|
106
|
390
|
5hdxA |
Bace-1 in complex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(4-ethoxy-5-fluoro-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4-d]pyrimidin-2-iminium |
|
108
|
390
|
5he4A |
Bace-1 in complex with (4ar,7as)-7a-(2,6-difluorophenyl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4-d]pyrimidin-2-iminium |
|
103
|
390
|
5hduA |
Bace-1 incomplex with (7ar)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-6-(5-fluoro-4-methoxypyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4-d]pyrimidin-2-iminium |
|
106
|
390
|
5he5A |
Bace-1 in complex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4-methyl-6-(methylamino)pyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4-d]pyrimidin-2-iminium |
|
103
|
390
|
5hdvA |
Bace-1 incomplex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4-d]pyrimidin-2-iminium |
|
103
|
390
|
5hdzA |
Bace-1 in complex with (7ar)-7a-(5-cyanothiophen-2-yl)-6-(5-fluoro-4-methyl-6-(methylthio)pyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4-d]pyrimidin-2-iminium |
|
105
|
390
|
5hd0A |
Bace-1 in complex with (7ar)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-6-(5-fluoropyrimidin-2-yl)-3-methyl-4-oxooctahydro-2h-pyrrolo[3,4-d]pyrimidin-2-iminium |
|
98
|
390
|
5f01A |
Crystal structure of bace-1 in complex with (1sr,2sr)-2-((r)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4h-1,3-oxazin-4-yl)-n-(3-chloroquinolin-8-yl)cyclopropanecarboxamide |
|
99
|
389
|
4zsqA |
Bace crystal structure with tricyclic aminothiazine inhibitor |
|
90
|
387
|
5enkA |
Compound 18 |
|
101
|
390
|
5ezzA |
Crystal structure of bace-1 in complex with (4s)-4-[3-(5-chloro-3-pyridyl)phenyl]-4-[4-(difluoromethoxy)-3-methyl-phenyl]-5h-oxazol-2-amine |
|
88
|
387
|
5enmA |
Compound 10 |
|
107
|
390
|
4zsrA |
Bace crystal structure with tricyclic aminothiazine inhibitor |
|
99
|
390
|
5f00A |
Crystal structure of bace-1 in complex with 5-[3-[(3-chloro-8-quinolyl)amino]phenyl]-5-methyl-2,6-dihydro-1,4-oxazin-3-amine |
|
101
|
389
|
4zsmA |
Bace crystal structure with bicyclic aminothiazine fragment |
|
106
|
390
|
4zspA |
Bace crystal structure with bicyclic aminothiazine inhibitor |
|
100
|
388
|
5dqcA |
Co-crystal of bace1 with compound 0211 |
|
98
|
389
|
4zpgA |
Bace1 in complex with 8-benzyl-4-(cyclohexylamino)-1-(3-fluorophenyl)-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one |
|
100
|
389
|
4zpfA |
Bace1 in complex with 8-(3-((1-aminopropan-2-yl)oxy)benzyl)-4-(cyclohexylamino)-1-(3-fluorophenyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one |
|
95
|
389
|
4zpeA |
Bace1 in complex with 4-(cyclohexylamino)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one |
|
105
|
389
|
4ybiA |
Crystal structure of bace with amino thiazine inhibitor ly2811376 |
|
91
|
387
|
5clmA |
1,4-oxazine bace1 inhibitors |
|
101
|
392
|
4xxsA |
Crystal structure of bace1 with a pyrazole-substituted tetrahydropyran thioamidine |
|
99
|
387
|
4xkxA |
Crystal structure of bace1 in complex with 2-aminooxazoline 3-azaxanthene inhibitor 28 |
|
102
|
387
|
4wtuA |
Crystal structure of bace1 in complex with 2-aminooxazoline 3-aza-4-fluoro-xanthene inhibitor 22 |
|
101
|
390
|
4x7iA |
Crystal structure of bace with amino thiazine inhibitor ly2886721 |
|
95
|
389
|
4wy6A |
Crystal structure of human bace-1 bound to compound 36 |
|
96
|
389
|
4x2lA |
Crystal structure of human bace-1 bound to compound 6 |
|
102
|
400
|
4wy1A |
Crystal structure of human bace-1 bound to compound 24b |
|
105
|
400
|
4rroA |
8-tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
94
|
389
|
4trwA |
Structure of bace1 complex with a syn-hea-type inhibitor |
|
98
|
387
|
4tryA |
Structure of bace1 complex with a hea-type inhibitor |
|
105
|
400
|
4rrnA |
8-tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
78
|
388
|
4trzA |
Structure of bace1 complex with 2-thiophenyl hea-type inhibitor |
|
106
|
400
|
4rrsA |
8-tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
95
|
387
|
4rceA |
Crystal structure of bace1 in complex with aminooxazoline xanthene inhibitor 2 |
|
105
|
389
|
4r93A |
Bace-1 in complex with (r)-4-(2-cyclohexylethyl)-1-methyl-5-oxo-4-(((1s,3r)-3-(3-phenylureido)cyclohexyl)methyl)imidazolidin-2-iminium |
|
106
|
390
|
4r91A |
Bace-1 in complex with (r)-4-(2-cyclohexylethyl)-4-(((1s,3r)-3-(cyclopentylamino)cyclohexyl)methyl)-1-methyl-5-oxoimidazolidin-2-iminium |
|
107
|
390
|
4r8yA |
Bace-1 in complex with (r)-4-(2-cyclohexylethyl)-4-(((r)-1-(2-cyclopentylacetyl)pyrrolidin-3-yl)methyl)-1-methyl-5-oxoimidazolidin-2-iminium |
|
103
|
390
|
4r95A |
Bace-1 in complex with 2-(((1r,3s)-3-(((r)-4-(2-cyclohexylethyl)-2-iminio-1-methyl-5-oxoimidazolidin-4-yl)methyl)cyclohexyl)amino)quinolin-1-ium |
|
101
|
388
|
4rcfA |
Crystal structure of bace1 in complex with 2-aminooxazoline 4-fluoroxanthene inhibitor 49 |
|
96
|
387
|
4rcdA |
Crystal structure of bace1 in complex with a 2-aminooxazoline 4-azaxanthene inhibitor |
|
101
|
391
|
4r92A |
Bace-1 in complex with (r)-4-(2-cyclohexylethyl)-4-(((1s,3r)-3-(isonicotinamido)cyclohexyl)methyl)-1-methyl-5-oxoimidazolidin-2-iminium |
|
106
|
400
|
4r5nA |
8-tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
107
|
403
|
4pzwA |
Synthesis, characterization and pk/pd studies of a series of spirocyclic pyranochromene bace1 inhibitors |
|
107
|
403
|
4pzxA |
Synthesis, characterization and pk/pd studies of a series of spirocyclic pyranochromene bace1 inhibitors |
|
105
|
400
|
4n00A |
Discovery of 7-thp chromans: bace1 inhibitors that reduce a-beta in the cns |
|
95
|
388
|
4lxmA |
Crystal structure of human beta secretase in complex with compound 12a |
|
95
|
388
|
4lxkA |
Crystal structure of human beta secretase in complex with compound 11d |
|
98
|
388
|
4lxaA |
Crystal structure of human beta secretase in complex with compound 11a |
