1SYLA

Crystal structure of inactive mutant dutpase complexed with substrate dutp
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
137
structure length
137
Chain Sequence
MMKKIDVKILDPRVGKEFPLPTYATSGSAGLDLRACLNDAVELAPGDTTLVPTGLAIHIADPSLAAMMLPRSGLGHKHGIVLGNLVGLINSDYQGQLMISVWNRGQDSFTIQPGERIAQMIFVPVVQAEFNLVEDFD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Insights into the Catalytic Mechanism of Phosphate Ester Hydrolysis by dUTPase
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Deoxyuridine 5'-triphosphate nucleotidohydrolase
total genus 22
structure length 137
sequence length 137
ec nomenclature ec 3.6.1.23: dUTP diphosphatase.
pdb deposition date 2004-04-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00692 dUTPase dUTPase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.40.10 Mainly Beta Distorted Sandwich Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A 1sylA00
1SM8A 3GF0A 3TPSA 3HZAA 2PY4A 2Y1TA 1DUNA 2XX6A 1XS1A 1DUCA 3TRNA 2J4HA 2BT1A 1OGHA 2PC5A 3TSLA 2J4QA 2HR6A 2QLPA 1F7RA 1SJNA 3T70A 1SMCA 4APZ1 5ECTA 2WE0A 1F7QA 1RN8A 3I93A 2XCEA 1SLHA 1F7KA 1VYQA 3TQZA 3TS6A 1MQ7A 3TQ4A 3HHQA 3TPWA 1SEHA 4GCYA 1PKHA 2Y8CA 3LQWA 1EU5A 2HRMA 3TP1A 1PKKA 4B0HA 5F9KA 4GK6A 3ZF2A 2BAZA 2D4MA 5CCOA 2WE2A 4AO5A 1DUTA 1XS4A 3TQ5A 3ECYA 3TTAA 3SO2A 4AOZA 1PKJA 1F7NA 2OL1A 2WE3A 4DHKA 3TPYA 3ARAA 4GV8A 2HXDA 3KM3A 2HQUA 5EDDA 1DUDA 4OOPA 3CA9A 3C3IA 3ZEZA 2QXXA 2R9QA 2OL0A 3P48A 3LOJA 1F7DA 1RNJA 3ARNA 3MDXA 1F7OA 2HXBA 2OKBA 3TRLA 1Q5UX 3T60A 3ZF3A 3H6XA 4AOOA 2XY3A 4XJCA 2OKEA 3ZF4A 1Q5HA 2V9XA 3MBQA 3H6DA 3TQ3A 3T6YA 1SNFA 2WE1A 2YZJA 2XCDA 2OKDA 1XS6A 2D4NA 1DUPA 3F4FA 4A6AA 5CCTA 3C2TA 3T64A 3TPNA 4LHRA 1EUWA 3ZF5A 4WRKA 2BSYA 4OOQA 1SYLA 1F7PA 2ZDCA 3ZF0A 1SIXA 3EHWA 3ZF1A 2D4LA 3ZF6A
chains in the Genus database with same CATH superfamily
1SM8A 3GF0A 3TPSA 3HZAA 2PY4A 2Y1TA 1DUNA 2XX6A 1XS1A 1DUCA 3TRNA 2J4HA 2BT1A 1OGHA 2PC5A 3TSLA 2J4QA 2HR6A 2QLPA 1F7RA 1SJNA 3T70A 1SMCA 4APZ1 5ECTA 2WE0A 1F7QA 1RN8A 3I93A 2XCEA 1SLHA 1F7KA 1VYQA 3TQZA 3TS6A 1MQ7A 3TQ4A 3HHQA 3TPWA 1SEHA 4GCYA 1PKHA 2Y8CA 3LQWA 1EU5A 2HRMA 3TP1A 1PKKA 4B0HA 5F9KA 4GK6A 3ZF2A 2BAZA 2D4MA 5CCOA 2WE2A 4AO5A 1DUTA 1XS4A 3TQ5A 3ECYA 3TTAA 3SO2A 4AOZA 1PKJA 1F7NA 2OL1A 2WE3A 4DHKA 3TPYA 3ARAA 4GV8A 2HXDA 3KM3A 2HQUA 5EDDA 1DUDA 4OOPA 3CA9A 3C3IA 3ZEZA 2QXXA 2R9QA 2OL0A 3P48A 3LOJA 1F7DA 1RNJA 3ARNA 3MDXA 1F7OA 2HXBA 2OKBA 3TRLA 1Q5UX 3T60A 3ZF3A 3H6XA 4AOOA 2XY3A 4XJCA 2OKEA 1TULA 3ZF4A 1Q5HA 2V9XA 3MBQA 3H6DA 3TQ3A 3T6YA 1SNFA 2WE1A 2YZJA 2XCDA 2OKDA 1XS6A 2D4NA 1DUPA 3F4FA 4A6AA 5CCTA 3C2TA 3T64A 3TPNA 4LHRA 1EUWA 3ZF5A 4WRKA 2BSYA 4OOQA 1SYLA 1F7PA 2ZDCA 3ZF0A 1SIXA 3EHWA 3ZF1A 2D4LA 3ZF6A
chains in the Genus database with same CATH topology
1SM8A 3GF0A 3TPSA 3HZAA 2PY4A 2Y1TA 1DUNA 2XX6A 1XS1A 1DUCA 3TRNA 2J4HA 2BT1A 1OGHA 2PC5A 3TSLA 2J4QA 2HR6A 2QLPA 1F7RA 1SJNA 3T70A 1SMCA 4APZ1 5ECTA 2WE0A 1F7QA 1RN8A 3I93A 2XCEA 1SLHA 1F7KA 1VYQA 3TQZA 3TS6A 1MQ7A 3TQ4A 3HHQA 3TPWA 1SEHA 4GCYA 1PKHA 2Y8CA 3LQWA 1EU5A 2HRMA 3TP1A 1PKKA 4B0HA 5F9KA 4GK6A 3ZF2A 2BAZA 2D4MA 5CCOA 2WE2A 4AO5A 1DUTA 1XS4A 3TQ5A 3ECYA 3TTAA 3SO2A 4AOZA 1PKJA 1F7NA 2OL1A 2WE3A 4DHKA 3TPYA 3ARAA 4GV8A 2HXDA 3KM3A 2HQUA 5EDDA 1DUDA 4OOPA 3CA9A 3C3IA 3ZEZA 2QXXA 2R9QA 2OL0A 3P48A 3LOJA 1F7DA 1RNJA 3ARNA 3MDXA 1F7OA 2HXBA 2OKBA 3TRLA 1Q5UX 3T60A 3ZF3A 3H6XA 4AOOA 2XY3A 4XJCA 2OKEA 3ZF4A 1Q5HA 2V9XA 3MBQA 3H6DA 3TQ3A 3T6YA 1SNFA 2WE1A 2YZJA 2XCDA 2OKDA 1XS6A 2D4NA 1DUPA 3F4FA 4A6AA 5CCTA 3C2TA 3T64A 3TPNA 4LHRA 1EUWA 3ZF5A 4WRKA 2BSYA 4OOQA 1SYLA 1F7PA 2ZDCA 3ZF0A 1SIXA 3EHWA 3ZF1A 2D4LA 3ZF6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SM8 A;  3GF0 A;  3TPS A;  3HZA A;  2PY4 A;  2Y1T A;  1DUN A;  2XX6 A;  1XS1 A;  1DUC A;  3TRN A;  2J4H A;  2BT1 A;  1OGH A;  2PC5 A;  3TSL A;  2J4Q A;  2HR6 A;  2QLP A;  1F7R A;  1SJN A;  3T70 A;  1SMC A;  4APZ 1;  5ECT A;  2WE0 A;  1F7Q A;  1RN8 A;  3I93 A;  2XCE A;  1SLH A;  1F7K A;  1VYQ A;  3TQZ A;  3TS6 A;  1MQ7 A;  3TQ4 A;  3HHQ A;  3TPW A;  1SEH A;  4GCY A;  1PKH A;  2Y8C A;  3LQW A;  1EU5 A;  2HRM A;  3TP1 A;  1PKK A;  4B0H A;  5F9K A;  4GK6 A;  3ZF2 A;  2BAZ A;  2D4M A;  5CCO A;  2WE2 A;  4AO5 A;  1DUT A;  1XS4 A;  3TQ5 A;  3ECY A;  3TTA A;  3SO2 A;  4AOZ A;  1PKJ A;  1F7N A;  2OL1 A;  2WE3 A;  4DHK A;  3TPY A;  3ARA A;  4GV8 A;  2HXD A;  3KM3 A;  2HQU A;  5EDD A;  1DUD A;  4OOP A;  3CA9 A;  3C3I A;  3ZEZ A;  2QXX A;  2R9Q A;  2OL0 A;  3P48 A;  3LOJ A;  1F7D A;  1RNJ A;  3ARN A;  3MDX A;  1F7O A;  2HXB A;  2OKB A;  3TRL A;  1Q5U X;  3T60 A;  3ZF3 A;  3H6X A;  4AOO A;  2XY3 A;  4XJC A;  2OKE A;  3ZF4 A;  1Q5H A;  2V9X A;  3MBQ A;  3H6D A;  3TQ3 A;  3T6Y A;  1SNF A;  2WE1 A;  2YZJ A;  2XCD A;  2OKD A;  1XS6 A;  2D4N A;  1DUP A;  3F4F A;  4A6A A;  5CCT A;  3C2T A;  3T64 A;  3TPN A;  4LHR A;  1EUW A;  3ZF5 A;  4WRK A;  2BSY A;  4OOQ A;  1SYL A;  1F7P A;  2ZDC A;  3ZF0 A;  1SIX A;  3EHW A;  3ZF1 A;  2D4L A;  3ZF6 A; 
#chains in the Genus database with same CATH topology
 1SM8 A;  3GF0 A;  3TPS A;  3HZA A;  2PY4 A;  2Y1T A;  1DUN A;  2XX6 A;  1XS1 A;  1DUC A;  3TRN A;  2J4H A;  2BT1 A;  1OGH A;  2PC5 A;  3TSL A;  2J4Q A;  2HR6 A;  2QLP A;  1F7R A;  1SJN A;  3T70 A;  1SMC A;  4APZ 1;  5ECT A;  2WE0 A;  1F7Q A;  1RN8 A;  3I93 A;  2XCE A;  1SLH A;  1F7K A;  1VYQ A;  3TQZ A;  3TS6 A;  1MQ7 A;  3TQ4 A;  3HHQ A;  3TPW A;  1SEH A;  4GCY A;  1PKH A;  2Y8C A;  3LQW A;  1EU5 A;  2HRM A;  3TP1 A;  1PKK A;  4B0H A;  5F9K A;  4GK6 A;  3ZF2 A;  2BAZ A;  2D4M A;  5CCO A;  2WE2 A;  4AO5 A;  1DUT A;  1XS4 A;  3TQ5 A;  3ECY A;  3TTA A;  3SO2 A;  4AOZ A;  1PKJ A;  1F7N A;  2OL1 A;  2WE3 A;  4DHK A;  3TPY A;  3ARA A;  4GV8 A;  2HXD A;  3KM3 A;  2HQU A;  5EDD A;  1DUD A;  4OOP A;  3CA9 A;  3C3I A;  3ZEZ A;  2QXX A;  2R9Q A;  2OL0 A;  3P48 A;  3LOJ A;  1F7D A;  1RNJ A;  3ARN A;  3MDX A;  1F7O A;  2HXB A;  2OKB A;  3TRL A;  1Q5U X;  3T60 A;  3ZF3 A;  3H6X A;  4AOO A;  2XY3 A;  4XJC A;  2OKE A;  1TUL A;  3ZF4 A;  1Q5H A;  2V9X A;  3MBQ A;  3H6D A;  3TQ3 A;  3T6Y A;  1SNF A;  2WE1 A;  2YZJ A;  2XCD A;  2OKD A;  1XS6 A;  2D4N A;  1DUP A;  3F4F A;  4A6A A;  5CCT A;  3C2T A;  3T64 A;  3TPN A;  4LHR A;  1EUW A;  3ZF5 A;  4WRK A;  2BSY A;  4OOQ A;  1SYL A;  1F7P A;  2ZDC A;  3ZF0 A;  1SIX A;  3EHW A;  3ZF1 A;  2D4L A;  3ZF6 A; 
#chains in the Genus database with same CATH homology
 1SM8 A;  3GF0 A;  3TPS A;  3HZA A;  2PY4 A;  2Y1T A;  1DUN A;  2XX6 A;  1XS1 A;  1DUC A;  3TRN A;  2J4H A;  2BT1 A;  1OGH A;  2PC5 A;  3TSL A;  2J4Q A;  2HR6 A;  2QLP A;  1F7R A;  1SJN A;  3T70 A;  1SMC A;  4APZ 1;  5ECT A;  2WE0 A;  1F7Q A;  1RN8 A;  3I93 A;  2XCE A;  1SLH A;  1F7K A;  1VYQ A;  3TQZ A;  3TS6 A;  1MQ7 A;  3TQ4 A;  3HHQ A;  3TPW A;  1SEH A;  4GCY A;  1PKH A;  2Y8C A;  3LQW A;  1EU5 A;  2HRM A;  3TP1 A;  1PKK A;  4B0H A;  5F9K A;  4GK6 A;  3ZF2 A;  2BAZ A;  2D4M A;  5CCO A;  2WE2 A;  4AO5 A;  1DUT A;  1XS4 A;  3TQ5 A;  3ECY A;  3TTA A;  3SO2 A;  4AOZ A;  1PKJ A;  1F7N A;  2OL1 A;  2WE3 A;  4DHK A;  3TPY A;  3ARA A;  4GV8 A;  2HXD A;  3KM3 A;  2HQU A;  5EDD A;  1DUD A;  4OOP A;  3CA9 A;  3C3I A;  3ZEZ A;  2QXX A;  2R9Q A;  2OL0 A;  3P48 A;  3LOJ A;  1F7D A;  1RNJ A;  3ARN A;  3MDX A;  1F7O A;  2HXB A;  2OKB A;  3TRL A;  1Q5U X;  3T60 A;  3ZF3 A;  3H6X A;  4AOO A;  2XY3 A;  4XJC A;  2OKE A;  3ZF4 A;  1Q5H A;  2V9X A;  3MBQ A;  3H6D A;  3TQ3 A;  3T6Y A;  1SNF A;  2WE1 A;  2YZJ A;  2XCD A;  2OKD A;  1XS6 A;  2D4N A;  1DUP A;  3F4F A;  4A6A A;  5CCT A;  3C2T A;  3T64 A;  3TPN A;  4LHR A;  1EUW A;  3ZF5 A;  4WRK A;  2BSY A;  4OOQ A;  1SYL A;  1F7P A;  2ZDC A;  3ZF0 A;  1SIX A;  3EHW A;  3ZF1 A;  2D4L A;  3ZF6 A; 
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similar chains in the Genus database (?% sequence similarity)
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