1WKWA

Crystal structure of the ternary complex of eif4e-m7gpppa-4ebp1 peptide
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
191
structure length
191
Chain Sequence
EVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods
pubmed doi rcsb
molecule tags Translation/protein binding
source organism Homo sapiens
molecule keywords Eukaryotic translation initiation factor 4E
total genus 59
structure length 191
sequence length 191
ec nomenclature
pdb deposition date 2004-06-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01652 IF4E Eukaryotic initiation factor 4E
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.760.10 Alpha Beta 2-Layer Sandwich RNA Cap, Translation Initiation Factor Eif4e RNA Cap, Translation Initiation Factor Eif4e 1wkwA00
3M93A 2V8WA 2W97A 5T46A 2GPQA 2IDRA 5EIRA 5T47A 4UEDA 1ZTPA 2W97B 1RF8A 5ABUA 2Q4KA 4UEBA 5EI3A 4UECA 5GW6A 2JGCA 4BEAA 5ABYA 4B6VA 4AXGA 1WKWA 5ABXA 2V8XA 2IDVA 4AZAA 5BXVA 5EHCA 1EJ4A 3AM7A 3HXIA 4UE8A 3TF2A 1L8BA 1IPBA 1AP8A 5T48A 4DUMA 5ABVA 2WMCA 4DT6A 5EKVA 4TQCA 1EJHA 3M94A 4TQBA 4UE9A 1EJ1A 1IPCA 4B6UA 3HXGA 3U7XA 2V8YA 4UEAA 4TPWA 2JGBA
chains in the Genus database with same CATH superfamily
3M93A 2V8WA 2W97A 5T46A 2GPQA 2IDRA 5EIRA 5T47A 4UEDA 1ZTPA 2W97B 1RF8A 5ABUA 2Q4KA 4UEBA 5EI3A 4UECA 5GW6A 2JGCA 4BEAA 5ABYA 4B6VA 4AXGA 1WKWA 5ABXA 2V8XA 2IDVA 4AZAA 5BXVA 5EHCA 1EJ4A 3AM7A 3HXIA 4UE8A 3TF2A 1L8BA 1IPBA 1AP8A 5T48A 4DUMA 5ABVA 2WMCA 4DT6A 5EKVA 4TQCA 1EJHA 3M94A 4TQBA 4UE9A 1EJ1A 1IPCA 4B6UA 3HXGA 3U7XA 2V8YA 4UEAA 4TPWA 2JGBA
chains in the Genus database with same CATH topology
3M93A 2V8WA 2W97A 5T46A 2GPQA 2IDRA 5EIRA 5T47A 4UEDA 1ZTPA 2W97B 1RF8A 5ABUA 2Q4KA 4UEBA 5EI3A 4UECA 5GW6A 2JGCA 4BEAA 5ABYA 4B6VA 4AXGA 1WKWA 5ABXA 2V8XA 2IDVA 4AZAA 5BXVA 5EHCA 1EJ4A 3AM7A 3HXIA 4UE8A 3TF2A 1L8BA 1IPBA 1AP8A 5T48A 4DUMA 5ABVA 2WMCA 4DT6A 5EKVA 4TQCA 1EJHA 3M94A 4TQBA 4UE9A 1EJ1A 1IPCA 4B6UA 3HXGA 3U7XA 2V8YA 4UEAA 4TPWA 2JGBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M93 A;  2V8W A;  2W97 A;  5T46 A;  2GPQ A;  2IDR A;  5EIR A;  5T47 A;  4UED A;  1ZTP A;  2W97 B;  1RF8 A;  5ABU A;  2Q4K A;  4UEB A;  5EI3 A;  4UEC A;  5GW6 A;  2JGC A;  4BEA A;  5ABY A;  4B6V A;  4AXG A;  1WKW A;  5ABX A;  2V8X A;  2IDV A;  4AZA A;  5BXV A;  5EHC A;  1EJ4 A;  3AM7 A;  3HXI A;  4UE8 A;  3TF2 A;  1L8B A;  1IPB A;  1AP8 A;  5T48 A;  4DUM A;  5ABV A;  2WMC A;  4DT6 A;  5EKV A;  4TQC A;  1EJH A;  3M94 A;  4TQB A;  4UE9 A;  1EJ1 A;  1IPC A;  4B6U A;  3HXG A;  3U7X A;  2V8Y A;  4UEA A;  4TPW A;  2JGB A; 
#chains in the Genus database with same CATH topology
 3M93 A;  2V8W A;  2W97 A;  5T46 A;  2GPQ A;  2IDR A;  5EIR A;  5T47 A;  4UED A;  1ZTP A;  2W97 B;  1RF8 A;  5ABU A;  2Q4K A;  4UEB A;  5EI3 A;  4UEC A;  5GW6 A;  2JGC A;  4BEA A;  5ABY A;  4B6V A;  4AXG A;  1WKW A;  5ABX A;  2V8X A;  2IDV A;  4AZA A;  5BXV A;  5EHC A;  1EJ4 A;  3AM7 A;  3HXI A;  4UE8 A;  3TF2 A;  1L8B A;  1IPB A;  1AP8 A;  5T48 A;  4DUM A;  5ABV A;  2WMC A;  4DT6 A;  5EKV A;  4TQC A;  1EJH A;  3M94 A;  4TQB A;  4UE9 A;  1EJ1 A;  1IPC A;  4B6U A;  3HXG A;  3U7X A;  2V8Y A;  4UEA A;  4TPW A;  2JGB A; 
#chains in the Genus database with same CATH homology
 3M93 A;  2V8W A;  2W97 A;  5T46 A;  2GPQ A;  2IDR A;  5EIR A;  5T47 A;  4UED A;  1ZTP A;  2W97 B;  1RF8 A;  5ABU A;  2Q4K A;  4UEB A;  5EI3 A;  4UEC A;  5GW6 A;  2JGC A;  4BEA A;  5ABY A;  4B6V A;  4AXG A;  1WKW A;  5ABX A;  2V8X A;  2IDV A;  4AZA A;  5BXV A;  5EHC A;  1EJ4 A;  3AM7 A;  3HXI A;  4UE8 A;  3TF2 A;  1L8B A;  1IPB A;  1AP8 A;  5T48 A;  4DUM A;  5ABV A;  2WMC A;  4DT6 A;  5EKV A;  4TQC A;  1EJH A;  3M94 A;  4TQB A;  4UE9 A;  1EJ1 A;  1IPC A;  4B6U A;  3HXG A;  3U7X A;  2V8Y A;  4UEA A;  4TPW A;  2JGB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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