|
87
|
284
|
5ugcA |
Crystal structure of the egfr kinase domain (l858r, t790m, v948r) in complex with a covalent inhibitor n-[(3r,4r)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1h-pyrazol-4-yl)amino]-9-methyl-9h-purin-2-yl}pyrrolidin-3-yl]propanamide |
|
88
|
284
|
5ug8A |
Crystal structure of the egfr kinase domain (l858r, t790m, v948r) in complex with a covalent inhibitor n-[(3r,4r)-4-fluoro-1-{6-[(1-methyl-1h-pyrazol-4-yl)amino]-9-(propan-2-yl)-9h-purin-2-yl}pyrrolidin-3-yl]propanamide |
|
90
|
323
|
5c8mA |
Egfr kinase domain mutant "tmlr" with compound 17 |
|
91
|
324
|
5hcyA |
Egfr kinase domain mutant "tmlr" with 3-carboxamide azaindole compound 13 |
|
88
|
283
|
5hg7A |
Egfr (l858r, t790m, v948r) in complex with 1-{(3r,4r)-3-[5-chloro-2-(1-methyl-1h-pyrazol-4-ylamino)-7h-pyrrolo[2,3-d]pyrimidin-4-yloxymethyl]-4-methoxy-pyrrolidin-1-yl}propenone (pf-06459988) |
|
86
|
284
|
5hg9A |
Egfr (l858r, t790m, v948r) in complex with 1-[(3r,4r)-3-[({2-[(1-methyl-1h-pyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-(trifluoromethyl)pyrrolidin-1-yl]prop-2-en-1-one |
|
91
|
323
|
5hibA |
Egfr kinase domain mutant "tmlr" with a pyrazolopyrimidine inhibitor |
|
90
|
323
|
5hcxA |
Egfr kinase domain mutant "tmlr" with azabenzimidazole compound 7 |
|
91
|
323
|
5hicA |
Egfr kinase domain mutant "tmlr" with a imidazopyridinyl-aminopyrimidine inhibitor |
|
91
|
324
|
5hczA |
Egfr kinase domain mutant "tmlr" with 3-azetidinyl azaindazole compound 21 |
|
91
|
302
|
5hg5A |
Egfr (l858r, t790m, v948r) in complex with n-{3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}prop-2-enamide |
|
92
|
300
|
5hg8A |
Egfr (l858r, t790m, v948r) in complex with n-[3-({2-[(1-methyl-1h-pyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)phenyl]prop-2-enamide |
|
85
|
324
|
5gmpA |
Crystal structure of egfr 696-1022 t790m in complex with xtf-262 |
|
94
|
324
|
5gtzA |
Crystal structure of egfr 696-1022 t790m in complex with jts-1-39 |
|
83
|
289
|
5gnkA |
Crystal structure of egfr 696-988 t790m in complex with lxx-6-34 |
|
81
|
315
|
5gtyA |
Crystal structure of egfr 696-1022 t790m in complex with lxx-6-26 |
|
89
|
322
|
5feeA |
Egfr kinase domain t790m mutant in complex with a covalent aminobenzimidazole inhibitor. |
|
92
|
321
|
5fedA |
Egfr kinase domain in complex with a covalent aminobenzimidazole inhibitor. |
|
85
|
321
|
5feqA |
Egfr kinase domain in complex with a covalent aminobenzimidazole |
|
86
|
322
|
5edqA |
Egfr kinase (t790m/l858r) with inhibitor compound 15: ~{n}-(7-chloranyl-1~{h}-indazol-3-yl)-7,7-dimethyl-2-(1~{h}-pyrazol-4-yl)-5~{h}-furo[3,4-d]pyrimidin-4-amine |
|
93
|
322
|
5edrA |
Egfr kinase (t790m/l858r) with inhibitor compound 27: ~{n}-(1~{h}-indazol-3-yl)-7,7-dimethyl-2-(2-methylpyrazol-3-yl)-5~{h}-furo[3,4-d]pyrimidin-4-amine |
|
90
|
322
|
5edpA |
Egfr kinase (t790m/l858r) apo |
|
90
|
323
|
5em8A |
Egfr kinase domain with pyridone compound 13: 4-[(2-methoxyphenyl)amino]-~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{h}-pyridine-3-carboxamide |
|
93
|
309
|
4zseA |
Crystal structure of egfr 696-1022 t790m/v948r, crystal form ii |
|
93
|
323
|
5em6A |
Egfr kinase domain mutant "tmlr" with pyridone compound 19: 4-[(2-azanylpyrimidin-4-yl)amino]-~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{h}-pyridine-3-carboxamide |
|
88
|
323
|
5em5A |
Egfr kinase domain mutant "tmlr" with pyridone compound 2: 4-[2-(4-chlorophenyl)ethylamino]-~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{h}-pyridine-3-carboxamide |
|
87
|
324
|
5em7A |
Egfr kinase domain mutant "tmlr" with pyridone compound 13: 4-[(2-methoxyphenyl)amino]-~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{h}-pyridine-3-carboxamide |
|
92
|
317
|
5d41A |
Egfr kinase domain in complex with mutant selective allosteric inhibitor |
|
94
|
316
|
5cnoA |
Crystal structure of the egfr kinase domain mutant v924r |
|
99
|
323
|
5cziA |
Egfr l858r mutant in complex with a shc peptide substrate |
|
1
|
9
|
5czhB |
Egfr l858r mutant in complex with an optimal peptide substrate |
|
92
|
323
|
5czhA |
Egfr l858r mutant in complex with an optimal peptide substrate |
|
93
|
316
|
5cnnA |
Crystal structure of the egfr kinase domain mutant i682q |
|
96
|
326
|
4wrgA |
1.9 angstrom structure of egfr kinase domain |
|
91
|
327
|
4wkqA |
1.85 angstrom structure of egfr kinase domain with gefitinib |
|
79
|
328
|
4wd5A |
Crystal structure of egfr 696-1022 t790m in complex with ql-x138 |
|
46
|
223
|
4uv7H |
The complex structure of extracellular domain of egfr and gc1118a |
|
51
|
216
|
4uv7L |
The complex structure of extracellular domain of egfr and gc1118a |
|
156
|
613
|
4uv7A |
The complex structure of extracellular domain of egfr and gc1118a |
|
144
|
612
|
4uipA |
The complex structure of extracellular domain of egfr with repebody (rac1). |
|
86
|
323
|
4tksA |
Native-sad phasing for human egfr kinase domain. |
|
73
|
238
|
4uipB |
The complex structure of extracellular domain of egfr with repebody (rac1). |
|
94
|
322
|
4rj8A |
Egfr kinase (t790m/l858r) with inhibitor compound 8 |
|
88
|
323
|
4rj5A |
Egfr kinase (t790m/l858r) with inhibitor compound 5 |
|
91
|
322
|
4rj6A |
Egfr kinase (t790m/l858r) with inhibitor compound 4 |
|
91
|
322
|
4rj4A |
Egfr kinase (t790m/l858r) with inhibitor compound 6 |
|
86
|
323
|
4r3pA |
Crystal structures of egfr in complex with mig6 |
|
86
|
323
|
4r3rA |
Crystal structures of egfr in complex with mig6 |
|
88
|
322
|
4r5sA |
Crystal structure of egfr 696-1022 l858r in complex with fiin-3 |
|
92
|
322
|
4rj7A |
Egfr kinase (t790m/l858r) with inhibitor compound 1 |
