|
68
|
237
|
4jasA |
Structural basis of a rationally rewired protein-protein interface (hk853mutant a268v, a271g, t275m, v294t and d297e and rr468mutant v13p, l14i, i17m and n21v) |
|
68
|
208
|
4hy6A |
Crystal structure of the human hsp90-alpha n-domain bound to the hsp90 inhibitor fj1 |
|
103
|
396
|
4i5sA |
Structure and function of sensor histidine kinase |
|
52
|
207
|
4hz5A |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity |
|
79
|
246
|
4javA |
Structural basis of a rationally rewired protein-protein interface (hk853wt and rr468mutant v13p, l14i, i17m and n21v) |
|
107
|
376
|
4hxzA |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. |
|
109
|
371
|
4hy1A |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. |
|
60
|
204
|
4hypA |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. |
|
56
|
203
|
4hz0A |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. |
|
110
|
371
|
4hymA |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. |
|
59
|
210
|
4hxwA |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. |
|
67
|
215
|
4jqlA |
Synthesis of benzoquinone-ansamycin-inspired macrocyclic lactams from shikimic acid |
|
106
|
332
|
4h7qA |
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase in complex with alpha-ketoisocaproic acid and adp |
|
111
|
331
|
4h81A |
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(r)-2-chloro-3-phenylpropanoic acid complex with adp |
|
109
|
332
|
4h85A |
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(r)-alpha-chloroisocaproate complex with adp |
|
67
|
209
|
4gqtA |
N-terminal domain of c. elegans hsp90 |
|
40
|
133
|
4gt8A |
Crystal structure of the catalytic and atp-binding domain from vras in complex with adp |
|
60
|
210
|
4gglA |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity |
|
59
|
210
|
4geeA |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. |
|
117
|
366
|
4gczA |
Structure of a blue-light photoreceptor |
|
57
|
210
|
4gfnA |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic |
|
66
|
205
|
4fppA |
Bacterial phosphotransferase |
|
63
|
208
|
4fcpA |
Targetting conserved water molecules: design of 4-aryl-5-cyanopyrrolo [2,3-d] pyrimidine hsp90 inhibitors using fragment-based screening and structure-based optimization |
|
71
|
209
|
4fmtA |
Crystal structure of a chpt protein (cc_3470) from caulobacter crescentus cb15 at 2.30 a resolution |
|
68
|
210
|
3r4oA |
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1h-pyrazol-1-yl)ethoxy]-6-methylphenyl}-n-(2,2-difluoropropyl)-5,7-dihydro-6h-pyrrolo[3,4-d]pyrimidine-6-carboxamide |
|
64
|
208
|
4fcrA |
Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine hsp90 inhibitors using fragment-based screening and structure-based optimization |
|
67
|
221
|
3r4nA |
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1h-pyrazol-1-yl)ethoxy]-6-methylphenyl}-n-(2,2-difluoropropyl)-5,7-dihydro-6h-pyrrolo[3,4-d]pyrimidine-6-carboxamide |
|
68
|
222
|
3r4pA |
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1h-pyrazol-1-yl)ethoxy]-6-methylphenyl}-n-(2,2-difluoropropyl)-5,7-dihydro-6h-pyrrolo[3,4-d]pyrimidine-6-carboxamide |
|
65
|
215
|
3r4mA |
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1h-pyrazol-1-yl)ethoxy]-6-methylphenyl}-n-(2,2-difluoropropyl)-5,7-dihydro-6h-pyrrolo[3,4-d]pyrimidine-6-carboxamide |
|
69
|
208
|
4fcqA |
Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine hsp90 inhibitors using fragment-based screening and structure-based optimization |
|
67
|
207
|
3qtfA |
Design and sar of macrocyclic hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity |
|
69
|
209
|
3qddA |
Hsp90a n-terminal domain in complex with biib021 |
|
61
|
215
|
3q5jA |
Crystal structure of the amino-terminal domain of hsp90 from leishmania major, lmjf33.0312:m1-k213 in the presence of 17-dmap-geldanamycin |
|
62
|
214
|
3q5lA |
Crystal structure of the amino-terminal domain of hsp90 from leishmania major, lmjf33.0312:m1-k 213 in the presence of 17-aep-geldanamycin |
|
62
|
218
|
3q5kA |
Crystal structure of the amino-terminal domain of hsp90 from leishmania major, lmjf33.0312:m1-k213 in the presence of an inhibitor |
|
78
|
261
|
3pehA |
Crystal structure of the n-terminal domain of an hsp90 from plasmodium falciparum, pfl1070c in the presence of a thienopyrimidine derivative |
|
75
|
258
|
3pejA |
Crystal structure of the n-terminal domain of an hsp90 from plasmodium falciparum, pfl1070c in the presence of macbecin |
|
65
|
207
|
3ow6A |
Crystal structure of hsp90 with n-aryl-benzimidazolone i |
|
70
|
208
|
3omuA |
Crystal structure of the n-terminal domain of an hsp90 from trypanosoma brucei, tb10.26.1080 in the presence of a thienopyrimidine derivative |
|
63
|
207
|
3owbA |
Crystal structure of hsp90 with ver-49009 |
|
64
|
207
|
3owdA |
Crystal structure of hsp90 with n-aryl-benzimidazolone ii |
|
67
|
210
|
3opdA |
Crystal structure of the n-terminal domain of an hsp90 from trypanosoma brucei, tb10.26.1080 in the presence of a benzamide derivative |
|
68
|
208
|
3o0iA |
Structure of the human hsp90-alpha n-domain bound to the hsp90 inhibitor pu-h54 |
|
67
|
209
|
3o6oA |
Crystal structure of the n-terminal domain of an hsp90 from trypanosoma brucei, tb10.26.1080 in the presence of an the inhibitor biib021 |
|
70
|
232
|
3o2fA |
Structure of the n-domain of grp94 bound to the hsp90 inhibitor pu-h54 |
|
68
|
214
|
3nmqA |
Hsp90b n-terminal domain in complex with ec44, a pyrrolo-pyrimidine methoxypyridine inhibitor |
|
68
|
209
|
3mnrP |
Crystal structure of benzamide snx-1321 bound to hsp90 |
|
108
|
364
|
3lnuA |
Crystal structure of pare subunit |
|
134
|
492
|
3lmmA |
Crystal structure of the dip2311 protein from corynebacterium diphtheriae, northeast structural genomics consortium target cdr35 |
|
110
|
364
|
3lpsA |
Crystal structure of pare |
