|
33
|
123
|
3zxqA |
Crystal structure of the atp-binding domain of mycobacterium tuberculosis dost |
|
64
|
213
|
4asfA |
The structure of modified benzoquinone ansamycins bound to yeast n- terminal hsp90 |
|
64
|
209
|
3whaA |
Hsp90 alpha n-terminal domain in complex with a tricyclic inhibitor |
|
109
|
409
|
3zm7A |
Crystal structure of the atpase region of mycobacterium tuberculosis gyrb with amppcp |
|
66
|
211
|
3wq9A |
Crystal structure of hsp90-alpha n-terminal domain in complex with 2-(4-hydroxy-cyclohexylamino)-4-[5-(4-phenyl-imidazol-1-yl)-isoquinolin-1-yl]-benzamide |
|
111
|
413
|
3zkdA |
Crystal structure of the atpase region of mycobacterium tuberculosis gyrb with amppnp |
|
120
|
413
|
3zkbA |
Crystal structure of the atpase region of mycobacterium tuberculosis gyrb with amppnp |
|
70
|
213
|
3vhdA |
Hsp90 alpha n-terminal domain in complex with a macrocyclic inhibitor, ch5164840 |
|
68
|
216
|
3vhcA |
Hsp90 alpha n-terminal domain in complex with a macrocyclic inhibitor |
|
66
|
215
|
3vhaA |
Hsp90 alpha n-terminal domain in complex with a macrocyclic inhibitor |
|
101
|
337
|
3vadA |
Crystal structure of i170f mutant branched-chain alpha-ketoacid dehydrogenase kinase in complex with 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid |
|
62
|
194
|
3ttzA |
Crystal structure of a topoisomerase atpase inhibitor |
|
108
|
338
|
3tz4A |
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/s-alpha-chloroisocaproate complex with adp |
|
109
|
339
|
3tz5A |
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/phenylbutyrate complex with adp |
|
99
|
336
|
3tz2A |
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/phenylbutyrate complex |
|
63
|
194
|
3u2dA |
S. aureus gyrb atpase domain in complex with small molecule inhibitor |
|
107
|
337
|
3tz0A |
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/s-alpha-chloroisocaproate complex |
|
64
|
194
|
3u2kA |
S. aureus gyrb atpase domain in complex with a small molecule inhibitor |
|
63
|
208
|
3t0hA |
Structure insights into mechanisms of atp hydrolysis and the activation of human hsp90 |
|
62
|
214
|
3t10A |
Hsp90 n-terminal domain bound to acp |
|
67
|
213
|
3t1kA |
Hsp90 n-terminal domain bound to anp |
|
68
|
213
|
3t0zA |
Hsp90 n-terminal domain bound to atp |
|
68
|
211
|
3t2sA |
Hsp90 n-terminal domain bound to ags |
|
38
|
153
|
3sl2A |
Atp forms a stable complex with the essential histidine kinase walk (yycg) domain |
|
124
|
397
|
5j5pA |
Amp-pnp-stabilized atpase domain of topoisomerase iv from streptococcus pneumoniae, complex type i |
|
67
|
217
|
3rlpA |
Co-crystal structure of the hsp90 atp binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-6-methylpyrimidin-2-amine |
|
68
|
222
|
3rlqA |
Co-crystal structure of the hsp90 atp binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7h-pyrrolo[2,3-d]pyrimidine-5- carbonitrile |
|
69
|
208
|
3rkzA |
Discovery of a stable macrocyclic o-aminobenzamide hsp90 inhibitor capable of significantly decreasing tumor volume in a mouse xenograft model. |
|
70
|
219
|
3rlrA |
Co-crystal structure of the hsp90 atp binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2,6-dimethyl-7h-pyrrolo[2,3-d]pyrimidine-5-carbonitrile |
|
70
|
207
|
3r91A |
Macrocyclic lactams as potent hsp90 inhibitors with excellent tumor exposure and extended biomarker activity. |
|
67
|
208
|
3r92A |
Discovery of a macrocyclic o-aminobenzamide hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model. |
|
284
|
1109
|
4i3hA |
A three-gate structure of topoisomerase iv from streptococcus pneumoniae |
|
70
|
207
|
5xrbA |
Crystal structure of the human hsp90-alpha n-domain bound to the hsp90 inhibitor fj5 |
|
70
|
208
|
5xr9A |
Crystal structure of human hsp90 with fs6 |
|
122
|
383
|
2q8hA |
Structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (dca) |
|
128
|
389
|
2q8iA |
Pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug radicicol |
|
128
|
383
|
2q8gA |
Structure of pyruvate dehydrogenase kinase isoform 1 in complex with glucose-lowering drug azd7545 |
|
129
|
383
|
2q8fA |
Structure of pyruvate dehydrogenase kinase isoform 1 |
|
63
|
208
|
5vyyA |
Structure of human hsp90-alpha bound to resorcinylic inhibitor bnim |
|
136
|
662
|
5ulsA |
Structure of grp94 in the active conformation |
|
80
|
237
|
5uhtA |
Structure of the thermotoga maritima hk853-bef3-rr468 complex at ph 5.0 |
|
68
|
218
|
5ucjA |
Hsp90b n-terminal domain with inhibitors |
|
70
|
219
|
5uchA |
Hsp90b n-terminal domain with inhibitors |
|
69
|
219
|
5uc4A |
Hsp90b n-terminal domain with inhibitors |
|
65
|
219
|
5uciA |
Hsp90b n-terminal domain with inhibitors |
|
62
|
227
|
5ttzA |
Crystal structure of grp94 bound to isoform-selective inhibitor methyl 2-(2-(1-(4-bromobenzyl)-1h-imidazol-2-yl)ethyl)-3-chloro-4,6-dihydroxybenzoate |
|
67
|
208
|
5t21A |
Crystal structure of hsp90 in complex with sar148019. |
|
70
|
209
|
5odxA |
Crystal structure of hsp90-alpha n-domain in complex with indazole derivative |
|
64
|
207
|
5ociA |
Human heat shock protein 90 bound to 6-hydroxy-3-(3-methyl-benzyl)-1h-indazole-5-carboxylic acid methyl-(4-morpholin-4-yl-phenyl)-amide |
|
68
|
209
|
5nyiA |
Crystal structure of hsp90-alpha n-domain in complex with resorcinol derivative |
