117EA

The r78k and d117e active site variants of saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implications
Total Genus 87
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
87
sequence length
282
structure length
282
Chain Sequence
TYTTRQIGAKNTLEYKVYIEKDGKPVSAFHDIPLYADKENNIFNMVVEIPRWTNAKLEITKEETLNPIIQDTKKGKLRFVRNCFPHHGYIHNYGAFPQTWEDPNVSHPETKAVGDNEPIDVLEIGETIAYTGQVKQVKALGIMALLDEGETDWKVIAIDINDPLAPKLNDIEDVEKYFPGLLRATNEWFRIYKIPDGKPENQFAFSGEAKNKKYALDIIKETHDSWKQLIAGKSSDSKGIDLTNVTLPDTPTYSKAASDAIPPASLKADAPIDKSIDKWFFI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implications.
pubmed doi rcsb
molecule tags Hydrolase
source organism Saccharomyces cerevisiae
molecule keywords PROTEIN (INORGANIC PYROPHOSPHATASE)
total genus 87
structure length 282
sequence length 282
chains with identical sequence B
ec nomenclature ec 3.6.1.1: Inorganic diphosphatase.
pdb deposition date 1998-09-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00719 Pyrophosphatase Inorganic pyrophosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.80.10 Alpha Beta Alpha-Beta Complex Inorganic Pyrophosphatase Inorganic pyrophosphatase 117eA00
5TEAA 3Q46A 1MJWA 2AU8A 3EIYA 4QMBA 1UDEA 4Z71A 3EIZA 5H4FA 3I4QA 4Z70A 3R6EA 1I40A 4QLZA 3Q4WA 1MJXA 117EA 3R5UA 3EMJA 1JFDA 2IHPA 3GVFA 4Z73A 1E6AA 4Z74A 1INOA 3R5VA 1YGZA 1M38A 1FAJA 3D63A 1TWLA 2AUUA 1OBWA 1SXVA 4LUGA 3EJ0A 2IK9A 1HUJA 4ECPA 3TR4A 3I98A 5KDFA 1PYPA 2IK7A 1I6TA 3D53A 4Z72A 3FQ3A 2IK6A 3LO0A 1IPWA 1YPPA 1WGJA 2BQXA 2BQYA 1WGIA 4UM4A 2AU7A 1WCFA 5KDEA 3EJ2A 3LD3A 2IK0A 1HUKA 2EIPA 2IK2A 1MJYA 2IK1A 1IGPA 2AU9A 3Q5VA 3Q3LA 4XELA 3SW5A 1MJZA 1E9GA 1QEZA 2IK4A 2PRDA 2AU6A 2UXSA 8PRKA
chains in the Genus database with same CATH superfamily
5TEAA 3Q46A 1MJWA 2AU8A 3EIYA 4QMBA 1UDEA 4Z71A 3EIZA 5H4FA 3I4QA 4Z70A 3R6EA 1I40A 4QLZA 3Q4WA 1MJXA 117EA 3R5UA 3EMJA 1JFDA 2IHPA 3GVFA 4Z73A 1E6AA 4Z74A 1INOA 3R5VA 1YGZA 1M38A 1FAJA 3D63A 1TWLA 2AUUA 1OBWA 1SXVA 4LUGA 3EJ0A 2IK9A 1HUJA 4ECPA 3TR4A 3I98A 5KDFA 1PYPA 2IK7A 1I6TA 3D53A 4Z72A 3FQ3A 2IK6A 3LO0A 1IPWA 1YPPA 1WGJA 2BQXA 2BQYA 1WGIA 4UM4A 2AU7A 1WCFA 5KDEA 3EJ2A 3LD3A 2IK0A 1HUKA 2EIPA 2IK2A 1MJYA 2IK1A 1IGPA 2AU9A 3Q5VA 3Q3LA 4XELA 3SW5A 1MJZA 1E9GA 1QEZA 2IK4A 2PRDA 2AU6A 2UXSA 8PRKA
chains in the Genus database with same CATH topology
5TEAA 3Q46A 1MJWA 2AU8A 3EIYA 4QMBA 1UDEA 4Z71A 3EIZA 5H4FA 3I4QA 4Z70A 3R6EA 1I40A 4QLZA 3Q4WA 1MJXA 117EA 3R5UA 3EMJA 1JFDA 2IHPA 3GVFA 4Z73A 1E6AA 4Z74A 1INOA 3R5VA 1YGZA 1M38A 1FAJA 3D63A 1TWLA 2AUUA 1OBWA 1SXVA 4LUGA 3EJ0A 2IK9A 1HUJA 4ECPA 3TR4A 3I98A 5KDFA 1PYPA 2IK7A 1I6TA 3D53A 4Z72A 3FQ3A 2IK6A 3LO0A 1IPWA 1YPPA 1WGJA 2BQXA 2BQYA 1WGIA 4UM4A 2AU7A 1WCFA 5KDEA 3EJ2A 3LD3A 2IK0A 1HUKA 2EIPA 2IK2A 1MJYA 2IK1A 1IGPA 2AU9A 3Q5VA 3Q3LA 4XELA 3SW5A 1MJZA 1E9GA 1QEZA 2IK4A 2PRDA 2AU6A 2UXSA 8PRKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5TEA A;  3Q46 A;  1MJW A;  2AU8 A;  3EIY A;  4QMB A;  1UDE A;  4Z71 A;  3EIZ A;  5H4F A;  3I4Q A;  4Z70 A;  3R6E A;  1I40 A;  4QLZ A;  3Q4W A;  1MJX A;  117E A;  3R5U A;  3EMJ A;  1JFD A;  2IHP A;  3GVF A;  4Z73 A;  1E6A A;  4Z74 A;  1INO A;  3R5V A;  1YGZ A;  1M38 A;  1FAJ A;  3D63 A;  1TWL A;  2AUU A;  1OBW A;  1SXV A;  4LUG A;  3EJ0 A;  2IK9 A;  1HUJ A;  4ECP A;  3TR4 A;  3I98 A;  5KDF A;  1PYP A;  2IK7 A;  1I6T A;  3D53 A;  4Z72 A;  3FQ3 A;  2IK6 A;  3LO0 A;  1IPW A;  1YPP A;  1WGJ A;  2BQX A;  2BQY A;  1WGI A;  4UM4 A;  2AU7 A;  1WCF A;  5KDE A;  3EJ2 A;  3LD3 A;  2IK0 A;  1HUK A;  2EIP A;  2IK2 A;  1MJY A;  2IK1 A;  1IGP A;  2AU9 A;  3Q5V A;  3Q3L A;  4XEL A;  3SW5 A;  1MJZ A;  1E9G A;  1QEZ A;  2IK4 A;  2PRD A;  2AU6 A;  2UXS A;  8PRK A; 
#chains in the Genus database with same CATH topology
 5TEA A;  3Q46 A;  1MJW A;  2AU8 A;  3EIY A;  4QMB A;  1UDE A;  4Z71 A;  3EIZ A;  5H4F A;  3I4Q A;  4Z70 A;  3R6E A;  1I40 A;  4QLZ A;  3Q4W A;  1MJX A;  117E A;  3R5U A;  3EMJ A;  1JFD A;  2IHP A;  3GVF A;  4Z73 A;  1E6A A;  4Z74 A;  1INO A;  3R5V A;  1YGZ A;  1M38 A;  1FAJ A;  3D63 A;  1TWL A;  2AUU A;  1OBW A;  1SXV A;  4LUG A;  3EJ0 A;  2IK9 A;  1HUJ A;  4ECP A;  3TR4 A;  3I98 A;  5KDF A;  1PYP A;  2IK7 A;  1I6T A;  3D53 A;  4Z72 A;  3FQ3 A;  2IK6 A;  3LO0 A;  1IPW A;  1YPP A;  1WGJ A;  2BQX A;  2BQY A;  1WGI A;  4UM4 A;  2AU7 A;  1WCF A;  5KDE A;  3EJ2 A;  3LD3 A;  2IK0 A;  1HUK A;  2EIP A;  2IK2 A;  1MJY A;  2IK1 A;  1IGP A;  2AU9 A;  3Q5V A;  3Q3L A;  4XEL A;  3SW5 A;  1MJZ A;  1E9G A;  1QEZ A;  2IK4 A;  2PRD A;  2AU6 A;  2UXS A;  8PRK A; 
#chains in the Genus database with same CATH homology
 5TEA A;  3Q46 A;  1MJW A;  2AU8 A;  3EIY A;  4QMB A;  1UDE A;  4Z71 A;  3EIZ A;  5H4F A;  3I4Q A;  4Z70 A;  3R6E A;  1I40 A;  4QLZ A;  3Q4W A;  1MJX A;  117E A;  3R5U A;  3EMJ A;  1JFD A;  2IHP A;  3GVF A;  4Z73 A;  1E6A A;  4Z74 A;  1INO A;  3R5V A;  1YGZ A;  1M38 A;  1FAJ A;  3D63 A;  1TWL A;  2AUU A;  1OBW A;  1SXV A;  4LUG A;  3EJ0 A;  2IK9 A;  1HUJ A;  4ECP A;  3TR4 A;  3I98 A;  5KDF A;  1PYP A;  2IK7 A;  1I6T A;  3D53 A;  4Z72 A;  3FQ3 A;  2IK6 A;  3LO0 A;  1IPW A;  1YPP A;  1WGJ A;  2BQX A;  2BQY A;  1WGI A;  4UM4 A;  2AU7 A;  1WCF A;  5KDE A;  3EJ2 A;  3LD3 A;  2IK0 A;  1HUK A;  2EIP A;  2IK2 A;  1MJY A;  2IK1 A;  1IGP A;  2AU9 A;  3Q5V A;  3Q3L A;  4XEL A;  3SW5 A;  1MJZ A;  1E9G A;  1QEZ A;  2IK4 A;  2PRD A;  2AU6 A;  2UXS A;  8PRK A; 
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