|
104
|
388
|
4l7gA |
Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxy-benzylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against beta-secretase-1 (bace1) |
|
103
|
388
|
4l7hA |
Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxy-benzylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against beta-secretase-1 (bace-1) |
|
95
|
388
|
4k9hA |
Bace-1 inhibitor complex |
|
102
|
388
|
4l7jA |
Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxy-benzylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against beta-secretase-1 (bace-1) |
|
96
|
388
|
4k8sA |
Hydroxyethylamine-based inhibitors of bace1: p1-p3 macrocyclization can improve potency, selectivity, and cell activity |
|
93
|
387
|
4ke1A |
Crystal structure of bace1 in complex with hydroxyethylamine-macrocyclic inhibitor 19 |
|
104
|
402
|
4lc7A |
Aminooxazoline inhibitor of bace-1 |
|
100
|
391
|
4ke0A |
Crystal structure of bace1 in complex with hydroxyethylamine-macrocyclic inhibitor 13 |
|
99
|
391
|
4ivtA |
Crystal structure of bace1 with its inhibitor |
|
96
|
397
|
4i12A |
Design and synthesis of thiophene dihydroisoquinolins as novel bace-1 inhibitors |
|
97
|
390
|
4j1kA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4r,5r,6s)-2-amino-5-fluoro-4-methyl-6-trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
100
|
401
|
4i0dA |
Design and synthesis of thiophene dihydroisoquinolins as novel bace-1 inhibitors |
|
109
|
403
|
4hztA |
Structure-based design of novel dihydroisoquinoline bace-1 inhibitors that do not engage the catalytic aspartates |
|
106
|
402
|
4jooA |
Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
104
|
390
|
4j0zA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4s,5r)-2-amino-5-fluoro-4-fluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
104
|
400
|
4i0zA |
Structure-based design of novel dihydroisoquinoline bace-1 inhibitors that do not engage the catalytic aspartates |
|
105
|
402
|
4jp9A |
Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
103
|
390
|
4j0yA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4r,5s)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
95
|
390
|
4j0pA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((s)-2-amino-4-methyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
95
|
389
|
4ivsA |
Crystal structure of bace1 with its inhibitor |
|
100
|
403
|
4i0fA |
Design and synthesis of thiophene dihydroisoquinolins as novel bace-1 inhibitors |
|
101
|
403
|
4i0jA |
Spr and structural analysis yield insight towards mechanism of inhibition of bace inhibitors |
|
98
|
390
|
4j1fA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4s,6s)-2-amino-4-methyl-6-trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
103
|
390
|
4j1eA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4s,6s)-2-amino-4-fluoromethyl-6-trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
101
|
400
|
4i10A |
Structure-based design of novel dihydroisoquinoline bace-1 inhibitors that do not engage the catalytic aspartates |
|
105
|
402
|
4jpcA |
Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
95
|
390
|
4j1iA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4r,5r,6r)-2-amino-5-fluoro-4-methyl-6-trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
100
|
390
|
4j1cA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((s)-2-amino-5,5-difluoro-4-fluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
94
|
399
|
4i1cA |
Design and synthesis of thiophene dihydroisoquinolins as novel bace-1 inhibitors |
|
102
|
390
|
4j0vA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4r,5r)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
104
|
403
|
4i11A |
Structure-based design of novel dihydroisoquinoline bace-1 inhibitors that do not engage the catalytic aspartates. |
|
99
|
403
|
4i0eA |
Design and synthesis of thiophene dihydroisoquinolins as novel bace-1 inhibitors |
|
103
|
388
|
4i0iA |
Spr and structural analysis yield insight towards mechanism of inhibition of bace inhibitors |
|
96
|
390
|
4j1hA |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((4s,6r)-2-amino-4-methyl-6-trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
100
|
390
|
4j0tA |
Crystal structure of bace-1 in complex with 5-ethoxy-pyridine-2-carboxylic acid [3-((r)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
101
|
390
|
4j17A |
Crystal structure of bace-1 in complex with 5-cyano-pyridine-2-carboxylic acid [3-((s)-2-amino-4-difluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide |
|
98
|
403
|
4i0gA |
Design and synthesis of thiophene dihydroisoquinolins as novel bace-1 inhibitors |
|
97
|
388
|
4i0hA |
Spr and structural analysis yield insight towards mechanism of inhibition of bace inhibitors. |
|
107
|
402
|
4jpeA |
Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (bace1) inhibitors |
|
104
|
390
|
4h3jA |
Structure of bace bound to 2-fluoro-5-(5-(2-imino-3-methyl-4-oxo-6-phenyloctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-2-yl)benzonitrile |
|
103
|
390
|
4h3fA |
Structure of bace bound to 3-(5-((7ar)-2-imino-6-(6-methoxypyridin-2-yl)-3-methyl-4-oxooctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-3-yl)benzonitrile |
|
104
|
390
|
4h3iA |
Structure of bace bound to 3-(5-((7ar)-2-imino-6-(3-methoxypyridin-2-yl)-3-methyl-4-oxooctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-3-yl)benzonitrile |
|
106
|
390
|
4h3gA |
Structure of bace bound to 2-((7ar)-7a-(4-(3-cyanophenyl)thiophen-2-yl)-2-imino-3-methyl-4-oxohexahydro-1h-pyrrolo[3,4-d]pyrimidin-6(2h)-yl)nicotinonitrile |
|
103
|
390
|
4ha5A |
Structure of bace bound to (s)-3-(5-(2-imino-1,4-dimethyl-6-oxohexahydropyrimidin-4-yl)thiophen-3-yl)benzonitrile |
|
103
|
389
|
4h1eA |
Structure of bace-1 bound to (7ar)-6-benzoyl-7a-(4-(3-cyanophenyl)thiophen-2-yl)-3-methyl-4-oxohexahydro-1h-pyrrolo[3,4-d]pyrimidin-2(3h)-iminium |
|
103
|
389
|
4gmiA |
Bace-1 in complex with hea-type macrocyclic inhibitor, mv078571 |
|
103
|
387
|
4gidA |
Structure of beta-secretase complexed with inhibitor |
|
99
|
387
|
4fseA |
Crystal structure of beta-site app-cleaving enzyme 1 (bace-wt) complex with n-(n-(4-amino-3,5- dichlorobenzyl)carbamimidoyl)-3-(4-methoxyphenyl)-5- methyl-4-isothiazolecarboxamide |
|
103
|
387
|
4frjA |
Crystal structure of bace1 in complex with aminooxazoline xanthene 9l |
|
96
|
388
|
4friA |
Crystal structure of bace1 in complex with biarylspiro aminooxazoline 6 |
