1IPCA

Crystal structure of eukaryotic initiation factor 4e complexed with 7-methyl gtp
Total Genus 58
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
191
structure length
186
Chain Sequence
EVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATTKNRFVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region
pubmed doi rcsb
molecule tags Rna binding protein
source organism Homo sapiens
molecule keywords EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
total genus 58
structure length 186
sequence length 191
ec nomenclature
pdb deposition date 2001-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01652 IF4E Eukaryotic initiation factor 4E
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.760.10 Alpha Beta 2-Layer Sandwich RNA Cap, Translation Initiation Factor Eif4e RNA Cap, Translation Initiation Factor Eif4e 1ipcA00
5ABUA 1EJHA 2V8WA 4DT6A 2V8XA 4AXGA 4TQCA 3M93A 4DUMA 4UEDA 2IDRA 2Q4KA 4TQBA 3HXGA 2GPQA 5EI3A 1IPBA 4AZAA 2W97A 1AP8A 5EHCA 5ABVA 4UECA 5EIRA 1RF8A 5T48A 1ZTPA 4UEAA 5T47A 4UE8A 3HXIA 4TPWA 4UE9A 1IPCA 3U7XA 2JGCA 5GW6A 1EJ1A 3M94A 5ABYA 5BXVA 2W97B 4B6UA 2IDVA 4UEBA 3TF2A 2JGBA 3AM7A 1EJ4A 1L8BA 2WMCA 4BEAA 4B6VA 5ABXA 5T46A 5EKVA 2V8YA 1WKWA
chains in the Genus database with same CATH superfamily
5ABUA 1EJHA 2V8WA 4DT6A 2V8XA 4AXGA 4TQCA 3M93A 4DUMA 4UEDA 2IDRA 2Q4KA 4TQBA 3HXGA 2GPQA 5EI3A 1IPBA 4AZAA 2W97A 1AP8A 5EHCA 5ABVA 4UECA 5EIRA 1RF8A 5T48A 1ZTPA 4UEAA 5T47A 4UE8A 3HXIA 4TPWA 4UE9A 1IPCA 3U7XA 2JGCA 5GW6A 1EJ1A 3M94A 5ABYA 5BXVA 2W97B 4B6UA 2IDVA 4UEBA 3TF2A 2JGBA 3AM7A 1EJ4A 1L8BA 2WMCA 4BEAA 4B6VA 5ABXA 5T46A 5EKVA 2V8YA 1WKWA
chains in the Genus database with same CATH topology
5ABUA 1EJHA 2V8WA 4DT6A 2V8XA 4AXGA 4TQCA 3M93A 4DUMA 4UEDA 2IDRA 2Q4KA 4TQBA 3HXGA 2GPQA 5EI3A 1IPBA 4AZAA 2W97A 1AP8A 5EHCA 5ABVA 4UECA 5EIRA 1RF8A 5T48A 1ZTPA 4UEAA 5T47A 4UE8A 3HXIA 4TPWA 4UE9A 1IPCA 3U7XA 2JGCA 5GW6A 1EJ1A 3M94A 5ABYA 5BXVA 2W97B 4B6UA 2IDVA 4UEBA 3TF2A 2JGBA 3AM7A 1EJ4A 1L8BA 2WMCA 4BEAA 4B6VA 5ABXA 5T46A 5EKVA 2V8YA 1WKWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5ABU A;  1EJH A;  2V8W A;  4DT6 A;  2V8X A;  4AXG A;  4TQC A;  3M93 A;  4DUM A;  4UED A;  2IDR A;  2Q4K A;  4TQB A;  3HXG A;  2GPQ A;  5EI3 A;  1IPB A;  4AZA A;  2W97 A;  1AP8 A;  5EHC A;  5ABV A;  4UEC A;  5EIR A;  1RF8 A;  5T48 A;  1ZTP A;  4UEA A;  5T47 A;  4UE8 A;  3HXI A;  4TPW A;  4UE9 A;  1IPC A;  3U7X A;  2JGC A;  5GW6 A;  1EJ1 A;  3M94 A;  5ABY A;  5BXV A;  2W97 B;  4B6U A;  2IDV A;  4UEB A;  3TF2 A;  2JGB A;  3AM7 A;  1EJ4 A;  1L8B A;  2WMC A;  4BEA A;  4B6V A;  5ABX A;  5T46 A;  5EKV A;  2V8Y A;  1WKW A; 
#chains in the Genus database with same CATH topology
 5ABU A;  1EJH A;  2V8W A;  4DT6 A;  2V8X A;  4AXG A;  4TQC A;  3M93 A;  4DUM A;  4UED A;  2IDR A;  2Q4K A;  4TQB A;  3HXG A;  2GPQ A;  5EI3 A;  1IPB A;  4AZA A;  2W97 A;  1AP8 A;  5EHC A;  5ABV A;  4UEC A;  5EIR A;  1RF8 A;  5T48 A;  1ZTP A;  4UEA A;  5T47 A;  4UE8 A;  3HXI A;  4TPW A;  4UE9 A;  1IPC A;  3U7X A;  2JGC A;  5GW6 A;  1EJ1 A;  3M94 A;  5ABY A;  5BXV A;  2W97 B;  4B6U A;  2IDV A;  4UEB A;  3TF2 A;  2JGB A;  3AM7 A;  1EJ4 A;  1L8B A;  2WMC A;  4BEA A;  4B6V A;  5ABX A;  5T46 A;  5EKV A;  2V8Y A;  1WKW A; 
#chains in the Genus database with same CATH homology
 5ABU A;  1EJH A;  2V8W A;  4DT6 A;  2V8X A;  4AXG A;  4TQC A;  3M93 A;  4DUM A;  4UED A;  2IDR A;  2Q4K A;  4TQB A;  3HXG A;  2GPQ A;  5EI3 A;  1IPB A;  4AZA A;  2W97 A;  1AP8 A;  5EHC A;  5ABV A;  4UEC A;  5EIR A;  1RF8 A;  5T48 A;  1ZTP A;  4UEA A;  5T47 A;  4UE8 A;  3HXI A;  4TPW A;  4UE9 A;  1IPC A;  3U7X A;  2JGC A;  5GW6 A;  1EJ1 A;  3M94 A;  5ABY A;  5BXV A;  2W97 B;  4B6U A;  2IDV A;  4UEB A;  3TF2 A;  2JGB A;  3AM7 A;  1EJ4 A;  1L8B A;  2WMC A;  4BEA A;  4B6V A;  5ABX A;  5T46 A;  5EKV A;  2V8Y A;  1WKW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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