|
45
|
124
|
9f1jA |
First bromodomain of brd4 in complex with isox-dual based degrader 14 |
|
42
|
124
|
9f1mA |
First bromodomain of brd4 in complex with isox-dual based degrader 45 |
|
44
|
125
|
9f1nA |
First bromodomain of brd4 in complex with isox-dual based degrader 46 |
|
43
|
124
|
9f1kA |
First bromodomain of brd4 in complex with isox-dual based inhibitor 30 |
|
43
|
126
|
9f1lA |
First bromodomain of brd4 in complex with isox-dual based degrader 35 |
|
43
|
126
|
8qapA |
Crystal structure of the first bromodomain of brd4 in complex with acetyl-pyrrole derivative compound 2 |
|
43
|
126
|
8qalA |
Crystal structure of the first bromodomain of brd4 in complex with acetyl-pyrrole derivative compound 83 |
|
43
|
126
|
8qarA |
Crystal structure of the first bromodomain of brd4 in complex with acetyl-pyrrole derivative compound 98 |
|
42
|
126
|
8qanA |
Crystal structure of the first bromodomain of brd4 in complex with acetyl-pyrrole derivative compound 79 |
|
24
|
97
|
8ymbC |
The crystal structure of shd931 in complex with brd4-bd2 and vcb |
|
42
|
125
|
8ymhA |
Brd4-bd1 in complex with 5-methyl-2-{[(2r)-2-methyl-4-methylsulfonyl-piperazin-1-yl]methyl}-7-(1-methylpyrazol-3-yl)furo[3,2-c]pyridin-4-one |
|
40
|
127
|
8ymeA |
Brd4-bd1 in complex with n-cyclohexyl-1-methyl-6-{[5-methyl-7-(1-methylpyrazol-3-yl)-4-oxo-pyrazolo[4,3-c]pyridin-2-yl]methyl}azepan-1-ium-4-carboxamide 2,2,2-trifluoroacetate |
|
37
|
125
|
8ymfA |
Brd4-bd1 in complex with 7-[2-(cyclopropylmethoxy)phenyl]-5-methyl-2-[(1-methylsulfonyl-4-piperidyl)methyl]pyrazolo[4,3-c]pyridin-4-one |
|
40
|
126
|
8ymiA |
Brd4-bd1 in complex with 2-{[(3s)-1-benzylpyrrolidin-3-yl]methyl}-5-methyl-7-(1-methylpyrazol-3-yl)pyrazolo[4,3-c]pyridin-4-one |
|
39
|
126
|
8ymgA |
Brd4-bd1 in complex with 7-[4-chloro-1-(tetrahydropyran-4-ylmethyl)imidazol-2-yl]-5-methyl-2-{[(2r)-2-methyl-4-methylsulfonyl-piperazin-1-yl]methyl}furo[3,2-c]pyridin-4-one |
|
39
|
148
|
8ymbD |
The crystal structure of shd931 in complex with brd4-bd2 and vcb |
|
30
|
108
|
8ymbA |
The crystal structure of shd931 in complex with brd4-bd2 and vcb |
|
20
|
104
|
8ymbB |
The crystal structure of shd931 in complex with brd4-bd2 and vcb |
|
44
|
126
|
8v9fA |
Brd4 bd1 liganded with macrocyclic compound 2d (jj-ii-363a) |
|
45
|
127
|
8v92A |
Brd4 bd1 liganded with macrocyclic compound 2b (jj-ii-352a) |
|
44
|
127
|
9qnvA |
Crystal structure of the first bromodomain of human brd4 in complex with compound 2 |
|
43
|
124
|
9qobA |
Crystal structure of the first bromodomain of human brd4 in complex with compound 4 |
|
39
|
123
|
9iv5A |
Brd4 in complex with compound7 |
|
44
|
127
|
9ht2A |
A novel bottom-up approach to find lead-compounds in billion-sized libraries |
|
42
|
127
|
9ht0A |
A novel bottom-up approach to find lead-compounds in billion-sized libraries |
|
42
|
127
|
9ht1A |
A novel bottom-up approach to find lead-compounds in billion-sized libraries |
|
42
|
125
|
8wypA |
High resolution crystal structure of brd4 bd-1 in complex with a novel inhibitor precursor |
|
44
|
127
|
8b96A |
Crystal structure of the human brd4-bd1 bromodomain in complex with the inhibitor crcm5464 |
|
42
|
127
|
8b98A |
Crystal structure of the human brd4-bd1 bromodomain in complex with the inhibitor crcm5483 |
|
42
|
131
|
8k14A |
X-ray crystal structure of 18a in brd4(1) |
|
43
|
127
|
8q34A |
Crystal structure of the first bromodomain of human brd4 in complex with the ligand zz001229a |
|
42
|
126
|
8fvkA |
First bromodomain of brd4 liganded with ccs-1477 |
|
32
|
107
|
8wy7A |
Crystal structure of the first bromodomain of human brd4 in complex with the inhibitor 22 |
|
34
|
107
|
8wy3A |
Crystal structure of the first bromodomain of human brd4 in complex with the inhibitor 21 |
|
34
|
107
|
8wxyA |
Crystal structure of the first bromodomain of human brd4 in complex with the inhibitor 23 |
|
40
|
129
|
8c11A |
Brd4 in complex with 2-(2-(4-(3,5-dimethylisoxazol-4-yl)-1h-pyrazol-1-yl)acetamido)-n-ethylpropanamide |
|
45
|
126
|
6zelAAA |
Crystal structure of the first bromodomain of human brd4 in complex with compound f5 |
|
46
|
127
|
6zedAAA |
Crystal structure of the first bromodomain of human brd4 in complex with compound f1 |
|
42
|
124
|
7rxrA |
Crystal structure of brd4(d1) with 4-[4-(4-bromophenyl)-1-(piperidin-4-yl)-1h-imidazol-5-yl]-n-(3,5-dimethylphenyl)pyrimidin-2-amine |
|
40
|
126
|
7rxtA |
Crystal of brd4(d1) with 2-[(3r)-3-{5-[2-(3,5-dimethylphenoxy)pyrimidin-4-yl]-4-(4-iodophenyl)-1h-imidazol-1-yl}pyrrolidin-1-yl]ethan-1-amine |
|
43
|
125
|
6z7mAAA |
N-terminal bromodomain of human brd4 (3r,4r)-n-cyclohexyl-4-((3-methyl-2-oxo-1,2-dihydro-1,7-naphthyridin-8-yl)amino)piperidine-3-carboxamide |
|
43
|
127
|
6z7lAAA |
N-terminal bromodomain of human brd4 with gsk789 |
|
44
|
127
|
6zf9AAA |
Crystal structure of the first bromodomain of human brd4 in complex with compound ssr4 |
|
45
|
124
|
7rxsA |
Crystal of brd4(d1) with 2-[(3s)-3-{5-[2-(3,5-dimethylphenoxy)pyrimidin-4-yl]-4-(4-iodophenyl)-1h-imidazol-1-yl}pyrrolidin-1-yl]ethan-1-amine |
|
42
|
127
|
6z7gAAA |
N-terminal bromodomain of human brd4 with n-(2-(1h-imidazol-4-yl)ethyl)-4-acetamido-3-(benzyloxy)benzamide |
|
33
|
105
|
7la9A |
Crystal structure of the first bromodomain (bd1) of human brd4 (brd4-1) in complex with bivalent inhibitor nc-iii-49-1 |
|
45
|
127
|
7l9mA |
Crystal structure of the first bromodomain (bd1) of human brd4 in complex with bivalent inhibitor gxh-ii-083 |
|
43
|
125
|
7ehyA |
Brd4-bd1 in complex with lt-448-138 |
|
43
|
125
|
7ehwA |
Brd4-bd1 in complex with lt-642-602 |
|
28
|
109
|
7aqtA |
Nmr2 structure of brd4-bd2 in complex with ibet-762 |
