|
18
|
99
|
3b7vA |
Hiv-1 protease complexed with gem-diol-amine tetrahedral intermediate nlltqi |
|
17
|
99
|
3b80A |
Hiv-1 protease mutant i54v complexed with gem-diol-amine intermediate nlltqi |
|
89
|
325
|
3aprE |
Binding of a reduced peptide inhibitor to the aspartic proteinase from rhizopus chinensis. implications for a mechanism of action |
|
85
|
323
|
3appA |
Structure and refinement of penicillopepsin at 1.8 angstroms resolution |
|
87
|
398
|
3aupA |
Crystal structure of basic 7s globulin from soybean |
|
16
|
99
|
3aidA |
A new class of hiv-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere |
|
17
|
99
|
3a2oA |
Crystal structure of hiv-1 protease complexed with kni-1689 |
|
16
|
99
|
2zyeA |
Structure of hiv-1 protease in complex with potent inhibitor kni-272 determined by neutron crystallography |
|
98
|
389
|
2zjmA |
Crystal structure of the human bace1 catalytic domain in complex with n-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide |
|
88
|
387
|
2zhsA |
Crystal structure of bace1 at ph 4.0 |
|
20
|
99
|
2z54A |
The influence of i47a mutation on reduced susceptibility to the protease inhibitor lopinavir |
|
90
|
389
|
2zjnA |
Crystal structure of the human bace1 catalytic domain in complex with n-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(2-methyl-4-sulfamoyl-phenoxy)-acetamide |
|
105
|
390
|
2zhrA |
Crystal structure of bace1 in complex with om99-2 at ph 5.0 |
|
90
|
389
|
2zjhA |
Crystal structure of the human bace1 catalytic domain in complex with n-(1-benzyl-piperidin-4-yl)-4-mercapto-butyramide |
|
93
|
387
|
2zhtA |
Crystal structure of bace1 at ph 4.5 |
|
18
|
99
|
2z4oA |
Wild type hiv-1 protease with potent antiviral inhibitor grl-98065 |
|
95
|
387
|
2zhvA |
Crystal structure of bace1 at ph 7.0 |
|
93
|
387
|
2zhuA |
Crystal structure of bace1 at ph 5.0 |
|
99
|
387
|
2zdzA |
X-ray structure of bace-1 in complex with compound 3.b.10 |
|
92
|
390
|
2zjiA |
Crystal structure of the human bace1 catalytic domain in complex with n-[1-(2,6-dimethoxy-benzyl)-piperidin-4-yl]-4-mercapto-butyramide |
|
82
|
390
|
2zjkA |
Crystal structure of the human bace1 catalytic domain in complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid(3-mercapto-propyl)-amide |
|
87
|
386
|
2ze1A |
X-ray structure of bace-1 in complex with compound 6g |
|
85
|
389
|
2zjlA |
Crystal structure of the human bace1 catalytic domain in complex with n-[1-(5-bromo-2,3-dimethoxy-benzyl)-piperidin-4-yl]-4-mercapto-butyramide |
|
89
|
389
|
2zjjA |
Crystal structure of the human bace1 catalytic domain in complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid (2-mercapto-ethyl)-amide |
|
20
|
99
|
2zgaA |
Hiv-1 protease in complex with a dimethylallyl decorated pyrrolidine based inhibitor (hexagonal space group) |
|
16
|
99
|
2xyfA |
Hiv-1 inhibitors with a tertiary-alcohol-containing transition-state mimic and various p2 and p1 prime substituents |
|
16
|
99
|
2xyeA |
Hiv-1 inhibitors with a tertiary-alcohol-containing transition-state mimic and various p2 and p1 prime substituents |
|
101
|
385
|
2xfiA |
Human bace-1 in complex with n-((1s,2r)-3-(((1s)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-((methylsulfonyl)(phenyl)amino)benzamide |
|
103
|
385
|
2xfjA |
Human bace-1 in complex with n-((1s,2r)-3-(((1s)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1-pyrrolidinyl)benzamide |
|
103
|
385
|
2xfkA |
Human bace-1 in complex with n-((1s,2r)-3-(((1s)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-(ethylamino)-5-((methylsulfonyl)(phenyl)amino)benzamide |
|
100
|
385
|
2wf1A |
Human bace-1 in complex with 7-ethyl-n-((1s,2r)-2-hydroxy-3-(((3-(methyloxy)phenyl(methyl)amino)-1-(phenylmethyl)propyl)-1-methyl-3,4- dihydro-1h-(1,2,5)thiadiazepino(3,4,5-hi)indole-9-carboxamide 2,2- dioxide |
|
49
|
203
|
2whhA |
Hiv-1 protease tethered dimer q-product complex along with nucleophilic water molecule |
|
102
|
385
|
2wf3A |
Human bace-1 in complex with 6-(ethylamino)-n-((1s,2r)-2-hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl)propyl)-1-methyl-1, 3,4,5-tetrahydro-2,1-benzothiazepine-8-carboxamide 2,2-dioxide |
|
88
|
323
|
2weaA |
Acid proteinase (penicillopepsin) (e.c.3.4.23.20) complex with phosphonate inhibitor: methyl[cyclo-7[(2r)-((n-valyl) amino)-2-(hydroxyl-(1s)-1-methyoxycarbonyl-2-phenylethoxy) phosphinyloxy-ethyl]-1-naphthaleneacetamide], sodium salt |
|
16
|
99
|
2wkzA |
Hiv-1 protease inhibitors containing a tertiary alcohol in the transition-state mimic with improved cell-based antiviral activity |
|
104
|
385
|
2wf2A |
Human bace-1 in complex with 8-ethyl-n-((1s,2r)-2-hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl)propyl)-1-methyl-3,4,7, 8-tetrahydro-1h,6h-(1,2,5)thiadiazepino(5,4,3-de)quinoxaline-10- carboxamide 2,2-dioxide |
|
97
|
385
|
2wf4A |
Human bace-1 in complex with 6-ethyl-1-methyl-n-((1s)-2-oxo-1-(phenylmethyl)-3-(tetrahydro-2h-pyran-4-ylamino)propyl)-1,3,4,6- tetrahydro(1,2)thiazepino(5,4,3-cd)indole-8-carboxamide 2,2-dioxide |
|
103
|
385
|
2wezA |
Human bace-1 in complex with 1-ethyl-n-((1s,2r)-2-hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl)propyl)-4-(2-oxo-1- pyrrolidinyl)-1h-indole-6-carboxamide |
|
95
|
389
|
2wjoA |
Human bace (beta secretase) in complex with cyclohexanecarboxylic acid (2-(2-am ino-6-phenoxy-4h-quinazolin-3-yl)-2 -cyclohexyl-ethyl)- amide |
|
102
|
385
|
2wf0A |
Human bace-1 in complex with 4-ethyl-n-((1s,2r)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)-8-(2-oxo-1-pyrrolidinyl)-6-quinolinecarboxamide |
|
88
|
323
|
2webA |
Acid proteinase (penicillopepsin) (e.c.3.4.23.20) complex with phosphonate inhibitor: methyl(2s)-[1-(((n-formyl)-l-valyl)amino-2-(2-naphthyl)ethyl)hydroxyphosphinyloxy]-3-phenylpropanoate, sodium salt |
|
16
|
99
|
2wl0A |
Hiv-1 protease inhibitors containing a tertiary alcohol in the transition-state mimic with improved cell-based antiviral activity |
|
87
|
323
|
2wedA |
Acid proteinase (penicillopepsin) (e.c.3.4.23.20) complex with phosphonate macrocyclic inhibitor:methyl[cyclo-7[(2r)-((n-valyl)amino)-2-(hydroxyl-(1s)-1-methyoxycarbonyl-2-phenylethoxy)phosphinyloxy-ethyl]-1-naphthaleneacetamide], sodium salt |
|
86
|
323
|
2wecA |
Acid proteinase (penicillopepsin) (e.c.3.4.23.20) complex with phosphonate inhibitor: methyl(2s)-[1-(((n-(1-naphthaleneacetyl))-l-valyl)aminomethyl)hydroxy phosphinyloxy]-3-phenylpropanoate, sodium salt |
|
104
|
385
|
2vieA |
Human bace-1 in complex with n-((1s,2r)-1-benzyl-2-hydroxy-3-((1,1,5- trimethylhexyl)amino)propyl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl) benzamide |
|
104
|
389
|
2vkmA |
Crystal structure of grl-8234 bound to bace (beta-secretase) |
|
101
|
385
|
2vnnA |
Human bace-1 in complex with 7-ethyl-n-((1s,2r)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)-1- methyl-3,4-dihydro-1h-(1,2,5)thiadiazepino(3,4,5-hi)indole-9- carboxamide 2,2-dioxide |
|
100
|
385
|
2vnmA |
Human bace-1 in complex with 3-(1,1-dioxidotetrahydro-2h-1,2-thiazin- 2-yl)-5-(ethylamino)-n-((1s,2r)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)benzamide |
|
99
|
385
|
2viyA |
Human bace-1 in complex with n-((1s,2r)-3-(((1s)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-(pentylsulfonyl)benzamide |
|
85
|
387
|
2va6A |
X-ray crystal structure of beta secretase complexed with compound 24 |
