1SM8A

M. tuberculosis dutpase complexed with chromium and dutp
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
131
structure length
131
Chain Sequence
STTLAIVRLDPGLPLPSRAHDGDAGVDLYSAEDVELAPGRRALVRTGVAVAVPFGMVGLVHPRSGLATRVGLSIVNSPGTIDAGYRGEIKVALINLDPAAPIVVHRGDRIAQLLVQRVELVELVEVSSFDE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism.
pubmed doi rcsb
molecule tags Hydrolase
source organism Mycobacterium tuberculosis
molecule keywords Deoxyuridine 5'-triphosphate nucleotidohydrolase
total genus 18
structure length 131
sequence length 131
chains with identical sequence B, C
ec nomenclature ec 3.6.1.23: dUTP diphosphatase.
pdb deposition date 2004-03-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00692 dUTPase dUTPase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.40.10 Mainly Beta Distorted Sandwich Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A 1sm8A00
2YZJA 1RN8A 1XS6A 3ZEZA 1OGHA 4GK6A 2D4MA 1PKHA 4B0HA 3SO2A 3T6YA 3ARNA 3ZF4A 4GV8A 3P48A 4OOPA 3I93A 1DUPA 2PY4A 4AOOA 3C2TA 4A6AA 3TTAA 3EHWA 2XX6A 5F9KA 4AOZA 3ECYA 4APZ1 2BAZA 1F7PA 2Y1TA 3TPWA 3TSLA 2WE2A 1SM8A 2OL0A 3LOJA 4GCYA 3GF0A 3TRNA 2BSYA 3HHQA 4OOQA 2HR6A 2HRMA 2D4NA 3T60A 2HXDA 1F7DA 1SYLA 3ZF2A 2Y8CA 2ZDCA 3HZAA 1VYQA 2QXXA 2OKDA 1SNFA 5EDDA 3F4FA 2D4LA 1DUNA 4AO5A 1SEHA 1SLHA 1Q5UX 3TPNA 1F7RA 1SIXA 3T64A 3TPYA 1RNJA 3ZF0A 2QLPA 1EU5A 3TQ5A 2V9XA 2OKBA 2XCEA 4WRKA 3TPSA 2XY3A 5CCOA 3ZF3A 1XS4A 5ECTA 3ZF5A 3ZF6A 2WE1A 3KM3A 3CA9A 2OKEA 2WE3A 3H6DA 1DUTA 2XCDA 1F7KA 2WE0A 1EUWA 2BT1A 2J4QA 4LHRA 3TQ4A 3C3IA 3ZF1A 5CCTA 1DUCA 1F7NA 4XJCA 2HQUA 3MDXA 3TQZA 3TRLA 3TQ3A 2R9QA 2PC5A 3T70A 1F7OA 1XS1A 3MBQA 1PKJA 1F7QA 1MQ7A 1PKKA 3ARAA 1DUDA 2J4HA 1Q5HA 1SMCA 1SJNA 3TP1A 3LQWA 3H6XA 2HXBA 3TS6A 2OL1A 4DHKA
chains in the Genus database with same CATH superfamily
2YZJA 1RN8A 1XS6A 3ZEZA 1OGHA 4GK6A 2D4MA 1PKHA 4B0HA 3SO2A 3T6YA 3ARNA 3ZF4A 4GV8A 3P48A 4OOPA 3I93A 1DUPA 2PY4A 4AOOA 3C2TA 4A6AA 3TTAA 3EHWA 2XX6A 5F9KA 4AOZA 3ECYA 4APZ1 2BAZA 1F7PA 2Y1TA 1TULA 3TPWA 3TSLA 2WE2A 1SM8A 2OL0A 3LOJA 4GCYA 3GF0A 3TRNA 2BSYA 3HHQA 4OOQA 2HR6A 2HRMA 2D4NA 3T60A 2HXDA 1F7DA 1SYLA 3ZF2A 2Y8CA 2ZDCA 3HZAA 1VYQA 2QXXA 2OKDA 1SNFA 5EDDA 3F4FA 2D4LA 1DUNA 4AO5A 1SEHA 1SLHA 1Q5UX 3TPNA 1F7RA 1SIXA 3T64A 3TPYA 1RNJA 3ZF0A 2QLPA 1EU5A 3TQ5A 2V9XA 2OKBA 2XCEA 4WRKA 3TPSA 2XY3A 5CCOA 3ZF3A 1XS4A 5ECTA 3ZF5A 3ZF6A 2WE1A 3KM3A 3CA9A 2OKEA 2WE3A 3H6DA 1DUTA 2XCDA 1F7KA 2WE0A 1EUWA 2BT1A 2J4QA 4LHRA 3TQ4A 3C3IA 3ZF1A 5CCTA 1DUCA 1F7NA 4XJCA 2HQUA 3MDXA 3TQZA 3TRLA 3TQ3A 2R9QA 2PC5A 3T70A 1F7OA 1XS1A 3MBQA 1PKJA 1F7QA 1MQ7A 1PKKA 3ARAA 1DUDA 2J4HA 1Q5HA 1SMCA 1SJNA 3TP1A 3LQWA 3H6XA 2HXBA 3TS6A 2OL1A 4DHKA
chains in the Genus database with same CATH topology
2YZJA 1RN8A 1XS6A 3ZEZA 1OGHA 4GK6A 2D4MA 1PKHA 4B0HA 3SO2A 3T6YA 3ARNA 3ZF4A 4GV8A 3P48A 4OOPA 3I93A 1DUPA 2PY4A 4AOOA 3C2TA 4A6AA 3TTAA 3EHWA 2XX6A 5F9KA 4AOZA 3ECYA 4APZ1 2BAZA 1F7PA 2Y1TA 3TPWA 3TSLA 2WE2A 1SM8A 2OL0A 3LOJA 4GCYA 3GF0A 3TRNA 2BSYA 3HHQA 4OOQA 2HR6A 2HRMA 2D4NA 3T60A 2HXDA 1F7DA 1SYLA 3ZF2A 2Y8CA 2ZDCA 3HZAA 1VYQA 2QXXA 2OKDA 1SNFA 5EDDA 3F4FA 2D4LA 1DUNA 4AO5A 1SEHA 1SLHA 1Q5UX 3TPNA 1F7RA 1SIXA 3T64A 3TPYA 1RNJA 3ZF0A 2QLPA 1EU5A 3TQ5A 2V9XA 2OKBA 2XCEA 4WRKA 3TPSA 2XY3A 5CCOA 3ZF3A 1XS4A 5ECTA 3ZF5A 3ZF6A 2WE1A 3KM3A 3CA9A 2OKEA 2WE3A 3H6DA 1DUTA 2XCDA 1F7KA 2WE0A 1EUWA 2BT1A 2J4QA 4LHRA 3TQ4A 3C3IA 3ZF1A 5CCTA 1DUCA 1F7NA 4XJCA 2HQUA 3MDXA 3TQZA 3TRLA 3TQ3A 2R9QA 2PC5A 3T70A 1F7OA 1XS1A 3MBQA 1PKJA 1F7QA 1MQ7A 1PKKA 3ARAA 1DUDA 2J4HA 1Q5HA 1SMCA 1SJNA 3TP1A 3LQWA 3H6XA 2HXBA 3TS6A 2OL1A 4DHKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YZJ A;  1RN8 A;  1XS6 A;  3ZEZ A;  1OGH A;  4GK6 A;  2D4M A;  1PKH A;  4B0H A;  3SO2 A;  3T6Y A;  3ARN A;  3ZF4 A;  4GV8 A;  3P48 A;  4OOP A;  3I93 A;  1DUP A;  2PY4 A;  4AOO A;  3C2T A;  4A6A A;  3TTA A;  3EHW A;  2XX6 A;  5F9K A;  4AOZ A;  3ECY A;  4APZ 1;  2BAZ A;  1F7P A;  2Y1T A;  3TPW A;  3TSL A;  2WE2 A;  1SM8 A;  2OL0 A;  3LOJ A;  4GCY A;  3GF0 A;  3TRN A;  2BSY A;  3HHQ A;  4OOQ A;  2HR6 A;  2HRM A;  2D4N A;  3T60 A;  2HXD A;  1F7D A;  1SYL A;  3ZF2 A;  2Y8C A;  2ZDC A;  3HZA A;  1VYQ A;  2QXX A;  2OKD A;  1SNF A;  5EDD A;  3F4F A;  2D4L A;  1DUN A;  4AO5 A;  1SEH A;  1SLH A;  1Q5U X;  3TPN A;  1F7R A;  1SIX A;  3T64 A;  3TPY A;  1RNJ A;  3ZF0 A;  2QLP A;  1EU5 A;  3TQ5 A;  2V9X A;  2OKB A;  2XCE A;  4WRK A;  3TPS A;  2XY3 A;  5CCO A;  3ZF3 A;  1XS4 A;  5ECT A;  3ZF5 A;  3ZF6 A;  2WE1 A;  3KM3 A;  3CA9 A;  2OKE A;  2WE3 A;  3H6D A;  1DUT A;  2XCD A;  1F7K A;  2WE0 A;  1EUW A;  2BT1 A;  2J4Q A;  4LHR A;  3TQ4 A;  3C3I A;  3ZF1 A;  5CCT A;  1DUC A;  1F7N A;  4XJC A;  2HQU A;  3MDX A;  3TQZ A;  3TRL A;  3TQ3 A;  2R9Q A;  2PC5 A;  3T70 A;  1F7O A;  1XS1 A;  3MBQ A;  1PKJ A;  1F7Q A;  1MQ7 A;  1PKK A;  3ARA A;  1DUD A;  2J4H A;  1Q5H A;  1SMC A;  1SJN A;  3TP1 A;  3LQW A;  3H6X A;  2HXB A;  3TS6 A;  2OL1 A;  4DHK A; 
#chains in the Genus database with same CATH topology
 2YZJ A;  1RN8 A;  1XS6 A;  3ZEZ A;  1OGH A;  4GK6 A;  2D4M A;  1PKH A;  4B0H A;  3SO2 A;  3T6Y A;  3ARN A;  3ZF4 A;  4GV8 A;  3P48 A;  4OOP A;  3I93 A;  1DUP A;  2PY4 A;  4AOO A;  3C2T A;  4A6A A;  3TTA A;  3EHW A;  2XX6 A;  5F9K A;  4AOZ A;  3ECY A;  4APZ 1;  2BAZ A;  1F7P A;  2Y1T A;  1TUL A;  3TPW A;  3TSL A;  2WE2 A;  1SM8 A;  2OL0 A;  3LOJ A;  4GCY A;  3GF0 A;  3TRN A;  2BSY A;  3HHQ A;  4OOQ A;  2HR6 A;  2HRM A;  2D4N A;  3T60 A;  2HXD A;  1F7D A;  1SYL A;  3ZF2 A;  2Y8C A;  2ZDC A;  3HZA A;  1VYQ A;  2QXX A;  2OKD A;  1SNF A;  5EDD A;  3F4F A;  2D4L A;  1DUN A;  4AO5 A;  1SEH A;  1SLH A;  1Q5U X;  3TPN A;  1F7R A;  1SIX A;  3T64 A;  3TPY A;  1RNJ A;  3ZF0 A;  2QLP A;  1EU5 A;  3TQ5 A;  2V9X A;  2OKB A;  2XCE A;  4WRK A;  3TPS A;  2XY3 A;  5CCO A;  3ZF3 A;  1XS4 A;  5ECT A;  3ZF5 A;  3ZF6 A;  2WE1 A;  3KM3 A;  3CA9 A;  2OKE A;  2WE3 A;  3H6D A;  1DUT A;  2XCD A;  1F7K A;  2WE0 A;  1EUW A;  2BT1 A;  2J4Q A;  4LHR A;  3TQ4 A;  3C3I A;  3ZF1 A;  5CCT A;  1DUC A;  1F7N A;  4XJC A;  2HQU A;  3MDX A;  3TQZ A;  3TRL A;  3TQ3 A;  2R9Q A;  2PC5 A;  3T70 A;  1F7O A;  1XS1 A;  3MBQ A;  1PKJ A;  1F7Q A;  1MQ7 A;  1PKK A;  3ARA A;  1DUD A;  2J4H A;  1Q5H A;  1SMC A;  1SJN A;  3TP1 A;  3LQW A;  3H6X A;  2HXB A;  3TS6 A;  2OL1 A;  4DHK A; 
#chains in the Genus database with same CATH homology
 2YZJ A;  1RN8 A;  1XS6 A;  3ZEZ A;  1OGH A;  4GK6 A;  2D4M A;  1PKH A;  4B0H A;  3SO2 A;  3T6Y A;  3ARN A;  3ZF4 A;  4GV8 A;  3P48 A;  4OOP A;  3I93 A;  1DUP A;  2PY4 A;  4AOO A;  3C2T A;  4A6A A;  3TTA A;  3EHW A;  2XX6 A;  5F9K A;  4AOZ A;  3ECY A;  4APZ 1;  2BAZ A;  1F7P A;  2Y1T A;  3TPW A;  3TSL A;  2WE2 A;  1SM8 A;  2OL0 A;  3LOJ A;  4GCY A;  3GF0 A;  3TRN A;  2BSY A;  3HHQ A;  4OOQ A;  2HR6 A;  2HRM A;  2D4N A;  3T60 A;  2HXD A;  1F7D A;  1SYL A;  3ZF2 A;  2Y8C A;  2ZDC A;  3HZA A;  1VYQ A;  2QXX A;  2OKD A;  1SNF A;  5EDD A;  3F4F A;  2D4L A;  1DUN A;  4AO5 A;  1SEH A;  1SLH A;  1Q5U X;  3TPN A;  1F7R A;  1SIX A;  3T64 A;  3TPY A;  1RNJ A;  3ZF0 A;  2QLP A;  1EU5 A;  3TQ5 A;  2V9X A;  2OKB A;  2XCE A;  4WRK A;  3TPS A;  2XY3 A;  5CCO A;  3ZF3 A;  1XS4 A;  5ECT A;  3ZF5 A;  3ZF6 A;  2WE1 A;  3KM3 A;  3CA9 A;  2OKE A;  2WE3 A;  3H6D A;  1DUT A;  2XCD A;  1F7K A;  2WE0 A;  1EUW A;  2BT1 A;  2J4Q A;  4LHR A;  3TQ4 A;  3C3I A;  3ZF1 A;  5CCT A;  1DUC A;  1F7N A;  4XJC A;  2HQU A;  3MDX A;  3TQZ A;  3TRL A;  3TQ3 A;  2R9Q A;  2PC5 A;  3T70 A;  1F7O A;  1XS1 A;  3MBQ A;  1PKJ A;  1F7Q A;  1MQ7 A;  1PKK A;  3ARA A;  1DUD A;  2J4H A;  1Q5H A;  1SMC A;  1SJN A;  3TP1 A;  3LQW A;  3H6X A;  2HXB A;  3TS6 A;  2OL1 A;  4DHK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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