|
84
|
340
|
4q1nA |
Structure-based design of 4-hydroxy-3,5-substituted piperidines as direct renin inhibitors |
|
107
|
403
|
4pzwA |
Synthesis, characterization and pk/pd studies of a series of spirocyclic pyranochromene bace1 inhibitors |
|
107
|
403
|
4pzxA |
Synthesis, characterization and pk/pd studies of a series of spirocyclic pyranochromene bace1 inhibitors |
|
90
|
338
|
4pyvA |
Crystal structure of renin in complex with compound4 |
|
77
|
326
|
4pepA |
The molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 angstroms resolution |
|
105
|
400
|
4n00A |
Discovery of 7-thp chromans: bace1 inhibitors that reduce a-beta in the cns |
|
95
|
388
|
4lxkA |
Crystal structure of human beta secretase in complex with compound 11d |
|
98
|
388
|
4lxaA |
Crystal structure of human beta secretase in complex with compound 11a |
|
95
|
388
|
4lxmA |
Crystal structure of human beta secretase in complex with compound 12a |
|
82
|
330
|
4lp9A |
Endothiapepsin complexed with phe-reduced-tyr peptide. |
|
85
|
330
|
4lapA |
Endothiapepsin in complex with thiophen-based inhibitor sap114 |
|
104
|
388
|
4l7gA |
Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxy-benzylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against beta-secretase-1 (bace1) |
|
95
|
388
|
4k9hA |
Bace-1 inhibitor complex |
|
86
|
330
|
4l6bA |
Endothiapepsin in complex with thiophen-based inhibitor sap128 |
|
103
|
388
|
4l7hA |
Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxy-benzylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against beta-secretase-1 (bace-1) |
|
93
|
387
|
4ke1A |
Crystal structure of bace1 in complex with hydroxyethylamine-macrocyclic inhibitor 19 |
|
87
|
330
|
4lhhA |
Endothiapepsin in complex with 2mm acylhydrazone inhibitor |
|
100
|
391
|
4ke0A |
Crystal structure of bace1 in complex with hydroxyethylamine-macrocyclic inhibitor 13 |
|
88
|
330
|
4lbtA |
Endothiapepsin in complex with 100mm acylhydrazone inhibitor |
|
90
|
330
|
4kupA |
Endothiapepsin in complex with 20mm acylhydrazone inhibitor |
|
104
|
402
|
4lc7A |
Aminooxazoline inhibitor of bace-1 |
|
96
|
388
|
4k8sA |
Hydroxyethylamine-based inhibitors of bace1: p1-p3 macrocyclization can improve potency, selectivity, and cell activity |
|
102
|
388
|
4l7jA |
Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxy-benzylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against beta-secretase-1 (bace-1) |
|
105
|
402
|
4jp9A |
Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
103
|
390
|
4j0yA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4r,5s)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
95
|
390
|
4j0pA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((s)-2-amino-4-methyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
95
|
389
|
4ivsA |
Crystal structure of bace1 with its inhibitor |
|
100
|
403
|
4i0fA |
Design and synthesis of thiophene dihydroisoquinolins as novel bace-1 inhibitors |
|
101
|
403
|
4i0jA |
Spr and structural analysis yield insight towards mechanism of inhibition of bace inhibitors |
|
99
|
391
|
4ivtA |
Crystal structure of bace1 with its inhibitor |
|
96
|
397
|
4i12A |
Design and synthesis of thiophene dihydroisoquinolins as novel bace-1 inhibitors |
|
97
|
390
|
4j1kA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4r,5r,6s)-2-amino-5-fluoro-4-methyl-6-trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
100
|
401
|
4i0dA |
Design and synthesis of thiophene dihydroisoquinolins as novel bace-1 inhibitors |
|
109
|
403
|
4hztA |
Structure-based design of novel dihydroisoquinoline bace-1 inhibitors that do not engage the catalytic aspartates |
|
106
|
402
|
4jooA |
Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
104
|
390
|
4j0zA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4s,5r)-2-amino-5-fluoro-4-fluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
104
|
400
|
4i0zA |
Structure-based design of novel dihydroisoquinoline bace-1 inhibitors that do not engage the catalytic aspartates |
|
99
|
403
|
4i0eA |
Design and synthesis of thiophene dihydroisoquinolins as novel bace-1 inhibitors |
|
103
|
388
|
4i0iA |
Spr and structural analysis yield insight towards mechanism of inhibition of bace inhibitors |
|
96
|
390
|
4j1hA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4s,6r)-2-amino-4-methyl-6-trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
100
|
390
|
4j0tA |
Crystal structure of bace-1 in complex with 5-ethoxy-pyridine-2-carboxylic acid [3-((r)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
101
|
390
|
4j17A |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((s)-2-amino-4-difluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
98
|
403
|
4i0gA |
Design and synthesis of thiophene dihydroisoquinolins as novel bace-1 inhibitors |
|
97
|
388
|
4i0hA |
Spr and structural analysis yield insight towards mechanism of inhibition of bace inhibitors. |
|
107
|
402
|
4jpeA |
Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
98
|
390
|
4j1fA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4s,6s)-2-amino-4-methyl-6-trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
103
|
390
|
4j1eA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4s,6s)-2-amino-4-fluoromethyl-6-trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
101
|
400
|
4i10A |
Structure-based design of novel dihydroisoquinoline bace-1 inhibitors that do not engage the catalytic aspartates |
|
105
|
402
|
4jpcA |
Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
95
|
390
|
4j1iA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4r,5r,6r)-2-amino-5-fluoro-4-methyl-6-trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
