Found 438 chains in Genus chains table. Displaying 1 - 50. Applied filters: Proteins

Search results query ec: 3.1.4.17

Total Genus Sequence Length pdb Title
127 319 7qpfA Discovery of lu af11167, a phosphodiesterase 10a inhibitor clinical candidate
130 315 7qpmA Discovery of lu af11167, a phosphodiesterase 10a inhibitor clinical candidate
123 312 7qq4A Discovery of lu af11167, a phosphodiesterase 10a inhibitor clinical candidate
129 312 7qpqA Discovery of lu af11167, a phosphodiesterase 10a inhibitor clinical candidate
122 312 7qpvA Discovery of lu af11167, a phosphodiesterase 10a inhibitor clinical candidate
126 320 8di4A Discovery of mk-8189, a highly potent and selective pde10a inhibitor for the treatment of schizophrenia
124 313 5se6A Crystal structure of human phosphodiesterase 10 in complex with 2,9-dimethyl-6-[(1-methyl-4-phenylimidazol-2-yl)methoxy]purine
125 313 5sehA Crystal structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-n-(2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyrazole-3-carboxamide
126 312 5se8A Crystal structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-n-[2-(2-methyl-5-phenyl-1,2,4-triazol-3-yl)ethyl]pyrazole-3-carboxamide
127 313 5skgA Crystal structure of human phosphodiesterase 10 in complex with 2-chloro-6-(cyclopropylamino)-n-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyridine-4-carboxamide
126 313 5skhA Crystal structure of human phosphodiesterase 10 in complex with 3-[2-(3-fluorophenyl)pyrazol-3-yl]-1-[3-(trifluoromethoxy)phenyl]pyridazin-4-one
125 313 5sepA Crystal structure of human phosphodiesterase 10 in complex with 2-[2-(4-cyclopentyl-1-methylimidazol-2-yl)ethyl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine
126 313 5skjA Crystal structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-n-[2-[2-(methylamino)-2-oxoethyl]phenyl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide
121 313 5skiA Crystal structure of human phosphodiesterase 10 in complex with n-[(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)methyl]-2-methyl-5-phenyl-1,2,4-triazol-3-amine
127 313 5skmA Crystal structure of human phosphodiesterase 10 in complex with 6-chloro-n,n-dimethyl-2-[2-(1-pyridin-2-ylpyrrolidin-3-yl)ethyl]quinazolin-4-amine
124 313 5sklA Crystal structure of human phosphodiesterase 10 in complex with n-(6-cyano-2-phenylimidazo[1,2-a]pyridin-7-yl)-2-methyl-4-(morpholine-4-carbonyl)pyrazole-3-carboxamide
127 313 5sfeA Crystal structure of human phosphodiesterase 10 in complex with 3-n-[2-(3-fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl]-4-n,4-n,2-trimethylpyrazole-3,4-dicarboxamide
128 315 5shrB Crystal structure of human phosphodiesterase 10 in complex with n-[(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)methyl]-n,2-dimethyl-5-phenyl-1,2,4-triazol-3-amine
126 313 5se9A Crystal structure of human phosphodiesterase 10 in complex with 2,3-dimethyl-6-[(1-methyl-4-phenylimidazol-2-yl)methoxy]imidazo[1,2-b]pyridazine
127 312 5shrA Crystal structure of human phosphodiesterase 10 in complex with n-[(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)methyl]-n,2-dimethyl-5-phenyl-1,2,4-triazol-3-amine
124 314 5sgiA Crystal structure of human phosphodiesterase 10 in complex with 6-(3-methylphenoxy)-2-(4-pyridin-2-ylpiperazin-1-yl)-9h-purine
126 313 5skuA Crystal structure of human phosphodiesterase 10 in complex with 3-[4-[2-[2-(2-ethoxy-4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]naphthalen-1-yl]-2-methoxypropanoic acid
124 313 5skkA Crystal structure of human phosphodiesterase 10 in complex with n-[1-methyl-5-(methylcarbamoyl)pyrazol-4-yl]-6-[(3s)-oxolan-3-yl]-3-(pyrimidin-5-ylamino)pyrazine-2-carboxamide
123 313 5sknA Crystal structure of human phosphodiesterase 10 in complex with n-[3-[3-[2-(2-fluorophenyl)pyrazol-3-yl]-4-oxopyridazin-1-yl]phenyl]acetamide
126 312 5sksA Crystal structure of human phosphodiesterase 10 in complex with ethyl 1-[3-[3-(4-ethoxycarbonyl-5-methyl-imidazol-1-yl)phenoxy]phenyl]-5-methyl-imidazole-4-carboxylate
123 313 5skvA Crystal structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-n-[3-[(2-hydroxy-2-methylpropyl)carbamoyl]-1-methylpyrazol-4-yl]-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide
123 313 5skrA Crystal structure of human phosphodiesterase 10 in complex with 1-methyl-n-(2-methyl-5-pyridin-2-ylpyrazol-3-yl)-4-pyridin-4-ylpyrazole-3-carboxamide
127 313 5skfA Crystal structure of human phosphodiesterase 10 in complex with 3-[5-[1-(2,2-difluoro-1,3-benzodioxol-4-yl)-4-oxopyridazin-3-yl]pyrazol-1-yl]benzonitrile
129 313 5skbA Crystal structure of human phosphodiesterase 10 in complex with 9-methoxy-3,5-dihydropyrimido[5,4-b]indol-4-one
125 314 5setA Crystal structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-n-(2-methyl-5-pyridin-2-ylpyrazol-3-yl)-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide
120 313 5skeA Crystal structure of human phosphodiesterase 10 in complex with 2-tert-butyl-5-(pyrimidin-5-ylamino)-n-[3-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide
130 313 5skqA Crystal structure of human phosphodiesterase 10 in complex with n-ethyl-6-(4-fluorophenyl)sulfanyl-n-methyl-9h-purin-2-amine
126 314 5skpA Crystal structure of human phosphodiesterase 10 in complex with [4-(2-methoxyphenyl)piperazin-1-yl]-(3-methyl-1-phenylthieno[2,3-c]pyrazol-5-yl)methanone
126 313 5selA Crystal structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-n-(2-methyl-5-pyridin-2-ylpyrazol-3-yl)pyrazole-3-carboxamide
125 313 5sf0A Crystal structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-n-(3-pyridin-2-yl-1h-pyrazol-5-yl)pyrazole-3-carboxamide
128 313 5sfuA Crystal structure of human phosphodiesterase 10 in complex with 6-cyclopropyl-3-(pyrimidin-5-ylamino)-n-[4-(pyrrolidine-1-carbonyl)pyridin-3-yl]pyridine-2-carboxamide
124 314 5silA Crystal structure of human phosphodiesterase 10 in complex with 4-chloro-n-[2-(3,5-dimethylphenyl)-1h-benzimidazol-5-yl]-2-methylpyrazole-3-carboxamide
118 312 5sjnA Crystal structure of human phosphodiesterase 10 in complex with 6,8-dichloro-2-[2-(6,7-dimethyl-1h-benzimidazol-2-yl)ethyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyridine
125 313 5secA Crystal structure of human phosphodiesterase 10 in complex with 2-[2-(1,4-diphenylimidazol-2-yl)ethyl]-3-methylquinoxaline
125 313 5shwA Crystal structure of human phosphodiesterase 10 in complex with (2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)methanol
123 313 5sejA Crystal structure of human phosphodiesterase 10 in complex with 6-chloro-2-[2-(2-methyl-5-pyrrolidin-1-yl-1,2,4-triazol-3-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyridine
122 315 5sk8A Crystal structure of human phosphodiesterase 10 in complex with 4-chloro-n-(2-phenyl-1h-benzimidazol-5-yl)-2-propylpyrazole-3-carboxamide
123 312 5sfiA Crystal structure of human phosphodiesterase 10 in complex with 5,8-dimethyl-2-[2-[2-methyl-5-(2-methylpyrrolidin-1-yl)-1,2,4-triazol-3-yl]ethyl]-[1,2,4]triazolo[1,5-a]pyrazine
126 313 5shbA Crystal structure of human phosphodiesterase 10 in complex with 3-[2-(3-bromophenyl)pyrazol-3-yl]-1-pyridin-4-ylpyridazin-4-one
124 313 5sh8A Crystal structure of human phosphodiesterase 10 in complex with 6-methyl-n-(5-methyl-2-phenylpyrazol-3-yl)-3-(pyrimidin-5-ylamino)pyridine-2-carboxamide
123 313 5sg8A Crystal structure of human phosphodiesterase 10 in complex with 5-butoxy-4-ethoxypyrimidin-2-amine
126 313 5sfnA Crystal structure of human phosphodiesterase 10 in complex with 4-(azetidine-1-carbonyl)-2-methyl-n-[2-(1-methylbenzimidazol-2-yl)ethyl]pyrazole-3-carboxamide
121 313 5sgjA Crystal structure of human phosphodiesterase 10 in complex with 6-[(3,6-dimethylpyridine-2-carbonyl)amino]-n-methyl-2-phenyl-3h-benzimidazole-5-carboxamide
126 313 5sijA Crystal structure of human phosphodiesterase 10 in complex with 5,8-dimethyl-2-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine
124 312 5sfyA Crystal structure of human phosphodiesterase 10 in complex with 5,8-dimethyl-2-[(e)-2-[2-methyl-5-(1h-pyrazol-4-yl)-1,2,4-triazol-3-yl]ethenyl]-[1,2,4]triazolo[1,5-a]pyrazine