1L8BA

Cocrystal structure of the messenger rna 5' cap-binding protein (eif4e) bound to 7-methylgpppg
Total Genus 55
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
55
sequence length
182
structure length
177
Chain Sequence
KHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIGRVYKERLGLPPKIVIGYQSHADTATKKNRFVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins.
pubmed doi rcsb
molecule tags Rna binding protein
source organism Mus musculus
molecule keywords EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
total genus 55
structure length 177
sequence length 182
chains with identical sequence B
ec nomenclature
pdb deposition date 2002-03-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01652 IF4E Eukaryotic initiation factor 4E
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.760.10 Alpha Beta 2-Layer Sandwich RNA Cap, Translation Initiation Factor Eif4e RNA Cap, Translation Initiation Factor Eif4e 1l8bA00
3HXGA 4UEAA 2WMCA 4B6VA 3HXIA 3TF2A 4UEDA 4AXGA 3M94A 2GPQA 1EJ4A 2Q4KA 2W97B 5EKVA 4TPWA 4DUMA 5GW6A 3U7XA 4BEAA 4UE9A 1IPCA 5EI3A 5T46A 4UE8A 4B6UA 2JGCA 4TQBA 1EJHA 1AP8A 2IDRA 5EHCA 1EJ1A 2JGBA 4UECA 4UEBA 5EIRA 2V8YA 2V8XA 3M93A 2V8WA 5ABUA 1L8BA 5ABYA 5BXVA 4DT6A 5T48A 5ABVA 4TQCA 3AM7A 1WKWA 1RF8A 2IDVA 4AZAA 1IPBA 2W97A 5ABXA 5T47A 1ZTPA
chains in the Genus database with same CATH superfamily
3HXGA 4UEAA 2WMCA 4B6VA 3HXIA 3TF2A 4UEDA 4AXGA 3M94A 2GPQA 1EJ4A 2Q4KA 2W97B 5EKVA 4TPWA 4DUMA 5GW6A 3U7XA 4BEAA 4UE9A 1IPCA 5EI3A 5T46A 4UE8A 4B6UA 2JGCA 4TQBA 1EJHA 1AP8A 2IDRA 5EHCA 1EJ1A 2JGBA 4UECA 4UEBA 5EIRA 2V8YA 2V8XA 3M93A 2V8WA 5ABUA 1L8BA 5ABYA 5BXVA 4DT6A 5T48A 5ABVA 4TQCA 3AM7A 1WKWA 1RF8A 2IDVA 4AZAA 1IPBA 2W97A 5ABXA 5T47A 1ZTPA
chains in the Genus database with same CATH topology
3HXGA 4UEAA 2WMCA 4B6VA 3HXIA 3TF2A 4UEDA 4AXGA 3M94A 2GPQA 1EJ4A 2Q4KA 2W97B 5EKVA 4TPWA 4DUMA 5GW6A 3U7XA 4BEAA 4UE9A 1IPCA 5EI3A 5T46A 4UE8A 4B6UA 2JGCA 4TQBA 1EJHA 1AP8A 2IDRA 5EHCA 1EJ1A 2JGBA 4UECA 4UEBA 5EIRA 2V8YA 2V8XA 3M93A 2V8WA 5ABUA 1L8BA 5ABYA 5BXVA 4DT6A 5T48A 5ABVA 4TQCA 3AM7A 1WKWA 1RF8A 2IDVA 4AZAA 1IPBA 2W97A 5ABXA 5T47A 1ZTPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HXG A;  4UEA A;  2WMC A;  4B6V A;  3HXI A;  3TF2 A;  4UED A;  4AXG A;  3M94 A;  2GPQ A;  1EJ4 A;  2Q4K A;  2W97 B;  5EKV A;  4TPW A;  4DUM A;  5GW6 A;  3U7X A;  4BEA A;  4UE9 A;  1IPC A;  5EI3 A;  5T46 A;  4UE8 A;  4B6U A;  2JGC A;  4TQB A;  1EJH A;  1AP8 A;  2IDR A;  5EHC A;  1EJ1 A;  2JGB A;  4UEC A;  4UEB A;  5EIR A;  2V8Y A;  2V8X A;  3M93 A;  2V8W A;  5ABU A;  1L8B A;  5ABY A;  5BXV A;  4DT6 A;  5T48 A;  5ABV A;  4TQC A;  3AM7 A;  1WKW A;  1RF8 A;  2IDV A;  4AZA A;  1IPB A;  2W97 A;  5ABX A;  5T47 A;  1ZTP A; 
#chains in the Genus database with same CATH topology
 3HXG A;  4UEA A;  2WMC A;  4B6V A;  3HXI A;  3TF2 A;  4UED A;  4AXG A;  3M94 A;  2GPQ A;  1EJ4 A;  2Q4K A;  2W97 B;  5EKV A;  4TPW A;  4DUM A;  5GW6 A;  3U7X A;  4BEA A;  4UE9 A;  1IPC A;  5EI3 A;  5T46 A;  4UE8 A;  4B6U A;  2JGC A;  4TQB A;  1EJH A;  1AP8 A;  2IDR A;  5EHC A;  1EJ1 A;  2JGB A;  4UEC A;  4UEB A;  5EIR A;  2V8Y A;  2V8X A;  3M93 A;  2V8W A;  5ABU A;  1L8B A;  5ABY A;  5BXV A;  4DT6 A;  5T48 A;  5ABV A;  4TQC A;  3AM7 A;  1WKW A;  1RF8 A;  2IDV A;  4AZA A;  1IPB A;  2W97 A;  5ABX A;  5T47 A;  1ZTP A; 
#chains in the Genus database with same CATH homology
 3HXG A;  4UEA A;  2WMC A;  4B6V A;  3HXI A;  3TF2 A;  4UED A;  4AXG A;  3M94 A;  2GPQ A;  1EJ4 A;  2Q4K A;  2W97 B;  5EKV A;  4TPW A;  4DUM A;  5GW6 A;  3U7X A;  4BEA A;  4UE9 A;  1IPC A;  5EI3 A;  5T46 A;  4UE8 A;  4B6U A;  2JGC A;  4TQB A;  1EJH A;  1AP8 A;  2IDR A;  5EHC A;  1EJ1 A;  2JGB A;  4UEC A;  4UEB A;  5EIR A;  2V8Y A;  2V8X A;  3M93 A;  2V8W A;  5ABU A;  1L8B A;  5ABY A;  5BXV A;  4DT6 A;  5T48 A;  5ABV A;  4TQC A;  3AM7 A;  1WKW A;  1RF8 A;  2IDV A;  4AZA A;  1IPB A;  2W97 A;  5ABX A;  5T47 A;  1ZTP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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