|
100
|
316
|
1njcA |
Thymidylate synthase, mutation, n229d with 2'-deoxycytidine 5'-monophosphate (dcmp) |
|
101
|
316
|
1njaA |
Thymidylate synthase, mutation, n229c with 2'-deoxycytidine 5'-monophosphate (dcmp) |
|
92
|
316
|
1njbA |
Thymidylate synthase |
|
80
|
316
|
1lceA |
Lactobacillus casei thymidylate synthase ternary complex with dump and ch2thf |
|
83
|
316
|
1lcaA |
Lactobacillus casei thymidylate synthase ternary complex with dump and cb3717 |
|
83
|
263
|
1kziA |
Crystal structure of ects/dump/thf complex |
|
80
|
263
|
1kzjA |
Crystal structure of ects w80g/dump/cb3717 complex |
|
89
|
263
|
1kceA |
E. coli thymidylate synthase mutant e58q in complex with cb3717 and 2'-deoxyuridine 5'-monophosphate (dump) |
|
95
|
286
|
1ju6A |
Human thymidylate synthase complex with dump and ly231514, a pyrrolo(2,3-d)pyrimidine-based antifolate |
|
83
|
263
|
1jtuA |
E. coli thymidylate synthase in a complex with dump and ly338913, a polyglutamylated pyrrolo(2,3-d)pyrimidine-based antifolate |
|
83
|
286
|
1jujA |
Human thymidylate synthase bound to dump and ly231514, a pyrrolo(2,3-d)pyrimidine-based antifolate |
|
88
|
263
|
1jtqA |
E. coli ts complex with dump and the pyrrolo(2,3-d)pyrimidine-based antifolate ly341770 |
|
82
|
263
|
1jutA |
E. coli thymidylate synthase bound to dump and ly338529, a pyrrolo(2,3-d)pyrimidine-based antifolate |
|
103
|
326
|
1j3jC |
Double mutant (c59r+s108n) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with pyrimethamine, nadph, and dump |
|
78
|
285
|
1hw3A |
Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors |
|
75
|
285
|
1hw4A |
Structure of thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors |
|
93
|
288
|
1hvyA |
Human thymidylate synthase complexed with dump and raltitrexed, an antifolate drug, is in the closed conformation |
|
92
|
278
|
1i00A |
Crystal structure of human thymidylate synthase, ternary complex with dump and tomudex |
|
93
|
280
|
1hzwA |
Crystal structure of human thymidylate synthase |
|
83
|
263
|
1fwmA |
Crystal structure of the thymidylate synthase r166q mutant |
|
92
|
316
|
1jmiA |
Contributions of orientation and hydrogen bonding to catalysis in asn-229 mutants of thymidylate synthase |
|
95
|
316
|
1jmfA |
Contributions of orientation and hydrogen bonding to catalysis in asn-229 mutants of thymidylate synthase |
|
104
|
316
|
1jmhA |
Contributions of orientation and hydrogen bonding to catalysis in asn-229 mutants of thymidylate synthase |
|
96
|
316
|
1jmgA |
Contributions of orientation and hydrogen bonding to catalysis in asn-229 mutants of thymidylate synthase |
|
80
|
261
|
1f4gA |
Crystal structure of e. coli thymidylate synthase complexed with sp-876 |
|
83
|
263
|
1fflA |
Crystal structure of the apo-thymidylate synthase r166q mutant |
|
83
|
263
|
1f4bA |
Crystal structure of escherichia coli thymidylate synthase |
|
76
|
263
|
1evgA |
Crystal structure analysis of cys167 mutant of escherichia coli with unmodified catalytic cysteine |
|
74
|
263
|
1evfA |
Crystal structure analysis of cys167 mutant of escherichia coli |
|
85
|
261
|
1f4cA |
Crystal structure of e. coli thymidylate synthase covalently modified at c146 with n-[tosyl-d-prolinyl]amino-ethanethiol |
|
72
|
263
|
1ev8A |
Crystal structure analysis of cys167 mutant of escherichia coli |
|
93
|
295
|
1f28A |
Crystal structure of thymidylate synthase from pneumocystis carinii bound to dump and bw1843u89 |
|
79
|
262
|
1jg0A |
Crystal structure of escherichia coli thymidylate synthase complexed with 2'-deoxyuridine-5'-monophosphate and n,o-didansyl-l-tyrosine |
|
77
|
263
|
1ev5A |
Crystal structure analysis of ala167 mutant of escherichia coli |
|
82
|
263
|
1f4dA |
Crystal structure of e. coli thymidylate synthase c146s, l143c covalently modified at c143 with n-[tosyl-d-prolinyl]amino-ethanethiol |
|
78
|
261
|
1f4fA |
Crystal structure of e. coli thymidylate synthase complexed with sp-722 |
|
81
|
263
|
1f4eA |
Crystal structure of e. coli thymidylate synthase complexed with tosyl-d-proline |
|
85
|
264
|
1dduA |
E. coli thymidylate synthase in complex with cb3717 and 2',5'-dideoxyuridine (ddurd) |
|
61
|
231
|
1j3kA |
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with wr99210, nadph, and dump |
|
85
|
263
|
1dnaA |
D221(169)n mutant does not promote opening of the cofactor imidazolidine ring |
|
106
|
326
|
1j3kC |
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with wr99210, nadph, and dump |
|
66
|
231
|
1j3jA |
Double mutant (c59r+s108n) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with pyrimethamine, nadph, and dump |
|
61
|
233
|
1j3iA |
Wild-type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with wr99210, nadph, and dump |
|
103
|
327
|
1j3iC |
Wild-type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with wr99210, nadph, and dump |
|
88
|
295
|
1ci7A |
Ternary complex of thymidylate synthase from pneumocystis carinii |
|
102
|
316
|
1bpjA |
Thymidylate synthase r178t, r179t double mutant |
|
77
|
278
|
1bsfA |
Thermostable thymidylate synthase a from bacillus subtilis |
|
98
|
316
|
1bp0A |
Thymidylate synthase r23i mutant |
|
77
|
263
|
1bq1A |
E. coli thymidylate synthase mutant n177a in complex with cb3717 and 2'-deoxyuridine 5'-monophosphate (dump) |
|
81
|
264
|
1bq2A |
E. coli thymidylate synthase mutant n177a |
