2W3NA

Structure and inhibition of the co2-sensing carbonic anhydrase can2 from the pathogenic fungus cryptococcus neoformans
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
230
structure length
230
Chain Sequence
PFHAEPLKPSDEIDMDLGHSVAAQKFKEIREVLEGNRYWARKVTSEEPEFMAEQVKGQAPNFLWIGCADSRVPEVTIMARKPGDVFVQRNVANQFKPEDDSSQALLNYAIMNVGVTHVMVVGHTGCGGCIAAFDQPLPTEENPGGTPLVRYLEPIIRLKHSLPEGSDVNDLIKENVKMAVKNVVNSPTIQGAWEQARKGEFREVFVHGWLYDLSTGNIVDLNVTQGPHPF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans.
pubmed doi rcsb
molecule keywords CARBONIC ANHYDRASE 2
molecule tags Lyase
source organism Cryptococcus neoformans
total genus 70
structure length 230
sequence length 230
chains with identical sequence B, C
ec nomenclature ec 4.2.1.1: Carbonic anhydrase.
pdb deposition date 2008-11-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00484 Pro_CA Carbonic anhydrase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1050.10 Alpha Beta 3-Layer(aba) Sandwich Beta-carbonic Anhydrase; Chain A Carbonic anhydrase 2w3nA02
1I6OA 3UCNA 4YF4A 3E24A 4RXYA 4YF5A 3UCJA 2A8CA 3VRKA 3LASA 2A8DA 3E3IA 4WAKA 3EYXA 3E3FA 4WAMA 4ZNZA 3E3GA 3E2AA 4YF6A 3E2WA 3UCKA 3TEOA 3QY1A 2ESFA 2W3NA 4WAJA 4O1KA 3E31A 3UCOA 3E2XA 3E1WA 4O1JA 5CXKA 3MF3A 1I6PA 2A5VA 5SWCA 3UCMA 1YLKA 5BQ1A 3VQJA 1YM3A 5JJ8A 1G5CA 1DDZA 1EKJA 3E28A 1T75A 3E1VA 3TENA 2W3QA
chains in the Genus database with same CATH superfamily
1I6OA 3UCNA 4YF4A 3E24A 4RXYA 4YF5A 3UCJA 2A8CA 3VRKA 3LASA 2A8DA 3E3IA 4WAKA 3EYXA 3E3FA 4WAMA 4ZNZA 3E3GA 3E2AA 4YF6A 3E2WA 3UCKA 3TEOA 3QY1A 2ESFA 2W3NA 4WAJA 4O1KA 3E31A 3UCOA 3E2XA 3E1WA 4O1JA 5CXKA 3MF3A 1I6PA 2A5VA 5SWCA 3UCMA 1YLKA 5BQ1A 3VQJA 1YM3A 5JJ8A 1G5CA 1DDZA 1EKJA 3E28A 1T75A 3E1VA 3TENA 2W3QA
chains in the Genus database with same CATH topology
1I6OA 3UCNA 4YF4A 3E24A 4RXYA 4YF5A 3UCJA 2A8CA 3VRKA 3LASA 2A8DA 3E3IA 4WAKA 3EYXA 3E3FA 4WAMA 4ZNZA 3E3GA 3E2AA 4YF6A 3E2WA 3UCKA 3TEOA 3QY1A 2ESFA 2W3NA 4WAJA 4O1KA 3E31A 3UCOA 3E2XA 3E1WA 4O1JA 5CXKA 3MF3A 1I6PA 2A5VA 5SWCA 3UCMA 1YLKA 5BQ1A 3VQJA 1YM3A 5JJ8A 1G5CA 1DDZA 1EKJA 3E28A 1T75A 3E1VA 3TENA 2W3QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I6O A;  3UCN A;  4YF4 A;  3E24 A;  4RXY A;  4YF5 A;  3UCJ A;  2A8C A;  3VRK A;  3LAS A;  2A8D A;  3E3I A;  4WAK A;  3EYX A;  3E3F A;  4WAM A;  4ZNZ A;  3E3G A;  3E2A A;  4YF6 A;  3E2W A;  3UCK A;  3TEO A;  3QY1 A;  2ESF A;  2W3N A;  4WAJ A;  4O1K A;  3E31 A;  3UCO A;  3E2X A;  3E1W A;  4O1J A;  5CXK A;  3MF3 A;  1I6P A;  2A5V A;  5SWC A;  3UCM A;  1YLK A;  5BQ1 A;  3VQJ A;  1YM3 A;  5JJ8 A;  1G5C A;  1DDZ A;  1EKJ A;  3E28 A;  1T75 A;  3E1V A;  3TEN A;  2W3Q A; 
#chains in the Genus database with same CATH topology
 1I6O A;  3UCN A;  4YF4 A;  3E24 A;  4RXY A;  4YF5 A;  3UCJ A;  2A8C A;  3VRK A;  3LAS A;  2A8D A;  3E3I A;  4WAK A;  3EYX A;  3E3F A;  4WAM A;  4ZNZ A;  3E3G A;  3E2A A;  4YF6 A;  3E2W A;  3UCK A;  3TEO A;  3QY1 A;  2ESF A;  2W3N A;  4WAJ A;  4O1K A;  3E31 A;  3UCO A;  3E2X A;  3E1W A;  4O1J A;  5CXK A;  3MF3 A;  1I6P A;  2A5V A;  5SWC A;  3UCM A;  1YLK A;  5BQ1 A;  3VQJ A;  1YM3 A;  5JJ8 A;  1G5C A;  1DDZ A;  1EKJ A;  3E28 A;  1T75 A;  3E1V A;  3TEN A;  2W3Q A; 
#chains in the Genus database with same CATH homology
 1I6O A;  3UCN A;  4YF4 A;  3E24 A;  4RXY A;  4YF5 A;  3UCJ A;  2A8C A;  3VRK A;  3LAS A;  2A8D A;  3E3I A;  4WAK A;  3EYX A;  3E3F A;  4WAM A;  4ZNZ A;  3E3G A;  3E2A A;  4YF6 A;  3E2W A;  3UCK A;  3TEO A;  3QY1 A;  2ESF A;  2W3N A;  4WAJ A;  4O1K A;  3E31 A;  3UCO A;  3E2X A;  3E1W A;  4O1J A;  5CXK A;  3MF3 A;  1I6P A;  2A5V A;  5SWC A;  3UCM A;  1YLK A;  5BQ1 A;  3VQJ A;  1YM3 A;  5JJ8 A;  1G5C A;  1DDZ A;  1EKJ A;  3E28 A;  1T75 A;  3E1V A;  3TEN A;  2W3Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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