2ASTC

Crystal structure of skp1-skp2-cks1 in complex with a p27 peptide
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
69
structure length
69
Chain Sequence
QIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIHEPEPHILLFRRPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis of the Cks1-Dependent Recognition of p27(Kip1) by the SCF(Skp2) Ubiquitin Ligase.
pubmed doi rcsb
molecule tags Ligase/ligase inhibitor
source organism Homo sapiens
molecule keywords S-phase kinase-associated protein 1A
total genus 14
structure length 69
sequence length 69
ec nomenclature
pdb deposition date 2005-08-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01111 CKS Cyclin-dependent kinase regulatory subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.170.10 Alpha Beta 2-Layer Sandwich Cyclin-Dependent Kinase Subunit Type 2 Cyclin-dependent kinase, regulatory subunit 2astC00
4LPAA 2ASTC 4YC6B 5HQ0C 1SCEA 4Y72C 1PUCA 1CKSA 1QB3A 2ASSC 3QY2A 5LQFC 1BUHB 1DKSA 4YC3C 1DKTA
chains in the Genus database with same CATH superfamily
4LPAA 2ASTC 4YC6B 5HQ0C 1SCEA 4Y72C 1PUCA 1CKSA 1QB3A 2ASSC 3QY2A 5LQFC 1BUHB 1DKSA 4YC3C 1DKTA
chains in the Genus database with same CATH topology
4LPAA 2ASTC 4YC6B 5HQ0C 1SCEA 4Y72C 1PUCA 1CKSA 1QB3A 2ASSC 3QY2A 5LQFC 1BUHB 1DKSA 4YC3C 1DKTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LPA A;  2AST C;  4YC6 B;  5HQ0 C;  1SCE A;  4Y72 C;  1PUC A;  1CKS A;  1QB3 A;  2ASS C;  3QY2 A;  5LQF C;  1BUH B;  1DKS A;  4YC3 C;  1DKT A; 
#chains in the Genus database with same CATH topology
 4LPA A;  2AST C;  4YC6 B;  5HQ0 C;  1SCE A;  4Y72 C;  1PUC A;  1CKS A;  1QB3 A;  2ASS C;  3QY2 A;  5LQF C;  1BUH B;  1DKS A;  4YC3 C;  1DKT A; 
#chains in the Genus database with same CATH homology
 4LPA A;  2AST C;  4YC6 B;  5HQ0 C;  1SCE A;  4Y72 C;  1PUC A;  1CKS A;  1QB3 A;  2ASS C;  3QY2 A;  5LQF C;  1BUH B;  1DKS A;  4YC3 C;  1DKT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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