|
83
|
330
|
5p04A |
Automated refinement of diffraction data obtained from an endothiapepsin crystal treated with fragment 51 |
|
83
|
330
|
5ozlA |
Automated refinement of diffraction data obtained from an endothiapepsin crystal treated with fragment 32 |
|
82
|
330
|
5ojeA |
Endothiapepsin with ligand vsk-b24 |
|
85
|
330
|
5og7A |
Endothiapepsin in complex with hydrazide fragment |
|
88
|
337
|
5n71A |
Crystal structure of mature cathepsin d from the tick ixodes ricinus (ircd1) |
|
86
|
337
|
5n7qA |
Crystal structure of mature cathepsin d from the tick ixodes ricinus (ircd1) in complex with the inhibitor pepstatin a |
|
94
|
361
|
5n7nA |
Crystal structure of cathepsin d zymogen from the tick ixodes ricinus (ircd1) |
|
86
|
330
|
5lwtA |
Endothiapepsin in complex with a methoxylated derivative of fragment 177 |
|
84
|
330
|
5mb5A |
Cocktail experiment c: fragments 103 and 171 in complex with endothiapepsin |
|
84
|
330
|
5lwuA |
Structure resulting from an endothiapepsin crystal soaked with a dimeric derivative of fragment 177 |
|
88
|
329
|
4z22A |
Structure of plasmepsin ii from plasmodium falciparum complexed with inhibitor dr718a |
|
93
|
387
|
5kqfA |
(4~{s},6~{s})-4-[2,4-bis(fluoranyl)phenyl]-4-methyl-6-pyrimidin-5-yl-5,6-dihydro-1,3-thiazin-2-amine (compound 12) bound to bace1 |
|
86
|
330
|
5hcoA |
Endothiapepsin in complex with hydrazide |
|
106
|
390
|
5hdxA |
Bace-1 in complex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(4-ethoxy-5-fluoro-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4-d]pyrimidin-2-iminium |
|
108
|
390
|
5he4A |
Bace-1 in complex with (4ar,7as)-7a-(2,6-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4-d]pyrimidin-2-iminium |
|
103
|
390
|
5hduA |
Bace-1 incomplex with (7ar)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-6-(5-fluoro-4-methoxypyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4-d]pyrimidin-2-iminium |
|
106
|
390
|
5he5A |
Bace-1 in complex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4-methyl-6-(methylamino)pyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4-d]pyrimidin-2-iminium |
|
81
|
330
|
4zeaA |
Endothiapepsin in complex with fragment b91 |
|
103
|
390
|
5hdvA |
Bace-1 incomplex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4-d]pyrimidin-2-iminium |
|
87
|
330
|
5hctA |
Endothiapepsin in complex with biacylhydrazone |
|
101
|
388
|
5i3vA |
Crystal structure of bace1 in complex with aminoquinoline compound 1 |
|
105
|
390
|
5he7A |
Bace-1 in complex with (4ar,7as)-7a-(2,4-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-2-imino-3-methyloctahydro-4h-pyrrolo[3,4-d]pyrimidin-4-one |
|
103
|
390
|
5hdzA |
Bace-1 in complex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4-methyl-6-(methylthio)pyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4-d]pyrimidin-2-iminium |
|
105
|
390
|
5hd0A |
Bace-1 in complex with (7ar)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-6-(5-fluoropyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4-d]pyrimidin-2-iminium |
|
98
|
390
|
5f01A |
Crystal structure of bace-1 in complex with (1sr,2sr)-2-((r)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4h-1,3-oxazin-4-yl)-n-(3-chloroquinolin-8-yl)cyclopropanecarboxamide |
|
107
|
390
|
4zsrA |
Bace crystal structure with tricyclic aminothiazine inhibitor |
|
101
|
389
|
4zsmA |
Bace crystal structure with bicyclic aminothiazine fragment |
|
99
|
390
|
5f00A |
Crystal structure of bace-1 in complex with 5-[3-[(3-chloro-8-quinolyl)amino]phenyl]-5-methyl-2,6-dihydro-1,4-oxazin-3-amine |
|
88
|
387
|
5enmA |
Compound 10 |
|
106
|
390
|
4zspA |
Bace crystal structure with bicyclic aminothiazine inhibitor |
|
90
|
387
|
5enkA |
Compound 18 |
|
99
|
389
|
4zsqA |
Bace crystal structure with tricyclic aminothiazine inhibitor |
|
73
|
330
|
5er1E |
A rational approach to the design of antihypertensives. x-ray studies of complexes between aspartic proteinases and aminoalcohol renin inhibitors |
|
101
|
390
|
5ezzA |
Crystal structure of bace-1 in complex with (4s)-4-[3-(5-chloro-3-pyridyl)phenyl]-4-[4-(difluoromethoxy)-3-methyl-phenyl]-5h-oxazol-2-amine |
|
80
|
330
|
5er2E |
High-resolution x-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor. the analysis of the inhibitor binding and description of the rigid body shift in the enzyme |
|
89
|
325
|
5aprE |
Structures of complexes of rhizopuspepsin with pepstatin and other statine-containing inhibitors |
|
85
|
330
|
5dr0A |
Endothiapepsin in complex with fragment 203 |
|
84
|
330
|
5dr7A |
Endothiapepsin in complex with fragment 311 |
|
83
|
330
|
5dpzA |
Endothiapepsin in complex with fragment 31 |
|
84
|
330
|
5dr3A |
Endothiapepsin in complex with fragment 333 |
|
82
|
330
|
5dq1A |
Endothiapepsin in complex with fragment 34 |
|
86
|
330
|
5dr8A |
Endothiapepsin in complex with fragment 330 |
|
86
|
330
|
5dr1A |
Endothiapepsin in complex with fragment 278 |
|
84
|
330
|
5dr4A |
Endothiapepsin in complex with fragment 231 |
|
100
|
388
|
5dqcA |
Co-crystal of bace1 with compound 0211 |
|
83
|
330
|
5dq2A |
Endothiapepsin in complex with fragment 48 |
|
85
|
330
|
5dq5A |
Endothiapepsin in complex with fragment 209 |
|
85
|
330
|
5dq4A |
Endothiapepsin in complex with fragment 66 |
|
100
|
389
|
4zpfA |
Bace1 in complex with 8-(3-((1-aminopropan-2-yl)oxy)benzyl)-4-(cyclohexylamino)-1-(3-fluorophenyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one |
|
98
|
389
|
4zpgA |
Bace1 in complex with 8-benzyl-4-(cyclohexylamino)-1-(3-fluorophenyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one |
