|
43
|
163
|
4fggA |
S. aureus dihydrofolate reductase co-crystallized with propyl-dap isobutenyl-dihydrophthalazine inhibitor |
|
41
|
159
|
4fhbA |
Enhancing dhfr catalysis by binding of an allosteric regulator nanobody (nb179) |
|
44
|
159
|
3r33A |
Evidence for dynamic motion in proteins as a mechanism for ligand dissociation |
|
40
|
163
|
4fghA |
S. aureus dihydrofolate reductase co-crystallized with ethyl-dap isobutenyl-dihydrophthalazine inhibitor |
|
45
|
159
|
3qyoA |
Sensitivity of receptor internal motions to ligand binding affinity and kinetic off-rate |
|
58
|
219
|
3qfxA |
Trypanosoma brucei dihydrofolate reductase pyrimethamine complex |
|
59
|
192
|
3qlrA |
Candida albicans dihydrofolate reductase complexed with nadph and 6-methyl-5-[(3r)-3-(3,4,5-trimethoxyphenyl)pent-1-yn-1-yl]pyrimidine-2,4-diamine (ucp112a) |
|
177
|
608
|
3qgtA |
Crystal structure of wild-type pfdhfr-ts complexed with nadph, dump and pyrimethamine |
|
56
|
192
|
3qlsA |
Candida albicans dihydrofolate reductase complexed with nadph and 6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine (ucp115a) |
|
43
|
160
|
3ql0A |
Crystal structure of n23pp/s148a mutant of e. coli dihydrofolate reductase |
|
173
|
608
|
3qg2A |
Plasmodium falciparum dhfr-ts qradruple mutant (n51i+c59r+s108n+i164l, v1/s) pyrimethamine complex |
|
46
|
159
|
3ql3A |
Re-refined coordinates for pdb entry 1rx2 |
|
53
|
190
|
3qlwA |
Candida albicans dihydrofolate reductase complexed with nadph and 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine (ucp120b) |
|
46
|
159
|
3qylA |
Sensitivity of receptor internal motions to ligand binding affinity and kinetic off-rate |
|
40
|
161
|
3q1hA |
Crystal structure of dihydrofolate reductase from yersinia pestis |
|
57
|
206
|
3nzbX |
Structural analysis of pneumocystis carinii and human dhfr complexes with nadph and a series of potent 5-(omega-carboxyl(alkyloxy)pyrido[2,-d]pyrimidine derivatives |
|
59
|
206
|
3nzcX |
Structural analysis of pneumocystis carinii and human dhfr complexes with nadph and a series of five potent 5-(omega-carboxy(alkyloxy)pyrido[2,3-d]pyridine derivativea |
|
54
|
186
|
3oafA |
Structural and kinetic data for antifolate interactions against pneumocystis jirovecii, pneumocystis carinii and human dihydrofolate reductase and thier active site mutants |
|
59
|
206
|
3nz9X |
Structural analysis of pneumocystis carinii and human dhfr complexes with nadph and a series of five potent 5-(omega-carboxy(alkyloxy)pyrido[2,3-d]pyrimidine derivatives |
|
59
|
186
|
3nzdA |
Structural analysis of pneumocystis carinii and human dhfr complexes with nadph and a series of five 5-(omega-carboxy(alkyloxy(pyrido[2,3-d]pyrimidine derivatives |
|
57
|
186
|
3nxvA |
Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the e- and z-isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with nadph and human dihydrofolate reductase |
|
58
|
186
|
3nxxA |
Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the e- and z-isomers of a series of 5-substituted 2,4-diaminofuro-2,3-d]pyrimidines as ternary complexes with nadph and human dihydrofolate reductase |
|
59
|
206
|
3nzaX |
Structural analysis of pneumocystis carinii and human dhfr complexes with nadph and a series of five potent 5-(omega-carboxy(alkyloxy)pyrido[2,3-d]pyrimidine derivatives |
|
55
|
186
|
3nxtA |
Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the e-and z-isomers of a series of 5-substituted 2,4-diaminofuro[2m,3-d]pyrimidines as ternary complexes with nadph and human dihydrofolate reductase |
|
53
|
186
|
3nxyA |
Preferential selection of isomer binding from chiral mixtures: alernate binding modes observed fro the e- and z-isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with nadph and human dihydrofolate reductase |
|
44
|
159
|
3ochA |
Chemically self-assembled antibody nanorings (csans): design and characterization of an anti-cd3 igm biomimetic |
|
54
|
186
|
3ntzA |
Design, synthesis, biological evaluation and x-ray crystal structures of novel classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors |
|
54
|
186
|
3nxoA |
Perferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the e- and z-isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with nadph and human dihydrofolate reductase |
|
48
|
206
|
3nz6X |
Structural analysis of pneumocystis carinii and human dhfr complexes with nadph and a series of five potent 5-(omega-carboxy(alkyloxy)pyrido[2,3-d]pyrimidine derivatives |
|
55
|
186
|
3nu0A |
Design, synthesis, biological evaluation and x-ray crystal structure of novel classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors |
|
57
|
186
|
3nxrA |
Perferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the e- and z-isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with nadph and human dihydrofolate reductase |
|
52
|
186
|
3n0hA |
Hdhfr double mutant q35s/n64f trimethoprim binary complex |
|
40
|
161
|
3m08A |
Wild type dihydrofolate reductase from staphylococcus aureus with inhibitor rab1 |
|
41
|
161
|
3m09A |
F98y tmp-resistant dihydrofolate reductase from staphylococcus aureus with inhibitor rab1 |
|
39
|
157
|
3lg4A |
Staphylococcus aureus v31y, f92i mutant dihydrofolate reductase complexed with nadph and 5-[(3s)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine |
|
57
|
186
|
3l3rA |
Structural, computational and kinetic data for antifolate interactions against pneumocystis jirovecii, pneumocystis carinii and human dihydrofolate reductase and their active site mutants |
|
152
|
514
|
3kjsA |
Crystal structure of t. cruzi dhfr-ts with 3 high affinity dhfr inhibitors: dq1 inhibitor complex |
|
44
|
159
|
3kfyA |
Dynamic switching and partial occupancies of a small molecule inhibitor complex of dhfr |
|
55
|
186
|
3k45A |
Alternate binding modes observed for the e- and z-isomers of 2,4-diaminofuro[2,3d]pyrimidines as ternary complexes with nadph and mouse dihydrofolate reductase |
|
177
|
606
|
3jsuA |
Quadruple mutant(n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(pfdhfr-ts) complexed with qn254, nadph, and dump |
|
43
|
159
|
3k74A |
Disruption of protein dynamics by an allosteric effector antibody |
|
40
|
165
|
3jw5A |
Crystal structure of bacillus anthracis (y102f) dihydrofolate reductase complexed with nadph and trimethoprim |
|
44
|
165
|
3jwcA |
Crystal structure of bacillus anthracis (y102f) dihydrofolate reductase complexed with nadph and 2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (ucp120a) |
|
45
|
165
|
3jwmA |
Crystal structure of bacillus anthracis dihydrofolate reductase complexed with nadph and (s)-2,4-diamino-5-(3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (ucp114a) |
|
45
|
166
|
3jvxA |
Crystal structure of bacillus anthracis dihydrofolate reductase complexed with nadph and 2,4-diamino-5-(3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (ucp120a) |
|
57
|
186
|
3k47A |
Alternate binding modes observed for the e- and z-isomers of 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with nadph and mouse dihydrofolate reductase |
|
42
|
165
|
3jw3A |
Crystal structure of bacillus anthracis (f96i) dihydrofolate reductase complexed with nadph and trimethoprim |
|
45
|
165
|
3jwkA |
Crystal structure of bacillus anthracis (y102f) dihydrofolate reductase complexed with nadph and (s)-2,4-diamino-5-(3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (ucp114a) |
|
43
|
165
|
3jwfA |
Crystal structure of bacillus anthracis (y102f) dihydrofolate reductase complexed with nadph and (r)-2,4-diamino-5-(3-hydroxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (ucp113a) |
|
160
|
514
|
3invA |
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase complexed with nadph, dump and c-448 antifolate |
