|
92
|
324
|
5casA |
Egfr kinase domain mutant "tmlr" with compound 41a |
|
94
|
290
|
5cf6A |
Crystal structure of janus kinase 2 in complex with n,n-dicyclopropyl-10-[(2s)-2,3-dihydroxypropyl]-3-methyl-7-(methylamino)-3,5,8,10-tetraazatricyclo [7.3.0.02,6]dodeca-1(9),2(6),4,7,11-pentaene-11-carboxamide |
|
87
|
324
|
5canA |
Egfr kinase domain mutant "tmlr" with compound 27 |
|
93
|
275
|
5cxzA |
Syk catalytic domain complexed with naphthyridine inhibitor |
|
85
|
282
|
5ceoA |
Dlk in complex with inhibitor 2-((6-(3,3-difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile |
|
90
|
324
|
5c8nA |
Egfr kinase domain mutant "tmlr" with compound 23 |
|
83
|
323
|
5caoA |
Egfr kinase domain mutant "tmlr" with compound 29 |
|
98
|
292
|
5cf5A |
Crystal structure of janus kinase 2 in complex with n,n-dicyclopropyl-7-[(dimethyl-1,3-thiazol-2-yl)amino]-10-ethyl-3-methyl-3,5,8,10-tetraazatricyclo[7.3.0.02,6] dodeca-1(9),2(6),4,7,11-pentaene-11-carboxamide |
|
91
|
323
|
5cauA |
Egfr kinase domain mutant "tmlr" with compound 41b |
|
94
|
309
|
5fdpA |
Structure of ddr1 receptor tyrosine kinase in complex with d2099 inhibitor at 2.25 angstroms resolution. |
|
93
|
289
|
5cf4A |
Crystal structure of janus kinase 2 in complex with n,n-dicyclopropyl-10-ethyl-7-[(3-methoxypropyl)amino] -3-methyl-3,5,8,10-tetraazatricyclo[7.3.0.0,6] dodeca-1(9),2(6),4,7,11-pentaene-11-carboxamide |
|
94
|
322
|
5caqA |
Egfr kinase domain mutant "tmlr" with compound 33 |
|
91
|
323
|
5capA |
Egfr kinase domain mutant "tmlr" with compound 30 |
|
88
|
324
|
5cavA |
Egfr kinase domain with compound 41a |
|
95
|
322
|
5c8kA |
Egfr kinase domain mutant "tmlr" with compound 1 |
|
91
|
308
|
5bvnA |
Fragment-based discovery of potent and selective ddr1/2 inhibitors |
|
92
|
308
|
5bvoA |
Fragment-based discovery of potent and selective ddr1/2 inhibitors |
|
93
|
274
|
5c26A |
Crystal structure of syk in complex with compound 1 |
|
89
|
271
|
5bq0A |
Crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with bms-824171 aka 6-[(3r)-3-(4-tert-bu tylbenzamido)piperidin-1-yl]-2-{[4-(morpholine-4-carbonyl) phenyl]amino}pyridine-3-carboxamide |
|
89
|
263
|
5bpyA |
Crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with bms-824171 aka 6-[(3r)-3-(4-tert-bu tylbenzamido)piperidin-1-yl]-2-{[4-(morpholine-4-carbonyl) phenyl]amino}pyridine-3-carboxamide |
|
90
|
300
|
5b7vA |
Human fgfr1 kinase in complex with ch5183284 |
|
99
|
292
|
5aepA |
Novel pyrrole carboxamide inhibitors of jak2 as potential treatment of myeloproliferative disorders |
|
97
|
309
|
5aa8A |
Structure of c1156y,l1198f mutant human anaplastic lymphoma kinase in complex with pf-06463922 ((10r)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile). |
|
98
|
309
|
5aacA |
Structure of c1156y mutant human anaplastic lymphoma kinase in complex with crizotinib |
|
100
|
309
|
5aa9A |
Structure of l1198f mutant human anaplastic lymphoma kinase in complex with pf-06463922 ((10r)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile). |
|
97
|
309
|
5aabA |
Structure of c1156y,l1198f mutant human anaplastic lymphoma kinase in complex with crizotinib |
|
98
|
309
|
5a9uA |
Structure of c1156y mutant human anaplastic lymphoma kinase in complex with pf-06463922 ((10r)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile). |
|
98
|
308
|
5aaaA |
Structure of l1198f mutant human anaplastic lymphoma kinase in complex with crizotinib |
|
86
|
302
|
5a46A |
Fgfr1 in complex with dovitinib |
|
88
|
302
|
5a4cA |
Fgfr1 ligand complex |
|
86
|
290
|
4hvgA |
Jak3 kinase domain in complex with 2-cyclopropyl-5h-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((s)-2-hydroxy-1,2-dimethyl-propyl)-amide |
|
94
|
301
|
4zsaA |
Crystal structure of fgfr1 kinase domain in complex with 7n |
|
90
|
270
|
4zlzA |
Crystal structure of bruton's tyrosine kinase in complex with a substituted cinnoline |
|
89
|
270
|
4zlyA |
Crystal structure of bruton's tyrosine kinase bound to a cinnoline fragment |
|
86
|
283
|
4zjvA |
Crystal structure of egfr kinase domain in complex with mitogen-inducible gene 6 protein |
|
98
|
298
|
4ztmA |
Irak4-inhibitor co-structure |
|
81
|
320
|
4zauA |
Azd9291 complex with wild type egfr |
|
99
|
289
|
4ytfA |
Discovery of vx-509 (decernotinib): a potent and selective janus kinase (jak) 3 inhibitor for the treatment of autoimmune diseases |
|
98
|
289
|
4ytcA |
Discovery of vx-509 (decernotinib): a potent and selective janus kinase (jak) 3 inhibitor for the treatment of autoimmune disease |
|
102
|
307
|
4z55A |
Anaplastic lymphoma kinase catalytic domain complexed with pyrazolopyrimidine derivative of ldk378 |
|
85
|
290
|
4z16A |
Crystal structure of the jak3 kinase domain covalently bound to n-(3-(((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)methyl)phenyl)acrylamide |
|
93
|
271
|
4z3vA |
Fragment-based discovery of a small molecule reversible inhibitor of bruton's tyrosine kinase |
|
89
|
291
|
4ymjA |
(r)-2-phenylpyrrolidine substitute imidazopyridazines: a new class of potent and selective pan-trk inhibitors |
|
96
|
265
|
4rx5A |
Bruton's tyrosine kinase (btk) with pyridazinone compound 23 |
|
71
|
274
|
4pp7A |
Highly potent and selective 3-n-methylquinazoline-4(3h)-one based inhibitors of b-rafv600e kinase |
|
82
|
287
|
4hviA |
Jak3 kinase domain in complex with 2-cyclopropyl-5h-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((r)-1-methyl-2-oxo-2-piperidin-1-yl-ethyl)-amide |
|
88
|
299
|
4f63A |
Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with compound 1 |
|
91
|
290
|
4f08A |
Discovery and optimization of c-2 methyl imidazo-pyrrolopyridines as potent and orally bioavailable jak1 inhibitors with selectivity over jak2 |
|
84
|
273
|
4f4pA |
Syk in complex with ligand lasw836 |
|
75
|
276
|
4f1oA |
Crystal structure of the l1180t mutant roco4 kinase domain from d. discoideum bound to appcp |
