|
48
|
159
|
1rx9A |
Dihydrofolate reductase (e.c.1.5.1.3) complexed with nicotinamide adenine dinucleotide phosphate (oxidized form) |
|
49
|
186
|
1s3vA |
Structure determination of tetrahydroquinazoline antifolates in complex with human and pneumocystis carinii dihydrofolate reductase: correlations of enzyme selectivity and stereochemistry |
|
42
|
159
|
1ra3A |
Dihydrofolate reductase complexed with methotrexate and nicotinamide adenine dinucleotide phosphate (oxidized form) |
|
42
|
159
|
1rh3A |
Dihydrofolate reductase complexed with methotrexate and nicotinamide adenine dinucleotide phosphate (reduced form) |
|
40
|
159
|
1rc4A |
Dihydrofolate reductase complexed with 5,10-dideazatetrahydrofolate and nicotinamide adenine dinucleotide phosphate (oxidized form) |
|
42
|
159
|
1ra2A |
Dihydrofolate reductase complexed with folate and nicotinamide adenine dinucleotide phosphate (oxidized form) |
|
42
|
159
|
1ra1A |
Dihydrofolate reductase complexed with nicotinamide adenine dinucleotide phosphate (reduced form) |
|
45
|
159
|
1rg7A |
Dihydrofolate reductase complexed with methotrexate |
|
43
|
159
|
1rb2A |
Dihydrofolate reductase complexed with folate and nicotinamide adenine dinucleotide phosphate (oxidized form) |
|
43
|
159
|
1re7A |
Dihydrofolate reductase complexed with folate |
|
166
|
519
|
1qzfA |
Crystal structure of dhfr-ts from cryptosporidium hominis |
|
40
|
159
|
1ra8A |
Dihydrofolate reductase complexed with folate and 2-monophosphoadenosine 5'-diphosphoribose |
|
45
|
159
|
1rd7A |
Dihydrofolate reductase complexed with folate |
|
46
|
159
|
1rf7A |
Structure of dihydrofolate reductase complexed with dihydrofolate |
|
41
|
159
|
1rb3A |
Dihydrofolate reductase complexed with methotrexate and nicotinamide adenine dinucleotide phosphate (oxidized form) |
|
42
|
159
|
1ra9A |
Dihydrofolate reductase complexed with nicotinamide adenine dinucleotide phosphate (oxidized form) |
|
50
|
186
|
1pdbA |
Analysis of three crystal structure determinations of a 5-methyl-6-n-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase |
|
53
|
186
|
1pd9A |
Analysis of three crystal structure determinations of a 5-methyl-6-n-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase |
|
50
|
186
|
1pd8A |
Analysis of three crystal structure determinations of a 5-methyl-6-n-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase |
|
43
|
186
|
1ohkA |
Human dihydrofolate reductase, orthorhombic (p21 21 21) crystal form |
|
41
|
186
|
1ohjA |
Human dihydrofolate reductase, monoclinic (p21) crystal form |
|
48
|
186
|
1mvsA |
Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine n9-c10 reverse-bridge antifolate binary complex with human dihydrofolate reductase |
|
47
|
186
|
1mvtA |
Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine n9-c10 reverse-bridge antifolate binary complex with human dihydrofolate reductase |
|
50
|
205
|
1ly4A |
Analysis of quinazoline and pyrido[2,3d]pyrimidine n9-c10 reversed bridge antifolates in complex with nadp+ and pneumocystis carinii dihydrofolate reductase |
|
34
|
162
|
1ludA |
Solution structure of dihydrofolate reductase complexed with trimethoprim and nadph, 24 structures |
|
59
|
192
|
1m79A |
Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (nadph) and 5-(4-methoxyphenoxy)-2,4-quinazolinediamine (gw1466) |
|
57
|
192
|
1m7aA |
Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (nadph) and 7-[2-methoxy-1-(methoxymethyl)ethyl]-7h-pyrrolo[3,2-f] quinazoline-1,3-diamine (gw557) |
|
56
|
206
|
1ly3A |
Analysis of quinazoline and pyridopyrimidine n9-c10 reversed bridge antifolates in complex with nadp+ and pneumocystis carinii dihydrofolate reductase |
|
58
|
192
|
1m78A |
Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (nadph) and 5-chloryl-2,4,6-quinazolinetriamine (gw1225) |
|
55
|
184
|
1kmsA |
Human dihydrofolate reductase complexed with nadph and 6-([5-quinolylamino]methyl)-2,4-diamino-5-methylpyrido[2,3-d]pyrimidine (sri-9439), a lipophilic antifolate |
|
50
|
185
|
1kmvA |
Human dihydrofolate reductase complexed with nadph and (z)-6-(2-[2,5-dimethoxyphenyl]ethen-1-yl)-2,4-diamino-5-methylpyrido[2,3-d]pyrimidine (sri-9662), a lipophilic antifolate |
|
52
|
203
|
1klkA |
Crystal structure of pneumocystis carinii dihydrofolate reductase ternary complex with pt653 and nadph |
|
50
|
193
|
1juvA |
Crystal structure analysis of dihydrofolate reductase from bacteriophage t4 |
|
47
|
159
|
1jomA |
The crystal structure of the binary complex between folinic acid (leucovorin) and e. coli dihydrofolate reductase |
|
60
|
192
|
1ia3A |
Candida albicans dihydrofolate reductase complex in which the dihydronicotinamide moiety of dihydro-nicotinamide-adenine-dinucleotide phosphate (nadph) is displaced by 5-[(4-tert-butylphenyl)sulfanyl]-2,4-quinazolinediamine (gw995) |
|
60
|
192
|
1ia4A |
Candida albicans dihydrofolate reductase complex in which the dihydronicotinamide moiety of dihydro-nicotinamide-adenine-dinucleotide phosphate (nadph) is displaced by 5-{[4-(4-morpholinyl)phenyl]sulfanyl}-2,4-quinazolinediamin (gw2021) |
|
57
|
192
|
1ia1A |
Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (nadph) and 5-(phenylsulfanyl)-2,4-quinazolinediamine (gw997) |
|
57
|
192
|
1ia2A |
Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (nadph) and 5-[(4-methylphenyl)sulfanyl]-2,4-quinazolinediamine (gw578) |
|
48
|
186
|
1hfrA |
Comparison of ternary crystal complexes of human dihydrofolate reductase with nadph and a classical antitumor furopyrimdine |
|
51
|
186
|
1hfqA |
Comparison of ternary crystal complexes of human dihydrofolate reductase with nadph and a classical antitumor furopyrimdine |
|
48
|
186
|
1hfpA |
Comparison of ternary crystal complexes of human dihydrofolate reductase with nadph and a classical antitumor furopyrimdine |
|
45
|
159
|
1jolA |
The crystal structure of the binary complex between folinic acid (leucovorin) and e. coli dihydrofolate reductase |
|
44
|
159
|
1draA |
Crystal structure of unliganded escherichia coli dihydrofolate reductase. ligand-induced conformational changes and cooperativity in binding |
|
57
|
205
|
1e26A |
Design, synthesis and x-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent. |
|
40
|
159
|
1drhA |
Isomorphous crystal structures of escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate and 5,10-dideazatetrahydrofolate: mechanistic implications |
|
43
|
159
|
1dyjA |
Isomorphous crystal structures of escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate and 5,10-dideazatetrahydrofolate: mechanistic implications |
|
52
|
186
|
1dr6A |
Crystal structures of organomercurial-activated chicken liver dihydrofolate reductase complexes |
|
49
|
186
|
1dr1A |
2.2 angstroms crystal structure of chicken liver dihydrofolate reductase complexed with nadp+ and biopterin |
|
47
|
186
|
1dr5A |
Crystal structures of organomercurial-activated chicken liver dihydrofolate reductase complexes |
|
44
|
159
|
1drbA |
Crystal structure of unliganded escherichia coli dihydrofolate reductase. ligand-induced conformational changes and cooperativity in binding |
