2W3NA

Structure and inhibition of the co2-sensing carbonic anhydrase can2 from the pathogenic fungus cryptococcus neoformans
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
230
structure length
230
Chain Sequence
PFHAEPLKPSDEIDMDLGHSVAAQKFKEIREVLEGNRYWARKVTSEEPEFMAEQVKGQAPNFLWIGCADSRVPEVTIMARKPGDVFVQRNVANQFKPEDDSSQALLNYAIMNVGVTHVMVVGHTGCGGCIAAFDQPLPTEENPGGTPLVRYLEPIIRLKHSLPEGSDVNDLIKENVKMAVKNVVNSPTIQGAWEQARKGEFREVFVHGWLYDLSTGNIVDLNVTQGPHPF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans.
pubmed doi rcsb
molecule keywords CARBONIC ANHYDRASE 2
molecule tags Lyase
source organism Cryptococcus neoformans
total genus 70
structure length 230
sequence length 230
chains with identical sequence B, C
ec nomenclature ec 4.2.1.1: Carbonic anhydrase.
pdb deposition date 2008-11-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00484 Pro_CA Carbonic anhydrase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1050.10 Alpha Beta 3-Layer(aba) Sandwich Beta-carbonic Anhydrase; Chain A Carbonic anhydrase 2w3nA02
3UCOA 1YLKA 1G5CA 1EKJA 3EYXA 4WAKA 5CXKA 5BQ1A 3MF3A 3UCKA 3E1WA 3E3FA 3E1VA 2A8DA 4WAMA 4YF6A 3E31A 2A5VA 1I6OA 3E3IA 3E2WA 3TENA 1I6PA 2A8CA 4YF5A 3E2XA 5SWCA 1T75A 3UCNA 3VQJA 1DDZA 3TEOA 2ESFA 4O1JA 3VRKA 4YF4A 4O1KA 3LASA 2W3NA 1YM3A 3E2AA 3E24A 2W3QA 3UCJA 4RXYA 3E3GA 4ZNZA 3QY1A 4WAJA 3UCMA 5JJ8A 3E28A
chains in the Genus database with same CATH superfamily
3UCOA 1YLKA 1G5CA 1EKJA 3EYXA 4WAKA 5CXKA 5BQ1A 3MF3A 3UCKA 3E1WA 3E3FA 3E1VA 2A8DA 4WAMA 4YF6A 3E31A 2A5VA 1I6OA 3E3IA 3E2WA 3TENA 1I6PA 2A8CA 4YF5A 3E2XA 5SWCA 1T75A 3UCNA 3VQJA 1DDZA 3TEOA 2ESFA 4O1JA 3VRKA 4YF4A 4O1KA 3LASA 2W3NA 1YM3A 3E2AA 3E24A 2W3QA 3UCJA 4RXYA 3E3GA 4ZNZA 3QY1A 4WAJA 3UCMA 5JJ8A 3E28A
chains in the Genus database with same CATH topology
3UCOA 1YLKA 1G5CA 1EKJA 3EYXA 4WAKA 5CXKA 5BQ1A 3MF3A 3UCKA 3E1WA 3E3FA 3E1VA 2A8DA 4WAMA 4YF6A 3E31A 2A5VA 1I6OA 3E3IA 3E2WA 3TENA 1I6PA 2A8CA 4YF5A 3E2XA 5SWCA 1T75A 3UCNA 3VQJA 1DDZA 3TEOA 2ESFA 4O1JA 3VRKA 4YF4A 4O1KA 3LASA 2W3NA 1YM3A 3E2AA 3E24A 2W3QA 3UCJA 4RXYA 3E3GA 4ZNZA 3QY1A 4WAJA 3UCMA 5JJ8A 3E28A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UCO A;  1YLK A;  1G5C A;  1EKJ A;  3EYX A;  4WAK A;  5CXK A;  5BQ1 A;  3MF3 A;  3UCK A;  3E1W A;  3E3F A;  3E1V A;  2A8D A;  4WAM A;  4YF6 A;  3E31 A;  2A5V A;  1I6O A;  3E3I A;  3E2W A;  3TEN A;  1I6P A;  2A8C A;  4YF5 A;  3E2X A;  5SWC A;  1T75 A;  3UCN A;  3VQJ A;  1DDZ A;  3TEO A;  2ESF A;  4O1J A;  3VRK A;  4YF4 A;  4O1K A;  3LAS A;  2W3N A;  1YM3 A;  3E2A A;  3E24 A;  2W3Q A;  3UCJ A;  4RXY A;  3E3G A;  4ZNZ A;  3QY1 A;  4WAJ A;  3UCM A;  5JJ8 A;  3E28 A; 
#chains in the Genus database with same CATH topology
 3UCO A;  1YLK A;  1G5C A;  1EKJ A;  3EYX A;  4WAK A;  5CXK A;  5BQ1 A;  3MF3 A;  3UCK A;  3E1W A;  3E3F A;  3E1V A;  2A8D A;  4WAM A;  4YF6 A;  3E31 A;  2A5V A;  1I6O A;  3E3I A;  3E2W A;  3TEN A;  1I6P A;  2A8C A;  4YF5 A;  3E2X A;  5SWC A;  1T75 A;  3UCN A;  3VQJ A;  1DDZ A;  3TEO A;  2ESF A;  4O1J A;  3VRK A;  4YF4 A;  4O1K A;  3LAS A;  2W3N A;  1YM3 A;  3E2A A;  3E24 A;  2W3Q A;  3UCJ A;  4RXY A;  3E3G A;  4ZNZ A;  3QY1 A;  4WAJ A;  3UCM A;  5JJ8 A;  3E28 A; 
#chains in the Genus database with same CATH homology
 3UCO A;  1YLK A;  1G5C A;  1EKJ A;  3EYX A;  4WAK A;  5CXK A;  5BQ1 A;  3MF3 A;  3UCK A;  3E1W A;  3E3F A;  3E1V A;  2A8D A;  4WAM A;  4YF6 A;  3E31 A;  2A5V A;  1I6O A;  3E3I A;  3E2W A;  3TEN A;  1I6P A;  2A8C A;  4YF5 A;  3E2X A;  5SWC A;  1T75 A;  3UCN A;  3VQJ A;  1DDZ A;  3TEO A;  2ESF A;  4O1J A;  3VRK A;  4YF4 A;  4O1K A;  3LAS A;  2W3N A;  1YM3 A;  3E2A A;  3E24 A;  2W3Q A;  3UCJ A;  4RXY A;  3E3G A;  4ZNZ A;  3QY1 A;  4WAJ A;  3UCM A;  5JJ8 A;  3E28 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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