|
120
|
324
|
4ia0A |
Crystal structure of the pde5a1 catalytic domain in complex with novel inhibitors |
|
139
|
340
|
4jibA |
Crystal structure of of pde2-inhibitor complex |
|
129
|
318
|
4hf4A |
Crystal structure of pde10a with a biaryl ether inhibitor (1-(1-(3-(4-(benzo[d]thiazol-2-ylamino)phenoxy)pyrazin-2-yl)piperidin-4-yl)ethanol) |
|
130
|
318
|
4heuA |
Crystal structure of pde10a with a biaryl ether inhibitor ((1-(3-(4-((1h-benzo[d]imidazol-2-yl)amino)phenoxy)pyridin-2-yl)piperidin-4-yl)methanol) |
|
133
|
326
|
4gh6A |
Crystal structure of the pde9a catalytic domain in complex with inhibitor 28 |
|
124
|
322
|
4g2wA |
Crystal structure of pde5a in complex with its inhibitor |
|
119
|
325
|
4g2yA |
Crystal structure of pde5a complexed with its inhibitor |
|
137
|
328
|
4g2lA |
Human pde9 in complex with selective compound |
|
128
|
328
|
4g2jA |
Human pde9 in complex with selective compound |
|
130
|
322
|
4fcbA |
Potent and selective phosphodiesterase 10a inhibitors |
|
132
|
322
|
4fcdA |
Potent and selective phosphodiesterase 10a inhibitors |
|
127
|
305
|
3qpnA |
Structure of pde10-inhibitor complex |
|
130
|
305
|
3qpoA |
Structure of pde10-inhibitor complex |
|
138
|
325
|
3qi4A |
Crystal structure of pde9a(q453e) in complex with ibmx |
|
126
|
305
|
3qppA |
Structure of pde10-inhibitor complex |
|
137
|
325
|
3qi3A |
Crystal structure of pde9a(q453e) in complex with inhibitor bay73-6691 |
|
138
|
335
|
3o56A |
Catalytic domain of human phosphodiesterase 4b2b in complex with a 5-heterocycle pyrazolopyridine inhibitor |
|
137
|
323
|
3o0jA |
Pde4b in complex with ligand an2898 |
|
142
|
336
|
3o57A |
Catalytic domain of human phosphodiesterase 4b2b in complex with a 5-heterocycle pyrazolopyridine inhibitor |
|
131
|
326
|
3n3zA |
Crystal structure of pde9a (e406a) mutant in complex with ibmx |
|
139
|
345
|
3ly2A |
Catalytic domain of human phosphodiesterase 4b in complex with a coumarin-based inhibitor |
|
126
|
308
|
3lxgA |
Crystal structure of rat phosphodiesterase 10a in complex with ligand web-3 |
|
128
|
347
|
3kktA |
Crystal structure of human pde4b with 5-[3-[(1s,2s,4r)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp henyl]tetrahydro-2(1h)-pyrimidinone reveals ordering of the c-terminal helix residues 502-509. |
|
133
|
324
|
3jwqA |
Crystal structure of chimeric pde5/pde6 catalytic domain complexed with sildenafil |
|
134
|
320
|
3k3hA |
Crystal structure of the pde9a catalytic domain in complex with (s)-bay73-6691 |
|
131
|
323
|
3jwrA |
Crystal structure of chimeric pde5/pde6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (ibmx) and pde6 gamma-subunit inhibitory peptide 70-87. |
|
134
|
319
|
3k3eA |
Crystal structure of the pde9a catalytic domain in complex with (r)-bay73-6691 |
|
136
|
329
|
3k4sA |
The structure of the catalytic domain of human pde4d with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone |
|
134
|
328
|
3jabC |
Domain organization and conformational plasticity of the g protein effector, pde6 |
|
128
|
328
|
3jsiA |
Human phosphodiesterase 9 in complex with inhibitor |
|
106
|
328
|
3jbqB |
Domain organization and conformational plasticity of the g protein effector, pde6 |
|
134
|
328
|
3jswA |
Human pde9 in complex with selective inhibitor |
|
117
|
314
|
3itmA |
Catalytic domain of hpde2a |
|
134
|
338
|
3ituA |
Hpde2a catalytic domain complexed with ibmx |
|
130
|
325
|
3iakA |
Crystal structure of human phosphodiesterase 4d (pde4d) with papaverine. |
|
211
|
678
|
3ibjA |
X-ray structure of pde2a |
|
131
|
335
|
3i8vA |
Crystal structure of human pde4a with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone |
|
138
|
358
|
3iadA |
Crystal structure of human phosphodiesterase 4d with bound allosteric modulator |
|
128
|
305
|
3hqyA |
Discovery of novel inhibitors of pde10a |
|
139
|
360
|
3hmvA |
Catalytic domain of human phosphodiesterase 4b2b in complex with a tetrahydrobenzothiophene inhibitor |
|
128
|
305
|
3hqzA |
Discovery of novel inhibitors of pde10a |
|
130
|
303
|
3hqwA |
Discovery of novel inhibitors of pde10a |
|
128
|
305
|
3hr1A |
Discovery of novel inhibitors of pde10a |
|
129
|
323
|
3hdzA |
Identification, synthesis, and sar of amino substituted pyrido[3,2b]pryaziones as potent and selective pde5 inhibitors |
|
131
|
324
|
3hc8A |
Investigation of aminopyridiopyrazinones as pde5 inhibitors: evaluation of modifications to the central ring system. |
|
139
|
336
|
3gwtA |
Catalytic domain of human phosphodiesterase 4b2b in complex with a quinoline inhibitor |
|
150
|
407
|
3g45A |
Crystal structure of human phosphodiesterase 4b with regulatory domain and d155988 |
|
139
|
329
|
3g4lA |
Crystal structure of human phosphodiesterase 4d with roflumilast |
|
139
|
335
|
3g58A |
Crystal structure of human phosphodiesterase 4d with d155988/pmnpq |
|
133
|
318
|
3g3nA |
Pde7a catalytic domain in complex with 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3h)-one |
