2GPQA

Cap-free structure of eif4e suggests basis for its allosteric regulation
Total Genus 36
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
36
sequence length
217
structure length
217
Chain Sequence
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands.
pubmed doi rcsb
molecule tags Translation
molecule keywords Eukaryotic translation initiation factor 4E
total genus 36
structure length 217
sequence length 217
ec nomenclature
pdb deposition date 2006-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01652 IF4E Eukaryotic initiation factor 4E
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.760.10 Alpha Beta 2-Layer Sandwich RNA Cap, Translation Initiation Factor Eif4e RNA Cap, Translation Initiation Factor Eif4e 2gpqA01
3M94A 5EKVA 2GPQA 3M93A 2Q4KA 2V8YA 2JGCA 2WMCA 4TQCA 4UEDA 4UEAA 4B6UA 3TF2A 4TQBA 4AXGA 1AP8A 5ABYA 4UE8A 1ZTPA 1L8BA 1EJ4A 4DT6A 3AM7A 1RF8A 2W97A 1EJ1A 1IPBA 5EHCA 5T47A 2IDRA 5ABUA 3HXGA 5EI3A 4TPWA 4UE9A 5EIRA 2W97B 1WKWA 3HXIA 3U7XA 2V8XA 5GW6A 5T46A 5T48A 4B6VA 5ABVA 5ABXA 4BEAA 2V8WA 4DUMA 1IPCA 4AZAA 5BXVA 4UECA 1EJHA 4UEBA 2JGBA 2IDVA
chains in the Genus database with same CATH superfamily
3M94A 5EKVA 2GPQA 3M93A 2Q4KA 2V8YA 2JGCA 2WMCA 4TQCA 4UEDA 4UEAA 4B6UA 3TF2A 4TQBA 4AXGA 1AP8A 5ABYA 4UE8A 1ZTPA 1L8BA 1EJ4A 4DT6A 3AM7A 1RF8A 2W97A 1EJ1A 1IPBA 5EHCA 5T47A 2IDRA 5ABUA 3HXGA 5EI3A 4TPWA 4UE9A 5EIRA 2W97B 1WKWA 3HXIA 3U7XA 2V8XA 5GW6A 5T46A 5T48A 4B6VA 5ABVA 5ABXA 4BEAA 2V8WA 4DUMA 1IPCA 4AZAA 5BXVA 4UECA 1EJHA 4UEBA 2JGBA 2IDVA
chains in the Genus database with same CATH topology
3M94A 5EKVA 2GPQA 3M93A 2Q4KA 2V8YA 2JGCA 2WMCA 4TQCA 4UEDA 4UEAA 4B6UA 3TF2A 4TQBA 4AXGA 1AP8A 5ABYA 4UE8A 1ZTPA 1L8BA 1EJ4A 4DT6A 3AM7A 1RF8A 2W97A 1EJ1A 1IPBA 5EHCA 5T47A 2IDRA 5ABUA 3HXGA 5EI3A 4TPWA 4UE9A 5EIRA 2W97B 1WKWA 3HXIA 3U7XA 2V8XA 5GW6A 5T46A 5T48A 4B6VA 5ABVA 5ABXA 4BEAA 2V8WA 4DUMA 1IPCA 4AZAA 5BXVA 4UECA 1EJHA 4UEBA 2JGBA 2IDVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M94 A;  5EKV A;  2GPQ A;  3M93 A;  2Q4K A;  2V8Y A;  2JGC A;  2WMC A;  4TQC A;  4UED A;  4UEA A;  4B6U A;  3TF2 A;  4TQB A;  4AXG A;  1AP8 A;  5ABY A;  4UE8 A;  1ZTP A;  1L8B A;  1EJ4 A;  4DT6 A;  3AM7 A;  1RF8 A;  2W97 A;  1EJ1 A;  1IPB A;  5EHC A;  5T47 A;  2IDR A;  5ABU A;  3HXG A;  5EI3 A;  4TPW A;  4UE9 A;  5EIR A;  2W97 B;  1WKW A;  3HXI A;  3U7X A;  2V8X A;  5GW6 A;  5T46 A;  5T48 A;  4B6V A;  5ABV A;  5ABX A;  4BEA A;  2V8W A;  4DUM A;  1IPC A;  4AZA A;  5BXV A;  4UEC A;  1EJH A;  4UEB A;  2JGB A;  2IDV A; 
#chains in the Genus database with same CATH topology
 3M94 A;  5EKV A;  2GPQ A;  3M93 A;  2Q4K A;  2V8Y A;  2JGC A;  2WMC A;  4TQC A;  4UED A;  4UEA A;  4B6U A;  3TF2 A;  4TQB A;  4AXG A;  1AP8 A;  5ABY A;  4UE8 A;  1ZTP A;  1L8B A;  1EJ4 A;  4DT6 A;  3AM7 A;  1RF8 A;  2W97 A;  1EJ1 A;  1IPB A;  5EHC A;  5T47 A;  2IDR A;  5ABU A;  3HXG A;  5EI3 A;  4TPW A;  4UE9 A;  5EIR A;  2W97 B;  1WKW A;  3HXI A;  3U7X A;  2V8X A;  5GW6 A;  5T46 A;  5T48 A;  4B6V A;  5ABV A;  5ABX A;  4BEA A;  2V8W A;  4DUM A;  1IPC A;  4AZA A;  5BXV A;  4UEC A;  1EJH A;  4UEB A;  2JGB A;  2IDV A; 
#chains in the Genus database with same CATH homology
 3M94 A;  5EKV A;  2GPQ A;  3M93 A;  2Q4K A;  2V8Y A;  2JGC A;  2WMC A;  4TQC A;  4UED A;  4UEA A;  4B6U A;  3TF2 A;  4TQB A;  4AXG A;  1AP8 A;  5ABY A;  4UE8 A;  1ZTP A;  1L8B A;  1EJ4 A;  4DT6 A;  3AM7 A;  1RF8 A;  2W97 A;  1EJ1 A;  1IPB A;  5EHC A;  5T47 A;  2IDR A;  5ABU A;  3HXG A;  5EI3 A;  4TPW A;  4UE9 A;  5EIR A;  2W97 B;  1WKW A;  3HXI A;  3U7X A;  2V8X A;  5GW6 A;  5T46 A;  5T48 A;  4B6V A;  5ABV A;  5ABX A;  4BEA A;  2V8W A;  4DUM A;  1IPC A;  4AZA A;  5BXV A;  4UEC A;  1EJH A;  4UEB A;  2JGB A;  2IDV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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