|
229
|
948
|
5jhbA |
Structure of phosphoinositide 3-kinase gamma (pi3k) bound to the potent inhibitor pikin3 |
|
269
|
917
|
5i4uA |
The crystal structure of pi3kdelta with compound 34 |
|
232
|
918
|
5i6uA |
The crystal structure of pi3kdelta with compound 32 |
|
340
|
1061
|
5fi4A |
Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-pi3 kinases that are efficacious in a mouse xenograft model |
|
294
|
1015
|
5dxuA |
P110delta/p85alpha with gdc-0326 |
|
321
|
1061
|
5dxhA |
P110alpha/p85alpha with compound 5 |
|
265
|
942
|
5edsA |
Crystal structure of human pi3k-gamma in complex with benzimidazole inhibitor 5 |
|
258
|
948
|
4urkA |
Pi3kg in complex with azd6482 |
|
243
|
942
|
6gq7A |
Pi3kg in complex with inh |
|
281
|
919
|
6ftnA |
Mpi3kd in complex with az2 |
|
293
|
926
|
6ez6A |
Pi3 kinase delta in complex with methyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1h-indazol-6-yl)-2-methoxynicotinate |
|
262
|
914
|
6dgtA |
Selective pi3k beta inhibitor bound to pi3k delta |
|
263
|
947
|
6c1sA |
Phosphoinositide 3-kinase gamma bound to an pyrrolopyridinone inhibitor |
|
274
|
949
|
6audA |
Pi3k-gamma k802t in complex with cpd 8 10-((1-(tert-butyl)piperidin-4-yl)sulfinyl)-2-(1-isopropyl-1h-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine |
|
395
|
1347
|
4yknA |
Pi3k alpha lipid kinase with active site inhibitor |
|
278
|
925
|
5ae9A |
Crystal structure of mouse pi3 kinase delta in complex with gsk2292767 |
|
277
|
925
|
5ae8A |
Crystal structure of mouse pi3 kinase delta in complex with gsk2269557 |
|
334
|
1060
|
4zopA |
Co-crystal structure of lipid kinase pi3k alpha with a selective phosphatidylinositol-3 kinase alpha inhibitor |
|
242
|
946
|
4hleA |
Compound 21 (1-alkyl-substituted 1,2,4-triazoles) |
|
279
|
951
|
4ezlA |
Potent and selective inhibitors of pi3k-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf |
|
264
|
947
|
4hvbA |
Catalytic unit of pi3kg in complex with pi3k/mtor dual inhibitor pf-04979064 |
|
267
|
949
|
4fa6A |
Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of pi3ka and mtor |
|
265
|
945
|
4f1sA |
Crystal structure of human pi3k-gamma in complex with a pyridyl-triazine-sulfonamide inhibitor |
|
275
|
949
|
4ezkA |
Potent and selective inhibitors of pi3k-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf |
|
253
|
950
|
4fadA |
Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of pi3ka and mtor |
|
273
|
951
|
4ezjA |
Potent and selective inhibitors of pi3k-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf |
|
256
|
945
|
4dk5A |
Crystal structure of human pi3k-gamma in complex with a pyridyl-triazine inhibitor |
|
249
|
945
|
4bfrA |
Discovery and optimization of pyrimidone indoline amide pi3kbeta inhibitors for the treatment of phosphatase and tensin homologue (pten)-deficient cancers |
|
277
|
1057
|
4a55A |
Crystal structure of p110alpha in complex with ish2 of p85alpha and the inhibitor pik-108 |
|
269
|
945
|
4anxA |
Complexes of pi3kgamma with isoform selective inhibitors. |
|
206
|
952
|
4aofA |
Selective small molecule inhibitor discovered by chemoproteomic assay platform reveals regulation of th17 cell differentiation by pi3kgamma |
|
256
|
945
|
4anwA |
Complexes of pi3kgamma with isoform selective inhibitors. |
|
280
|
940
|
3zimA |
Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase pi3kalpha |
|
274
|
949
|
3zvvA |
Fragment bound to pi3kinase gamma |
|
249
|
945
|
4anuA |
Complexes of pi3kgamma with isoform selective inhibitors. |
|
212
|
916
|
4ajwA |
Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective pi3kbeta inhibitors for the treatment of phosphatase and tensin homologue (pten)-deficient cancers |
|
282
|
947
|
3zw3A |
Fragment based discovery of a novel and selective pi3 kinase inhibitor |
|
249
|
946
|
4anvA |
Complexes of pi3kgamma with isoform selective inhibitors. |
|
258
|
949
|
3tl5A |
Discovery of gdc-0980: a potent, selective, and orally available class i phosphatidylinositol 3-kinase (pi3k)/mammalian target of rapamycin (mtor) kinase inhibitor for the treatment of cancer |
|
250
|
950
|
3tjpA |
Crystal structure of pi3k gamma with n6-(3,4-dimethoxyphenyl)-2-morpholino-[4,5'-bipyrimidine]-2',6-diamine |
|
270
|
949
|
3t8mA |
Rational design of pi3k-alpha inhibitors that exhibit selectivity over the pi3k-beta isoform |
|
251
|
949
|
3sd5A |
Crystal structure of pi3k gamma with 5-(2,4-dimorpholinopyrimidin-6-yl)-4-(trifluoromethyl)pyridin-2-amine |
|
261
|
945
|
3s2aA |
Crystal structure of pi3k-gamma in complex with a quinoline inhibitor |
|
284
|
924
|
6q74A |
Pi3k delta in complex with 1benzyln[5(3,6dihydro2hpyran4yl)2methoxypyridin3yl]2methyl1himidazole4sulfonamide |
|
269
|
949
|
3r7qA |
Structure-based design of thienobenzoxepin inhibitors of pi3- kinase |
|
268
|
949
|
3r7rA |
Structure-based design of thienobenzoxepin inhibitors of pi3-kinase |
|
332
|
1052
|
5ukjA |
The co-structure of n,n-dimethyl-4-[(6r)-6-methyl-5-(1h-pyrrolo[2,3- b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5- a]pyrazin-3-yl]benzenesulfonamide and a rationally designed pi3k-alpha mutant that mimics atr |
|
327
|
1052
|
5ul1A |
The co-structure of 3-amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)phenyl)-n-phenylpyrazine-2-carboxamide and a rationally designed pi3k-alpha mutant that mimics atr |
|
334
|
1056
|
5uk8A |
The co-structure of (r)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1h-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine and a rationally designed pi3k-alpha mutant that mimics atr |
|
303
|
944
|
5ubrA |
Crystal structure of pi3k alpha in complex with a 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4] triazin-4-amine deriviatine |
