|
44
|
165
|
3jwcA |
Crystal structure of bacillus anthracis (y102f) dihydrofolate reductase complexed with nadph and 2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (ucp120a) |
|
45
|
165
|
3jwmA |
Crystal structure of bacillus anthracis dihydrofolate reductase complexed with nadph and (s)-2,4-diamino-5-(3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (ucp114a) |
|
43
|
159
|
3k74A |
Disruption of protein dynamics by an allosteric effector antibody |
|
55
|
186
|
3k45A |
Alternate binding modes observed for the e- and z-isomers of 2,4-diaminofuro[2,3d]pyrimidines as ternary complexes with nadph and mouse dihydrofolate reductase |
|
177
|
606
|
3jsuA |
Quadruple mutant(n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(pfdhfr-ts) complexed with qn254, nadph, and dump |
|
40
|
165
|
3jw5A |
Crystal structure of bacillus anthracis (y102f) dihydrofolate reductase complexed with nadph and trimethoprim |
|
57
|
186
|
3k47A |
Alternate binding modes observed for the e- and z-isomers of 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with nadph and mouse dihydrofolate reductase |
|
42
|
165
|
3jw3A |
Crystal structure of bacillus anthracis (f96i) dihydrofolate reductase complexed with nadph and trimethoprim |
|
45
|
165
|
3jwkA |
Crystal structure of bacillus anthracis (y102f) dihydrofolate reductase complexed with nadph and (s)-2,4-diamino-5-(3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (ucp114a) |
|
43
|
165
|
3jwfA |
Crystal structure of bacillus anthracis (y102f) dihydrofolate reductase complexed with nadph and (r)-2,4-diamino-5-(3-hydroxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (ucp113a) |
|
163
|
508
|
3k2hA |
Co-crystal structure of dihydrofolate reductase/thymidylate synthase from babesia bovis with dump, pemetrexed and nadp |
|
45
|
166
|
3jvxA |
Crystal structure of bacillus anthracis dihydrofolate reductase complexed with nadph and 2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (ucp120a) |
|
160
|
514
|
3invA |
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase complexed with nadph, dump and c-448 antifolate |
|
152
|
516
|
3irnA |
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase complexed with nadph and cycloguanil |
|
44
|
166
|
3ix9A |
Crystal structure of streptococcus pneumoniae dihydrofolate reductase - sp9 mutant |
|
156
|
518
|
3iroA |
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase complexed with nadph and q-8 antifolate |
|
161
|
520
|
3irmA |
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase complexed with cycloguanil |
|
42
|
161
|
3ia4A |
Moritella profunda dihydrofolate reductase (dhfr) in complex with nadph and methotrexate (mtx) |
|
44
|
161
|
3ia5A |
Moritella profunda dihydrofolate reductase (dhfr) |
|
41
|
157
|
3i8aX |
Staphylococcus aureus h30n, f98y dihydrofolate reductase complexed with nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (ucp120b) |
|
155
|
506
|
3i3rA |
X-ray structure dihydrofolate reductase/thymidylate synthase from babesia bovis at 2.35a resolution |
|
157
|
515
|
3hbbA |
Structures of dihydrofolate reductase-thymidylate synthase of trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate |
|
55
|
186
|
3ghcA |
Design, synthesis, and x-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agenst |
|
53
|
186
|
3ghwA |
Human dihydrofolate reductase inhibitor complex |
|
53
|
186
|
3ghvA |
Human dihydrofolate reductase q35k/n64f double mutant inhibitor complex |
|
53
|
186
|
3gi2A |
Human dihydrofolate reductase q35k mutant inhibitor complex |
|
47
|
186
|
3gyfA |
Human dhfr with z-isomer in orthorhombic lattice |
|
42
|
157
|
3fy9X |
Staph. aureus dhfr f98y complexed with ar-102 |
|
42
|
158
|
3fyvX |
Staph. aureus dhfr complexed with nadph and ar-102 |
|
41
|
158
|
3frfX |
S. aureus dhfr complexed with nadph and iclaprim |
|
40
|
158
|
3fywX |
Staph. aureus dhfr complexed with nadph and ar-101 |
|
40
|
157
|
3freX |
S. aureus dhfr complexed with nadph and tmp |
|
42
|
157
|
3frbX |
S. aureus f98y dhfr complexed with tmp |
|
54
|
186
|
3fs6A |
Correlations of inhibitor kinetics for pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes |
|
41
|
157
|
3fy8X |
Crystal structure of staph. aureus dhfr complexed with nadph and ar-101 |
|
40
|
157
|
3frdX |
S. aureus dhfr complexed with nadph and folate |
|
42
|
157
|
3fraX |
Staphylococcus aureus f98y dhfr complexed with iclaprim |
|
56
|
186
|
3f8yA |
Correlations of human dihydrofolate reductase with structural data for human active site mutant enzyme complexes |
|
41
|
166
|
3fl8A |
Crystal structure of b. anthracis dihydrofolate reductase (dhfr) with rab1, a tmp-dihydrophthalazine derivative |
|
34
|
166
|
3fl9A |
Crystal structure of b. anthracis dihydrofolate reductase (dhfr) with trimethoprim |
|
52
|
186
|
3f91A |
Structural data for human active site mutant enzyme complexes |
|
55
|
186
|
3f8zA |
Human dihydrofolate reductase structural data with active site mutant enzyme complexes |
|
61
|
225
|
3eejA |
Candida glabrata dihydrofolate reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-phenylphenyl)prop-1-ynyl]-6-methylpyrimidine(ucp111d) and nadph |
|
49
|
186
|
3eigA |
Crystal structure of a methotrexate-resistant mutant of human dihydrofolate reductase |
|
60
|
225
|
3eemA |
Candida glabrata dihydrofolate reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)prop-1-ynyl]-6-methylpyrimidine(ucp111d26m) and nadph |
|
60
|
225
|
3eekA |
Candida glabrata dihydrofolate reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-(4-methylphenyl)phenyl)prop-1-ynyl]-6-methylpyrimidine(ucp111d4m) and nadph |
|
64
|
225
|
3eelA |
Candida glabrata dihydrofolate reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-(3,5-dimethylphenyl)phenyl)prop-1-ynyl]-6-methylpyrimidine(ucp11153tm) and nadph |
|
43
|
166
|
3e0bA |
Bacillus anthracis dihydrofolate reductase complexed with nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (ucp120b) |
|
63
|
230
|
3dgaA |
Wild-type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with rjf01302, nadph, and dump |
|
58
|
231
|
3dg8A |
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with rjf670, nadph, and dump |
