1SMCA

Mycobacterium tuberculosis dutpase complexed with dutp in the absence of metal ion.
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
130
structure length
130
Chain Sequence
TTLAIVRLDPGLPLPSRAHDGDAGVDLYSAEDVELAPGRRALVRTGVAVAVPFGMVGLVHPRSGLATRVGLSIVNSPGTIDAGYRGEIKVALINLDPAAPIVVHRGDRIAQLLVQRVELVELVEVSSFDE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism.
pubmed doi rcsb
molecule tags Hydrolase
source organism Mycobacterium tuberculosis
molecule keywords Deoxyuridine 5'-triphosphate nucleotidohydrolase
total genus 19
structure length 130
sequence length 130
chains with identical sequence B, C
ec nomenclature ec 3.6.1.23: dUTP diphosphatase.
pdb deposition date 2004-03-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00692 dUTPase dUTPase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.40.10 Mainly Beta Distorted Sandwich Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A 1smcA00
1XS6A 2HRMA 4A6AA 2BT1A 4DHKA 1F7RA 3I93A 3MDXA 3ARNA 3TPNA 3ZF1A 1SJNA 2HR6A 3TPSA 2Y8CA 2WE3A 1F7DA 1DUCA 1DUDA 2D4MA 1SMCA 1F7QA 1PKJA 2Y1TA 3MBQA 5F9KA 4OOPA 2R9QA 1SNFA 2D4NA 2YZJA 1SIXA 2OKDA 1XS4A 3TRLA 1F7OA 1DUTA 2OKBA 3ZF5A 2D4LA 3LOJA 3TQ4A 1SLHA 2HXBA 5CCOA 2WE0A 1RN8A 2QLPA 2HQUA 2V9XA 2QXXA 3KM3A 3TS6A 3T60A 3TRNA 2WE1A 3H6DA 4GK6A 3H6XA 3LQWA 1DUNA 3T70A 1EUWA 4AOOA 2XY3A 3ARAA 2OKEA 3HHQA 1SM8A 3SO2A 1Q5HA 2J4HA 3TP1A 4AOZA 3TQ5A 2OL1A 2BAZA 3TTAA 2PC5A 3T64A 3ZF0A 4GCYA 3C3IA 2WE2A 1SYLA 4OOQA 2XCDA 3ZEZA 1XS1A 5CCTA 3C2TA 4GV8A 3TSLA 1RNJA 3F4FA 1F7PA 3ECYA 3TQ3A 4LHRA 2XCEA 2XX6A 3HZAA 1PKKA 3P48A 4AO5A 3CA9A 4B0HA 3TPYA 4XJCA 1OGHA 3EHWA 2ZDCA 2OL0A 5EDDA 1EU5A 4WRKA 1SEHA 1Q5UX 5ECTA 3ZF3A 3ZF4A 2HXDA 1DUPA 2BSYA 1F7NA 3TQZA 3TPWA 1PKHA 1MQ7A 2PY4A 3ZF2A 4APZ1 1VYQA 3T6YA 2J4QA 3GF0A 1F7KA 3ZF6A
chains in the Genus database with same CATH superfamily
1XS6A 2HRMA 4A6AA 2BT1A 4DHKA 1F7RA 3I93A 3MDXA 3ARNA 3TPNA 3ZF1A 1SJNA 2HR6A 3TPSA 2Y8CA 2WE3A 1F7DA 1DUCA 1DUDA 2D4MA 1SMCA 1F7QA 1PKJA 2Y1TA 3MBQA 5F9KA 4OOPA 2R9QA 1SNFA 2D4NA 2YZJA 1SIXA 2OKDA 1XS4A 3TRLA 1F7OA 1DUTA 2OKBA 3ZF5A 2D4LA 3LOJA 3TQ4A 1SLHA 2HXBA 5CCOA 2WE0A 1RN8A 2QLPA 2HQUA 2V9XA 2QXXA 3KM3A 3TS6A 3T60A 3TRNA 2WE1A 3H6DA 4GK6A 3H6XA 3LQWA 1DUNA 3T70A 1EUWA 4AOOA 2XY3A 3ARAA 2OKEA 3HHQA 1SM8A 3SO2A 1Q5HA 2J4HA 3TP1A 4AOZA 3TQ5A 2OL1A 2BAZA 3TTAA 2PC5A 3T64A 3ZF0A 4GCYA 3C3IA 2WE2A 1SYLA 4OOQA 2XCDA 3ZEZA 1XS1A 5CCTA 3C2TA 4GV8A 3TSLA 1RNJA 3F4FA 1F7PA 3ECYA 3TQ3A 1TULA 4LHRA 2XCEA 2XX6A 3HZAA 1PKKA 3P48A 4AO5A 3CA9A 4B0HA 3TPYA 4XJCA 1OGHA 3EHWA 2ZDCA 2OL0A 5EDDA 1EU5A 4WRKA 1SEHA 1Q5UX 5ECTA 3ZF3A 3ZF4A 2HXDA 1DUPA 2BSYA 1F7NA 3TQZA 3TPWA 1PKHA 1MQ7A 2PY4A 3ZF2A 4APZ1 1VYQA 3T6YA 2J4QA 3GF0A 1F7KA 3ZF6A
chains in the Genus database with same CATH topology
1XS6A 2HRMA 4A6AA 2BT1A 4DHKA 1F7RA 3I93A 3MDXA 3ARNA 3TPNA 3ZF1A 1SJNA 2HR6A 3TPSA 2Y8CA 2WE3A 1F7DA 1DUCA 1DUDA 2D4MA 1SMCA 1F7QA 1PKJA 2Y1TA 3MBQA 5F9KA 4OOPA 2R9QA 1SNFA 2D4NA 2YZJA 1SIXA 2OKDA 1XS4A 3TRLA 1F7OA 1DUTA 2OKBA 3ZF5A 2D4LA 3LOJA 3TQ4A 1SLHA 2HXBA 5CCOA 2WE0A 1RN8A 2QLPA 2HQUA 2V9XA 2QXXA 3KM3A 3TS6A 3T60A 3TRNA 2WE1A 3H6DA 4GK6A 3H6XA 3LQWA 1DUNA 3T70A 1EUWA 4AOOA 2XY3A 3ARAA 2OKEA 3HHQA 1SM8A 3SO2A 1Q5HA 2J4HA 3TP1A 4AOZA 3TQ5A 2OL1A 2BAZA 3TTAA 2PC5A 3T64A 3ZF0A 4GCYA 3C3IA 2WE2A 1SYLA 4OOQA 2XCDA 3ZEZA 1XS1A 5CCTA 3C2TA 4GV8A 3TSLA 1RNJA 3F4FA 1F7PA 3ECYA 3TQ3A 4LHRA 2XCEA 2XX6A 3HZAA 1PKKA 3P48A 4AO5A 3CA9A 4B0HA 3TPYA 4XJCA 1OGHA 3EHWA 2ZDCA 2OL0A 5EDDA 1EU5A 4WRKA 1SEHA 1Q5UX 5ECTA 3ZF3A 3ZF4A 2HXDA 1DUPA 2BSYA 1F7NA 3TQZA 3TPWA 1PKHA 1MQ7A 2PY4A 3ZF2A 4APZ1 1VYQA 3T6YA 2J4QA 3GF0A 1F7KA 3ZF6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XS6 A;  2HRM A;  4A6A A;  2BT1 A;  4DHK A;  1F7R A;  3I93 A;  3MDX A;  3ARN A;  3TPN A;  3ZF1 A;  1SJN A;  2HR6 A;  3TPS A;  2Y8C A;  2WE3 A;  1F7D A;  1DUC A;  1DUD A;  2D4M A;  1SMC A;  1F7Q A;  1PKJ A;  2Y1T A;  3MBQ A;  5F9K A;  4OOP A;  2R9Q A;  1SNF A;  2D4N A;  2YZJ A;  1SIX A;  2OKD A;  1XS4 A;  3TRL A;  1F7O A;  1DUT A;  2OKB A;  3ZF5 A;  2D4L A;  3LOJ A;  3TQ4 A;  1SLH A;  2HXB A;  5CCO A;  2WE0 A;  1RN8 A;  2QLP A;  2HQU A;  2V9X A;  2QXX A;  3KM3 A;  3TS6 A;  3T60 A;  3TRN A;  2WE1 A;  3H6D A;  4GK6 A;  3H6X A;  3LQW A;  1DUN A;  3T70 A;  1EUW A;  4AOO A;  2XY3 A;  3ARA A;  2OKE A;  3HHQ A;  1SM8 A;  3SO2 A;  1Q5H A;  2J4H A;  3TP1 A;  4AOZ A;  3TQ5 A;  2OL1 A;  2BAZ A;  3TTA A;  2PC5 A;  3T64 A;  3ZF0 A;  4GCY A;  3C3I A;  2WE2 A;  1SYL A;  4OOQ A;  2XCD A;  3ZEZ A;  1XS1 A;  5CCT A;  3C2T A;  4GV8 A;  3TSL A;  1RNJ A;  3F4F A;  1F7P A;  3ECY A;  3TQ3 A;  4LHR A;  2XCE A;  2XX6 A;  3HZA A;  1PKK A;  3P48 A;  4AO5 A;  3CA9 A;  4B0H A;  3TPY A;  4XJC A;  1OGH A;  3EHW A;  2ZDC A;  2OL0 A;  5EDD A;  1EU5 A;  4WRK A;  1SEH A;  1Q5U X;  5ECT A;  3ZF3 A;  3ZF4 A;  2HXD A;  1DUP A;  2BSY A;  1F7N A;  3TQZ A;  3TPW A;  1PKH A;  1MQ7 A;  2PY4 A;  3ZF2 A;  4APZ 1;  1VYQ A;  3T6Y A;  2J4Q A;  3GF0 A;  1F7K A;  3ZF6 A; 
#chains in the Genus database with same CATH topology
 1XS6 A;  2HRM A;  4A6A A;  2BT1 A;  4DHK A;  1F7R A;  3I93 A;  3MDX A;  3ARN A;  3TPN A;  3ZF1 A;  1SJN A;  2HR6 A;  3TPS A;  2Y8C A;  2WE3 A;  1F7D A;  1DUC A;  1DUD A;  2D4M A;  1SMC A;  1F7Q A;  1PKJ A;  2Y1T A;  3MBQ A;  5F9K A;  4OOP A;  2R9Q A;  1SNF A;  2D4N A;  2YZJ A;  1SIX A;  2OKD A;  1XS4 A;  3TRL A;  1F7O A;  1DUT A;  2OKB A;  3ZF5 A;  2D4L A;  3LOJ A;  3TQ4 A;  1SLH A;  2HXB A;  5CCO A;  2WE0 A;  1RN8 A;  2QLP A;  2HQU A;  2V9X A;  2QXX A;  3KM3 A;  3TS6 A;  3T60 A;  3TRN A;  2WE1 A;  3H6D A;  4GK6 A;  3H6X A;  3LQW A;  1DUN A;  3T70 A;  1EUW A;  4AOO A;  2XY3 A;  3ARA A;  2OKE A;  3HHQ A;  1SM8 A;  3SO2 A;  1Q5H A;  2J4H A;  3TP1 A;  4AOZ A;  3TQ5 A;  2OL1 A;  2BAZ A;  3TTA A;  2PC5 A;  3T64 A;  3ZF0 A;  4GCY A;  3C3I A;  2WE2 A;  1SYL A;  4OOQ A;  2XCD A;  3ZEZ A;  1XS1 A;  5CCT A;  3C2T A;  4GV8 A;  3TSL A;  1RNJ A;  3F4F A;  1F7P A;  3ECY A;  3TQ3 A;  1TUL A;  4LHR A;  2XCE A;  2XX6 A;  3HZA A;  1PKK A;  3P48 A;  4AO5 A;  3CA9 A;  4B0H A;  3TPY A;  4XJC A;  1OGH A;  3EHW A;  2ZDC A;  2OL0 A;  5EDD A;  1EU5 A;  4WRK A;  1SEH A;  1Q5U X;  5ECT A;  3ZF3 A;  3ZF4 A;  2HXD A;  1DUP A;  2BSY A;  1F7N A;  3TQZ A;  3TPW A;  1PKH A;  1MQ7 A;  2PY4 A;  3ZF2 A;  4APZ 1;  1VYQ A;  3T6Y A;  2J4Q A;  3GF0 A;  1F7K A;  3ZF6 A; 
#chains in the Genus database with same CATH homology
 1XS6 A;  2HRM A;  4A6A A;  2BT1 A;  4DHK A;  1F7R A;  3I93 A;  3MDX A;  3ARN A;  3TPN A;  3ZF1 A;  1SJN A;  2HR6 A;  3TPS A;  2Y8C A;  2WE3 A;  1F7D A;  1DUC A;  1DUD A;  2D4M A;  1SMC A;  1F7Q A;  1PKJ A;  2Y1T A;  3MBQ A;  5F9K A;  4OOP A;  2R9Q A;  1SNF A;  2D4N A;  2YZJ A;  1SIX A;  2OKD A;  1XS4 A;  3TRL A;  1F7O A;  1DUT A;  2OKB A;  3ZF5 A;  2D4L A;  3LOJ A;  3TQ4 A;  1SLH A;  2HXB A;  5CCO A;  2WE0 A;  1RN8 A;  2QLP A;  2HQU A;  2V9X A;  2QXX A;  3KM3 A;  3TS6 A;  3T60 A;  3TRN A;  2WE1 A;  3H6D A;  4GK6 A;  3H6X A;  3LQW A;  1DUN A;  3T70 A;  1EUW A;  4AOO A;  2XY3 A;  3ARA A;  2OKE A;  3HHQ A;  1SM8 A;  3SO2 A;  1Q5H A;  2J4H A;  3TP1 A;  4AOZ A;  3TQ5 A;  2OL1 A;  2BAZ A;  3TTA A;  2PC5 A;  3T64 A;  3ZF0 A;  4GCY A;  3C3I A;  2WE2 A;  1SYL A;  4OOQ A;  2XCD A;  3ZEZ A;  1XS1 A;  5CCT A;  3C2T A;  4GV8 A;  3TSL A;  1RNJ A;  3F4F A;  1F7P A;  3ECY A;  3TQ3 A;  4LHR A;  2XCE A;  2XX6 A;  3HZA A;  1PKK A;  3P48 A;  4AO5 A;  3CA9 A;  4B0H A;  3TPY A;  4XJC A;  1OGH A;  3EHW A;  2ZDC A;  2OL0 A;  5EDD A;  1EU5 A;  4WRK A;  1SEH A;  1Q5U X;  5ECT A;  3ZF3 A;  3ZF4 A;  2HXD A;  1DUP A;  2BSY A;  1F7N A;  3TQZ A;  3TPW A;  1PKH A;  1MQ7 A;  2PY4 A;  3ZF2 A;  4APZ 1;  1VYQ A;  3T6Y A;  2J4Q A;  3GF0 A;  1F7K A;  3ZF6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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