Found 166 chains in Genus chains table. Displaying 1 - 50. Applied filters: Proteins

Search results query ec: 3.1.4.17

Total Genus Sequence Length pdb Title
127 326 6zndA [1,2,4]triazolo[1,5-a]pyrimidine phosphodiesterase 2 inhibitors
142 354 6blfA Pde2 complexed with 2-[6-fluoro-8-methylsulfonyl-9-[(1r)-1-[4-(trifluoromethyl)phenyl]ethyl]-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid
130 328 6msaA Novel, potent, selective and brain penetrant phosphodiesterase 10a inhibitors
134 322 6mscA Novel, potent, selective and brain penetrant phosphodiesterase 10a inhibitors
120 323 5znlA Crystal structure of pde10a catalytic domain complexed with lhb-6
113 324 6ijiA Crystal structure of pde10 in complex with inhibitor 2b
122 322 6ijhA Crystal structure of pde10 in complex with inhibitor af-399/14387019
115 312 5k9rA Pde10a with imidazopyrazine inhibitor
130 313 5i2rA Human pde10a in complex with 3-(2-phenylpyrazol-3-yl)-1-[3-(trifluoromethoxy)phenyl]pyridazin-4-one
140 342 6ezfA Pde2 in complex with molecule 5
135 352 6cycA Pde2 in complex with compound 5
132 352 6cydA Pde2 in complex with compound 7
134 352 6cybA Pde2 in complex with compound 7
135 342 6c7dA Crystal structure of human phosphodiesterase 2a with n-(1-adamantyl)-1-(2-chlorophenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
137 342 6c7eA Crystal structure of human phosphodiesterase 2a with 1-(2-chlorophenyl)-n,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
140 339 6c7fA Crystal structure of human phosphodiesterase 2a with 1-(2-chloro-5-isobutoxy-phenyl)-n,4-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
136 342 6c7jA Crystal structure of human phosphodiesterase 2a with 1-(5-tert-butoxy-2-chloro-phenyl)-n-isobutyl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
136 342 6c7iA Crystal structure of human phosphodiesterase 2a with 1-(2-chloro-5-methoxy-phenyl)-n-isobutyl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
133 341 6c7gA Crystal structure of human phosphodiesterase 2a with n-(1-adamantyl)-1-(2-chloro-5-isobutoxy-phenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide
134 352 6b97A Crystal structure of pde2 in complex with complex 9
130 353 6b98A Pde2 in complex with compound 1
136 352 6b96A Crystal structure of pde2 in complex with compound 16
132 340 5xkmA Crystal structure of human phosphodiesterase 2a in complex with 6-methyl-n-(1-(4-(trifluoromethoxy)phenyl)propyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
125 322 5xuiA Crystal structure of pde10a in complex with 2-methyl-5-[2-([1,2,4]triazolo[1,5-a]pyrimidin-2-yl)et hyl]pyrazolo[1,5-a]pyrimidin-7-ol
121 322 5xujA Crystal structure of pde10a in complex with 7-(4-chlorophenyl)-2-methylpyrazolo[1,5-a]pyrimidine
135 353 5w6eA Pde1b complexed with compound 3s
130 338 5u7iA Pde2 catalytic domain complexed with inhibitors
126 307 5c29A Pde10 complexed with 6-chloro-2-cyclopropyl-5-methyl-n-propyl-pyrimidin-4-amine
127 323 5c2eA Pde10 complexed with6-chloro-n-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-2-[2-(2-pyridyl)ethoxy]pyrimidin-4-amine
136 325 5c28A Pde10 complexed with 6-chloro-2-cyclopropyl-5-methyl-pyrimidin-4-amine
126 308 5c2hA Pde10 complexed with 6-chloro-n-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-2-[3-(2-quinolyl)propoxy]pyrimidin-4-amine
135 325 5c1wA Pde10 complexed with 4,6-dichloro-2-cyclopropyl-5-methyl-pyrimidine
133 323 5c2aA Pde10 complexed with 6-chloro-2-cyclopropyl-n-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-pyrimidin-4-amine
147 335 5b25A Crystal structure of human pde1b with inhibitor 3
125 315 5b4lA Crystal structure of the catalytic domain of human pde10a complexed with 1-(cyclopropylmethyl)-5-(2-(2,3-dihydro-1h-imidazo[1,2-a]benzimidazol-1-yl)ethoxy)-3-(1-phenyl-1h-pyrazol-5-yl)pyridazin-4(1h)-one
126 322 4ys7A Co-crystal structure of 2-[2-(5,8-dimethyl[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethyl]-3-methyl-3h-imidazo[4,5-f]quinoline (compound 39) with pde10a
128 321 4yqhA 2-[2-(4-phenyl-1h-imidazol-2-yl)ethyl]quinoxaline (sunovion compound 14) co-crystallized with pde10a
137 338 4htzA Crystal structure of pde2 catalytic domain in space group p1
135 338 4htxA Crystal structure of pde2 catalytic domain in complex with bay60-7550
128 318 4ddlA Pde10a crystal structure complexed with novel inhibitor
124 307 4dffA The sar development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10a inhibitors for the treatment of schizophrenia
131 340 4d09A Pde2a catalytic domain in complex with a brain penetrant inhibitor
136 339 4d08A Pde2a catalytic domain in complex with a brain penetrant inhibitor
128 325 4c1iA Selective inhibitors of pde2, pde9, and pde10: modulators of activity of the central nervous system
124 312 4bbxA Discovery of a potent, selective and orally active pde10a inhibitor for the treatment of schizophrenia
140 328 4ajfA Identification and structural characterization of pde10 fragment inhibitors
131 320 4aelA Pde10a in complex with the inhibitor az5
133 324 4ajdA Identification and structural characterization of pde10 fragment inhibitors
135 320 4ajmA Development of a plate-based optical biosensor methodology to identify pde10 fragment inhibitors
131 321 4ajgA Identification and structural characterization of pde10 fragment inhibitors