|
94
|
388
|
3ixkA |
Potent beta-secretase 1 inhibitor |
|
93
|
388
|
3ixjA |
Crystal structure of beta-secretase 1 in complex with selective beta-secretase 1 inhibitor |
|
100
|
388
|
3ineA |
Bace1 with the aminohydantoin compound s-34 |
|
100
|
388
|
3igbA |
Bace-1 with compound 3 |
|
91
|
390
|
3hvgA |
Structure of bace (beta secretase) in complex with ev0 |
|
97
|
389
|
3hw1A |
Structure of bace (beta secretase) in complex with ligand ev2 |
|
91
|
388
|
3i25A |
Potent beta-secretase 1 hydroxyethylene inhibitor |
|
97
|
388
|
3h0bA |
Discovery of aminoheterocycles as a novel beta-secretase inhibitor class |
|
95
|
387
|
3fktA |
Crystal structure of human beta secretase complexed with spiropiperdine iminohydantoin inhibitor |
|
96
|
389
|
3exoA |
Crystal structure of bace1 bound to inhibitor |
|
98
|
388
|
3dv5A |
Crystal structure of human beta-secretase in complex with nvp-bav544 |
|
96
|
388
|
3duyA |
Crystal structure of human beta-secretase in complex with nvp-afj144 |
|
95
|
388
|
3dv1A |
Crystal structure of human beta-secretase in complex with nvp-arv999 |
|
92
|
388
|
3dm6A |
Beta-secretase 1 complexed with statine-based inhibitor |
|
104
|
390
|
3cibA |
Structure of bace bound to sch727596 |
|
84
|
392
|
3ckrA |
Crystal structure of bace-1 in complex with inhibitor |
|
104
|
390
|
3cicA |
Structure of bace bound to sch709583 |
|
93
|
392
|
3ckpA |
Crystal structure of bace-1 in complex with inhibitor |
|
103
|
390
|
3cidA |
Structure of bace bound to sch726222 |
|
91
|
388
|
3bugA |
Bace-1 complexed with compound 3 |
|
98
|
391
|
3buhA |
Bace-1 complexed with compound 4 |
|
93
|
391
|
3braA |
Bace-1 complexed with compound 1 |
|
95
|
391
|
3bufA |
Bace-1 complexed with compound 2 |
|
90
|
389
|
2zjhA |
Crystal structure of the human bace1 catalytic domain in complex with n-(1-benzyl-piperidin-4-yl)-4-mercapto-butyramide |
|
93
|
387
|
2zhtA |
Crystal structure of bace1 at ph 4.5 |
|
95
|
387
|
2zhvA |
Crystal structure of bace1 at ph 7.0 |
|
98
|
389
|
2zjmA |
Crystal structure of the human bace1 catalytic domain in complex with n-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide |
|
88
|
387
|
2zhsA |
Crystal structure of bace1 at ph 4.0 |
|
90
|
389
|
2zjnA |
Crystal structure of the human bace1 catalytic domain in complex with n-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)-piperidin-4-yl]-2-(2-methyl-4-sulfamoyl-phenoxy)-acetamide |
|
105
|
390
|
2zhrA |
Crystal structure of bace1 in complex with om99-2 at ph 5.0 |
|
92
|
390
|
2zjiA |
Crystal structure of the human bace1 catalytic domain in complex with n-[1-(2,6-dimethoxy-benzyl)-piperidin-4-yl]-4-mercapto-butyramide |
|
82
|
390
|
2zjkA |
Crystal structure of the human bace1 catalytic domain in complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid(3-mercapto-propyl)-amide |
|
85
|
389
|
2zjlA |
Crystal structure of the human bace1 catalytic domain in complex with n-[1-(5-bromo-2,3-dimethoxy-benzyl)-piperidin-4-yl]-4-mercapto-butyramide |
|
89
|
389
|
2zjjA |
Crystal structure of the human bace1 catalytic domain in complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid (2-mercapto-ethyl)-amide |
|
99
|
387
|
2zdzA |
X-ray structure of bace-1 in complex with compound 3.b.10 |
|
93
|
387
|
2zhuA |
Crystal structure of bace1 at ph 5.0 |
|
87
|
386
|
2ze1A |
X-ray structure of bace-1 in complex with compound 6g |
|
101
|
385
|
2xfiA |
Human bace-1 in complex with n-((1s,2r)-3-(((1s)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-((methylsulfonyl)(phenyl)amino)benzamide |
|
103
|
385
|
2xfkA |
Human bace-1 in complex with n-((1s,2r)-3-(((1s)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-(ethylamino)-5-((methylsulfonyl)(phenyl)amino)benzamide |
|
103
|
385
|
2xfjA |
Human bace-1 in complex with n-((1s,2r)-3-(((1s)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1-pyrrolidinyl)benzamide |
|
102
|
385
|
2wf0A |
Human bace-1 in complex with 4-ethyl-n-((1s,2r)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)-8-(2-oxo-1-pyrrolidinyl)-6-quinolinecarboxamide |
|
100
|
385
|
2wf1A |
Human bace-1 in complex with 7-ethyl-n-((1s,2r)-2-hydroxy-3-(((3-(methyloxy)phenyl(methyl)amino)-1-(phenylmethyl)propyl)-1-methyl-3,4- dihydro-1h-(1,2,5)thiadiazepino(3,4,5-hi)indole-9-carboxamide 2,2- dioxide |
|
95
|
389
|
2wjoA |
Human bace (beta secretase) in complex with cyclohexanecarboxylic acid (2-(2-am ino-6-phenoxy-4h-quinazolin-3-yl)-2 -cyclohexyl-ethyl)- amide |
|
102
|
385
|
2wf3A |
Human bace-1 in complex with 6-(ethylamino)-n-((1s,2r)-2-hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl)propyl)-1-methyl-1, 3,4,5-tetrahydro-2,1-benzothiazepine-8-carboxamide 2,2-dioxide |
|
104
|
385
|
2wf2A |
Human bace-1 in complex with 8-ethyl-n-((1s,2r)-2-hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl)propyl)-1-methyl-3,4,7, 8-tetrahydro-1h,6h-(1,2,5)thiadiazepino(5,4,3-de)quinoxaline-10- carboxamide 2,2-dioxide |
|
97
|
385
|
2wf4A |
Human bace-1 in complex with 6-ethyl-1-methyl-n-((1s)-2-oxo-1-(phenylmethyl)-3-(tetrahydro-2h-pyran-4-ylamino)propyl)-1,3,4,6- tetrahydro(1,2)thiazepino(5,4,3-cd)indole-8-carboxamide 2,2-dioxide |
|
103
|
385
|
2wezA |
Human bace-1 in complex with 1-ethyl-n-((1s,2r)-2-hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl)propyl)-4-(2-oxo-1- pyrrolidinyl)-1h-indole-6-carboxamide |
|
104
|
389
|
2vkmA |
Crystal structure of grl-8234 bound to bace (beta-secretase) |
|
101
|
385
|
2vnnA |
Human bace-1 in complex with 7-ethyl-n-((1s,2r)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)-1- methyl-3,4-dihydro-1h-(1,2,5)thiadiazepino(3,4,5-hi)indole-9- carboxamide 2,2-dioxide |
|
104
|
385
|
2vieA |
Human bace-1 in complex with n-((1s,2r)-1-benzyl-2-hydroxy-3-((1,1,5- trimethylhexyl)amino)propyl)-3-(ethylamino)-5-(2-oxopyrrolidin-1-yl) benzamide |
