|
5sctA |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-783 |
|
42
|
167
|
5scsA |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-781 |
|
39
|
166
|
5sd3A |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-1088 |
|
45
|
166
|
5sczA |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-1224 |
|
42
|
166
|
5scqA |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-614 |
|
41
|
166
|
5sd5A |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-1230 |
|
52
|
186
|
5sd9A |
Crystal structure of dihydrofolate reductase from homo sapiens bound to nadp and sddc inhibitor sddc-1096 |
|
43
|
166
|
5scoA |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-m7 |
|
44
|
166
|
5sd4A |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-1218 |
|
44
|
168
|
5scpA |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-23 |
|
54
|
187
|
5sd6A |
Crystal structure of dihydrofolate reductase from homo sapiens bound to nadp and sddc inhibitor sddc-892 |
|
40
|
171
|
5sd2A |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-1236 (enantiomer) |
|
42
|
172
|
5scxA |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-1190 (racemic mixture) |
|
40
|
165
|
5scmA |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-22 |
|
46
|
173
|
5scvA |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-889 |
|
54
|
186
|
5sd8A |
Crystal structure of dihydrofolate reductase from homo sapiens bound to nadp and sddc inhibitor sddc-1190 (racemic mixture) |
|
54
|
186
|
5sd7A |
Crystal structure of dihydrofolate reductase from homo sapiens bound to nadp and sddc inhibitor sddc-735 |
|
44
|
169
|
5sd1A |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-1235 (enantiomer) |
|
42
|
168
|
5scyA |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-1198 |
|
42
|
166
|
5sd0A |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-1225 |
|
39
|
166
|
5scwA |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis bound to nadp and sddc inhibitor sddc-916 |
