|
59
|
234
|
2vh6A |
Structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with biaryl p4 motifs |
|
12
|
54
|
2vh6B |
Structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with biaryl p4 motifs |
|
12
|
52
|
2uwpB |
Factor xa inhibitor complex |
|
59
|
234
|
2uwlA |
Selective and dual action orally active inhibitors of thrombin and factor xa |
|
12
|
52
|
2uwoB |
Selective and dual action orally active inhibitors of thrombin and factor xa |
|
12
|
51
|
2ra0L |
X-ray structure of fxa in complex with 7-fluoroindazole |
|
61
|
234
|
2uwoA |
Selective and dual action orally active inhibitors of thrombin and factor xa |
|
58
|
234
|
2ra0A |
X-ray structure of fxa in complex with 7-fluoroindazole |
|
60
|
234
|
2q1jA |
The discovery of glycine and related amino acid-based factor xa inhibitors |
|
12
|
51
|
2q1jB |
The discovery of glycine and related amino acid-based factor xa inhibitors |
|
11
|
50
|
2pr3B |
Factor xa inhibitor |
|
9
|
51
|
2p3fL |
Crystal structure of the factor xa/nap5 complex |
|
10
|
51
|
2phbB |
An orally efficacious factor xa inhibitor |
|
59
|
234
|
2p95A |
Factor xa in complex with the inhibitor 5-chloro-n-((1r,2s)-2-(4-(2-oxopyridin-1(2h)-yl)benzamido) cyclopentyl)thiophene-2-carboxamide |
|
59
|
235
|
2p3fH |
Crystal structure of the factor xa/nap5 complex |
|
60
|
234
|
2pr3A |
Factor xa inhibitor |
|
13
|
52
|
2p95L |
Factor xa in complex with the inhibitor 5-chloro-n-((1r,2s)-2-(4-(2-oxopyridin-1(2h)-yl)benzamido) cyclopentyl)thiophene-2-carboxamide |
|
60
|
234
|
2p94A |
Factor xa in complex with the inhibitor 3-chloro-n-((1r,2s)-2-(4-(2-oxopyridin-1(2h)-yl)benzamido)cyclohexyl)-1h-indole-6-carboxamide |
|
13
|
52
|
2p16L |
Factor xa in complex with the inhibitor apixaban (bms-562247) aka 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1-piperidinyl)phenyl)-4,5,6,7-tetrahydro-1h-pyrazolo[3, 4-c]pyridine-3-carboxamide |
|
58
|
234
|
2p93A |
Factor xa in complex with the inhibitor 5-chloro-n-(2-(4-(2-oxopyridin-1(2h)-yl)benzamido)ethyl)thiophene-2-carboxamide |
|
13
|
52
|
2p94L |
Factor xa in complex with the inhibitor 3-chloro-n-((1r,2s)-2-(4-(2-oxopyridin-1(2h)-yl)benzamido)cyclohexyl)-1h-indole-6-carboxamide |
|
61
|
233
|
2p3tB |
Crystal structure of human factor xa complexed with 3-chloro-4-(2-methylamino-imidazol-1-ylmethyl)-thiophene-2-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-6-methoxy-phenyl]-amide |
|
60
|
234
|
2p16A |
Factor xa in complex with the inhibitor apixaban (bms-562247) aka 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1-piperidinyl)phenyl)-4,5,6,7-tetrahydro-1h-pyrazolo[3, 4-c]pyridine-3-carboxamide |
|
13
|
52
|
2p93L |
Factor xa in complex with the inhibitor 5-chloro-n-(2-(4-(2-oxopyridin-1(2h)-yl)benzamido)ethyl)thiophene-2-carboxamide |
|
12
|
51
|
2p3uA |
Crystal structure of human factor xa complexed with 3-chloro-n-(4-chloro-2-{[(5-chloropyridin-2-yl)amino]carbonyl}-6-methoxyphenyl)-4-[(1-methyl-1h-imidazol-2-yl)methyl]thiophene-2-carboxamide {pfizer 320663} |
|
12
|
52
|
2p3tA |
Crystal structure of human factor xa complexed with 3-chloro-4-(2-methylamino-imidazol-1-ylmethyl)-thiophene-2-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-6-methoxy-phenyl]-amide |
|
57
|
234
|
2phbA |
An orally efficacious factor xa inhibitor |
|
57
|
233
|
2p3uB |
Crystal structure of human factor xa complexed with 3-chloro-n-(4-chloro-2-{[(5-chloropyridin-2-yl)amino]carbonyl}-6-methoxyphenyl)-4-[(1-methyl-1h-imidazol-2-yl)methyl]thiophene-2-carboxamide {pfizer 320663} |
|
65
|
233
|
2jkhA |
Factor xa - cation inhibitor complex |
|
63
|
234
|
2j94A |
Crystal structure of a human factor xa inhibitor complex |
|
60
|
234
|
2j95A |
Crystal structure of a human factor xa inhibitor complex |
|
12
|
54
|
2jkhL |
Factor xa - cation inhibitor complex |
|
12
|
52
|
2j95B |
Crystal structure of a human factor xa inhibitor complex |
|
12
|
52
|
2j4iB |
Crystal structure of a human factor xa inhibitor complex |
|
62
|
233
|
2j2uA |
Crystal structure of a human factor xa inhibitor complex |
|
11
|
51
|
2j38B |
Crystal structure of a human factor xa inhibitor complex |
|
12
|
52
|
2j34B |
Crystal structure of a human factor xa inhibitor complex |
|
13
|
52
|
2j94B |
Crystal structure of a human factor xa inhibitor complex |
|
12
|
52
|
2j2uB |
Crystal structure of a human factor xa inhibitor complex |
|
53
|
234
|
2j38A |
Crystal structure of a human factor xa inhibitor complex |
|
58
|
234
|
2j34A |
Crystal structure of a human factor xa inhibitor complex |
|
60
|
234
|
2j4iA |
Crystal structure of a human factor xa inhibitor complex |
|
9
|
48
|
2h9eL |
Crystal structure of fxa/selectide/napc2 ternary complex |
|
61
|
233
|
2h9eH |
Crystal structure of fxa/selectide/napc2 ternary complex |
|
11
|
52
|
2gd4A |
Crystal structure of the antithrombin-s195a factor xa-pentasaccharide complex |
|
54
|
239
|
2gd4B |
Crystal structure of the antithrombin-s195a factor xa-pentasaccharide complex |
|
12
|
52
|
2g00L |
Factor xa in complex with the inhibitor 3-(6-(2'-((dimethylamino)methyl)-4-biphenylyl)-7-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1h-pyrazolo[3,4-c]pyridin-1-yl)benzamide |
|
13
|
52
|
2fzzL |
Factor xa in complex with the inhibitor 1-(3-amino-1,2-benzisoxazol-5-yl)-6-(2'-(((3r)-3-hydroxy-1-pyrrolidinyl)methyl)-4-biphenylyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7h-pyrazolo[3,4-c]pyridin-7-one |
|
61
|
234
|
2g00A |
Factor xa in complex with the inhibitor 3-(6-(2'-((dimethylamino)methyl)-4-biphenylyl)-7-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1h-pyrazolo[3,4-c]pyridin-1-yl)benzamide |
|
60
|
234
|
2fzzA |
Factor xa in complex with the inhibitor 1-(3-amino-1,2-benzisoxazol-5-yl)-6-(2'-(((3r)-3-hydroxy-1-pyrrolidinyl)methyl)-4-biphenylyl)-3-(trifluoromethyl)-1,4,5,6-tetrahydro-7h-pyrazolo[3,4-c]pyridin-7-one |
