|
63
|
230
|
3dgaA |
Wild-type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with rjf01302, nadph, and dump |
|
56
|
186
|
3d84X |
Structural analysis of a holo enzyme complex of mouse dihydrofolate reductase with nadph and a ternary complex with the potent and selective inhibitor 2.4-diamino-6-(-2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine |
|
47
|
159
|
3dauA |
Crystal structure of the ternary mtx nadph complex of escherichia coli dihydrofolate reductase |
|
35
|
161
|
3datA |
Crystal structure of the ternary mtx nadph complex of bacillus anthracis dihydrofolate reductase |
|
51
|
186
|
3d80A |
Structural analysis of a holo enzyme complex of mouse dihydrofolate reductase with nadph and a ternary complex wtih the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine |
|
153
|
515
|
3clbA |
Structure of bifunctional tcdhfr-ts in complex with tmq |
|
140
|
513
|
3cl9A |
Structure of bifunctional tcdhfr-ts in complex with mtx |
|
61
|
225
|
3cseA |
Candida glabrata dihydrofolate reductase complexed with nadph and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (ucp120b) |
|
54
|
206
|
3cd2A |
Ligand induced conformational changes in the crystal structures of pneumocystis carinii dihydrofolate reductase complexes with folate and nadp+ |
|
45
|
161
|
2zzaA |
Moritella profunda dihydrofolate reductase complex with nadp+ and folate |
|
47
|
157
|
2w9hA |
Wild-type staphylococcus aureus dhfr in complex with trimethoprim |
|
39
|
157
|
2w9sA |
Staphylococcus aureus s1:dhfr in complex with trimethoprim |
|
48
|
186
|
2w3mA |
Human dihydrofolate reductase complexed with nadph and folate |
|
42
|
159
|
2w9tA |
Staphylococcus aureus s1:dhfr |
|
48
|
186
|
2w3aA |
Human dihydrofolate reductase complexed with nadph and trimethoprim |
|
42
|
157
|
2w9gA |
Wild-type staphylococcus aureus dhfr in complex with nadph and trimethoprim |
|
49
|
185
|
2w3bA |
Human dihydrofolate reductase complexed with nadph and a lipophilic antifolate selective for mycobacterium avium dhfr, 6-((2,5- diethoxyphenyl)aminomethyl)-2,4-diamino-5-methylpyrido(2,3-d) pyrimidine (sri-8686) |
|
48
|
164
|
2w3wA |
Mycobacterium avium dihydrofolate reductase complexed with nadph and a lipophilic antifolate selective for m. avium dhfr, 6-((2,5- diethoxyphenyl)aminomethyl)-2,4-diamino-5-methylpyrido(2,3-d) pyrimidine (sri-8686) |
|
47
|
165
|
2w3vA |
Mycobacterium avium dihydrofolate reductase complexed with nadph and trimethoprim |
|
38
|
162
|
2qk8A |
Crystal structure of the anthrax drug target, bacillus anthracis dihydrofolate reductase |
|
31
|
162
|
2kgkA |
Solution structure of bacillus anthracis dihydrofolate reductase |
|
34
|
162
|
2jybA |
Binary hvdhfr1:folate complex |
|
32
|
162
|
2ithA |
Nmr structure of haloferax volcanii dhfr |
|
33
|
159
|
2inqA |
Neutron crystal structure of escherichia coli dihydrofolate reductase bound to the anti-cancer drug, methotrexate |
|
160
|
514
|
2h2qA |
Crystal structure of trypanosoma cruzi dihydrofolate reductase-thymidylate synthase |
|
58
|
206
|
2fziA |
New insights into dhfr interactions: analysis of pneumocystis carinii and mouse dhfr complexes with nadph and two highly potent trimethoprim derivatives |
|
52
|
186
|
2fzjA |
New insights into dhfr interactions: analysis of pneumocystis carinii and mouse dhfr complexes with nadph and two highly potent trimethoprim derivatives |
|
56
|
206
|
2fzhA |
New insights into dihydrofolate reductase interactions: analysis of pneumocystis carinii and mouse dhfr complexes with nadph and two highly potent trimethoprim derivatives |
|
45
|
159
|
2drcA |
Investigation of the functional role of tryptophan-22 in escherichia coli dihydrofolate reductase by site-directed mutagenesis |
|
51
|
182
|
2dhfA |
Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazofolate |
|
41
|
159
|
2d0kA |
Methionine-free mutant of escherichia coli dihydrofolate reductase |
|
54
|
186
|
2c2tA |
Human dihydrofolate reductase complexed with nadph and 2,4-diamino-5-((7,8-dicarbaundecaboran-7-yl)methyl)-6-methylpyrimidine, a novel boron containing, nonclassical antifolate |
|
42
|
159
|
2cigA |
Dihydrofolate reductase from mycobacterium tuberculosis inhibited by the acyclic 4r isomer of inh-nadp a derivative of the prodrug isoniazid. |
|
57
|
206
|
2cd2A |
Ligand induced conformational changes in the crystal structures of pneumocystis carinii dihydrofolate reductase complexes with folate and nadp+ |
|
53
|
186
|
2c2sA |
Human dihydrofolate reductase complexed with nadph and 2,4-diamino-5-(1-o-carboranylmethyl)-6-methylpyrimidine, a novel boron containing, nonclassical antifolate |
|
58
|
237
|
2blaA |
Sp21 double mutant p. vivax dihydrofolate reductase in complex with pyrimethamine |
|
56
|
237
|
2blcA |
Sp21 double mutant p. vivax dihydrofolate reductase in complex with des-chloropyrimethamine |
|
62
|
237
|
2blbA |
X-ray crystal structure of plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative |
|
66
|
237
|
2bl9A |
X-ray crystal structure of plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative |
|
43
|
159
|
2anoA |
Crystal structure of e.coli dihydrofolate reductase in complex with nadph and the inhibitor ms-sh08-17 |
|
44
|
159
|
2anqA |
Crystal structure of e.coli dhfr in complex with nadph and the inhibitor compound 10a. |
|
45
|
161
|
1zdrA |
Dhfr from bacillus stearothermophilus |
|
35
|
186
|
1yhoA |
Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures |
|
54
|
205
|
1vj3A |
Structural studies on bio-active compounds. crystal structure and molecular modeling studies on the pneumocystis carinii dihydrofolate reductase cofactor complex with tab, a highly selective antifolate. |
|
36
|
157
|
1vdrA |
Dihydrofolate reductase |
|
48
|
186
|
1u70A |
Understanding the role of leu22 variants in methotrexate resistance: comparison of wild-type and leu22arg variant mouse and human dihydrofolate reductase |
|
52
|
186
|
1u71A |
Understanding the role of leu22 variants in methotrexate resistance: comparison of wild-type and leu22arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and nadph |
|
48
|
186
|
1u72A |
Understanding the role of leu22 variants in methotrexate resistance: comparison of wild-type and leu22arg variant mouse and human dihydrfolate reductase ternary crystal complexes with methotrexate and nadph |
|
41
|
159
|
1tdrA |
Expression, characterization, and crystallographic analysis of telluromethionyl dihydrofolate reductase |
|
163
|
519
|
1sejA |
Crystal structure of dihydrofolate reductase-thymidylate synthase from cryptosporidium hominis bound to 1843u89/nadph/dump |
