117EA

The r78k and d117e active site variants of saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implications
Total Genus 87
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
87
sequence length
282
structure length
282
Chain Sequence
TYTTRQIGAKNTLEYKVYIEKDGKPVSAFHDIPLYADKENNIFNMVVEIPRWTNAKLEITKEETLNPIIQDTKKGKLRFVRNCFPHHGYIHNYGAFPQTWEDPNVSHPETKAVGDNEPIDVLEIGETIAYTGQVKQVKALGIMALLDEGETDWKVIAIDINDPLAPKLNDIEDVEKYFPGLLRATNEWFRIYKIPDGKPENQFAFSGEAKNKKYALDIIKETHDSWKQLIAGKSSDSKGIDLTNVTLPDTPTYSKAASDAIPPASLKADAPIDKSIDKWFFI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implications.
pubmed doi rcsb
molecule tags Hydrolase
source organism Saccharomyces cerevisiae
molecule keywords PROTEIN (INORGANIC PYROPHOSPHATASE)
total genus 87
structure length 282
sequence length 282
chains with identical sequence B
ec nomenclature ec 3.6.1.1: Inorganic diphosphatase.
pdb deposition date 1998-09-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00719 Pyrophosphatase Inorganic pyrophosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.80.10 Alpha Beta Alpha-Beta Complex Inorganic Pyrophosphatase Inorganic pyrophosphatase 117eA00
3I98A 4ECPA 4LUGA 3GVFA 3D63A 4Z73A 1UDEA 3EIZA 117EA 1E9GA 1I6TA 1YGZA 3EJ0A 2BQXA 1MJXA 1WGJA 3TR4A 4XELA 4Z71A 4QMBA 4Z70A 5KDEA 2IK9A 2IK2A 1QEZA 4Z72A 2UXSA 1TWLA 2PRDA 3R6EA 1MJYA 3R5UA 1OBWA 1HUJA 3EIYA 2AUUA 3LD3A 3LO0A 3Q3LA 5KDFA 1YPPA 3I4QA 1MJZA 2IK4A 1INOA 1E6AA 3Q5VA 1I40A 1FAJA 3EJ2A 2AU6A 1MJWA 3Q4WA 1M38A 4QLZA 1SXVA 2AU8A 1JFDA 2EIPA 3D53A 1WCFA 3R5VA 2IK1A 1IPWA 1WGIA 2IK6A 3Q46A 5H4FA 4Z74A 2IK0A 2BQYA 3SW5A 2IHPA 1HUKA 2IK7A 4UM4A 8PRKA 2AU9A 1PYPA 3EMJA 5TEAA 2AU7A 3FQ3A 1IGPA
chains in the Genus database with same CATH superfamily
3I98A 4ECPA 4LUGA 3GVFA 3D63A 4Z73A 1UDEA 3EIZA 117EA 1E9GA 1I6TA 1YGZA 3EJ0A 2BQXA 1MJXA 1WGJA 3TR4A 4XELA 4Z71A 4QMBA 4Z70A 5KDEA 2IK9A 2IK2A 1QEZA 4Z72A 2UXSA 1TWLA 2PRDA 3R6EA 1MJYA 3R5UA 1OBWA 1HUJA 3EIYA 2AUUA 3LD3A 3LO0A 3Q3LA 5KDFA 1YPPA 3I4QA 1MJZA 2IK4A 1INOA 1E6AA 3Q5VA 1I40A 1FAJA 3EJ2A 2AU6A 1MJWA 3Q4WA 1M38A 4QLZA 1SXVA 2AU8A 1JFDA 2EIPA 3D53A 1WCFA 3R5VA 2IK1A 1IPWA 1WGIA 2IK6A 3Q46A 5H4FA 4Z74A 2IK0A 2BQYA 3SW5A 2IHPA 1HUKA 2IK7A 4UM4A 8PRKA 2AU9A 1PYPA 3EMJA 5TEAA 2AU7A 3FQ3A 1IGPA
chains in the Genus database with same CATH topology
3I98A 4ECPA 4LUGA 3GVFA 3D63A 4Z73A 1UDEA 3EIZA 117EA 1E9GA 1I6TA 1YGZA 3EJ0A 2BQXA 1MJXA 1WGJA 3TR4A 4XELA 4Z71A 4QMBA 4Z70A 5KDEA 2IK9A 2IK2A 1QEZA 4Z72A 2UXSA 1TWLA 2PRDA 3R6EA 1MJYA 3R5UA 1OBWA 1HUJA 3EIYA 2AUUA 3LD3A 3LO0A 3Q3LA 5KDFA 1YPPA 3I4QA 1MJZA 2IK4A 1INOA 1E6AA 3Q5VA 1I40A 1FAJA 3EJ2A 2AU6A 1MJWA 3Q4WA 1M38A 4QLZA 1SXVA 2AU8A 1JFDA 2EIPA 3D53A 1WCFA 3R5VA 2IK1A 1IPWA 1WGIA 2IK6A 3Q46A 5H4FA 4Z74A 2IK0A 2BQYA 3SW5A 2IHPA 1HUKA 2IK7A 4UM4A 8PRKA 2AU9A 1PYPA 3EMJA 5TEAA 2AU7A 3FQ3A 1IGPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3I98 A;  4ECP A;  4LUG A;  3GVF A;  3D63 A;  4Z73 A;  1UDE A;  3EIZ A;  117E A;  1E9G A;  1I6T A;  1YGZ A;  3EJ0 A;  2BQX A;  1MJX A;  1WGJ A;  3TR4 A;  4XEL A;  4Z71 A;  4QMB A;  4Z70 A;  5KDE A;  2IK9 A;  2IK2 A;  1QEZ A;  4Z72 A;  2UXS A;  1TWL A;  2PRD A;  3R6E A;  1MJY A;  3R5U A;  1OBW A;  1HUJ A;  3EIY A;  2AUU A;  3LD3 A;  3LO0 A;  3Q3L A;  5KDF A;  1YPP A;  3I4Q A;  1MJZ A;  2IK4 A;  1INO A;  1E6A A;  3Q5V A;  1I40 A;  1FAJ A;  3EJ2 A;  2AU6 A;  1MJW A;  3Q4W A;  1M38 A;  4QLZ A;  1SXV A;  2AU8 A;  1JFD A;  2EIP A;  3D53 A;  1WCF A;  3R5V A;  2IK1 A;  1IPW A;  1WGI A;  2IK6 A;  3Q46 A;  5H4F A;  4Z74 A;  2IK0 A;  2BQY A;  3SW5 A;  2IHP A;  1HUK A;  2IK7 A;  4UM4 A;  8PRK A;  2AU9 A;  1PYP A;  3EMJ A;  5TEA A;  2AU7 A;  3FQ3 A;  1IGP A; 
#chains in the Genus database with same CATH topology
 3I98 A;  4ECP A;  4LUG A;  3GVF A;  3D63 A;  4Z73 A;  1UDE A;  3EIZ A;  117E A;  1E9G A;  1I6T A;  1YGZ A;  3EJ0 A;  2BQX A;  1MJX A;  1WGJ A;  3TR4 A;  4XEL A;  4Z71 A;  4QMB A;  4Z70 A;  5KDE A;  2IK9 A;  2IK2 A;  1QEZ A;  4Z72 A;  2UXS A;  1TWL A;  2PRD A;  3R6E A;  1MJY A;  3R5U A;  1OBW A;  1HUJ A;  3EIY A;  2AUU A;  3LD3 A;  3LO0 A;  3Q3L A;  5KDF A;  1YPP A;  3I4Q A;  1MJZ A;  2IK4 A;  1INO A;  1E6A A;  3Q5V A;  1I40 A;  1FAJ A;  3EJ2 A;  2AU6 A;  1MJW A;  3Q4W A;  1M38 A;  4QLZ A;  1SXV A;  2AU8 A;  1JFD A;  2EIP A;  3D53 A;  1WCF A;  3R5V A;  2IK1 A;  1IPW A;  1WGI A;  2IK6 A;  3Q46 A;  5H4F A;  4Z74 A;  2IK0 A;  2BQY A;  3SW5 A;  2IHP A;  1HUK A;  2IK7 A;  4UM4 A;  8PRK A;  2AU9 A;  1PYP A;  3EMJ A;  5TEA A;  2AU7 A;  3FQ3 A;  1IGP A; 
#chains in the Genus database with same CATH homology
 3I98 A;  4ECP A;  4LUG A;  3GVF A;  3D63 A;  4Z73 A;  1UDE A;  3EIZ A;  117E A;  1E9G A;  1I6T A;  1YGZ A;  3EJ0 A;  2BQX A;  1MJX A;  1WGJ A;  3TR4 A;  4XEL A;  4Z71 A;  4QMB A;  4Z70 A;  5KDE A;  2IK9 A;  2IK2 A;  1QEZ A;  4Z72 A;  2UXS A;  1TWL A;  2PRD A;  3R6E A;  1MJY A;  3R5U A;  1OBW A;  1HUJ A;  3EIY A;  2AUU A;  3LD3 A;  3LO0 A;  3Q3L A;  5KDF A;  1YPP A;  3I4Q A;  1MJZ A;  2IK4 A;  1INO A;  1E6A A;  3Q5V A;  1I40 A;  1FAJ A;  3EJ2 A;  2AU6 A;  1MJW A;  3Q4W A;  1M38 A;  4QLZ A;  1SXV A;  2AU8 A;  1JFD A;  2EIP A;  3D53 A;  1WCF A;  3R5V A;  2IK1 A;  1IPW A;  1WGI A;  2IK6 A;  3Q46 A;  5H4F A;  4Z74 A;  2IK0 A;  2BQY A;  3SW5 A;  2IHP A;  1HUK A;  2IK7 A;  4UM4 A;  8PRK A;  2AU9 A;  1PYP A;  3EMJ A;  5TEA A;  2AU7 A;  3FQ3 A;  1IGP A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...