|
103
|
390
|
4j1eA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4s,6s)-2-amino-4-fluoromethyl-6-trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
101
|
400
|
4i10A |
Structure-based design of novel dihydroisoquinoline bace-1 inhibitors that do not engage the catalytic aspartates |
|
105
|
402
|
4jpcA |
Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
95
|
390
|
4j1iA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4r,5r,6r)-2-amino-5-fluoro-4-methyl-6-trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
103
|
390
|
4h3fA |
Structure of bace bound to 3-(5-((7ar)-2-imino-6-(6-methoxypyridin-2-yl)-3-methyl-4-oxooctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-3-yl)benzonitrile |
|
104
|
390
|
4h3iA |
Structure of bace bound to 3-(5-((7ar)-2-imino-6-(3-methoxypyridin-2-yl)-3-methyl-4-oxooctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-3-yl)benzonitrile |
|
104
|
390
|
4h3jA |
Structure of bace bound to 2-fluoro-5-(5-(2-imino-3-methyl-4-oxo-6-phenyloctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-2-yl)benzonitrile |
|
106
|
390
|
4h3gA |
Structure of bace bound to 2-((7ar)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-2-imino-3-methyl-4-oxohexahydro-1h-pyrrolo[3,4-d]pyrimidin-6(2h)-yl)nicotinonitrile |
|
103
|
390
|
4ha5A |
Structure of bace bound to (s)-3-(5-(2-imino-1,4-dimethyl-6-oxohexahydropyrimidin-4-yl)thiophen-3-yl)benzonitrile |
|
103
|
389
|
4h1eA |
Structure of bace-1 bound to (7ar)-6-benzoyl-7a-(4-(3-cyanophenyl)thiophen-2-yl)-3-methyl-4-oxohexahydro-1h-pyrrolo[3,4-d]pyrimidin-2(3h)-iminium |
|
88
|
339
|
4gj7A |
Crystal structure of renin in complex with nvp-bca079 (compound 12a) |
|
103
|
387
|
4gidA |
Structure of beta-secretase complexed with inhibitor |
|
82
|
340
|
4gj5A |
Crystal structure of renin in complex with nvp-amq838 (compound 5) |
|
85
|
339
|
4gj6A |
Crystal structure of renin in complex with nvp-ayz832 (compound 6a) |
|
88
|
340
|
4gj8A |
Crystal structure of renin in complex with pkf909-724 (compound 3) |
|
82
|
340
|
4gjbA |
Crystal structure of renin in complex with nvp-bbv031 (compound 6) |
|
103
|
389
|
4gmiA |
Bace-1 in complex with hea-type macrocyclic inhibitor, mv078571 |
|
83
|
338
|
4gj9A |
Crystal structure of renin in complex with gp055321 (compound 4) |
|
89
|
340
|
4gjaA |
Crystal structure of renin in complex with nvp-ayl747 (compound 5) |
|
88
|
340
|
4gjcA |
Crystal structure of renin in complex with nvp-bch965 (compound 9) |
|
87
|
339
|
4gjdA |
Crystal structure of renin in complex with nvp-bgq311 (compound 12) |
|
99
|
387
|
4fslA |
Crystal structure of beta-site app-cleaving enzyme 1 (bace-db-mut) complex with n-(n-(4- acetamido-3-chloro-5-methylbenzyl)carbamimidoyl)-3-(4- methoxyphenyl)-5-methyl-4-isothiazolecarboxamide |
|
99
|
387
|
4fseA |
Crystal structure of beta-site app-cleaving enzyme 1 (bace-wt) complex with n-(n-(4-amino-3,5- dichlorobenzyl)carbamimidoyl)-3-(4-methoxyphenyl)-5- methyl-4-isothiazolecarboxamide |
|
103
|
387
|
4frjA |
Crystal structure of bace1 in complex with aminooxazoline xanthene 9l |
|
96
|
388
|
4friA |
Crystal structure of bace1 in complex with biarylspiro aminooxazoline 6 |
|
98
|
387
|
4frkA |
Crystal structure of bace1 in complex with aminooxazoline xanthene 11a |
|
106
|
389
|
4frsA |
Structure of bace in complex with (s)-4-(3-chloro-5-(5-(prop-1-yn-1-yl)pyridin-3-yl)thiophen-2-yl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1h)-iminium |
|
105
|
390
|
4fs4A |
Structure of bace bound to (s)-4-(3'-methoxy-[1,1'-biphenyl]-3-yl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1h)-iminium |
|
103
|
400
|
4fm7A |
Crystal structure of bace with compound 14g |
|
97
|
389
|
4fcoA |
Crystal structure of bace1 with its inhibitor |
|
102
|
400
|
4fm8A |
Crystal structure of bace with compound 12a |
|
98
|
389
|
4fgxA |
Crystal structure of bace1 with novel inhibitor |
|
93
|
392
|
3r1gB |
Structure basis of allosteric inhibition of bace1 by an exosite-binding antibody |
|
97
|
386
|
3r2fA |
Crystal structure of beta-site app-cleaving enzyme 1 (bace-wt) complex with bms-693391 aka (2s)-2-((3r)-3-acetamido-3-isobutyl-2-oxo-1-pyrrolidinyl)-n-((1s,2r)-1-(3,5-difluorobenzyl)-2-hydroxy-2-((2r,4r)-4-propoxy-2-pyrrolidinyl)ethyl)-4-phenylbutanamide |
|
81
|
327
|
3qviA |
Crystal structure of kni-10395 bound histo-aspartic protease (hap) from plasmodium falciparum |
|
97
|
389
|
3qi1A |
Design and synthesis of hydroxyethylamine (hea) bace-1 inhibitors: prime side chromane-containing inhibitors |
|
77
|
327
|
3qs1A |
Crystal structure of kni-10006 complex of plasmepsin i (pmi) from plasmodium falciparum |
|
75
|
328
|
3qrvA |
Crystal structure of plasmepsin i (pmi) from plasmodium falciparum |
|
80
|
375
|
3qvcA |
Crystal structure of histo-aspartic protease (hap) zymogen from plasmodium falciparum |
|
92
|
342
|
3q70A |
Secreted aspartic protease in complex with ritonavir |
|
86
|
330
|
3pwwA |
Endothiapepsin in complex with saquinavir |
|
84
|
337
|
3q4bA |
Clinically useful alkyl amine renin inhibitors |
|
95
|
340
|
3pvkA |
Secreted aspartic protease 2 in complex with benzamidine |
|
99
|
388
|
3qbhA |
Structure based design, synthesis and sar of cyclic hydroxyethylamine (hea) bace-1 inhibitors |
|
84
|
337
|
3q3tA |
Alkyl amine renin inhibitors: filling s1 from s3 |
|
77
|
330
|
3q6yA |
Endothiapepsin in complex with a pyrrolidine based inhibitor |
|
80
|
337
|
3q5hA |
Clinically useful alkyl amine renin inhibitors |
|
79
|
370
|
3psgA |
The high resolution crystal structure of porcine pepsinogen |
|
83
|
330
|
3pgiA |
Endothiapepsin in complex with a fragment |
|
82
|
330
|
3pb5A |
Endothiapepsin in complex with a fragment |
