|
21
|
204
|
9ip9C |
Poly-alanine model for hl-type bispecific diabody ex3 composed of 528 and okt3 fvs in ternary complex with segfr and cd3gamma-epsilon (middle conformation) |
|
39
|
584
|
9ipaA |
Poly-alanine model for hl-type bispecific diabody ex3 composed of 528 and okt3 fvs in ternary complex with segfr and cd3gamma-epsilon (open conformation) |
|
59
|
593
|
9ipdA |
Poly-alanine model for lh-type bispecific diabody ex3 composed of 528 and okt3 fvs in ternary complex with segfr and cd3gamma-epsilon (middle conformation) |
|
22
|
204
|
9ip8C |
Poly-alanine model for hl-type bispecific diabody ex3 composed of 528 and okt3 fvs in ternary complex with segfr and cd3gamma-epsilon (closed conformation) |
|
38
|
584
|
9ip9A |
Poly-alanine model for hl-type bispecific diabody ex3 composed of 528 and okt3 fvs in ternary complex with segfr and cd3gamma-epsilon (middle conformation) |
|
93
|
316
|
9by4A |
Co-crystal structure of the kinase domain of egfr with non-covalent osimertinib |
|
94
|
314
|
9gc5A |
Highly optimized cns penetrant inhibitors of egfr exon20 insertion mutations |
|
80
|
285
|
9gc4A |
Highly optimized cns penetrant inhibitors of egfr exon20 insertion mutations |
|
77
|
284
|
9gdvA |
Highly optimized cns penetrant inhibitors of egfr exon20 insertion mutations |
|
88
|
317
|
9gc6A |
Highly optimized cns penetrant inhibitors of egfr exon20 insertion mutations |
|
78
|
288
|
9hboA |
Highly optimized cns penetrant inhibitors of egfr exon20 insertion mutations. compound 51 bound to egfrinsnpg [v948r] |
|
93
|
322
|
9fqsA |
Egfr exon20 insertion mutant npg bound with compound 39 |
|
82
|
323
|
9fqpA |
Egfr exon20 insertion mutant npg bound with compound 23 |
|
96
|
327
|
9frdA |
Wildtype egfr bound with compound 23 |
|
74
|
324
|
9h46A |
Egfr wild type in complex with 25328 |
|
85
|
306
|
8to3A |
Egfr(t790m/v948r) in complex with ln5461 |
|
83
|
321
|
8to4A |
Egfr(t790m/v948r) in complex with the allosteric inhibitor frf-06-057 |
|
87
|
322
|
8kfqA |
The crystal structure of egfr(t797m/l858r) with small molecule inhibitor b6 |
|
86
|
311
|
8gk5A |
Egfr(t790m/v948r) kinase in complex with osimertinib and benzimidazole allosteric inhibitor |
|
63
|
321
|
8ukvA |
Crystal structure of nanobody/vhh domain of 34e5 in complex with the extracellular region of the epidermal growth factor variant iii (egfrviii) |
|
29
|
119
|
8ukvC |
Crystal structure of nanobody/vhh domain of 34e5 in complex with the extracellular region of the epidermal growth factor variant iii (egfrviii) |
|
61
|
321
|
8ukxA |
Crystal structure the extracellular region of the epidermal growth factor receptor variant iii (egfrviii) at ph 7.0 |
|
85
|
309
|
8ukwA |
Crystal structure the extracellular region of the epidermal growth factor receptor variant iii (egfrviii) at ph 5.0 |
|
98
|
326
|
8sc7A |
Structure of egfr in complex with mtx-531 |
|
87
|
296
|
8po3A |
Discovery and optimisation of potent, efficacious and selective inhibitors targeting egfr exon20 insertion mutations. compound 18 bound to egfr[v948r] |
|
84
|
289
|
8po1A |
Discovery and optimisation of potent, efficacious and selective inhibitors targeting egfr exon20 insertion mutations. compound 22 bound to egfrinsnpg [v948r] |
|
64
|
327
|
8po0A |
Discovery and optimisation of potent, efficacious and selective inhibitors targeting egfr exon20 insertion mutations. compound 12 bound to egfrinsnpg |
|
89
|
324
|
8pnzA |
Discovery and optimisation of potent, efficacious and selective inhibitors targeting egfr exon20 insertion mutations. compound 16 bound to egfr |
|
91
|
315
|
8po4A |
Discovery and optimisation of potent, efficacious and selective inhibitors targeting egfr exon20 insertion mutations. compound 33 bound to egfr[v948r] |
|
83
|
283
|
8po2A |
Discovery and optimisation of potent, efficacious and selective inhibitors targeting egfr exon20 insertion mutations. compound 33 bound to egfrinsnpg [v948r] |
|
72
|
285
|
9ewsA |
Optimisation of potent, efficacious, selective and blood-brain barrier penetrating inhibitors targeting egfr exon20 insertion mutations |
|
75
|
285
|
9ewtA |
Optimisation of potent, efficacious, selective and blood-brain barrier penetrating inhibitors targeting egfr exon20 insertion mutations |
|
85
|
312
|
9by6A |
Crystal structure of the kinase domain of egfr soaked with non-covalent osimertinib |
|
84
|
304
|
9n6gA |
Egfr(t790m/v948r) in complex with ln2827 |
|
83
|
325
|
9klwA |
Crystal structure of egfr t790m, l858r mutant complexed with n-[4-[4-amino-6-ethynyl-5-(3-quinolyl)pyrrolo[2,3-d]pyrimidin-7-yl]norbornan-1-yl]pyrimidine-5-carboxamide |
|
88
|
324
|
9kl4A |
Crystal structure of egfr complexed with n-[4-[4-amino-6-ethynyl-5-(3-quinolyl)pyrrolo[2,3-d]pyrimidin-7-yl]norbornan-1-yl]pyrimidine-5-carboxamide |
|
90
|
324
|
9jq1A |
Crystal structure of egfr t790m/c797s/l858r mutant in complex with 2,2-dichloro-n-(5-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)acetamide |
|
94
|
324
|
9fzrA |
Wild-type egfr in covalent complex with poziotinib analogue |
|
91
|
324
|
9fzsA |
Wild-type egfr in complex with non-covalent poziotinib analogue |
|
86
|
308
|
8gb4A |
Egfr(t790m/v948r) kinase in complex with benzimidazole allosteric inhibitor |
|
88
|
324
|
8tjlA |
Egfr kinase in complex with pyrazolopyrimidine covalent inhibitor |
|
91
|
314
|
8fv3A |
Egfr(t790m/v948r) in complex with compound 1 (ln4503) |
|
93
|
313
|
8fv4A |
Egfr(t790m/v948r) in complex with compound 2 (ln5993) |
|
90
|
326
|
8wd4A |
Egfr(l858r/t790/c797s) in complex with compound 5j |
|
130
|
500
|
7lfrA |
Crystal structure of the epidermal growth factor receptor extracellular region with r84k mutation in complex with epiregulin crystallized with spermine |
|
104
|
614
|
7sydA |
Cryo-em structure of the extracellular module of the full-length egfr bound to egf "tips-juxtaposed" conformation |
|
7
|
47
|
7lfrC |
Crystal structure of the epidermal growth factor receptor extracellular region with r84k mutation in complex with epiregulin crystallized with spermine |
|
84
|
309
|
7tvdA |
Crystal structure of the kinase domain of egfr exon-19 (del-747-749) mutant |
|
86
|
614
|
7sz1A |
Cryo-em structure of the extracellular module of the full-length egfr l834r bound to egf. "tips-separated" conformation |
|
5
|
50
|
7sz7C |
Cryo-em structure of the extracellular module of the full-length egfr bound to tgf-alpha. "tips-juxtaposed" conformation |
