|
40
|
157
|
3frdX |
S. aureus dhfr complexed with nadph and folate |
|
41
|
166
|
3fl8A |
Crystal structure of b. anthracis dihydrofolate reductase (dhfr) with rab1, a tmp-dihydrophthalazine derivative |
|
34
|
166
|
3fl9A |
Crystal structure of b. anthracis dihydrofolate reductase (dhfr) with trimethoprim |
|
56
|
186
|
3f8yA |
Correlations of human dihydrofolate reductase with structural data for human active site mutant enzyme complexes |
|
55
|
186
|
3f8zA |
Human dihydrofolate reductase structural data with active site mutant enzyme complexes |
|
52
|
186
|
3f91A |
Structural data for human active site mutant enzyme complexes |
|
39
|
157
|
3f0qX |
Staphylococcus aureus dihydrofolate reductase complexed with nadph and 2,4-diamino-5-[3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine |
|
40
|
157
|
3f0xX |
Staphylococcus aureus f98y mutant dihydrofolate reductase complexed with nadph and 2,4-diamino-5-[3-(3-methoxy-5-(3,5-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine |
|
44
|
157
|
3f0uX |
Staphylococcus aureus f98y mutant dihydrofolate reductase complexed with nadph and 2,4-diamino-5-[3-(3-methoxy-5-phenylphenyl)but-1-ynyl]-6-methylpyrimidine |
|
41
|
157
|
3f0bX |
Staphylococcus aureus dihydrofolate reductase complexed with nadph and 2,4-diamino-5-[3-(3-methoxy-5-phenylphenyl)but-1-ynyl]-6-methylpyrimidine |
|
41
|
157
|
3f0vX |
Staphylococcus aureus f98y mutant dihydrofolate reductase complexed with nadph and 2,4-diamino-5-[3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine |
|
104
|
359
|
3ex8A |
Complex structure of bacillus subtilis ribg reduction mechanism in riboflavin biosynthesis |
|
43
|
157
|
3f0sX |
Staphylococcus aureus dihydrofolate reductase complexed with nadph and 2,4-diamino-5-[3-(3-methoxy-5-(3,5-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine |
|
60
|
225
|
3eemA |
Candida glabrata dihydrofolate reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)prop-1-ynyl]-6-methylpyrimidine(ucp111d26m) and nadph |
|
61
|
225
|
3eejA |
Candida glabrata dihydrofolate reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-phenylphenyl)prop-1-ynyl]-6-methylpyrimidine(ucp111d) and nadph |
|
49
|
186
|
3eigA |
Crystal structure of a methotrexate-resistant mutant of human dihydrofolate reductase |
|
64
|
225
|
3eelA |
Candida glabrata dihydrofolate reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-(3,5-dimethylphenyl)phenyl)prop-1-ynyl]-6-methylpyrimidine(ucp11153tm) and nadph |
|
60
|
225
|
3eekA |
Candida glabrata dihydrofolate reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-(4-methylphenyl)phenyl)prop-1-ynyl]-6-methylpyrimidine(ucp111d4m) and nadph |
|
43
|
166
|
3e0bA |
Bacillus anthracis dihydrofolate reductase complexed with nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (ucp120b) |
|
156
|
519
|
3dl6A |
Crystal structure of the a287f/s290g active site mutant of ts-dhfr from cryptosporidium hominis |
|
45
|
162
|
3dfrA |
Crystal structures of escherichia coli and lactobacillus casei dihydrofolate reductase refined at 1.7 angstroms resolution. i. general features and binding of methotrexate |
|
168
|
519
|
3dl5A |
Crystal structure of the a287f active site mutant of ts-dhfr from cryptosporidium hominis |
|
58
|
231
|
3dg8A |
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with rjf670, nadph, and dump |
|
44
|
159
|
3drcA |
Investigation of the functional role of tryptophan-22 in escherichia coli dihydrofolate reductase by site-directed mutagenesis |
|
63
|
230
|
3dgaA |
Wild-type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with rjf01302, nadph, and dump |
|
56
|
186
|
3d84X |
Structural analysis of a holo enzyme complex of mouse dihydrofolate reductase with nadph and a ternary complex with the potent and selective inhibitor 2.4-diamino-6-(-2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine |
|
47
|
159
|
3dauA |
Crystal structure of the ternary mtx nadph complex of escherichia coli dihydrofolate reductase |
|
35
|
161
|
3datA |
Crystal structure of the ternary mtx nadph complex of bacillus anthracis dihydrofolate reductase |
|
51
|
186
|
3d80A |
Structural analysis of a holo enzyme complex of mouse dihydrofolate reductase with nadph and a ternary complex wtih the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine |
|
153
|
515
|
3clbA |
Structure of bifunctional tcdhfr-ts in complex with tmq |
|
140
|
513
|
3cl9A |
Structure of bifunctional tcdhfr-ts in complex with mtx |
|
61
|
225
|
3cseA |
Candida glabrata dihydrofolate reductase complexed with nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (ucp120b) |
|
54
|
206
|
3cd2A |
Ligand induced conformational changes in the crystal structures of pneumocystis carinii dihydrofolate reductase complexes with folate and nadp+ |
|
45
|
161
|
2zzaA |
Moritella profunda dihydrofolate reductase complex with nadp+ and folate |
|
45
|
175
|
2xw7A |
Structure of mycobacterium smegmatis putative reductase ms0308 |
|
47
|
157
|
2w9hA |
Wild-type staphylococcus aureus dhfr in complex with trimethoprim |
|
42
|
157
|
2w9gA |
Wild-type staphylococcus aureus dhfr in complex with nadph and trimethoprim |
|
39
|
157
|
2w9sA |
Staphylococcus aureus s1:dhfr in complex with trimethoprim |
|
48
|
186
|
2w3mA |
Human dihydrofolate reductase complexed with nadph and folate |
|
42
|
159
|
2w9tA |
Staphylococcus aureus s1:dhfr |
|
48
|
186
|
2w3aA |
Human dihydrofolate reductase complexed with nadph and trimethoprim |
|
48
|
164
|
2w3wA |
Mycobacterium avium dihydrofolate reductase complexed with nadph and a lipophilic antifolate selective for m. avium dhfr, 6-((2,5- diethoxyphenyl)aminomethyl)-2,4-diamino-5-methylpyrido(2,3-d) pyrimidine (sri-8686) |
|
47
|
165
|
2w3vA |
Mycobacterium avium dihydrofolate reductase complexed with nadph and trimethoprim |
|
49
|
185
|
2w3bA |
Human dihydrofolate reductase complexed with nadph and a lipophilic antifolate selective for mycobacterium avium dhfr, 6-((2,5- diethoxyphenyl)aminomethyl)-2,4-diamino-5-methylpyrido(2,3-d) pyrimidine (sri-8686) |
|
38
|
162
|
2qk8A |
Crystal structure of the anthrax drug target, bacillus anthracis dihydrofolate reductase |
|
80
|
248
|
2p4gA |
Crystal structure of a pyrimidine reductase-like protein (dip1392) from corynebacterium diphtheriae nctc at 2.30 a resolution |
|
95
|
372
|
2o7pA |
The crystal structure of ribd from escherichia coli in complex with the oxidised nadp+ cofactor in the active site of the reductase domain |
|
166
|
519
|
2oipA |
Crystal structure of the s290g active site mutant of ts-dhfr from cryptosporidium hominis |
|
96
|
372
|
2obcA |
The crystal structure of ribd from escherichia coli in complex with a substrate analogue, ribose 5-phosphate (beta form), bound to the active site of the reductase domain |
|
31
|
162
|
2lf1A |
Solution structure of l. casei dihydrofolate reductase complexed with nadph, 30 structures |
