|
154
|
554
|
5vqrA |
Crystal structure of hiv-1 reverse transcriptase in complex with n-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-n-methylacrylamide (jlj684), a non-nucleoside inhibitor |
|
152
|
554
|
5vqyA |
Crystal structure of hiv-1 reverse transcriptase (k103n, y181c) variant in complex with n-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-n-methylacrylamide (jlj684), a non-nucleoside inhibitor |
|
111
|
424
|
5vqvB |
Crystal structure of hiv-1 reverse transcriptase (y181c) variant in complex with n-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-n-methylacrylamide (jlj684), a non-nucleoside inhibitor |
|
113
|
424
|
5vqxB |
Crystal structure of hiv-1 reverse transcriptase (y181c) variant in complex with 2-chloro-n-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-n-methylacetamide (jlj686), a non-nucleoside inhibitor |
|
109
|
424
|
5vqrB |
Crystal structure of hiv-1 reverse transcriptase in complex with n-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-n-methylacrylamide (jlj684), a non-nucleoside inhibitor |
|
154
|
554
|
5vqxA |
Crystal structure of hiv-1 reverse transcriptase (y181c) variant in complex with 2-chloro-n-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-n-methylacetamide (jlj686), a non-nucleoside inhibitor |
|
113
|
424
|
5vqzB |
Crystal structure of hiv-1 reverse transcriptase (k103n, y181c) variant in complex with 2-chloro-n-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-n-methylacetamide (jlj686), a non-nucleoside inhibitor |
|
113
|
424
|
5vquB |
Crystal structure of hiv-1 reverse transcriptase (y181c) variant in complex with n-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)-2-fluoro-n-methylacetamide (jlj683), a non-nucleoside inhibitor |
|
108
|
424
|
5vqwB |
Crystal structure of hiv-1 reverse transcriptase (y181c) variant in complex with n-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acrylamide (jlj685), a non-nucleoside inhibitor |
|
158
|
553
|
5vqsA |
Crystal structure of hiv-1 reverse transcriptase in complex with n-(6-cyano-3-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-4-methylnaphthalen-1-yl)acrylamide (jlj685), a non-nucleoside inhibitor |
|
111
|
424
|
5tw3B |
Crystal structure of hiv-1 reverse transcriptase in complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)-4-fluorophenoxy)-7-fluoro-2-naphthonitrile (jlj636), a non-nucleoside inhibitor |
|
144
|
550
|
5tw3A |
Crystal structure of hiv-1 reverse transcriptase in complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)-4-fluorophenoxy)-7-fluoro-2-naphthonitrile (jlj636), a non-nucleoside inhibitor |
|
146
|
555
|
5tuqA |
Crystal structure of a 6-cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione inhibitor in complex with hiv reverse transcriptase |
|
100
|
424
|
5terB |
Crystal structure of hiv-1 reverse transcriptase in complex with 5-chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile (jlj651), a non-nucleoside inhibitor |
|
142
|
554
|
5terA |
Crystal structure of hiv-1 reverse transcriptase in complex with 5-chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile (jlj651), a non-nucleoside inhibitor |
|
109
|
424
|
5tuqB |
Crystal structure of a 6-cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione inhibitor in complex with hiv reverse transcriptase |
|
136
|
550
|
5tepA |
Crystal structure of hiv-1 reverse transcriptase in complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-2-naphthonitrile (jlj649), a non-nucleoside inhibitor |
|
102
|
424
|
5tepB |
Crystal structure of hiv-1 reverse transcriptase in complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-2-naphthonitrile (jlj649), a non-nucleoside inhibitor |
|
103
|
428
|
5ovnB |
Crystal strucure of fiv reverse transcriptase |
|
113
|
532
|
5ovnA |
Crystal strucure of fiv reverse transcriptase |
|
151
|
537
|
5c24A |
Crystal structure of hiv-1 reverse transcriptase in complex with 7-((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-6,8-dimethylindolizine-2-carbonitrile (jlj605), a non-nucleoside inhibitor |
|
156
|
543
|
5k14A |
Hiv-1 reverse transcriptase in complex with a 2,6-difluorophenyl dapy analog |
|
111
|
424
|
5k14B |
Hiv-1 reverse transcriptase in complex with a 2,6-difluorophenyl dapy analog |
|
161
|
554
|
5hbmA |
Crystal structure of a dihydroxycoumarin rnase h active-site inhibitor in complex with hiv-1 reverse transcriptase |
|
106
|
422
|
5fdlB |
Crystal structure of k103n/y181c mutant hiv-1 reverse transcriptase (rt) in complex with idx899 |
|
144
|
554
|
5fdlA |
Crystal structure of k103n/y181c mutant hiv-1 reverse transcriptase (rt) in complex with idx899 |
|
117
|
424
|
5cyqB |
Hiv-1 reverse transcriptase complexed with 4-bromopyrazole |
|
111
|
424
|
5cymB |
Hiv-1 reverse transcriptase complexed with 4-iodopyrazole |
|
154
|
548
|
5cyqA |
Hiv-1 reverse transcriptase complexed with 4-bromopyrazole |
|
151
|
556
|
5cymA |
Hiv-1 reverse transcriptase complexed with 4-iodopyrazole |
|
106
|
425
|
4we1B |
Crystal structure of hiv-1 reverse transcriptase in complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-2-naphthonitrile (jlj600) |
|
140
|
547
|
4we1A |
Crystal structure of hiv-1 reverse transcriptase in complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)-2-naphthonitrile (jlj600) |
|
138
|
554
|
4rw9A |
Crystal structure of hiv-1 reverse transcriptase (y181c) variant in complex with (e)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (jlj532), a non-nucleoside inhibitor |
|
102
|
424
|
4rw7B |
Crystal structure of hiv-1 reverse transcriptase (k103n, y181c) variant in complex with (e)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (jlj532), a non-nucleoside inhibitor |
|
110
|
424
|
4rw4B |
Crystal structure of hiv-1 reverse transcriptase (k103n,y181c) variant in complex with (e)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (jlj494), a non-nucleoside inhibitor |
|
138
|
554
|
4rw7A |
Crystal structure of hiv-1 reverse transcriptase (k103n, y181c) variant in complex with (e)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (jlj532), a non-nucleoside inhibitor |
|
146
|
554
|
4rw6A |
Crystal structure of hiv-1 reverse transcriptase (y181c) variant in complex with (e)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (jlj494), a non-nucleoside inhibitor |
|
136
|
548
|
4rw8A |
Crystal structure of hiv-1 reverse transcriptase in complex with (e)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (jlj532), a non-nucleoside inhibitor' |
|
145
|
554
|
4rw4A |
Crystal structure of hiv-1 reverse transcriptase (k103n,y181c) variant in complex with (e)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (jlj494), a non-nucleoside inhibitor |
|
109
|
424
|
4rw9B |
Crystal structure of hiv-1 reverse transcriptase (y181c) variant in complex with (e)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (jlj532), a non-nucleoside inhibitor |
|
111
|
424
|
4rw6B |
Crystal structure of hiv-1 reverse transcriptase (y181c) variant in complex with (e)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (jlj494), a non-nucleoside inhibitor |
|
110
|
427
|
4rw8B |
Crystal structure of hiv-1 reverse transcriptase in complex with (e)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (jlj532), a non-nucleoside inhibitor' |
|
100
|
428
|
4o4gB |
Crystal structure of hiv-1 reverse transcriptase in complex with 4-((4-(mesitylamino)-1,3,5-triazin-2-yl)amino)benzonitrile (jlj527), a non-nucleoside inhibitor |
|
165
|
556
|
4ncgA |
Discovery of doravirine, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant hiv viruses |
|
134
|
554
|
4o4gA |
Crystal structure of hiv-1 reverse transcriptase in complex with 4-((4-(mesitylamino)-1,3,5-triazin-2-yl)amino)benzonitrile (jlj527), a non-nucleoside inhibitor |
|
140
|
552
|
4o44A |
Crystal structure of hiv-1 reverse transcriptase in complex with 4-((4-(mesitylamino)-6-(3-morpholinopropoxy)-1,3,5-triazin-2-yl)amino)benzonitrile (jlj529), a non-nucleoside inhibitor |
|
108
|
425
|
4ncgB |
Discovery of doravirine, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant hiv viruses |
|
99
|
427
|
4o44B |
Crystal structure of hiv-1 reverse transcriptase in complex with 4-((4-(mesitylamino)-6-(3-morpholinopropoxy)-1,3,5-triazin-2-yl)amino)benzonitrile (jlj529), a non-nucleoside inhibitor |
|
101
|
425
|
4mfbB |
Crystal structure of hiv-1 reverse transcriptase in complex with 8-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)indolizine-2-carbonitrile (jlj555), a non-nucleoside inhibitor |
|
101
|
428
|
4lsnB |
Crystal structure of hiv-1 reverse transcriptase in complex with (e)-3-(3-bromo-5-(4-chloro-2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (jlj518), a non-nucleoside inhibitor |
