|
66
|
219
|
4kp4A |
Deciphering cis-trans directionality and visualizing autophosphorylation in histidine kinases. |
|
60
|
210
|
4ktnA |
Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor ((3s)-1-[2-(pyrido[2,3-b]pyrazin-7-ylsulfanyl)-9h-pyrimido[4,5-b]indol-4-yl]pyrrolidin-3-amine) |
|
59
|
205
|
4kfgA |
The dna gyrase b atp binding domain of escherichia coli in complex with a small molecule inhibitor. |
|
62
|
210
|
4ksgA |
Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (4-[(1s,5r,6r)-6-amino-1-methyl-3-azabicyclo[3.2.0]hept-3-yl]-6-fluoro-n-methyl-2-[(2-methylpyrimidin-5-yl)oxy]-9h-pyrimido[4,5-b]indol-8-amine) |
|
70
|
207
|
4l91A |
Crystal structure of human hsp90 with x29 |
|
59
|
210
|
4kshA |
Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (7-({4-[(3r)-3-aminopyrrolidin-1-yl]-5-chloro-6-ethyl-7h-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)-1,5-naphthyridin-1(4h)-ol) |
|
76
|
241
|
4jauA |
Structural basis of a rationally rewired protein-protein interface (hk853mutant a268v, a271g, t275m, v294t and d297e) |
|
68
|
237
|
4jasA |
Structural basis of a rationally rewired protein-protein interface (hk853mutant a268v, a271g, t275m, v294t and d297e and rr468mutant v13p, l14i, i17m and n21v) |
|
68
|
208
|
4hy6A |
Crystal structure of the human hsp90-alpha n-domain bound to the hsp90 inhibitor fj1 |
|
103
|
396
|
4i5sA |
Structure and function of sensor histidine kinase |
|
52
|
207
|
4hz5A |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity |
|
79
|
246
|
4javA |
Structural basis of a rationally rewired protein-protein interface (hk853wt and rr468mutant v13p, l14i, i17m and n21v) |
|
107
|
376
|
4hxzA |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. |
|
109
|
371
|
4hy1A |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. |
|
60
|
204
|
4hypA |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. |
|
56
|
203
|
4hz0A |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. |
|
110
|
371
|
4hymA |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. |
|
67
|
215
|
4jqlA |
Synthesis of benzoquinone-ansamycin-inspired macrocyclic lactams from shikimic acid |
|
59
|
210
|
4hxwA |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. |
|
24
|
131
|
4jpbA |
The structure of a ternary complex between chea domains p4 and p5 with chew and with an unzipped fragment of tm14, a chemoreceptor analog from thermotoga maritima. |
|
106
|
332
|
4h7qA |
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase in complex with alpha-ketoisocaproic acid and adp |
|
111
|
331
|
4h81A |
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(r)-2-chloro-3-phenylpropanoic acid complex with adp |
|
109
|
332
|
4h85A |
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(r)-alpha-chloroisocaproate complex with adp |
|
67
|
209
|
4gqtA |
N-terminal domain of c. elegans hsp90 |
|
40
|
133
|
4gt8A |
Crystal structure of the catalytic and atp-binding domain from vras in complex with adp |
|
60
|
210
|
4gglA |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity |
|
59
|
210
|
4geeA |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. |
|
117
|
366
|
4gczA |
Structure of a blue-light photoreceptor |
|
57
|
210
|
4gfnA |
Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic |
|
63
|
208
|
4fcpA |
Targetting conserved water molecules: design of 4-aryl-5-cyanopyrrolo [2,3-d] pyrimidine hsp90 inhibitors using fragment-based screening and structure-based optimization |
|
68
|
210
|
3r4oA |
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1h-pyrazol-1-yl)ethoxy]-6-methylphenyl}-n-(2,2-difluoropropyl)-5,7-dihydro-6h-pyrrolo[3,4-d]pyrimidine-6-carboxamide |
|
64
|
208
|
4fcrA |
Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine hsp90 inhibitors using fragment-based screening and structure-based optimization |
|
67
|
221
|
3r4nA |
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1h-pyrazol-1-yl)ethoxy]-6-methylphenyl}-n-(2,2-difluoropropyl)-5,7-dihydro-6h-pyrrolo[3,4-d]pyrimidine-6-carboxamide |
|
68
|
222
|
3r4pA |
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1h-pyrazol-1-yl)ethoxy]-6-methylphenyl}-n-(2,2-difluoropropyl)-5,7-dihydro-6h-pyrrolo[3,4-d]pyrimidine-6-carboxamide |
|
65
|
215
|
3r4mA |
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1h-pyrazol-1-yl)ethoxy]-6-methylphenyl}-n-(2,2-difluoropropyl)-5,7-dihydro-6h-pyrrolo[3,4-d]pyrimidine-6-carboxamide |
|
69
|
208
|
4fcqA |
Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine hsp90 inhibitors using fragment-based screening and structure-based optimization |
|
69
|
209
|
3qddA |
Hsp90a n-terminal domain in complex with biib021 |
|
67
|
207
|
3qtfA |
Design and sar of macrocyclic hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity |
|
61
|
215
|
3q5jA |
Crystal structure of the amino-terminal domain of hsp90 from leishmania major, lmjf33.0312:m1-k213 in the presence of 17-dmap-geldanamycin |
|
62
|
214
|
3q5lA |
Crystal structure of the amino-terminal domain of hsp90 from leishmania major, lmjf33.0312:m1-k 213 in the presence of 17-aep-geldanamycin |
|
62
|
218
|
3q5kA |
Crystal structure of the amino-terminal domain of hsp90 from leishmania major, lmjf33.0312:m1-k213 in the presence of an inhibitor |
|
78
|
261
|
3pehA |
Crystal structure of the n-terminal domain of an hsp90 from plasmodium falciparum, pfl1070c in the presence of a thienopyrimidine derivative |
|
75
|
258
|
3pejA |
Crystal structure of the n-terminal domain of an hsp90 from plasmodium falciparum, pfl1070c in the presence of macbecin |
|
70
|
208
|
3omuA |
Crystal structure of the n-terminal domain of an hsp90 from trypanosoma brucei, tb10.26.1080 in the presence of a thienopyrimidine derivative |
|
65
|
207
|
3ow6A |
Crystal structure of hsp90 with n-aryl-benzimidazolone i |
|
63
|
207
|
3owbA |
Crystal structure of hsp90 with ver-49009 |
|
64
|
207
|
3owdA |
Crystal structure of hsp90 with n-aryl-benzimidazolone ii |
|
67
|
210
|
3opdA |
Crystal structure of the n-terminal domain of an hsp90 from trypanosoma brucei, tb10.26.1080 in the presence of a benzamide derivative |
|
68
|
208
|
3o0iA |
Structure of the human hsp90-alpha n-domain bound to the hsp90 inhibitor pu-h54 |
|
67
|
209
|
3o6oA |
Crystal structure of the n-terminal domain of an hsp90 from trypanosoma brucei, tb10.26.1080 in the presence of an the inhibitor biib021 |
