|
206
|
568
|
4mz4A |
Discovery of an irreversible hcv ns5b polymerase inhibitor |
|
166
|
505
|
4nldA |
Crystal structure of the hepatitis c virus ns5b rna-dependent rna polymerase complex with bms-791325 also known as (1ar,12bs)-8-cyclohexyl-n-(dimethylsulfamoyl)-11-methoxy-1a-{[(1r,5s)-3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide and 2-(4-fluorophenyl)-n-methyl-6-[(me |
|
200
|
554
|
4obcA |
Crystal structure of hcv polymerase ns5b genotype 2a jfh-1 isolate with the s15g, c223h, v321i resistance mutations against the guanosine analog gs-0938 (psi-3529238) |
|
3
|
11
|
4n0yA |
Structure of the hepatitis c envelope glycoprotein e1 antigenic region 314-324 bound to the cross-neutralizing antibody igh526 |
|
28
|
203
|
4mwfC |
Structure of hepatitis c virus envelope glycoprotein e2 core bound to broadly neutralizing antibody ar3c |
|
204
|
562
|
4mkaA |
Hepatitis c virus polymerase ns5b genotype 1b (bk) in complex with inhibitor 13 (n-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]-1,3-benzoxazol-5-yl}methanesulfonamide) |
|
203
|
562
|
4mk7A |
Hepatitis c virus polymerase ns5b genotype 1b (bk) in complex with inhibitor 2 (3-(3-tert-butyl-4-methoxyphenyl)pyridin-2(1h)-one) |
|
206
|
562
|
4mkbA |
Hepatitis c virus polymerase ns5b genotype 1b (bk) in complex with inhibitor 14 (n-(4-{(e)-2-[3-tert-butyl-2-methoxy-5-(3-oxo-2,3-dihydropyridazin-4-yl)phenyl]ethenyl}phenyl)methanesulfonamide) |
|
195
|
562
|
4miaA |
Hepatitis c virus polymerase ns5b genotype 1b (bk) in complex with rg7109 (n-{4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-2,5-dihydropyridin-3-yl)quinolin-3-yl]phenyl}methanesulfonamide) |
|
202
|
562
|
4mibA |
Hepatitis c virus polymerase ns5b genotype 1b (bk) in complex with compound 48 (n-({(3s)-1-[6-tert-butyl-5-methoxy-8-(2-oxo-1,2-dihydropyridin-3-yl)quinolin-3-yl]pyrrolidin-3-yl}methyl)methanesulfonamide) |
|
201
|
562
|
4mk9A |
Hepatitis c virus polymerase ns5b genotype 1b (bk) in complex with inhibitor 12 (n-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]-1,3-benzoxazol-5-yl}methanesulfonamide) |
|
202
|
563
|
4jjsA |
Crystal structure of hcv ns5b polymerase in complex with compound 2 |
|
203
|
563
|
4ju4A |
Crystal structure of hcv ns5b polymerase in complex with compound 22 |
|
201
|
564
|
4kaiA |
Hcv ns5b gt1b n316 with gsk5852a |
|
198
|
563
|
4jy0A |
Crystal structure of hcv ns5b polymerase in complex with compound 3 |
|
199
|
563
|
4ke5A |
Hcv ns5b gt1b n316y with gsk5852 |
|
200
|
563
|
4jjuA |
Crystal structure of hcv ns5b polymerase in complex with compound 29 |
|
200
|
563
|
4ju1A |
Crystal structure of hcv ns5b polymerase in complex with compound 6 |
|
197
|
563
|
4jy1A |
Crystal structure of hcv ns5b polymerase in complex with compound 5 |
|
202
|
563
|
4kb7A |
Hcv ns5b gt1b n316y with cmpd 32 |
|
205
|
563
|
4ju3A |
Crystal structure of hcv ns5b polymerase in complex with compound 8 |
|
199
|
563
|
4kbiA |
Hcv ns5b gt1b n316y with cmpd 4 |
|
201
|
563
|
4ju7A |
Crystal structure of hcv ns5b polymerase in complex with compound 24 |
|
201
|
563
|
4jtyA |
Crystal structure of hcv ns5b polymerase with compound 2 |
|
200
|
563
|
4jtwA |
Crystal structure of hcv ns5b polymerase in complex with coupound 1 |
|
201
|
563
|
4ju6A |
Crystal structure of hcv ns5b polymerase in complex with compound 24 |
|
40
|
175
|
4ktcA |
Ns3/ns4a protease with inhibitor |
|
195
|
563
|
4jtzA |
Crystal structure of hcv ns5b polymerase in complex with compound 4 |
|
202
|
563
|
4ju2A |
Crystal structure of hcv ns5b polymerase in complex with compound 12 |
|
201
|
563
|
4jvqA |
Crystal structure of hcv ns5b polymerase in complex with compound 9 |
|
206
|
563
|
4j04A |
Crystal structure of hcv ns5b polymerase in complex with 4-chloro-2-{[(2,4,5-trichlorophenyl)sulfonyl]amino}benzoic acid |
|
46
|
182
|
4i33A |
Crystal structure of hcv ns3/4a r155k protease complexed with compound 4 |
|
207
|
563
|
4j08A |
Crystal structure of hcv ns5b polymerase in complex with 2-{[(4-methylphenyl)sulfonyl]amino}-5-phenoxybenzoic acid |
|
205
|
562
|
4ih7A |
Hepatitis c virus polymerase ns5b (bk) with fragment-based compounds |
|
206
|
562
|
4ih6A |
Hepatitis c virus polymerase ns5b (bk) with fragment-based compounds |
|
197
|
563
|
4iz0A |
Crystal structure of hcv ns5b polymerase in complex with 2,4,5-trichloro-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide |
|
209
|
562
|
4ih5A |
Hepatitis c virus polymerase ns5b (bk) with fragment-based compounds |
|
200
|
563
|
4j06A |
Crystal structure of hcv ns5b polymerase in complex with 2-{[(5-bromothiophen-2-yl)sulfonyl]amino}-4-chlorobenzoic acid |
|
205
|
563
|
4j02A |
Crystal structure of hcv ns5b polymerase in complex with [(1r)-5,8-dichloro-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl]acetic acid |
|
42
|
182
|
4i32A |
Crystal structure of hcv ns3/4a d168v protease complexed with compound 4 |
|
1
|
12
|
4jznK |
Three dimensional structure of broadly neutralizing human anti - hepatitis c virus (hcv) glycoprotein e2 fab fragment hc84-1 |
|
204
|
563
|
4j0aA |
Crystal structure of hcv ns5b polymerase in complex with 2-{[(4-methylphenyl)sulfonyl]amino}-4-phenoxybenzoic acid |
|
42
|
182
|
4i31A |
Crystal structure of hcv ns3/ns4a protease complexed with compound 4 |
|
1
|
11
|
4jzoI |
Three dimensional structure of broadly neutralizing human anti - hepatitis c virus (hcv) glycoprotein e2 fab fragment hc84-27 |
|
200
|
563
|
4gmcA |
Crystal structure of hcv ns5b polymerase in complex with a thumb inhibitor |
|
207
|
563
|
3qgiA |
Crystal structure of the hepatitis c virus ns5b rna-dependent rna polymerase genotype 1a complex with n-[(2s)-butan-2-yl]-6-[(3r)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide |
|
190
|
564
|
3qgeA |
Crystal structure of the hepatitis c virus ns5b rna-dependent rna polymerase complex with (2e)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid and (2r)-4-(2,6-dimethoxypyrimidin-4-yl)-n-(4-methoxybenzyl)-1-{[4-(trifluoromethoxy)phenyl]sulfonyl}p |
|
206
|
561
|
3qghA |
Crystal structure of the hepatitis c virus ns5b rna-dependent rna polymerase genotype 1a complex with n-cyclopropyl-6-[(3r)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide |
|
188
|
566
|
3qgdA |
Crystal structure of the hepatitis c virus ns5b rna-dependent rna polymerase complex with (2e)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid and (2r)-4-(2,6-dimethoxypyrimidin-4-yl)-1-[(4-ethylphenyl)sulfonyl]-n-(4-methoxybenzyl)piperazine-2-c |
|
184
|
559
|
3qgfA |
Crystal structure of the hepatitis c virus ns5b rna-dependent rna polymerase complex with (2e)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5h-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid and (2r)-4-(6-chloropyridazin-3-yl)-n-(4-methoxybenzyl)-1-{[4-(trifluoromethoxy)phenyl]sulfonyl}pipera |
